Retinal microglia and uveal tract dendritic cells and macrophages are not CX3CR1 dependent in their recruitment and distribution in the young mouse eye.

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Investigative Ophthalmology and Visual Science

• Publication date

  2008-04-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1167/iovs.07-0953PMID 18385080
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2003influential reference
• Constitutive and inflammatory mediator-regulated fractalkine expression in human ocular tissues and cultured cells.

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• Role of fractalkine in leukocyte adhesion and migration and in vascular injury.

  2001cited by this paper
• Analysis of Fractalkine Receptor CX3CR1 Function by Targeted Deletion and Green Fluorescent Protein Reporter Gene Insertion

  2000cited by this paper
• Fractalkine is an epithelial and endothelial cell-derived chemoattractant for intraepithelial lymphocytes in the small intestinal mucosa.

  2000cited by this paper
• Optimal methods for preparation and immunostaining of iris, ciliary body, and choroidal wholemounts.

  2000cited by this paper
• Dendritic cells and macrophages in the uveal tract of the normal mouse eye

  1999cited by this paper
• Immunopathogenic mechanisms in intraocular inflammation.

  1999cited by this paper
• Fractalkine, a CX3C chemokine, is expressed by dendritic cells and is up‐regulated upon dendritic cell maturation

  1999cited by this paper
• Macrophages and dendritic cells in IRBP-induced experimental autoimmune uveoretinitis in B10RIII mice.

  1999cited by this paper
• Abnormalities in Monocyte Recruitment and Cytokine Expression in Monocyte Chemoattractant Protein 1–deficient Mice

  1998cited by this paper
• Marrow-derived activated macrophages are required during the effector phase of experimental autoimmune uveoretinitis in rats.

  1998cited by this paper
• A new class of membrane-bound chemokine with a CX3C motif

  1997cited by this paper
• Severe reduction in leukocyte adhesion and monocyte extravasation in mice deficient in CC chemokine receptor 2.

  1997cited by this paper
• Identification and Molecular Characterization of Fractalkine Receptor CX3CR1, which Mediates Both Leukocyte Migration and Adhesion

  1997cited by this paper
• The distribution of immune cells in the uveal tract of the normal eye

  1997cited by this paper
• Microglia in human retina: a heterogeneous population with distinct ontogenies.

  1996cited by this paper
• Resident and infiltrating immune cells in the uveal tract in the early and late stages of experimental autoimmune uveoretinitis.

  1996cited by this paper
• Development of microglial topography in human retina

  1995cited by this paper
• Flow cytometric identification of a minority population of MHC class II positive cells in the normal rat retina distinct from CD45lowCD11b/c+CD4low parenchymal microglia.

  1995cited by this paper
• Normal adult ramified microglia separated from other central nervous system macrophages by flow cytometric sorting. Phenotypic differences defined and direct ex vivo antigen presentation to myelin basic protein-reactive CD4+ T cells compared.

  1995cited by this paper
• In situ characterization of the human hyalocyte.

  1994cited by this paper
• Localization and characterization of major histocompatibility complex class II-positive cells in the posterior segment of the eye: implications for induction of autoimmune uveoretinitis.

  1994cited by this paper
• Immunomorphologic studies of macrophages and MHC class II-positive dendritic cells in the iris and ciliary body of the rat, mouse, and human eye.

  1994cited by this paper
• Dendritic cells and "dendritic" macrophages in the uveal tract.

  1993cited by this paper
• Class II major histocompatibility complex (Ia) antigen-bearing dendritic cells within the iris and ciliary body of the rat eye: distribution, phenotype and relation to retinal microglia.

  1992cited by this paper
• Morphologic and ultrastructural examination of I-A+ cells in the murine iris.

  1991cited by this paper
• Isolation and direct characterization of resident microglial cells from the normal and inflamed central nervous system.

  1991cited by this paper
• Macrophages related to Bruch's membrane in age-related macular degeneration

  1990cited by this paper
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  year unknowncited by this paper

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