Role of androgen and gonadotrophins in the development and function of the Sertoli cells and Leydig cells: data from mutant and genetically modified mice.

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Molecular and Cellular Endocrinology

• Publication date

  2009-07-10

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.mce.2008.11.005PMID 19059463
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Sex determination involves synergistic action of SRY and SF1 on a specific Sox9 enhancer

  2008cited by this paper
• Sex determination involves synergistic action of SRY and SF1 on a specific Sox9 enhancer

  2008cited by this paper
• Spermatogenesis and sertoli cell activity in mice lacking sertoli cell receptors for follicle-stimulating hormone and androgen.

  2008cited by this paper
• Leydig cell re-generation and expression of cell signaling molecules in the germ cell-free testis.

  2008cited by this paper
• Hormonal regulation of testicular steroid and cholesterol homeostasis.

  2008cited by this paper
• Altered expression of genes involved in regulation of vitamin A metabolism, solute transportation, and cytoskeletal function in the androgen-insensitive tfm mouse testis.

  2007cited by this paper
• Distinct roles for steroidogenic factor 1 and desert hedgehog pathways in fetal and adult Leydig cell development.

  2007cited by this paper
• The Leydig cell in health and disease

  2007cited by this paper
• Luteinizing hormone beta mutation and hypogonadism in men and women.

  2007cited by this paper
• Effects of ACTH and expression of the melanocortin-2 receptor in the neonatal mouse testis.

  2007cited by this paper
• The development of rat Leydig cell progenitors in vitro: how essential is luteinising hormone?

  2007cited by this paper
• Transcriptional profiling of androgen receptor (AR) mutants suggests instructive and permissive roles of AR signaling in germ cell development.

  2007cited by this paper
• In search of rat stem Leydig cells: identification, isolation, and lineage-specific development.

  2006cited by this paper
• Retinoids and spermatogenesis: Lessons from mutant mice lacking the plasma retinol binding protein

  2006cited by this paper
• Testicular development in the complete androgen insensitivity syndrome

  2006cited by this paper
• Mutations along the pituitary-gonadal axis affecting sexual maturation: novel information from transgenic and knockout mice.

  2006cited by this paper
• The effect of a sertoli cell-selective knockout of the androgen receptor on testicular gene expression in prepubertal mice.

  2006influential reference
• Rhox: a new homeobox gene cluster.

  2005cited by this paper
• The role of androgens in sertoli cell proliferation and functional maturation: studies in mice with total or Sertoli cell-selective ablation of the androgen receptor.

  2005cited by this paper
• Androgen-Regulated Transcripts in the Neonatal Mouse Testis as Determined Through Microarray Analysis1

  2005cited by this paper
• Androgens regulate the permeability of the blood-testis barrier.

  2005cited by this paper
• Mutations in human gonadotropin and gonadotropin-receptor genes

  2005cited by this paper
• Follicle-stimulating hormone induced changes in gene expression of murine testis.

  2004cited by this paper
• Regulation of Sertoli cell number and activity by follicle-stimulating hormone and androgen during postnatal development in the mouse.

  2004cited by this paper
• A Sertoli cell-selective knockout of the androgen receptor causes spermatogenic arrest in meiosis.

  2004cited by this paper
• Hypogonadism in a patient with a mutation in the luteinizing hormone beta-subunit gene.

  2004cited by this paper
• Identification of testosterone-regulated genes in testes of hypogonadal mice using oligonucleotide microarray.

  2004cited by this paper
• Targeted disruption of luteinizing hormone beta-subunit leads to hypogonadism, defects in gonadal steroidogenesis, and infertility.

  2004cited by this paper
• Molecular and genetic regulation of testis descent and external genitalia development.

  2004cited by this paper
• Progenitor cells of the testosterone-producing Leydig cells revealed

  2004influential reference
• Molecular characterization of postnatal development of testicular steroidogenesis in luteinizing hormone receptor knockout mice.

  2004cited by this paper
• Infertility with defective spermatogenesis and hypotestosteronemia in male mice lacking the androgen receptor in Sertoli cells.

