Para-inflammation in the aging retina.

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Progress in retinal and eye research

• Publication date

  2009-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.preteyeres.2009.06.001PMID 19560552
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Oxidative stress in primary open-angle glaucoma.

  2011cited by this paper
• [Epidemiology of age related macular degeneration].

  2009cited by this paper
• Decreased expression of CD200 and CD200 receptor in Alzheimer's disease: a potential mechanism leading to chronic inflammation.

  2009cited by this paper
• Autophagy, exosomes and drusen formation in age-related macular degeneration

  2009cited by this paper
• Macrophages in neovascular age-related macular degeneration: friends or foes?

  2009cited by this paper
• Normal aging involves modulation of specific inflammatory markers in the rat retina and choroid.

  2009cited by this paper
• Immunoregulation of retinal ganglion cell fate in glaucoma.

  2009cited by this paper
• Advanced glycation end product (AGE) accumulation on Bruch's membrane: links to age-related RPE dysfunction.

  2009cited by this paper
• T-cell suppression by programmed cell death 1 ligand 1 on retinal pigment epithelium during inflammatory conditions.

  2009cited by this paper
• A targeted inhibitor of the alternative complement pathway reduces angiogenesis in a mouse model of age-related macular degeneration.

  2009cited by this paper
• Regulated secretion of complement factor H by RPE and its role in RPE migration

  2009influential reference
• Oxygen and blood flow: players in the pathogenesis of glaucoma

  2008cited by this paper
• The inflammatory response to cell death.

  2008cited by this paper
• Induced Autoimmunity to Heat Shock Proteins Elicits Glaucomatous Loss of Retinal Ganglion Cell Neurons via Activated T-Cell-Derived Fas-Ligand

  2008cited by this paper
• Photoreceptor Mitochondrial Oxidative Stress in Experimental Autoimmune Uveitis

  2008cited by this paper
• Age‐dependent accumulation of lipofuscin in perivascular and subretinal microglia in experimental mice

  2008influential reference
• Retinal pigment epithelium-derived CTLA-2alpha induces TGFbeta-producing T regulatory cells.

  2008cited by this paper
• Normal aging involves altered expression of growth factors in the rat choroid.

  2008cited by this paper
• Oxidative stress and open angle glaucoma: is oxidative stress a mechanism for glaucomatous damage or a by-product of topical antiglaucoma medication?

  2008cited by this paper
• How dying cells alert the immune system to danger

  2008cited by this paper
• Microglial activation in human diabetic retinopathy.

  2008cited by this paper
• Increased mitochondrial DNA damage and down-regulation of DNA repair enzymes in aged rodent retinal pigment epithelium and choroid

  2008cited by this paper
• Retinal microglia and uveal tract dendritic cells and macrophages are not CX3CR1 dependent in their recruitment and distribution in the young mouse eye.

  2008cited by this paper
• Complement Receptor of the Ig Superfamily Enhances Complement-Mediated Phagocytosis in a Subpopulation of Tissue Resident Macrophages

  2008cited by this paper
• Functional expression of B7H1 on retinal pigment epithelial cells.

  2008cited by this paper
• Mitochondrial oxidative DNA damage in experimental autoimmune uveitis.

  2008cited by this paper
• Structures of the toll-like receptor family and its ligand complexes.

  2008influential reference
• Expression of nitrotyrosine and oxidative consequences in the trabecular meshwork of patients with primary open-angle glaucoma.

  2008cited by this paper
• Retinal Pigment Epithelium-Derived CTLA-2α Induces TGFβ-Producing T Regulatory Cells12

  2008cited by this paper
• Origin and physiological roles of inflammation

  2008influential reference
• Autophagy in neuroprotection and neurodegeneration: A question of balance.

  2008cited by this paper
• Modulation of neuro-inflammation and vascular response by oxidative stress following cerebral ischemia-reperfusion injury.

  2008cited by this paper
• Oxidative damage–induced inflammation initiates age-related macular degeneration

  2008cited by this paper
• Immunological mechanisms in the pathogenesis of diabetic retinopathy

  2008cited by this paper
• The Aged Retinal Pigment Epithelium/Choroid: A Potential Substratum for the Pathogenesis of Age-Related Macular Degeneration

  2008influential reference
• Risk factors for glaucoma onset and progression.

