Ras-dependent induction of cellular responses by constitutively active phosphatidylinositol-3 kinase.

No abstract is available for this paper.

• Publication year

  1995

• Venue

  Science

• Publication date

  1995-04-07

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1126/SCIENCE.7701328PMID 7701328
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Direct association of p110 beta phosphatidylinositol 3-kinase with p85 is mediated by an N-terminal fragment of p110 beta

  1994cited by this paper
• PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase

  1994cited by this paper
• A mammalian protein targeted by G1-arresting rapamycin–receptor complex

  1994cited by this paper
• PI 3‐kinase: structural and functional analysis of intersubunit interactions.

  1994cited by this paper
• Phosphatidylinositol-3-OH kinase direct target of Ras

  1994cited by this paper
• Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation

  1994cited by this paper
• RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs.

  1994cited by this paper
• Disruption of PDGF receptor trafficking by mutation of its PI-3 kinase binding sites.

  1994cited by this paper
• Regulation of chemotaxis by the platelet-derived growth factor receptor-β

  1994cited by this paper
• Phosphatidylinositol 3-kinase activation is mediated by high-affinity interactions between distinct domains within the p110 and p85 subunits

  1994cited by this paper
• Phospholipase C-γ1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signal

  1993cited by this paper
• Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression.

  1993cited by this paper
• Phosphatidylinositol 3-kinase encoded by yeast VPS34 gene essential for protein sorting.

  1993cited by this paper
• A region of the 85-kilodalton (kDa) subunit of phosphatidylinositol 3-kinase binds the 110-kDa catalytic subunit in vivo.

  1993cited by this paper
• Raf-1 protein kinase is important for progesterone-induced Xenopus oocyte maturation and acts downstream of mos

  1993cited by this paper
• Dominant missense mutations in a novel yeast protein related to mammalian phosphatidylinositol 3-kinase and VPS34 abrogate rapamycin cytotoxicity

  1993cited by this paper
• Raf-1 kinase is essential for early Xenopus development and mediates the induction of mesoderm by FGF.

  1993cited by this paper
• Platelet-derived growth factor receptor mediates activation of ras through different signaling pathways in different cell types

  1993cited by this paper
• Distinct phosphotyrosines on a growth factor receptor bind to specific molecules that mediate different signaling pathways.

  1992cited by this paper
• Oncogenes and signal transduction.

  1991cited by this paper
• Eukaryotic proteins expressed in Escherichia coli: an improved thrombin cleavage and purification procedure of fusion proteins with glutathione S-transferase.

  1991cited by this paper
• Platelet-derived growth factor stimulates formation of active p21ras.GTP complex in Swiss mouse 3T3 cells.

  1990cited by this paper
• SR alpha promoter: an efficient and versatile mammalian cDNA expression system composed of the simian virus 40 early promoter and the R-U5 segment of human T-cell leukemia virus type 1 long terminal repeat

  1988cited by this paper
• Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate

  1988cited by this paper
• A cytoplasmic protein stimulates normal N-ras p21 GTPase, but does not affect oncogenic mutants.

  1987cited by this paper
• Common elements in growth factor stimulation and oncogenic transformation: 85 kd phosphoprotein and phosphatidylinositol kinase activity.

  1987cited by this paper
• Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product

  1985cited by this paper
• The structure of an antigenic determinant in a protein.

  1984cited by this paper

• Phosphorylation of the β2 integrin subunit CD18 contributes to Actinobacillus pleuropneumoniae ApxI-induced cytotoxicity through the downregulation of Akt activity

  2025influential citation
• Phosphoinositide 3-kinase regulates wild-type RAS signaling to confer resistance to KRAS inhibition

  2025cites this paper
• Non-catalytic role of phosphoinositide 3-kinase in mesenchymal cell migration through non-canonical induction of p85β/AP2-mediated endocytosis

  2024cites this paper
• Cellular signals integrate cell cycle and metabolic control in cancer.

  2023cites this paper
• Non-catalytic role of phosphoinositide 3-kinase in mesenchymal cell migration through non-canonical induction of p85β/AP-2-mediated endocytosis

  2023cites this paper
• Non-catalytic role of phosphoinositide 3-kinase in mesenchymal cell migration through non-canonical induction of p85β/AP-2-mediated endocytosis

  2023cites this paper
• Novel wiring of the AKT-RSK2 signaling pathway plays an essential role in cancer cell proliferation via a G1/S cell cycle transition.

