Abnormal centrosome amplification in cells through the targeting of Ran-binding protein-1 by the human T cell leukemia virus type-1 Tax oncoprotein.

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Proceedings of the National Academy of Sciences of the United States of America

• Publication date

  2005-12-27

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1073/PNAS.0506659103PMID 16365316PMCID PMC1323167
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Emerging roles of centrosomal amplification and genomic instability in cancer.

  2005cited by this paper
• Human T-cell leukemia virus type I (HTLV-I) infection and the onset of adult T-cell leukemia (ATL)

  2005cited by this paper
• The discovery of the first human retrovirus: HTLV-1 and HTLV-2

  2005cited by this paper
• Discovery of adult T-cell leukemia

  2005cited by this paper
• Aneuploidy and genetic instability in cancer.

  2005cited by this paper
• Life, Death, and Tax: Role of HTLV-I Oncoprotein in Genetic Instability and Cellular Transformation*

  2004cited by this paper
• Aneuploidy and cancer

  2004cited by this paper
• The role of cyclin D2 and p21/waf1 in human T-cell leukemia virus type 1 infected cells

  2004cited by this paper
• Genetic immune modulation of Ran GTPase against different microbial pathogens.

  2004cited by this paper
• Centrosome Amplification and the Origin of Chromosomal Instability in Breast Cancer

  2004cited by this paper
• The Centrosome in Normal and Transformed Cells

  2004cited by this paper
• Protein Profile of Tax-associated Complexes*

  2004cited by this paper
• The HTLV-1 tax oncoprotein attenuates DNA damage induced G1 arrest and enhances apoptosis in p53 null cells.

  2003cited by this paper
• Mammalian RanBP1 regulates centrosome cohesion during mitosis

  2003cited by this paper
• Centrosomal aberrations in primary invasive breast cancer are associated with nodal status and hormone receptor expression

  2003cited by this paper
• Interaction of retroviral Tax oncoproteins with tristetraprolin and regulation of tumor necrosis factor-alpha expression.

  2003cited by this paper
• Human T-Lymphotropic Virus Type 1 Oncoprotein Tax Promotes Unscheduled Degradation of Pds1p/Securin and Clb2p/Cyclin B1 and Causes Chromosomal Instability

  2003cited by this paper
• Human T-cell Leukemia Virus-I Tax Oncoprotein Functionally Targets a Subnuclear Complex Involved in Cellular DNA Damage-Response*

  2003cited by this paper
• The centrosome cycle

  2002cited by this paper
• Transcriptional Activity of HTLV-I Tax Influences the Expression of Marker Genes Associated with Cellular Transformation

  2002cited by this paper
• Loss of p53 and centrosome hyperamplification

  2002cited by this paper
• Physical Interaction of Human T-Cell Leukemia Virus Type 1 Tax with Cyclin-Dependent Kinase 4 Stimulates the Phosphorylation of Retinoblastoma Protein

  2002cited by this paper
• Damaged DNA and miscounted chromosomes: human T cell leukemia virus type I tax oncoprotein and genetic lesions in transformed cells.

  2002cited by this paper
• Human papillomaviruses and centrosome duplication errors: modeling the origins of genomic instability

  2002cited by this paper
• Centrosome replication, genomic instability and cancer

  2002cited by this paper
• Prevalent Loss of Mitotic Spindle Checkpoint in Adult T-cell Leukemia Confers Resistance to Microtubule Inhibitors*

  2002cited by this paper
• Centrosome amplification and the development of cancer

  2002cited by this paper
• Centrosome aberrations: cause or consequence of cancer progression?

  2002cited by this paper
• Human T-Lymphotropic Virus Type 1 Oncoprotein Tax Promotes S-Phase Entry but Blocks Mitosis

  2002cited by this paper
• The Ran GTPase: theme and variations.

  2002cited by this paper
• Genome-wide expression changes induced by HTLV-1 Tax: evidence for MLK-3 mixed lineage kinase involvement in Tax-mediated NF-kappaB activation.