  2008cited by this paper
• Microglial dystrophy in the aged and Alzheimer's disease brain is associated with ferritin immunoreactivity

  2008cited by this paper
• Oxidative-induced apoptosis to an immortalized ganglion cell line is caspase independent but involves the activation of poly(ADP-ribose)polymerase and apoptosis-inducing factor.

  2008cited by this paper
• The role of inflammatory cytokines in diabetes and its complications.

  2008cited by this paper
• Contribution of TRPV1 to microglia-derived IL-6 and NFkappaB translocation with elevated hydrostatic pressure.

  2008cited by this paper
• Oxidative Stress in Primary Open-angle Glaucoma

  2008cited by this paper
• Immunopathological aspects of age-related macular degeneration

  2008cited by this paper
• Aging is associated with greater nuclear NFκB, reduced IκBα, and increased expression of proinflammatory cytokines in vascular endothelial cells of healthy humans

  2008cited by this paper
• Oxidative Inactivation of the Proteasome in Retinal Pigment Epithelial Cells

  2008cited by this paper
• Systemic Complement Activation in Age-Related Macular Degeneration

  2008influential reference
• Reduced retina microglial activation and improved optic nerve integrity with minocycline treatment in the DBA/2J mouse model of glaucoma.

  2008cited by this paper
• Up-regulation of complement factor B in retinal pigment epithelial cells is accompanied by complement activation in the aged retina.

  2008influential reference
• CD59, a Complement Regulatory Protein, Controls Choroidal Neovascularization in a Mouse Model of Wet-Type Age-Related Macular Degeneration1

  2007cited by this paper
• Distinct Functions between Toll-Like Receptors 3 and 9 in Retinal Pigment Epithelial Cells

  2007influential reference
• Monoclonal antibody-mediated CD200 receptor signaling suppresses macrophage activation and tissue damage in experimental autoimmune uveoretinitis.

  2007cited by this paper
• Receptor for advanced glycation end products (RAGE) in a dash to the rescue: inflammatory signals gone awry in the primal response to stress

  2007cited by this paper
• CXC chemokine receptor 4 regulates neuronal migration and axonal pathfinding in the developing nervous system: implications for neuronal regeneration in the adult brain.

  2007cited by this paper
• Eliminating complement factor D reduces photoreceptor susceptibility to light-induced damage.

  2007cited by this paper
• Signaling to NF-?B by Toll-like receptors

  2007influential reference
• Receptor for AGE (RAGE): weaving tangled webs within the inflammatory response.

  2007cited by this paper
• ROLE OF GENETIC FACTORS AND INFLAMMATION IN AGE-RELATED MACULAR DEGENERATION

  2007influential reference
• Entrapment of CD11b Positive Monocyte in Diabetic Retinopathy

  2007cited by this paper
• RAGE and its ligands in retinal disease.

  2007cited by this paper
• Innate immune sensing of pathogens and danger signals by cell surface Toll-like receptors.

  2007influential reference
• Immunosuppressive properties of the pigmented epithelial cells and the subretinal space.

  2007influential reference
• Senescence regulates macrophage activation and angiogenic fate at sites of tissue injury in mice.

  2007influential reference
• Turnover of resident retinal microglia in the normal adult mouse

  2007influential reference
• Signaling to NF-kappaB by Toll-like receptors.

  2007influential reference
• LYVE-1-positive macrophages are present in normal murine eyes.

  2007influential reference
• Age-related structural abnormalities in the human retina-choroid complex revealed by two-photon excited autofluorescence imaging.

  2007cited by this paper
• Complement, innate immunity and ocular disease.

  2007cited by this paper
• Expression of neuronal nitric oxide synthase in the retina of a rat model of chronic glaucoma.

  2007cited by this paper
• High‐mobility group box 1 (HMGB1) protein at the crossroads between innate and adaptive immunity

  2007influential reference
• Role of complement in neurodegeneration and neuroinflammation.

  2007cited by this paper
• Innate immunity and protective neuroinflammation: new emphasis on the role of neuroimmune regulatory proteins.

  2007cited by this paper
• CX3CR1-dependent subretinal microglia cell accumulation is associated with cardinal features of age-related macular degeneration.