  2022cites this paper
• Structural Plasticity of Dopaminergic Neurons Requires the Activation of the D3R-nAChR Heteromer and the PI3K-ERK1/2/Akt-Induced Expression of c-Fos and p70S6K Signaling Pathway

  2022cites this paper
• Akt phosphorylates insulin receptor substrate to limit PI3K-mediated PIP3 synthesis

  2021cites this paper
• Regulation of Cell Cycle Progression by Growth Factor-Induced Cell Signaling

  2021cites this paper
• Cushing syndrome and glucocorticoids: T-cell lymphopenia, apoptosis and rescue by IL-21.

  2021cites this paper
• Concepts and Application of DNA Origami and DNA Self-Assembly: A Systematic Review

  2021cites this paper
• Microtubule Stabilization Promotes Microcirculation Reconstruction After Spinal Cord Injury

  2020cites this paper
• CD146, from a melanoma cell adhesion molecule to a signaling receptor

  2020cites this paper
• Constitutively active PIK3CA mutations are expressed by lymphatic and vascular endothelial cells in capillary lymphatic venous malformation

  2020cites this paper
• A Novel Mechanism of bta-miR-210 in Bovine Early Intramuscular Adipogenesis

  2020cites this paper
• The liver fibrosis niche: Novel insights into the interplay between fibrosis-composing mesenchymal cells, immune cells, endothelial cells, and extracellular matrix.

  2020cites this paper
• Fibrotic Signaling Pathways of Skin Fibroblasts in Nephrogenic Systemic Fibrosis

  2019cites this paper
• p110γ deficiency protects against pancreatic carcinogenesis yet predisposes to diet-induced hepatotoxicity

  2019influential citation
• Epimagnolin targeting on an active pocket of mammalian target of rapamycin suppressed cell transformation and colony growth of lung cancer cells

  2019cites this paper
• Cellular and molecular mechanisms of PIK3CA-related vascular anomalies

  2019cites this paper
• p85α Inactivates MMP-2 and Suppresses Bladder Cancer Invasion by Inhibiting MMP-14 Transcription and TIMP-2 Degradation

  2019cites this paper
• Network-based predictions of in vivo cardiac hypertrophy.

  2018cites this paper
• PTPRS Regulates Colorectal Cancer RAS Pathway Activity by Inactivating Erk and Preventing Its Nuclear Translocation

  2018cites this paper
• Identification of the Binding Sites on Rab5 and p110beta Phosphatidylinositol 3-kinase

  2017cites this paper
• Epidermal Growth Factor Receptor Cell Proliferation Signaling Pathways

  2017cites this paper
• Molecular Regulation of Sprouting Angiogenesis.

  2017cites this paper
• Direct binding of MEK1 and MEK2 to AKT induces Foxo1 phosphorylation, cellular migration and metastasis

  2017cites this paper
• PDGFR Signaling Mediates Hyperproliferation and Fibrotic Responses of Subsynovial Connective Tissue Cells in Idiopathic Carpal Tunnel Syndrome

  2017cites this paper
• response to urea PI3K signaling in the murine kidney inner medullary cell

  2016cites this paper
• Upregulation of SQSTM1/p62 contributes to nickel-induced malignant transformation of human bronchial epithelial cells

  2016cites this paper
• Protein Complex Production from the Drug Discovery Standpoint.

  2016cites this paper
• Outside-in integrin signalling regulates haematopoietic stem cell function via Periostin-Itgav axis

  2016cites this paper
• (-)-Liriopein B Suppresses Breast Cancer Progression via Inhibition of Multiple Kinases.

  2015cites this paper
• Platelet-derived growth factor signaling in the lung. From lung development and disease to clinical studies.

  2015cites this paper
• Ras activation revisited: role of GEF and GAP systems

  2015cites this paper
• ADAM9 disintegrin domain activates human neutrophils through an autocrine circuit involving integrins and CXCR2

  2015cites this paper
• PIP3 Induces the Recycling of Receptor Tyrosine Kinases

  2014influential citation
• Platelet-derived Growth Factor-C (PDGF-C) Induces Anti-apoptotic Effects on Macrophages through Akt and Bad Phosphorylation*

  2014cites this paper
• Untersuchung zur Rolle Ras-vermittelter Signaltransduktion in Hydractinia echinata (Cnidarier)

  2014influential citation
• A review of platelet derived growth factor playing pivotal role in bone regeneration.