  2004cited by this paper
• Adrenocorticotropic hormone directly stimulates testosterone production by the fetal and neonatal mouse testis.

  2003cited by this paper
• Androgen receptor function is required in Sertoli cells for the terminal differentiation of haploid spermatids

  2003cited by this paper
• Sertoli and germ cell development in hypogonadal (hpg) mice expressing transgenic follicle-stimulating hormone alone or in combination with testosterone.

  2003cited by this paper
• Pdgfr-alpha mediates testis cord organization and fetal Leydig cell development in the XY gonad.

  2003cited by this paper
• Pituitary hormones are not required for sexual differentiation of male mice: phenotype of the T/ebp/Nkx2.1 null mutant mice.

  2002cited by this paper
• The expression of the follicle-stimulating hormone receptor in spermatogenesis.

  2002cited by this paper
• Mutation of ARX causes abnormal development of forebrain and testes in mice and X-linked lissencephaly with abnormal genitalia in humans

  2002cited by this paper
• Sertoli and granulosa cell‐specific Cre recombinase activity in transgenic mice

  2002cited by this paper
• Failure of normal adult Leydig cell development in androgen-receptor-deficient mice.

  2002cited by this paper
• Desert Hedgehog/Patched 1 signaling specifies fetal Leydig cell fate in testis organogenesis.

  2002cited by this paper
• FSH beta gene mutations in a female with partial breast development and a male sibling with normal puberty and azoospermia.

  2002cited by this paper
• Normal prenatal but arrested postnatal sexual development of luteinizing hormone receptor knockout (LuRKO) mice.

  2001cited by this paper
• A Developmental Study of the Desert Hedgehog-Null Mouse Testis1

  2001cited by this paper
• Role of gonadotrophins in regulating numbers of Leydig and Sertoli cells during fetal and postnatal development in mice.

  2001cited by this paper
• The effect of a null mutation in the follicle-stimulating hormone receptor gene on mouse reproduction.

  2000cited by this paper
• Studies on the onset of Leydig precursor cell differentiation in the prepubertal rat testis.

  2000cited by this paper
• Studies on the Onset of Leydig Precursor Cell Differentiation in the Prepubertal Rat Testis

  2000cited by this paper
• Leydig Cell Loss and Spermatogenic Arrest in Platelet-Derived Growth Factor (Pdgf)-a–Deficient Mice

  2000cited by this paper
• A molecular basis for estrogen-induced cryptorchidism.

  2000cited by this paper
• Mutations of gonadotropins and gonadotropin receptors: elucidating the physiology and pathophysiology of pituitary-gonadal function.

  2000cited by this paper
• Desert hedgehog (Dhh) Gene Is Required in the Mouse Testis for Formation of Adult-Type Leydig Cells and Normal Development of Peritubular Cells and Seminiferous Tubules

  2000cited by this paper
• Expression of 3beta-hydroxysteroid dehydrogenase type I and type VI isoforms in the mouse testis during development.

  1999cited by this paper
• Male hypogonadism due to a mutation in the gene for the beta-subunit of follicle-stimulating hormone.

  1998cited by this paper
• Androgen receptor expression in the testes and epididymides of prenatal and postnatal sprague-dawley rats

  1998cited by this paper
• Sertoli cells of the mouse testis originate from the coelomic epithelium.

  1998cited by this paper
• Impairing follicle-stimulating hormone (FSH) signaling in vivo: targeted disruption of the FSH receptor leads to aberrant gametogenesis and hormonal imbalance.

  1998cited by this paper
• Direct Interaction of SRY-Related Protein SOX9 and Steroidogenic Factor 1 Regulates Transcription of the Human Anti-Müllerian Hormone Gene

  1998cited by this paper
• Fetal development of Leydig cell activity in the mouse is independent of pituitary gonadotroph function.

  1998cited by this paper
• Ultracytochemistry of 3β-hydroxysteroid dehydrogenase in Leydig cell precursors and vascular endothelial cells of the postnatal rat testis

  1998cited by this paper
• Gonadotropin-independent regulation of steroidogenesis in the fetal rat testis.