  2007cited by this paper
• The role of complement system in ocular diseases including uveitis and macular degeneration.

  2007cited by this paper
• Restoring the dysfunctional endothelium.

  2007cited by this paper
• Genetic susceptibility to age-related macular degeneration: a paradigm for dissecting complex disease traits.

  2007cited by this paper
• Inflammation in Dry Age-Related Macular Degeneration

  2007cited by this paper
• Inducible nitric oxide synthase isoform is a key mediator of leukostasis and blood-retinal barrier breakdown in diabetic retinopathy.

  2007cited by this paper
• Identification of novel dendritic cell populations in normal mouse retina.

  2007influential reference
• Inflammation and Breakdown of the Blood–Retinal Barrier During “Physiological Aging” in the Rat Retina: A Model for CNS Aging

  2007cited by this paper
• Synthesis of complement factor H by retinal pigment epithelial cells is down-regulated by oxidized photoreceptor outer segments.

  2007influential reference
• TLR signaling

  2006cited by this paper
• Faculty Opinions recommendation of CRIg: a macrophage complement receptor required for phagocytosis of circulating pathogens.

  2006cited by this paper
• The expression of advanced glycation endproduct receptors in rpe cells associated with basal deposits in human maculas.

  2006influential reference
• Selective Inhibition by Grape Seed Proanthocyanidin Extracts of Cell Adhesion Molecule Expression Induced by Advanced Glycation End Products in Endothelial Cells

  2006influential reference
• Inflammation and atherosclerosis.

  2006cited by this paper
• Complement component 1Q (C1Q) upregulation in retina of murine, primate, and human glaucomatous eyes.

  2006cited by this paper
• Retinal synthesis and deposition of complement components induced by ocular hypertension.

  2006cited by this paper
• Atherosclerosis and the Lectin-like OXidized low-density lipoprotein scavenger receptor.

  2006cited by this paper
• Hyaluronan fragments: an information-rich system.

  2006cited by this paper
• The complement system plays a critical role in the development of experimental autoimmune anterior uveitis.

  2006cited by this paper
• High mobility group box 1 protein interacts with multiple Toll-like receptors.

  2006cited by this paper
• Theories of biological aging: Genes, proteins, and free radicals

  2006cited by this paper
• The number of people with glaucoma worldwide in 2010 and 2020

  2006cited by this paper
• Relationships among acylation stimulating protein, adiponectin and complement C3 in lean vs obese type 2 diabetes

  2006cited by this paper
• Nitric oxide release is impaired in hypertensive individuals with familial history of stroke.

  2006cited by this paper
• Retinal autoantibody profile in early age‐related macular degeneration: preliminary findings from the Blue Mountains Eye Study

  2006cited by this paper
• Peroxyl radicals: inductors of neurodegenerative and other inflammatory diseases. Their origin and how they transform cholesterol, phospholipids, plasmalogens, polyunsaturated fatty acids, sugars, and proteins into deleterious products.

  2006cited by this paper
• Hyaluronan: the Jekyll and Hyde molecule.

  2006cited by this paper
• Constitutive nitric oxide synthase activity is required to trigger ischemic tolerance in mouse retina.

  2006cited by this paper
• Mammalian toll-like receptors: from endogenous ligands to tissue regeneration

  2006influential reference
• Involvement of Inflammation, Degradation, and Apoptosis in a Mouse Model of Glaucoma*♦

  2005cited by this paper

• GLP-1 receptor agonists in eye disease: a comprehensive review of current research and future potential

  2026cites this paper
• Viral triggers and genetic predisposition in ocular autoimmunity: unraveling the breakdown of immune privilege and advancing targeted therapeutics.

  2026cites this paper
• Caffeine intake and late dry age-related macular degeneration: tea's protective role-insights from NHANES and Mendelian randomization.

  2026cites this paper
• Retinal Amyloid Clearance Enhanced by 40-Hz Light Flicker via MHC-II+ Microglia Regulation in Mice

  2026cites this paper
• Comparative value of retinal structural features versus systemic inflammatory and renal indicators in predicting short-term anti-VEGF response in diabetic macular edema: focus on OCT biomarkers.

  2026cites this paper
• Pan-Cell Death Protein Signature as a Novel Diagnostic and Prognostic Biomarker for Intracerebral Hemorrhage.

