Glycosidase inhibitors: a patent review (2008 – 2013)

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Expert Opinion on Therapeutic Patents

• Publication date

  2014-07-18

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1517/13543776.2014.916280PMID 24958352
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Recent developments in design and synthesis of bicyclic azasugars, carbasugars and related molecules as glycosidase inhibitors.

  2013cited by this paper
• Conformational analyses of the reaction coordinate of glycosidases.

  2012cited by this paper
• Hijacking a biosynthetic pathway yields a glycosyltransferase inhibitor within cells

  2011cited by this paper
• QM/MM study of the catalytic mechanism of GalNAc removal from GM2 ganglioside catalyzed by human β-hexosaminidaseA.

  2011cited by this paper
• Pharmacological chaperone therapy for Gaucher disease: a patent review

  2011cited by this paper
• Iminosugars as therapeutic agents: recent advances and promising trends.

  2011cited by this paper
• Nucleotidylation of unsaturated carbasugar in validamycin biosynthesis.

  2011cited by this paper
• Enzymatic glycosyl transfer: mechanisms and applications

  2011cited by this paper
• Iminosugars past, present and future: medicines for tomorrow.

  2011influential reference
• Iminosugars and methods of treating bunyaviral and togaviral diseases

  2010cited by this paper
• QM/MM Studies on the β-Galactosidase Catalytic Mechanism: Hydrolysis and Transglycosylation Reactions.

  2010cited by this paper
• Docking and SAR studies of salacinol derivatives as alpha-glucosidase inhibitors.

  2010cited by this paper
• Synthesis and glycosidase inhibition of the enantiomer of (-)-steviamine, the first example of a new class of indolizidine alkaloid.

  2010cited by this paper
• Molecular mechanism of the glycosylation step catalyzed by Golgi alpha-mannosidase II: a QM/MM metadynamics investigation.

  2010cited by this paper
• DFT studies on the β-glycosidase catalytic mechanism: The deglycosylation step

  2010cited by this paper
• Design and synthesis of 5a-carbaglycopyranosylamime glycosidase inhibitors.

  2009cited by this paper
• Iminosugars: from botanical curiosities to licensed drugs

  2009influential reference
• Docking and molecular dynamics studies on the stereoselectivity in the enzymatic synthesis of carbohydrates

  2009cited by this paper
• Glycomimetics at the mirror: medicinal chemistry of L-iminosugars.

  2009cited by this paper
• Glycosidase inhibition: assessing mimicry of the transition state

  2009cited by this paper
• Molecular interaction of imino sugars with human alpha-galactosidase: Insight into the mechanism of complex formation and pharmacological chaperone action in Fabry disease.

  2009cited by this paper
• Sugar-mimicking glycosidase inhibitors: bioactivity and application

  2009cited by this paper
• Pandemic Influenza: An Inconvenient Mutation

  2009cited by this paper
• Divergence of Catalytic Mechanism within a Glycosidase Family Provides Insight into Evolution of Carbohydrate Metabolism by Human Gut Flora

  2008cited by this paper
• Crystal structures of oseltamivir-resistant influenza virus neuraminidase mutants

  2008cited by this paper
• The Structure of a New Piperidine Derivative from Buckwheat Seeds ( Fagopyrum esculentum Moench )

  2008cited by this paper
• Fabry's disease.

  2008cited by this paper
• Carbohydrate‐binding modules from family 11: Understanding the binding mode of polysaccharides

  2008cited by this paper
• Mechanistic insights into glycosidase chemistry.

  2008cited by this paper
• The Carbohydrate-Active EnZymes database (CAZy): an expert resource for Glycogenomics

  2008cited by this paper
• Mechanistic studies on the formation of glycosidase‐substrate and glycosidase‐inhibitor covalent intermediates

  2008cited by this paper
• Molecular determinants of ligand specificity in family 11 carbohydrate binding modules – an NMR, X‐ray crystallography and computational chemistry approach

  2008cited by this paper
• Lysosomal Storage Disease 3 Fabry's disease

  2008cited by this paper
• Ribonucleotide reductase: a critical enzyme for cancer chemotherapy and antiviral agents.

  2007cited by this paper
• Influenza Neuraminidase Inhibitors as Antiviral Agents

  2006cited by this paper
• Oseltamivir (Tamiflu) and its potential for use in the event of an influenza pandemic.