  1998cited by this paper
• Follitropin (FSH) Deficiency in an Infertile Male due to FSHβ Gene Mutation. A Syndrome of Normal Puberty and Virilization but Under-developed Testicles with Azoospermia, Low FSH but High Lutropin and Normal Serum Testosterone Concentrations

  1998cited by this paper
• Follicle stimulating hormone is required for ovarian follicle maturation but not male fertility

  1997cited by this paper
• Men homozygous for an inactivating mutation of the follicle-stimulating hormone (FSH) receptor gene present variable suppression of spermatogenesis and fertility

  1997cited by this paper
• Hormonal and cellular regulation of Sertoli cell anti-Müllerian hormone production in the postnatal mouse.

  1997cited by this paper
• Pem: a testosterone- and LH-regulated homeobox gene expressed in mouse Sertoli cells and epididymis.

  1996cited by this paper
• Induction of spermatogenesis by androgens in gonadotropin-deficient (hpg) mice.

  1995cited by this paper
• Morphological studies on the origin of adult-type Leydig cells in rat testis.

  1995cited by this paper
• The effects of recombinant follicle-stimulating hormone on the restoration of spermatogenesis in the gonadotropin-releasing hormone-immunized adult rat.

  1995cited by this paper
• Characteristics of mitotic cells in developing and adult testes with observations on cell lineages.

  1995cited by this paper
• Abnormal Leydig cell development at puberty in the androgen-resistant Tfm mouse.

  1994cited by this paper
• Junction-related Sertoli cell cytoskeleton in testosterone-treated hypophysectomized rats.

  1993cited by this paper
• Postnatal development of testicular cell populations in mice.

  1993cited by this paper
• Recombinant human follicle-stimulating hormone is capable of exerting a biological effect in the adult hypophysectomized rat by reducing the numbers of degenerating germ cells.

  1993cited by this paper
• Hypogonadism caused by a single amino acid substitution in the beta subunit of luteinizing hormone.

  1992cited by this paper
• Effects of FSH on Leydig cell morphology and function in the hypogonadal mouse.

  1992cited by this paper
• In situ analysis of fetal, prepuberal and adult XX----XY chimaeric mouse testes: Sertoli cells are predominantly, but not exclusively, XY.

  1991influential reference
• Stimulatory effects of recombinant follicle-stimulating hormone on Leydig cell function and spermatogenesis in immature hypophysectomized rats.

  1991cited by this paper
• Effects of pure FSH and LH preparations on the number and function of Leydig cells in immature hypophysectomized rats.

  1989cited by this paper
• Differentiation of mammalian embryonic gonad.

  1986influential reference
• Follicle-stimulating hormone induction of Leydig cell maturation.

  1985cited by this paper
• Follicle-Stimulating Hormone Induction of Ley dig Cell Maturation

  1985cited by this paper
• Evidence for a defective seminiferous tubule barrier in testes of Tfm and Sxr mice.

  1983cited by this paper
• Histopathology of undescended testes

  1982cited by this paper
• FSH Stimulation of Leydig Cell Function in the Hypophysectomized Immature Rat

  1976cited by this paper
• X-linked Gene for Testicular Feminization in the Mouse

  1970cited by this paper
• THE SPERMATOGENIC AND SECRETORY FUNCTION OF THE GONADS OF HYPOPHYSECTOMIZED ADULT RATS TREATED WITH PITUITARY FSH AND LH

  1937cited by this paper
• THE PHYSIOLOGIC MAINTENANCE OF THE MALE SEX GLANDS

  1934cited by this paper
• Experimental evidence regarding the rôle of the anterior pituitary in the development and regulation of the genital system

  1927cited by this paper
• Reproductive Biology and Endocrinology Differentiation of Adult-type Leydig Cells Occurs in Gonadotrophin-deficient Mice

  year unknowncited by this paper

• Follicle-Stimulating Hormone and Testosterone Play a Role in the Regulation of Sertoli Cell Functions Following Germ Cell Depletion In Vitro

  2025cites this paper
• Research progress on the adverse effects of high-altitude environment to the male reproductive system: a review study