  2001cited by this paper
• Targeting of Ran: variation on a common theme?

  2001cited by this paper
• Centrosome defects can account for cellular and genetic changes that characterize prostate cancer progression.

  2001cited by this paper
• CREB/ATF-Dependent Repression of Cyclin A by Human T-Cell Leukemia Virus Type 1 Tax Protein

  2001cited by this paper
• Functional activities of the human T-cell leukemia virus type I Tax oncoprotein: cellular signaling through NF-kappa B.

  2001cited by this paper
• Genome-wide expression changes induced by HTLV-1 Tax: evidence for MLK-3 mixed lineage kinase involvement in Tax-mediated NF-κB activation

  2001cited by this paper
• Centrosome Aberrations and Cancer

  2001cited by this paper
• Human T-cell leukemia virus type 2 tax mutants that selectively abrogate NFkappaB or CREB/ATF activation fail to transform primary human T cells.

  2000cited by this paper
• HTLV-I Tax and cell cycle progression.

  2000cited by this paper
• The ran decathlon: multiple roles of Ran.

  2000cited by this paper
• Human T-Cell Leukemia Virus Type 1 Tax Shuttles between Functionally Discrete Subcellular Targets

  2000cited by this paper
• The centrosome and parthenogenesis.

  2000cited by this paper
• Human T-Cell Leukemia Virus Type 2 Tax Mutants That Selectively Abrogate NFκB or CREB/ATF Activation Fail To Transform Primary Human T Cells

  2000cited by this paper
• Regulated Ran-binding protein 1 activity is required for organization and function of the mitotic spindle in mammalian cells in vivo.

  2000cited by this paper
• Cell cycle: driving the centrosome cycle.

  1999cited by this paper
• Centrosome dynamics in living cells.

  1999cited by this paper
• A new role of ran GTPase.

  1999cited by this paper
• Beyond Nuclear Transport: Ran-Gtp as a Determinant of Spindle Assembly

  1999cited by this paper
• pRb is required for MEF2-dependent gene expression as well as cell-cycle arrest during skeletal muscle differentiation.

  1999cited by this paper
• Beyond Nuclear Transport

  1999cited by this paper
• Genetic instabilities in human cancers

  1998cited by this paper
• Centrosome defects and genetic instability in malignant tumors.

  1998cited by this paper
• Human T cell leukemia virus type 1 oncoprotein Tax targets the human mitotic checkpoint protein MAD1.

  1998cited by this paper
• Stimulation of Cyclin-Dependent Kinase Activity and G1- to S-Phase Transition in Human Lymphocytes by the Human T-Cell Leukemia/Lymphotropic Virus Type 1 Tax Protein

  1998cited by this paper
• HTLV‐1 Tax protein interacts with cyclin‐dependent kinase inhibitor p16INK4A and counteracts its inhibitory activity towards CDK4.

  1996cited by this paper
• Expression of Bcl-xL and loss of p53 can cooperate to overcome a cell cycle checkpoint induced by mitotic spindle damage.

  1996cited by this paper
• Transcriptional control of the Htf9-A/RanBP-1 gene during the cell cycle.

  1995cited by this paper
• The centrosome.

  1993cited by this paper
• The GTP-binding protein Ran/TC4 is required for protein import into the nucleus

  1993cited by this paper
• HTLV-1 Tax induces expression of various immediate early serum responsive genes.

  1991cited by this paper
• Regulation of human T cell leukemia virus expression 1

  1990cited by this paper
• Isolation and characterization of retrovirus from cell lines of human adult T-cell leukemia and its implication in the disease.

  1982cited by this paper
• Adult T-cell leukemia: antigen in an ATL cell line and detection of antibodies to the antigen in human sera.