  2014cites this paper
• Nerve Growth Factor (NGF) Regulates Activity of Nuclear Factor of Activated T-cells (NFAT) in Neurons via the Phosphatidylinositol 3-Kinase (PI3K)-Akt-Glycogen Synthase Kinase 3β (GSK3β) Pathway*

  2014cites this paper
• The Regulation of TiPARP by the Aryl Hydrocarbon Receptor, the Platelet-derived Growth Factor Receptor, and the Estrogen Receptor Alpha

  2013cites this paper
• prostaglandin E2-induced fos gene transcription Hematopoietic progenitor kinase 1 (HPK1) negatively regulates

  2013cites this paper
• Antitumor activity of methyl gallate by inhibition of focal adhesion formation and Akt phosphorylation in glioma cells.

  2013cites this paper
• PLC-γ and PI3K Link Cytokines to ERK Activation in Hematopoietic Cells with Normal and Oncogenic Kras

  2013cites this paper
• Phosphoinositides: tiny lipids with giant impact on cell regulation.

  2013cites this paper
• Platelet derived growth factor receptor alpha (PDGFRα) signaling in liver biology: Promises and Perils

  2013cites this paper
• The Insulin-Like Growth Factor 1 Receptor Is Essential for Axonal Regeneration in Adult Central Nervous System Neurons

  2013cites this paper
• Insulin suppression of apolipoprotein B in McArdle RH7777 cells involves increased sortilin 1 interaction and lysosomal targeting.

  2013influential citation
• PI 3 K Link Cytokines to ERK Activation in Hematopoietic Cells with Normal and Oncogenic Kras

  2013cites this paper
• Regulation of Ras Exchange Factors and Cellular Localization of Ras Activation by Lipid Messengers in T Cells

  2013cites this paper
• Platelet-derived growth factors and their receptors: structural and functional perspectives.

  2013cites this paper
• The TGF-co-receptor endoglin modulates the expression and transforming potential of HRas

  2013cites this paper
• Role of inhibitors of mammalian target of rapamycin in the treatment of luminal breast cancer

  2013cites this paper
• Understanding the Role of Stromal PTEN Regulated miR-101 and miR-130b in Tumor Microenvironment

  2012cites this paper
• Akt promotes cell survival by inactivating several targets, including forkhead transcription factors, p53, GSK-3B and caspase-9 and activating Bad,

  2012influential citation
• PTEN regulation of ERK1/2 signaling in cancer

  2012cites this paper
• Phospholipase D1 mediates bFGF-induced Bcl-2 expression leading to neurite outgrowth in H19-7 cells.

  2012cites this paper
• β‐arrestin 2‐dependent activation of ERK1/2 is required for ADP‐induced paxillin phosphorylation at Ser83 and microglia chemotaxis

  2012cites this paper
• Targeting angiogenesis in ovarian cancer.

  2012cites this paper
• Targeting the Phosphatidylinositol 3-Kinase Pathway in Airway Smooth Muscle

  2012cites this paper
• LPA stimulates intestinal DRA gene transcription via LPA2 receptor, PI3K/AKT, and c-Fos-dependent pathway.

  2012cites this paper
• Rôle des lipides-phosphate phosphatases dans la modulation des voies de signalisation impliquées dans les léiomyomes utérins

  2012cites this paper
• Compendium Model of AkT for Cell Survival/Death and its Equivalent Bio-Circuit

  2012cites this paper
• Serotonin transporter interacts with the PDGFβ receptor in PDGF-BB-induced signaling and mitogenesis in pulmonary artery smooth muscle cells.

  2011cites this paper
• Role of Lipid Rafts in Enterohemorragic Escherichia coli 0157:H7 Mediated Hijacking of Host Cell Signalling Pathways to Induce Intestinal Injury

  2011cites this paper
• The ERK Cascade: Distinct Functions within Various Subcellular Organelles.