  2005cited by this paper
• Imino sugar inhibitors for treating the lysosomal glycosphingolipidoses.

  2005cited by this paper
• Thiosugars: new perspectives regarding availability and potential biochemical and medicinal applications

  2005cited by this paper
• Iminosugar-producing Thai medicinal plants.

  2005cited by this paper
• Overview of ribonucleotide reductase inhibitors: an appealing target in anti-tumour therapy.

  2005cited by this paper
• Microsomal glucosidases of rat liver. Partial purification and inhibition by disaccharides.

  2005cited by this paper
• Biological properties of D- and L-1-deoxyazasugars.

  2005cited by this paper
• Celgosivir: α-Glucosidase inhibitor anti-hepatitis C virus drug

  2005cited by this paper
• Penasulfate A, a new alpha-glucosidase inhibitor from a marine sponge Penares sp.

  2004cited by this paper
• Structure-activity relationships for alpha-glucosidase inhibition of baicalein, 5,6,7-trihydroxyflavone: the effect of A-ring substitution.

  2004cited by this paper
• Cellular effects of deoxynojirimycin analogues: uptake, retention and inhibition of glycosphingolipid biosynthesis.

  2004cited by this paper
• Schulzeines A-C, new alpha-glucosidase inhibitors from the marine sponge Penares schulzei.

  2004cited by this paper
• Penasulfate A, a new α-glucosidase inhibitor from a marine sponge Penares sp.

  2004cited by this paper
• Inhibitory activity of corn-derived bisamide compounds against alpha-glucosidase.

  2003cited by this paper
• Glycosidase inhibitors: update and perspectives on practical use.

  2003cited by this paper
• Synthesis and partial biological evaluation of a small library of differentially-linked beta-C-disaccharides.

  2003cited by this paper
• Miglustat: Treatment of Gaucher's disease ceramide glucosyltransferase inhibitor α-glucosidase inhibitor

  2003cited by this paper
• Inhibitory activity of corn-derived bisamide compounds against α-glucosidase

  2003cited by this paper
• Glycosidase mechanisms.

  2002cited by this paper
• Absolute stereostructure of potent alpha-glucosidase inhibitor, Salacinol, with unique thiosugar sulfonium sulfate inner salt structure from Salacia reticulata.

  2002cited by this paper
• Chemical chaperones increase the cellular activity of N370S β-glucosidase: A therapeutic strategy for Gaucher disease

  2002cited by this paper
• Recent developments of transition-state analogue glycosidase inhibitors of non-natural product origin.

  2002cited by this paper
• Alpha-glucosidase inhibitors with a 4,5,6,7-tetrachlorophthalimide skeleton pendanted with a cycloalkyl or dicarba-closo-dodecaborane group.

  2001cited by this paper
• The biosynthesis of acarbose and validamycin.

  2001cited by this paper
• Novel α-glucosidase inhibitors with a tetrachlorophthalimide skeleton

  2000cited by this paper
• Water soluble nortropane alkaloids in crude drugs, edible fruits and vegetables: biological activities and therapeutic applications.

  2000cited by this paper
• Sugar-mimic glycosidase inhibitors: natural occurrence, biological activity and prospects for therapeutic application

  2000influential reference
• Thiolactomycin and Related Analogues as Novel Anti-mycobacterial Agents Targeting KasA and KasB Condensing Enzymes inMycobacterium tuberculosis *

  2000cited by this paper
• Novel alpha-glucosidase inhibitors with a tetrachlorophthalimide skeleton.

  2000cited by this paper
• Structural Basis for Catalysis and Inhibition ofN-Glycan Processing Class I α1,2-Mannosidases*

  2000cited by this paper
• Glycosidase mechanisms: anatomy of a finely tuned catalyst.

  1999cited by this paper
• Involvement of Endoplasmic Reticulum Chaperones in the Folding of Hepatitis C Virus Glycoproteins

  1998cited by this paper
• Syntheses of 1-deoxy-3-S-(1-thio-α-d-glucopyranosyl)-mannojirimycin and 1-deoxy-3-O-(5-thio-α-d-glucopyranosyl)-mannojirimycin as potential inhibitors of endo-α-d-mannosidase

  1998cited by this paper
• α‐Glucosidase inhibitors as potential broad based anti‐viral agents

  1998cited by this paper
• Kotalanol, a potent alpha-glucosidase inhibitor with thiosugar sulfonium sulfate structure, from antidiabetic ayurvedic medicine Salacia reticulata.