  1981cited by this paper
• Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma

  1980cited by this paper

• ISG15 Differentially Modulates Clade Ib and II MPXV Infection in MEF cells

  2025cites this paper
• Betrayal From the Core: Centriolar and Cytoskeletal Subversion by Infectious Pathogens

  2025cites this paper
• In Search of a Mechanistic Link between Chlamydia trachomatis-Induced Cellular Pathophysiology and Oncogenesis

  2023cites this paper
• Centrosome amplification in cancer and cancer-associated human diseases.

  2021cites this paper
• How Do Flaviviruses Hijack Host Cell Functions by Phase Separation?

  2021cites this paper
• Coordination of Zika Virus Infection and Viroplasm Organization by Microtubules and Microtubule-Organizing Centers

  2021cites this paper
• Human T-cell lymphotropic virus HBZ and tax mRNA expression are associated with specific clinicopathological features in adult T-cell leukemia/lymphoma

  2020cites this paper
• Comparative analyses of tumorigenic mechanisms of Merkel cell polyomavirus T antigens

  2020cites this paper
• Mechanisms of Oncogenesis by HTLV-1 Tax

  2020cites this paper
• Aneuploidy and oncoviruses

  2019cites this paper
• The human T-cell leukemia virus type-1 tax oncoprotein dissociates NF-κB p65RelA-Stathmin complexes and causes catastrophic mitotic spindle damage and genomic instability.

  2019influential citation
• Zika virus causes supernumerary foci with centriolar proteins and impaired spindle positioning

  2017cites this paper
• Merkel cell polyomavirus small T antigen induces genome instability by E3 ubiquitin ligase targeting

  2017cites this paper
• New insights into the colorectal carcinogenesis: from early precursor lesions to the role of aneuploidy

  2017cites this paper
• The GTPase RAN regulates multiple steps of the centrosome life cycle

  2016cites this paper
• The Tax-Inducible Actin-Bundling Protein Fascin Is Crucial for Release and Cell-to-Cell Transmission of Human T-Cell Leukemia Virus Type 1 (HTLV-1)

  2016cites this paper
• HTLV-1 Infection and Adult T-Cell Leukemia/Lymphoma—A Tale of Two Proteins: Tax and HBZ

  2016cites this paper
• Modulation de la machinerie de O-GlcNACylation par l’oncoprotéineTax du virus HTLV-1 et implication dans la transactivation du promoteur viral

  2016cites this paper
• CADM1/TSLC1 Identifies HTLV-1-Infected Cells and Determines Their Susceptibility to CTL-Mediated Lysis

  2016cites this paper
• Multiple Pathways Control the Reactivation of Telomerase in HTLV-I-Associated Leukemia.

  2015cites this paper
• The effects of chromosome number changes on mitotic fidelity and karyotype stability

  2015cites this paper
• HTLV-I Tax-Mediated Inactivation of Cell Cycle Checkpoints and DNA Repair Pathways Contribute to Cellular Transformation: "A Random Mutagenesis Model".

  2015cites this paper
• Modes of Human T Cell Leukemia Virus Type 1 Transmission, Replication and Persistence

  2015cites this paper
• HTLV-1 and leukemogenesis: virus-cell interactions in the development of adult T-cell leukemia.

  2014cites this paper
• The intricate interplay between RNA viruses and NF-κB

  2014cites this paper
• Human T-Cell Leukemia Virus Type 1: Pathogenesis and Host Immune Response

  2014cites this paper
• The role of small non-coding RNAs in human T-cell leukemia virus type 1 (HTLV-1) infection and transformation

  2014cites this paper
• The role of mitotic kinases in coupling the centrosome cycle with the assembly of the mitotic spindle

  2014cites this paper
• Diferentes abordagens para o entendimento da aneuploidia: interferindo na mitose com o uso de crisotila e vincristina

  2014cites this paper
• Ran GTPase in nuclear envelope formation and cancer metastasis.