  2025cites this paper
• NR5A1 and cell population heterogeneity: Insights into developmental and functional disparities and regulatory mechanisms

  2025cites this paper
• Characterization of Metabolic Patterns in Mouse Spermatogenesis and Its Clinical Implications in Humans

  2025cites this paper
• Effectiveness of stem cell therapy for male infertility restoration: A systematic review

  2024cites this paper
• Spermatogenesis in mouse testicular organoids with testis-specific architecture, improved germ cell survival and testosterone production

  2024cites this paper
• Effects of Growth Factors on In Vitro Culture of Neonatal Piglet Testicular Tissue Fragments

  2023cites this paper
• Adverse effects of aspirin on hormonal and hastopathlogical changes in male rats

  2022cites this paper
• Kiss1-dependent and independent release of luteinizing hormone and testosterone in perinatal male rats.

  2022cites this paper
• Intracellular flow cytometric lipid analysis: A multiparametric system to assess distinct lipid classes in live cells.

  2021cites this paper
• Spatiotemporal Small Non-coding RNAs Expressed in the Germline as an Early Biomarker of Testicular Toxicity and Transgenerational Effects Caused by Prenatal Exposure to Nanosized Particles

  2021cites this paper
• Role of the kisspeptin/KISS1 receptor system in the testicular development of mice.

  2021cites this paper
• SEXUAL DIFFERENTIATION

  2020cites this paper
• Prenatal exposure to excess chromium attenuates transcription factors regulating expression of androgen and follicle stimulating hormone receptors in Sertoli cells of prepuberal rats.

  2020cites this paper
• Development and Function of the Ovaries and Testes in the Fetus and Neonate

  2020cites this paper
• Role of the Kisspeptin/KISS1 Receptor System in the Testicular Development of Mice.

  2020cites this paper
• In Vitro and In Vivo Culture Systems for Development of Porcine Testis Cells and Tissue

  2019cites this paper
• The application of the improved 3D rat testicular cells co-culture model on the in vitro toxicity research of HZ1006

  2019cites this paper
• Attenuation of Ifosfamide Adverse Effect on Leydig, Sertoli and Spermatogonia Cells of Ram Testis by Liposome Technique in vitro

  2019cites this paper
• Safety of standardised treatments for haematologic malignancies as regards to testicular endocrine function in children and teenagers.

  2019cites this paper
• Hepatocyte Growth Factor Is a Mouse Fetal Leydig Cell Terminal Differentiation Factor 1

  2019cites this paper
• The Insulin/IGF System in Mammalian Sexual Development and Reproduction

  2019cites this paper
• Evaluation of Antiandrogenic Effects in Castrated Rats Treated with Cassia tora Extract

  2019cites this paper
• Unripe Papaya Seed Ethanol Extract (Carica Papaya, Linn.) Inhibits FSH and LH of Male Mice (Mus Musculus)

  2018cites this paper
• Advances in computational modeling approaches of pituitary gonadotropin signaling

  2018cites this paper
• The Human Leydig Cell

  2018cites this paper
• Protective Effects of Uncultured Adipose‐Derived Stromal Vascular Fraction on Testicular Injury Induced by Torsion‐Detorsion in Rats

  2018cites this paper
• Effects of adipose derived mesenchymal stem cells and erythropoietin in testicular torsion-induced the germ cell injury in the adult albino rat

  2018cites this paper
• The application of the improved 3 D rat testicular cells co-culture model on the in vitro toxicity research of HZ 1006

  2018cites this paper
• Unripe Papaya Seed Ethanol Extract (Carica papaya, Linn.) Inhibits FSH and LH of Male Mice (Mus musculus)

  2018cites this paper
• Effects of glyphosate exposure on sperm concentration in rodents: A systematic review and meta-analysis.

  2017cites this paper
• The Human Leydig Cell

  2017cites this paper
• Salivary Testosterone during the Minipuberty of Infancy


  2017cites this paper
• Mixture effects of azole fungicides on the adrenal gland in a broad dose range.

  2017cites this paper
• Mouse minipuberty coincides with gonocyte transformation into spermatogonial stem cells: a model for human minipuberty.