  1998cited by this paper
• Syntheses of 1-deoxy-3-s-(1-thio-alpha-D-glucopyranosyl)-mannojirimycin and 1-deoxy-3-O-(5-thio-alpha-D-glucopyranosyl)-mannojirimycin as potential inhibitors of endo-alpha-D-mannosidase.

  1998cited by this paper
• Spontaneous Hydrolysis of Glycosides

  1998cited by this paper
• Glycosidase-inhibiting pyrrolidine alkaloids from Hyacinthoides non-scripta

  1997cited by this paper
• Structural and sequence-based classification of glycoside hydrolases.

  1997cited by this paper
• Salacinol, potent antidiabetic principle with unique thiosugar sulfonium sulfate structure from the Ayurvedic traditional medicine Salacia reticulata in Sri Lanka and India

  1997cited by this paper
• Fluorinated Sugars as Probes of Glycosidase Mechanisms

  1996cited by this paper
• Biological activities of the nortropane alkaloid, calystegine B2, and analogs: structure-function relationships.

  1996cited by this paper
• Substituted glycals as probes of glycosidase mechanisms.

  1996cited by this paper
• Approaches to labeling and identification of active site residues in glycosidases

  1995cited by this paper
• The Trehalase Inhibitor Salbostatin, a Novel Metabolite from Streptomyces albus, ATCC21838

  1994cited by this paper
• Synthesis of isofagomine, a novel glycosidase inhibitor

  1994cited by this paper
• Isofagomine, a potent, new glycosidase inhibitor

  1994cited by this paper
• Calystegines in Solanum and Datura species and the death's-head hawk-moth (Acherontia atropus)

  1993cited by this paper
• Enzyme-Catalyzed Aldol Condensation for Asymmetric Synthesis of Azasugars: Synthesis, Evaluation, and Modeling of Glycosidase Inhibitors.

  1991cited by this paper
• α-Homonojirimycin and 2,5-dihydroxymethyl-3,4-dihydroxy-pyrrolidine: Alkaloidal glycosidase inhibitors in the moth Urania fulgens

  1990cited by this paper
• Alkaloids of Rothia trifoliata and Rothia hirsuta.

  1988cited by this paper
• A plasmid of Rhizobium meliloti 41 encodes catabolism of two compounds from root exudate of Calystegium sepium

  1988cited by this paper
• Isolation from and x-ray crystal structure of alexine, (1r,2r,3r,7s,8s)-3-hydroxymethyl-1,2,7-trihydroxypyrrolizidine [(2r,3r,4r,5s,6s)-2-hydroxymethyl-1-azabicyclo[3.3.0]octan-3,4,6-triol], a unique pyrrolizidine alkaloid

  1988cited by this paper
• Aminosugar derivatives as potential anti-human immunodeficiency virus agents.

  1988cited by this paper
• Australine, a Novel Pyrrolizidine Alkaloid Glucosidase Inhibitor from Castanospermum australe

  1988cited by this paper
• Effect of validamycins on glycohydrolases of Rhizoctonia solani.

  1987cited by this paper
• Synthesis of amylostatin (XG), α-glucosidase inhibitor with basic pseudotrisaccharide structure

  1983cited by this paper
• NEW α-AMYLASE INHIBITOR, TRESTATINS

  1983cited by this paper
• New alpha-amylase inhibitor, trestatins. I. Isolation, characterization and biological activities of trestatins A, B and C.

  1983cited by this paper
• Studies on the alpha-glucoside hydrolase inhibitor, adiposin. III. alpha Glucoside hydrolase inhibitory activity and antibacterial activity in vitro.

  1982cited by this paper
• Loco intoxication: indolizidine alkaloids of spotted locoweed (Astragalus lentiginosus).

  1982cited by this paper
• Studies on the alpha-glucoside hydrolase inhibitor, adiposin. I. Isolation and physicochemical properties.