  2014cites this paper
• The primary cilium as a regulator of cellular senescence in human fibroblasts

  2014cites this paper
• Rôle des protéines AID et Bfl-1 dans les processus d'instabilité génomique et de survie cellulaire induits par l'oncoprotéine Tax au cours de la lymphomagénèse associée à l'infection par HTLV-1

  2014cites this paper
• Functional interactions of the Tax and p13 proteins of Human T-cell Leukemia Virus Type I

  2013cites this paper
• Perinatal exposure of patas monkeys to antiretroviral nucleoside reverse-transcriptase inhibitors induces genotoxicity persistent for up to 3 years of age.

  2013cites this paper
• Sgk1 enhances RANBP1 transcript levels and decreases taxol sensitivity in RKO colon carcinoma cells

  2013cites this paper
• Ran Binding Protein 1 Affects Macronuclear and Micronuclear Division in Tetrahymena thermophila

  2013cites this paper
• Centriolar and ciliary responses to DNA damage

  2012cites this paper
• Unstabilized DNA breaks in HTLV-1 Tax expressing cells correlate with functional targeting of Ku80, not PKcs, XRCC4, or H2AX

  2012cites this paper
• HTLV-1 and Oncogenesis

  2012cites this paper
• iArc monogrAphs on the evAluAtion oF cArcinogenic risks to humAns

  2012cites this paper
• The Cellular Autophagy Pathway Modulates Human T-Cell Leukemia Virus Type 1 Replication

  2012cites this paper
• Phosphorylation of Ran-binding Protein-1 by Polo-like Kinase-1 Is Required for Interaction with Ran and Early Mitotic Progression*

  2011cites this paper
• Molecular analysis of HTLV-2 APH-2 in viral transformation, persistence and host immune response

  2011cites this paper
• A Clinical Overview of Centrosome Amplification in Human Cancers

  2011cites this paper
• RAN (RAN, member RAS oncogene family)

  2011cites this paper
• The control of centrosome duplication after genotoxic stress

  2011cites this paper
• Human T-cell leukemia virus type 1 (HTLV-1) and leukemic transformation: viral infectivity, Tax, HBZ and therapy

  2011cites this paper
• How mitotic errors contribute to karyotypic diversity in cancer.

  2011cites this paper
• Targeting aneuploid cancer cells

  2011cites this paper
• Ran control of mitosis in human cells: gradients and local signals.

  2010cites this paper
• HTLV-1 Tax: Linking transformation, DNA damage and apoptotic T-cell death.

  2010cites this paper
• Impact of EMS outreach: Successful developments in Latin America

  2010cites this paper
• View and review on viral oncology research

  2010cites this paper
• Induction of Reactive Oxygen Species by Human T-Cell Leukemia Virus Type 1 Tax Correlates with DNA Damage and Expression of Cellular Senescence Marker

  2010cites this paper
• Human T-Cell Leukemia Virus Type 1, Cellular Transformation, and Adult T-Cell Leukemia

  2010cites this paper
• Destabilizing aneuploidy by targeting cell cycle and mitotic checkpoint proteins in cancer cells.

  2010cites this paper
• Retroviruses and Insights into Cancer: Retroviral Regulatory/Accessory Genes and Cancer

  2010cites this paper
• Regulation of HTLV-I oncoprotein Tax by PDLIM2

  2010cites this paper
• Viral transformation and aneuploidy

  2009cites this paper
• Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis

  2009cites this paper
• HTLV-1-Tax and ICAM-1 act on T-cell signal pathways to polarize the microtubule-organizing center at the virological synapse.

  2009cites this paper
• Centrosomal amplification and aneuploidy induced by the antiretroviral drug AZT in hamster and human cells.

  2009influential citation
• entrosomal amplification and aneuploidy induced by the antiretroviral drug AZT n hamster and human cells

  2009cites this paper
• Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

  2009cites this paper
• Human T-Cell Leukemia Virus 1 and Cellular Transformation

  2009cites this paper
• L’oncoprotéine Tax délocalise le suppresseur de tumeur hScrib

  2009cites this paper
• Peptidylproline cis-trans-Isomerase Pin1 Interacts with Human T-Cell Leukemia Virus Type 1 Tax and Modulates Its Activation of NF-κB

  2009cites this paper
• HTLV-1-Tax and ICAM-1 act on T-cell signal pathways to polarize the MTOC at the virological synapse

  2009cites this paper
• Peptidylproline cis - trans -Isomerase Pin1 Interacts with Human T-Cell Leukemia Virus Type 1 Tax and Modulates Its Activation of NF- (cid:2) B (cid:1)

  2009cites this paper
• The role of HBZ in HTLV-1 biology.