  2017cites this paper
• CHROMIUM INHIBITS IN VITRO VIABILITY AND STEROIDOGENIC IN RAM LEYDIG CELLS

  2017cites this paper
• Gonadotropin and Steroid Hormone Control of Spermatogonial Differentiation

  2017cites this paper
• Prevention of CCl4 induced hypogonadism with Raphanus sativus seeds in rat.

  2017cites this paper
• Pyrethroid Insecticide Cypermethrin Accelerates Pubertal Onset in Male Mice via Disrupting Hypothalamic-Pituitary-Gonadal Axis.

  2017cites this paper
• Effects of sex steroid hormones on the neurovascular unit in the mouse hypothalamus

  2016cites this paper
• MiRNA-133 b promotes the proliferation of human Sertoli cells through targeting GLI 3

  2016cites this paper
• Structural features of the interstitial tissue of the rats’ testes on exposure to bacterial lipopolysaccharide S. marcescens

  2016cites this paper
• Aspirin affect on Reproduction of Male Rat an-Overview

  2016cites this paper
• EFFECT OF ASPIRIN ON REPRODUCTIVE PROFILE OF MALE RAT AN-OVERVIEW

  2016cites this paper
• Exploration of Steroidoginic Activity of Ketorolac on Isolated Leydig Cells of Goat (Capra hircus) In Vitro: Part II

  2016cites this paper
• MiRNA-133b promotes the proliferation of human Sertoli cells through targeting GLI3

  2016cites this paper
• Investigations on the effects of Typha capensis on male reproductive functions

  2016cites this paper
• Complete Meiosis from Embryonic Stem Cell-Derived Germ Cells In Vitro.

  2016cites this paper
• Gonadotropin suppression in men leads to a reduction in claudin-11 at the Sertoli cell tight junction.

  2016cites this paper
• Hypothalamic control of the male neonatal testosterone surge

  2016cites this paper
• Modèle in vitro pour l'étude de l'expression d'INSL3 en présence de perturbateurs endocriniens

  2016cites this paper
• Effect of Vitamin D on basal and Luteinizing Hormone (LH) induced testosterone production and mitochondrial dehydrogenase activity in cultured Leydig cells from immature and mature rams.

  2015cites this paper
• Chapter 14 – Testicular Development

  2015cites this paper
• Morphological and functional maturation of Leydig cells: from rodent models to primates.

  2015cites this paper
• Novel Role for p110β PI 3-Kinase in Male Fertility through Regulation of Androgen Receptor Activity in Sertoli Cells

  2015cites this paper
• Local injection of mesenchymal stem cells protects testicular torsion-induced germ cell injury

  2015cites this paper
• Androgen receptors in the bonnethead, Sphyrna tiburo: cDNA cloning and tissue-specific expression in the male reproductive tract.

  2015cites this paper
• A Critical Point of Male Gonad Development: Neuroendocrine Correlates of Accelerated Testicular Growth in Rats during Early Life

  2014influential citation
• A remarkable activity of steroid biosynthesis in captopril preserved Leydig cells of mice implicated leukotriene B4 and gonadotropin releasing hormones in vitro

  2014influential citation
• Effect of pyrimethamine treatment on male rat testicular cell population development

  2014cites this paper
• Endocrine control of spermatogenesis: Role of FSH and LH/ testosterone

  2014cites this paper
• Apolipoprotein E Induction in Syrian Hamster Testis Following Tributyltin Exposure

  2014cites this paper
• Development of an in vitro test system for assessment of male, reproductive toxicity.

  2014cites this paper
• Molecular regulation of hypothalamus-pituitary-gonads axis in males.

  2014cites this paper
• Sertoli Cells Maintain Leydig Cell Number and Peritubular Myoid Cell Activity in the Adult Mouse Testis

  2014cites this paper
• Effects of thyroxine treatment during lactation on the testicular function of rats across different ages.

  2013cites this paper
• The ERK1/2 pathway regulates testosterone synthesis by coordinately regulating the expression of steroidogenic genes in Leydig cells.