  1982cited by this paper
• Swainsonine: an inhibitor of glycoprotein processing.

  1981cited by this paper
• Castanospermine, A 1,6,7,8-tetrahydroxyoctahydroindolizine alkaloid, from seeds of Castanospermum australe

  1981cited by this paper
• A Spectroscopic Investigation of Swainsonine: An α-Mannosidase Inhibitor Isolated from Swainsona canescens

  1979cited by this paper

• Stereoselective Synthesis of C‑Glycosylated Pyrrolizidines through Nitrone Cycloadditions

  2026cites this paper
• 1-Deoxynojirimycin-producing bacteria: production, optimization, biosynthesis, biological activities

  2024cites this paper
• Acremonium sp. diglycosidase-aid chemical diversification: valorization of industry by-products

  2024cites this paper
• Spirocyclopropyl carbohydrates: Synthesis and applications

  2023cites this paper
• Eugenia sonderiana O. Berg leaves: Phytochemical characterization, evaluation of in vitro and in vivo antidiabetic effects, and structure-activity correlation.

  2023cites this paper
• Borylated 2,3,4,5-Tetrachlorophthalimide and Their 2,3,4,5-Tetrachlorobenzamide Analogues: Synthesis, Their Glycosidase Inhibition and Anticancer Properties in View to Boron Neutron Capture Therapy

  2022cites this paper
• Enzyme-responsive smart nanocarriers for targeted chemotherapy: an overview

  2021cites this paper
• Structure based virtual screening of natural product molecules as glycosidase inhibitors

  2021cites this paper
• Cyclisations and Strategies for Stereoselective Synthesis of Piperidine Iminosugars

  2021cites this paper
• Piperidine Azasugars Bearing Lipophilic Chains: Stereoselective Synthesis and Biological Activity as Inhibitors of Glucocerebrosidase (GCase)

  2021cites this paper
• An overview of therapeutic potential of N-alkylated 1-deoxynojirimycin congeners.

  2021cites this paper
• Assessment of Free radical scavenging and digestive enzyme inhibitory activities of extract, fractions and isolated compounds from Tetracera macrophylla leaves

  2020cites this paper
• Natural and synthetic sugar mimics

  2020cites this paper
• Fluorescent glycoconjugates and their applications.

  2020cites this paper
• A versatile stereocontrolled synthesis of 2-deoxyiminosugar C-glycosides and their evaluation as glycosidase inhibitors.

  2020cites this paper
• Intramolecular Tandem seleno-Michael/Aldol Reaction - Novel Strategy in Carbasugars Synthesis

  2020cites this paper
• Synthesis and Glycosidase Inhibition Properties of Calix[8]arene-Based Iminosugar Click Clusters

  2020cites this paper
• Stereospecific Synthesis of Glycoside Mimics Through Migita‐Kosugi‐Stille Cross‐Coupling Reactions of Chemically and Configurationally Stable 1‐ C ‐Tributylstannyl Iminosugars

  2020cites this paper
• Conformationally Restricted Oxazolidin‐2‐one Fused Bicyclic Iminosugars as Potential Glycosidase Inhibitors

  2020cites this paper
• 1-Ethyl 2-methyl 3,4-bis(acetyloxy)pyrrolidine-1,2-dicarboxylate: crystal structure, Hirshfeld surface analysis and computational chemistry

  2020cites this paper
• Synthesis and Therapeutic Applications of Iminosugars in Cystic Fibrosis

  2020cites this paper
• Reductive Amination Routes in the Synthesis of Piperidine IminoSugars

  2020cites this paper
• Studies for the Multimerization of DAB-1-Based Iminosugars through Iteration of the Nitrone Cycloaddition/Ring-Opening/Allylation Sequence

  2019cites this paper
• In silico Leishmania proteome mining applied to identify drug target potential to be used to treat against visceral and tegumentary leishmaniasis.

  2019cites this paper
• High‐Throughput Approaches in Carbohydrate‐Active Enzymology: Glycosidase and Glycosyl Transferase Inhibitors, Evolution, and Discovery

  2019cites this paper
• Selective synthesis of 3-deoxy-5-hydroxy-1-amino-carbasugars as potential α-glucosidase inhibitors.