  2026cites this paper
• Epigenetic Reprogramming for Ocular Aging and Disease: Mechanisms, Biomarkers, and the Road to the Clinic.

  2026cites this paper
• Evaluation of Octenidine Dihydrochloride-Induced Cytotoxicity, Apoptosis, and Inflammatory Responses in Human Ocular Epithelial and Retinal Cells

  2025cites this paper
• Dry eye and systemic diseases

  2025cites this paper
• Heterochronic parabiosis uncovers AdipoR1 as a critical player in retinal rejuvenation

  2025cites this paper
• Relationship between Periodontitis and Open-Angle Glaucoma: The Korea National Health and Nutrition Examination Survey.

  2025cites this paper
• Identification and validation of tricarboxylic acid cycle-related diagnostic biomarkers for diabetic nephropathy via weighted gene co-expression network analysis and single-cell transcriptome analysis

  2025cites this paper
• Ozone exposure and increased risk of age-related macular degeneration: Evidence from nationwide cohort and toxicological studies

  2025cites this paper
• The blood–retinal barrier in ocular pathologies: an updated narrative review

  2025cites this paper
• Lycium Barbarum Glycopeptide Alleviates Retinal Inflammation by Suppressing Microglial M1 Polarization via NF-κB/MAPK Pathways.

  2025cites this paper
• Parainflammation in the Ocular System: Considerations on the Underlying Mechanisms and Treatment of Dry Eye Disease

  2025cites this paper
• Exploring Endothelial Cell Dysfunction’s Impact on the Brain-Retina Microenvironment Connection: Molecular Mechanisms and Implications

  2025cites this paper
• Myeloid cell protein tyrosine phosphatase 1B (PTP1B) drives retinal neurodegeneration in diabetic mice

  2025cites this paper
• Relationship of Choroidal Thickness With Age-Related Macular Degeneration in Asians: An Asian Eye Epidemiology Consortium Meta-Analysis

  2025cites this paper
• Advances in Regenerative Medicine, Cell Therapy, and 3D Bioprinting for Glaucoma and Retinal Diseases.

  2025cites this paper
• Unlocking the Potential of Histone Deacetylase Inhibitors in Combatting Age-Related Retinal Degenerative Diseases.

  2025cites this paper
• Macrophage-derived S100A9 promotes diabetic cardiomyopathy by disturbing mitochondrial quality control via STAT3 activation

  2025cites this paper
• Senescence Alters Antimicrobial Peptide Expression and Induces Amyloid‐β Production in Retinal Pigment Epithelial Cells

  2025cites this paper
• Impaired Vagal Tone Function-Based Regulation of Systemic Inflammation in Patients With Neovascular Age-Related Macular Degeneration

  2025cites this paper
• Dual role of microglia in glaucoma: Regulation of neuroinflammation and neuroregeneration.

  2025cites this paper
• Transcriptional Heterogeneity and Differential Response of Rod Photoreceptor Pathway Uncovered by Single‐Cell RNA Sequencing of the Aging Mouse Retina

  2025cites this paper
• Integrating plasma proteomics and genome-wide association data to identify therapeutic targets for retinal neurodegenerative diseases in Europeans.

  2025cites this paper
• The Role of Cytokines in Degenerative Retinal Diseases: A Comprehensive Review

  2025influential citation
• Choroidal macrophages in homeostasis, aging and age-related macular degeneration.

  2024cites this paper
• JR5558 mice are a reliable model to investigate subretinal fibrosis

  2024cites this paper
• The adaptive immune system in the retina of diabetes.

  2024cites this paper
• Dysregulated energy and protein homeostasis and the loss of GABAergic amacrine cells in aging retina.

  2024cites this paper
• The effects of time restricted feeding on age-related changes in the mouse retina.

  2024cites this paper
• The Role of Gut Microbiota in the Pathogenesis of Glaucoma: Evidence from Bibliometric Analysis and Comprehensive Review

  2024cites this paper
• Neuroretinal degeneration in a mouse model of systemic chronic immune activation observed by proteomics

  2024cites this paper
• Complement regulation in the eye: implications for age-related macular degeneration

  2024cites this paper
• Addressing neurodegeneration in glaucoma: Mechanisms, challenges, and treatments.