  2013cites this paper
• Immunohistochemical analysis of steroidogenic acute regulatory protein (StAR) and StAR-binding protein (SBP) expressions in the testes of mice during fetal development.

  2013cites this paper
• Fsh Controls Gene Expression in Fish both Independently of and through Steroid Mediation

  2013cites this paper
• Androgen Receptor (AR) Physiological Roles in Male and Female Reproductive Systems: Lessons Learned from AR-Knockout Mice Lacking AR in Selective Cells1

  2013cites this paper
• AKAP9 Is Essential for Spermatogenesis and Sertoli Cell Maturation in Mice

  2013cites this paper
• The Roles of Fibroblast Growth Factors in the Testicular Development and Tumor

  2013cites this paper
• RiboTag Analysis of Actively Translated mRNAs in Sertoli and Leydig Cells In Vivo

  2013cites this paper
• Leydig cell survival and regeneration in autografted adult mice testis

  2012cites this paper
• Hepatocyte Growth Factor Is a Mouse Fetal Leydig Cell Terminal Differentiation Factor1

  2012cites this paper
• Sexually dimorphic testosterone secretion in prenatal and neonatal mice is independent of kisspeptin-Kiss1r and GnRH signaling.

  2012cites this paper
• Hydroxysteroid Dehydrogenases – Localization, Function and Regulation in the Testis

  2012cites this paper
• Testosterone: List of Contributors

  2012cites this paper
• Testosterone: The role of testosterone in spermatogenesis

  2012cites this paper
• Identification and characterization of new genes and pathways regulating spermatogonial cell fate

  2012cites this paper
• The Investigation on the Mechanism of Neuroprotection by Adenosine in 1,3-Dinitrobenzene Toxicity.

  2012cites this paper
• Running Title: HGF is a FLC terminal differentiation factor

  2012cites this paper
• Etude des mécanismes d'action mis en jeu par la testostérone dans la régulation du comportement sexuel mâle

  2012cites this paper
• Hypogonadism in a patient with two novel mutations of the luteinizing hormone β-subunit gene expressed in a compound heterozygous form.

  2012cites this paper
• Proteomic Changes in Rat Spermatogenesis in Response to In Vivo Androgen Manipulation; Impact on Meiotic Cells

  2012cites this paper
• Comportement d'un "Perturbateur Endocrinien" et d'un "non Perturbateur Endocrinien" vis à vis de la toxicité testiculaire chez le rat

  2011cites this paper
• Social regulation of gene expression in the hypothalamic-pituitary-gonadal axis.

  2011cites this paper
• INFLUÊNCIA DO HORMÔNIO TIREOIDEANO NA ATIVIDADE DO GONADOTROFO

  2011cites this paper
• Isolation of Sertoli, Leydig, and spermatogenic cells from the mouse testis.

  2011cites this paper
• Hormonal regulation of spermatogenesis: insights from constructing genetic models.

  2011cites this paper
• MARINA GRIGOROVA Fine-scale genetic variation of follicle-stimulating hormone beta-subunit coding gene (FSHB) and its association with reproductive health

  2011cites this paper
• Rex1 (Zfp42) null mice show impaired testicular function, abnormal testis morphology, and aberrant gene expression.

  2011cites this paper
• Expression of KIT in the ovary, and the role of somatic precursor cells.

  2011cites this paper
• The Leydig cell MEK/ERK pathway is critical for maintaining a functional population of adult Leydig cells and for fertility.

  2011cites this paper
• Endocrinology of the mammalian fetal testis.

  2011cites this paper
• Hypothalamic-Pituitary-Gonadal Axis Social Regulation of Gene Expression in the

  2011cites this paper
• Testicular Signaling Is the Potential Target of Perfluorooctanesulfonate-Mediated Subfertility in Male Mice1

  2011cites this paper
• Characterisation of androgen receptor function in the male reproductive system through conditional gene targeting

  2011cites this paper
• Innovative non-animal testing strategies for reproductive toxicology: the contribution of Italian partners within the EU project ReProTect.

  2011cites this paper
• GPR56 is essential for testis development and male fertility in mice

  2010cites this paper