  2019cites this paper
• Screening of 1,2-furanonaphthoquinones 1,2,3-1H-triazoles for glycosidases inhibitory activity and free radical scavenging potential: an insight in anticancer activity

  2019cites this paper
• Iminosugars: Effects of Stereochemistry, Ring Size, and N-Substituents on Glucosidase Activities

  2019cites this paper
• α-GLUCOSIDASE INHIBITION OF LACTONE INTERMEDIATES OF THE IMINOSUGAR DEOXYNOJIRIMYCIN

  2019cites this paper
• Divergent Synthesis of Bicyclic Iminosugars: Preparation of (−)‐Swainsonine‐Based Alkaloids and Their Inhibition Study towardsα‐Human Mannosidases

  2019cites this paper
• Giant Glycosidase Inhibitors: First- and Second-Generation Fullerodendrimers with a Dense Iminosugar Shell.

  2018cites this paper
• Short synthesis, X-ray and conformational analysis of a cyclic peracetylated L-sorbose-derived nitrone, a useful intermediate towards N–O-containing D-gluco-iminosugars

  2018cites this paper
• Evaluación del efecto antioxidante e hipoglicemiante del extracto hidroalcohólico de la corteza de Curarea tecunarum “abuta” en ratones albinos con hiperglicemia inducida por aloxano

  2018cites this paper
• Regio- and stereospecific synthesis of rac-carbasugar-based cyclohexane pentols; Investigations of their α- and β-glucosidase inhibitions.

  2018cites this paper
• Stereocontrolled synthesis of polyhydroxylated bicyclic azetidines as a new class of iminosugars.

  2018cites this paper
• High-Throughput In Vitro Screening for Inhibitors of Cereal α-Glucosidase.

  2018cites this paper
• Structural Basis of Outstanding Multivalent Effects in Jack Bean α-Mannosidase Inhibition.

  2018cites this paper
• Transient Sulfenic Acids in the Synthesis of Biologically Relevant Products

  2018cites this paper
• Selective glycosidase inhibitors: A patent review (2012-present).

  2018cites this paper
• Aziridination of Cyclic Nitrones Targeting Constrained Iminosugars.

  2017cites this paper
• The induction of oxidative stress in cervix carcinoma cells by levoglucosenone derived 4-S-salicyl derivative and (1-4)-S-thio-disaccharides. Part 4.

  2017cites this paper
• The Synthesis and Biological Characterization of Acetal-Free Mimics of the Tumor-Associated Carbohydrate Antigens.

  2017cites this paper
• Polyhydroxylated Quinolizidine Iminosugars as Nanomolar Selective Inhibitors of α-Glucosidases.

  2017cites this paper
• Synthesis of Highly Substituted and Enantiomerically Pure 2,3,4‐Tris(hydroxyalkyl)pyrrolidines Using a 1,3‐Dipolar Cycloaddition Reaction as Key Step

  2017cites this paper
• The effects of selective inhibitors of N-Glycosylation and Endoplasmic Reticulum stress inducers on Neuroblastoma cell proliferation and Apoptosis

  2017cites this paper
• Ethyl 2-(4-methoxyphenyl)-6-oxa-3-azabicyclo[3.1.0]hexane-3-carboxylate: crystal structure and Hirshfeld analysis

  2017cites this paper
• Antioxidant and Antidiabetic Effects of Flavonoids: A Structure-Activity Relationship Based Study

  2017cites this paper
• Bicyclic isoureas derived from 1-deoxynojirimycin are potent inhibitors of β-glucocerebrosidase.

  2016cites this paper
• Efficacy and risk profile of anti-diabetic therapies: Conventional vs traditional drugs-A mechanistic revisit to understand their mode of action.

  2016cites this paper
• Understanding multivalent effects in glycosidase inhibition using C-glycoside click clusters as molecular probes

  2016cites this paper
• Conformationally-locked N-glycosides: exploiting long-range non-glycone interactions in the design of pharmacological chaperones for Gaucher disease.

  2015cites this paper
• Re-exploring promising α-glucosidase inhibitors for potential development into oral anti-diabetic drugs: Finding needle in the haystack.

  2015cites this paper
• Hydroxymethyl-Branched Polyhydroxylated Indolizidines: Novel Selective α-Glucosidase Inhibitors.

  2015cites this paper