  2024cites this paper
• Multifunctional nano-in-micro delivery systems for targeted therapy in fundus neovascularization diseases

  2024cites this paper
• The complement pathway as a therapeutic target for neovascular age-related macular degeneration-mediated subretinal fibrosis.

  2024cites this paper
• Disease Associations among Patients Afflicted with Both Glaucoma and Age-Related Macular Degeneration

  2024cites this paper
• Gliosis-dependent expression of complement factor H truncated variants attenuates retinal neurodegeneration following ischemic injury

  2024cites this paper
• Glaucoma: from pathogenic mechanisms to retinal glial cell response to damage

  2024cites this paper
• Effects and potential mechanisms of exercise and physical activity on eye health and ocular diseases

  2024cites this paper
• Chrysin alleviates DNA damage to improve disturbed immune homeostasis and pro-angiogenic environment in laser-induced choroidal neovascularization.

  2024cites this paper
• Ephrin B1 Regulates Inflammatory Pathways in Retinal Müller Cells

  2024cites this paper
• The Role of Complement Dysregulation in Glaucoma

  2024cites this paper
• Persistence of Contact Lens-Induced Corneal Parainflammation Following Lens Removal

  2024cites this paper
• Mitochondrial damage and clearance in retinal pigment epithelial cells

  2024cites this paper
• Age-Related RPE changes in Wildtype C57BL/6J Mice between 2 and 32 Months

  2024cites this paper
• Cytokine Profiling in Aqueous Humor of Glaucoma Patients and in Retinas from an Ex Vivo Glaucoma Animal Model.

  2024cites this paper
• A Novel Bispecific Anti-IL17/VEGF Fusion Trap Exhibits Potent and Long-Lasting Inhibitory Effects on the Development of Age-Related Macular Degeneration

  2024cites this paper
• Inflammatory mechanisms contributing to retinal alterations in HIV infection and long-term ART

  2024influential citation
• Neuroinflammation as a factor of pathogenesis of glaucomatous optic neuropathy

  2024cites this paper
• A Better Understanding of the Clinical and Pathological Changes in Viral Retinitis: Steps to Improve Visual Outcomes

  2024cites this paper
• Loss of Pigment Epithelium Derived Factor Sensitizes C57BL/6J Mice to Light-Induced Retinal Damage

  2024cites this paper
• Mechanism and Therapeutic Targets of Circulating Immune Cells in Diabetic Retinopathy.

  2024cites this paper
• Evolution of the ocular immune system

  2024cites this paper
• Pharmacologic Treatments for Dementia and the Risk of Developing Age-Related Macular Degeneration

  2024cites this paper
• Higher Intraocular Levels of Inflammatory Factors are Related to Retinal Vascular and Neurodegeneration in Myopic Retinopathy

  2024cites this paper
• Distribution and associated factors of choroidal thickness in highly myopic eyes—a real-world study based on a Chinese population

  2024cites this paper
• Corneal application of SOCS1/3 peptides for the treatment of eye diseases mediated by inflammation and oxidative stress

  2024cites this paper
• Efficacy of dexamethasone implant in the management of chronic central serous chorioretinopathy without choroidal neovascularization

  2024cites this paper
• The contribution of pattern recognition receptor signalling in the development of age related macular degeneration: the role of toll-like-receptors and the NLRP3-inflammasome

  2024cites this paper
• Causal associations between circulating inflammatory cytokines and blinding eye diseases: a bidirectional Mendelian randomization analysis

  2024cites this paper
• Role of microglia/macrophage polarisation in intraocular diseases (Review)

  2024cites this paper
• Eye on the horizon: The metabolic landscape of the RPE in aging and disease

  2024cites this paper
• CCL2-mediated inflammatory pathogenesis underlies high myopia-related anxiety

  2023cites this paper
• Retinal ganglion cell repopulation for vision restoration in optic neuropathy: a roadmap from the RReSTORe Consortium

  2023cites this paper
• Beyond the Complement Cascade: Insights into Systemic Immunosenescence and Inflammaging in Age-Related Macular Degeneration and Current Barriers to Treatment

  2023cites this paper
• The possible Role of IFN-γ & TNF-α in bacterial eye infection patients

  2023cites this paper
• Choroidal morphology and microvascular structure in eyes of patients with idiopathic normal pressure hydrocephalus before and after ventriculo-peritoneal shunt surgery

  2023cites this paper
• The central role of the NLRP3 inflammasome pathway in the pathogenesis of age-related diseases in the eye and the brain.