  2011cites this paper
• Addition of N-terminal peptide sequences activates the oncogenic and signaling potentials of the catalytic subunit p110α of phosphoinositide-3-kinase

  2011cites this paper
• The role of platelet-derived growth factor in radiation injury to the lower urinary tract

  2011cites this paper
• Ca2+ dependent activation of extracellular signal regulatedkinases 1 and 2: role of intrasynaptosomal Ca2+ stores

  2011influential citation
• Zac1 functional interactions mediate AP-1 transcriptional activity.

  2011cites this paper
• Nuclear but Not Cytosolic Phosphoinositide 3-Kinase Beta Has an Essential Function in Cell Survival

  2011cites this paper
• The ATP-sensitive K(+)-channel (K(ATP)) controls early left-right patterning in Xenopus and chick embryos.

  2010cites this paper
• c-Met overexpression contributes to the acquired apoptotic resistance of nonadherent ovarian cancer cells through a cross talk mediated by phosphatidylinositol 3-kinase and extracellular signal-regulated kinase 1/2.

  2010cites this paper
• The TGF-beta co-receptor endoglin modulates the expression and transforming potential of H-Ras.

  2010cites this paper
• The p85beta regulatory subunit of PI3K serves as a substrate for PTEN protein phosphatase activity during insulin mediated signaling.

  2010cites this paper
• Serotonin, But Not N-Methyltryptamines, Activates the Serotonin 2A Receptor Via a β-Arrestin2/Src/Akt Signaling Complex In Vivo

  2010cites this paper
• Effects of The BCR-ABLl Oncogene on DNA Damage and Repair

  2010cites this paper
• Baculovirus production of fully-active phosphoinositide 3-kinase alpha as a p85alpha-p110alpha fusion for X-ray crystallographic analysis with ATP competitive enzyme inhibitors.

  2010cites this paper
• The mitogen‐activated protein kinase signaling pathways: role in megakaryocyte differentiation

  2010cites this paper
• Interaction of neurotrophin signaling with Bcl‐2 localized to the mitochondria and endoplasmic reticulum on spiral ganglion neuron survival and neurite growth

  2010cites this paper
• PI 3-kinase/Akt and STAT3 are required for the prevention of TGF-beta-induced Hep3B cell apoptosis by autocrine motility factor/phosphoglucose isomerase.

  2010cites this paper
• Protein Tyrosine Kinase Receptor Signaling Overview

  2010cites this paper
• Angiogenesis inhibition in cancer therapy: platelet-derived growth factor (PDGF) and vascular endothelial growth factor (VEGF) and their receptors: biological functions and role in malignancy.

  2010cites this paper
• The regulation of class IA PI 3-kinases by inter-subunit interactions.

  2010cites this paper
• Role of platelet-derived growth factors in the testis.

  2010cites this paper
• Activation of PI 3-kinase/Akt/NF-kappaB and Stat3 signaling by avian reovirus S1133 in the early stages of infection results in an inflammatory response and delayed apoptosis.

  2010cites this paper
• Phosphoinositide 3-kinase Akt signaling pathway interacts with protein kinase Cbeta2 in the regulation of physiologic developmental hypertrophy and heart function.

  2009cites this paper
• Noncontractile functions of airway smooth muscle cells in asthma.

  2009cites this paper
• Negative RegulatioN of ReceptoR tyRosiNe KiNases by t-cell pRoteiN tyRosiNe phosphatase

  2009cites this paper
• O-17: Overexpression of a constitutively active form of Phosphatidylinositol 3 kinase is sufficient to Promote GLUT 4 translocation in transfected rat adipose cells

  2009cites this paper
• Immunohistochemical analysis of the mammalian target of rapamycin signalling pathway in extramammary Paget’s disease

  2009cites this paper
• Intracellular signaling pathways involved in inhibition of PAI-1 expression by CNP in endothelial cells.

  2009cites this paper
• PI3K-dependent cross-talk interactions converge with Ras as quantifiable inputs integrated by Erk

  2009cites this paper
• Involvement of the p110α isoform of PI3K in early development of mouse embryos

  2009cites this paper
• Airway Smooth Muscle

  2009cites this paper
• High Expression of Mammalian Target of Rapamycin Is Associated with Better Outcome for Patients with Early Stage Lung Adenocarcinoma

  2009cites this paper
• Negative Regulation of Receptor Tyrosine Kinases by T-cell Protein Tyrosine Phosphatase

  2009cites this paper
• Genome-wide overexpression screen for activators of antioxidant gene transcription.

  2008cites this paper