  2008cites this paper
• Viruses associated with human cancer.

  2008cites this paper
• Spatial and temporal coordination of mitosis by Ran GTPase

  2008cites this paper
• The ups and downs of Tax and histones in adult T-cell leukemogenesis.

  2008cites this paper
• Chromosomal Instability and Human T Cell Leukemia Virus 1 Transformation

  2008cites this paper
• The GTPase Ran: regulation of cell life and potential roles in cell transformation.

  2008cites this paper
• The HTLV-1 Tax interactome

  2008cites this paper
• Human T-Cell Leukemia Virus Type 1 Infection Leads to Arrest in the G1 Phase of the Cell Cycle

  2008cites this paper
• An Interaction between the Human T Cell Leukemia Virus Type 1 Basic Leucine Zipper Factor (HBZ) and the KIX Domain of p300/CBP Contributes to the Down-regulation of Tax-dependent Viral Transcription by HBZ*

  2008cites this paper
• Aneuploidy and cancer

  2007cites this paper
• Small GTP-binding Proteins and their Functions in Plants

  2007cites this paper
• Human T-cell leukemia virus type-1 Tax oncoprotein regulates G-protein signaling.

  2007cites this paper
• Epstein-Barr Virus Thymidine Kinase Is a Centrosomal Resident Precisely Localized to the Periphery of Centrioles

  2007cites this paper
• Does the HBZ Gene Represent a New Potential Target for the Treatment of Adult T-Cell Leukemia?

  2007cites this paper
• Spatial control of mitosis by the GTPase Ran

  2007cites this paper
• Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation

  2007cites this paper
• Human T-Cell Leukemia Virus Type 1 Tax and Cellular Transformation

  2007cites this paper
• CREB − a real culprit in oncogenesis

  2007cites this paper
• Human T cell leukemia virus type 1 Tax‐induced signals in cell survival, proliferation, and transformation

  2007cites this paper
• Preferential Selection of Human T-Cell Leukemia Virus Type 1 Provirus Lacking the 5′ Long Terminal Repeat during Oncogenesis

  2007cites this paper
• Centrosome and retroviruses: The dangerous liaisons

  2007cites this paper
• Evidence for Cooperative Transforming Activity of the Human Pituitary Tumor Transforming Gene and Human T-Cell Leukemia Virus Type 1 Tax

  2007cites this paper
• Neoplastic transformation of human bronchial cells by lead chromate particles.

  2007cites this paper
• Phosphorylation of Maskin by Aurora-A Is Regulated by RanGTP and Importin β*

  2006cites this paper
• [HTLV-I and leukemogenesis].

  2006cites this paper
• The retroviral oncoprotein Tax targets the coiled-coil centrosomal protein TAX1BP2 to induce centrosome overduplication

  2006cites this paper
• Role for Akt/Protein Kinase B and Activator Protein-1 in Cellular Proliferation Induced by the Human T-cell Leukemia Virus Type 1 Tax Oncoprotein*

  2006cites this paper
• Mechanism limiting centrosome duplication to once per cell cycle

  2006cites this paper
• Centrosome amplification in adult T‐cell leukemia and human T‐cell leukemia virus type 1 Tax‐induced human T cells

  2006cites this paper
• Human T-cell Lymphotropic Virus Type 1 1. Exposure Data

  year unknowncites this paper
• Retroviral oncoprotein Tax targets coiled-coil centrosomal protein TAX 1 BP 2 to induce centrosome overduplication

  year unknowncites this paper