Beyond Nuclear Transport

Address correspondence to Don Cleveland, Ludwig Institute for Cancer Research, Departments of Medicine and Neuroscience, University of California San Diego, 9500 Gilman Drive, Department 0660, La Jolla, CA 92093. Tel.: (858) 534-7811. Fax: (858) 534-7659. E-mail: dcleveland @ucsd.edu I T ’ S not easy being a nuclear transport factor. During the G1, S, and G2 phases of the cell cycle, the nucleocytoplasmic transport machinery must tirelessly zigzag between the nucleus and cytoplasm while directing other proteins to the correct subcellular compartment. When M phase finally arrives, and the nucleus breaks down, do these proteins finally get to take a break? Apparently not. In the case of the Ran-GTPase and its associated nuclear transport factors, there is no rest for the weary. Instead, Ran and its associated proteins shift their focus from nuclear transport to the regulation of microtubule dynamics. Recent findings by several groups have shown that the GTP-bound form of Ran is necessary for the nucleation and organization of microtubule structures during M phase. Moreover, the implication that the active form of Ran is concentrated in the vicinity of chromosomes suggests that these findings may resolve the longstanding question of how chromosomes can influence spindle assembly in the absence of microtubule-nucleating organelles (i.e., as in plant mitosis or mammalian meiosis).

• Publication year

  1999

• Venue

  Journal of Cell Biology

• Publication date

  1999-09-20

• Fields of study

  Biology, Medicine

• Identifiers
  PMID 10491385PMCID 2156118
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• ReviewImportin Beta : Conducting a Much Larger

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