  2023cites this paper
• Three Major Causes of Metabolic Retinal Degenerations and Three Ways to Avoid Them

  2023cites this paper
• Forward genetic screening using fundus spot scale identifies an essential role for Lipe in murine retinal homeostasis

  2023cites this paper
• Homeostasis and dyshomeostasis of the retina

  2023cites this paper
• Emerging strategies of engineering retinal organoids and organoid-on-a-chip in modeling intraocular drug delivery: current progress and future perspectives.

  2023cites this paper
• Short exposure to photo-oxidative damage triggers molecular signals indicative of early retinal degeneration

  2023cites this paper
• Atherosclerosis and Inflammation: Insights from the Theory of General Pathological Processes

  2023cites this paper
• Cerebrospinal Fluid Pressure Reduction Induces Glia-Mediated Retinal Inflammation and Leads to Retinal Ganglion Cell Injury in Rats

  2023cites this paper
• Microphysiological Constructs and Systems: Biofabrication Tactics, Biomimetic Evaluation Approaches, and Biomedical Applications

  2023cites this paper
• Beyond VEGF: Targeting Inflammation and Other Pathways for Treatment of Retinal Disease

  2023cites this paper
• Peripheral Blood Mononuclear Cells from Patients with Type 1 Diabetes and Diabetic Retinopathy Produce Higher Levels of IL-17A, IL-10 and IL-6 and Lower Levels of IFN-γ—A Pilot Study

  2023cites this paper
• Old age promotes retinal fibrosis in choroidal neovascularization through circulating fibrocytes and profibrotic macrophages

  2023cites this paper
• Intraocular neutralizing antibodies against aflibercept in patients with age related macular degeneration

  2023cites this paper
• Melatonin protects retinal integrity through mediated immune homeostasis in the sodium iodate-induced mouse model of age-related macular degeneration.

  2023cites this paper
• The Impact of Aging on the Function of Retinal Ganglion Cells

  2023cites this paper
• Sialic Acid Mimetic Microglial Sialic Acid-Binding Immunoglobulin-like Lectin Agonism: Potential to Restore Retinal Homeostasis and Regain Visual Function in Age-Related Macular Degeneration

  2023cites this paper
• Role of immune inflammation regulated by macrophage in the pathogenesis of age-related macular degeneration.

  2023cites this paper
• The gut microbiome and primary open angle glaucoma: Evidence for a ‘gut-glaucoma’ axis?

  2023cites this paper
• Past history of obesity triggers persistent epigenetic changes in innate immunity and exacerbates neuroinflammation

  2023cites this paper
• Dealing with the Persistent Pathogenic Issues of Dry Eye Disease: The Importance of External and Internal Stimuli and Tissue Responses

  2023cites this paper
• Significant loss of retinal nerve fibre layer and contrast sensitivity in people with well controlled HIV disease: implications for aging with HIV

  2023cites this paper
• Retinal age gap as a predictive biomarker for future risk of clinically significant diabetic retinopathy

  2023cites this paper
• Discussing pathologic mechanisms of Diabetic retinopathy & therapeutic potentials of curcumin and β-glucogallin in the management of Diabetic retinopathy.

  2023cites this paper
• PolySialic acid-nanoparticles inhibit macrophage mediated inflammation through Siglec agonism: a potential treatment for age related macular degeneration

  2023influential citation
• Recent advances in age-related meibomian gland dysfunction (ARMGD).

  2023cites this paper
• HYPERREFLECTIVE FOCI NOT SEEN AS HYPERPIGMENTARY ABNORMALITIES ON COLOR FUNDUS PHOTOGRAPHS IN AGE-RELATED MACULAR DEGENERATION

  2023cites this paper
• Regulatory T cells limit age-associated retinal inflammation and neurodegeneration

  2023cites this paper
• A Review on Diabetic Retinopathy.

  2023cites this paper
• Microglia preserve visual function in the aging retina by supporting retinal pigment epithelial health

  2023cites this paper