Muscle atrophy and preferential loss of myosin in prolonged critically ill patients*

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Critical Care Medicine

• Publication date

  2012-01-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1097/CCM.0b013e31822d7c18PMID 21926599
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Insufficient activation of autophagy allows cellular damage to accumulate in critically ill patients.

  2011cited by this paper
• Hormonal status and ICU-acquired paresis in critically ill patients

  2010cited by this paper
• Myosin and actin content of human skeletal muscle fibers following 35 days bed rest

  2010cited by this paper
• Sepsis downregulates myostatin mRNA levels without altering myostatin protein levels in skeletal muscle

  2010cited by this paper
• Sepsis increases the expression and activity of the transcription factor Forkhead Box O 1 (FOXO1) in skeletal muscle by a glucocorticoid-dependent mechanism.

  2010cited by this paper
• Increasing intravenous glucose load in the presence of normoglycemia: Effect on outcome and metabolism in critically ill rabbits

  2010cited by this paper
• Intensive care unit-acquired weakness: Risk factors and prevention

  2009cited by this paper
• Gene expression and muscle fiber function in a porcine ICU model.

  2009cited by this paper
• Physical inactivity and muscle weakness in the critically ill

  2009cited by this paper
• Effects of a preferential myosin loss on Ca2+ activation of force generation in single human skeletal muscle fibres

  2008cited by this paper
• Acute quadriplegic myopathy: an acquired "myosinopathy".

  2008cited by this paper
• Treating hyperglycemia improves skeletal muscle protein metabolism in cancer patients after major surgery

  2008cited by this paper
• Critical illness myopathy and neuropathy.

  2008cited by this paper
• Mechanisms of glucocorticoid-induced myopathy.

  2008cited by this paper
• Muscle paralysis and myosin loss in a patient with cancer cachexia.

  2007cited by this paper
• Age-related decline in actomyosin structure and function.

  2007cited by this paper
• Transcription Factors in Muscle Atrophy Caused by Blocked Neuromuscular Transmission and Muscle Unloading In Rats

  2007cited by this paper
• Ubiquitination, phosphorylation, and acetylation—triple threat in muscle wasting

  2007cited by this paper
• The temporal responses of protein synthesis, gene expression and cell signalling in human quadriceps muscle and patellar tendon to disuse

  2007influential reference
• The Histone Deacetylase HDAC4 Connects Neural Activity to Muscle Transcriptional Reprogramming*

  2007cited by this paper
• Myostatin gene deletion prevents glucocorticoid-induced muscle atrophy.

  2007cited by this paper
• Burn-induced increase in atrogin-1 and MuRF-1 in skeletal muscle is glucocorticoid independent but downregulated by IGF-I.

  2007cited by this paper
• Proteasome proteolytic activity in skeletal muscle is increased in patients with sepsis.

  2007cited by this paper
• Impact of intensive insulin therapy on neuromuscular complications and ventilator dependency in the medical intensive care unit.

  2007influential reference
• A porcine model of acute quadriplegic myopathy: a feasibility study

  2006cited by this paper
• Intensive insulin therapy in the medical ICU.

  2006influential reference
• Myosin and actin expression and oxidation in aging muscle.

  2006cited by this paper
• Human muscle aging: ROS-mediated alterations in rectus abdominis and vastus lateralis muscles.

  2005cited by this paper
• Critical illness myopathy and neuropathy

  2005cited by this paper
• Insulin therapy protects the central and peripheral nervous system of intensive care patients

  2005cited by this paper
• Risk factors for critical illness polyneuromyopathy

  2005cited by this paper
• Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy.

  2004cited by this paper
• Extremity hyperinsulinemia stimulates muscle protein synthesis in severely injured patients.

  2004cited by this paper
• One-year outcomes in survivors of the acute respiratory distress syndrome.

  2003cited by this paper
• Electrophoretic determination of the myosin/actin ratio in the diagnosis of critical illness myopathy

  2003influential reference
• Critical illness polyneuromyopathy: the electrophysiological components of a complex entity

  2003cited by this paper
• Critical illness polyneuropathy

  2002cited by this paper
• Paresis acquired in the intensive care unit: a prospective multicenter study.

  2002cited by this paper
• Intensive insulin therapy in critically ill patients.

  2002influential reference
• The effect of prolonged euglycemic hyperinsulinemia on lean body mass after severe burn.

  2002cited by this paper
• Regulation of Myostatin by Glucocorticoids After Thermal Injury

  2001cited by this paper
• Risk factors for the development of polyneuropathy and myopathy in critically ill patients

  2001cited by this paper
• Disparate dysfunction of skeletal muscles located near and distant from burn site in the rat

  2001cited by this paper
• Intensive insulin therapy in critically ill patients.

  2001cited by this paper
• Critical illness polyneuropathy: risk factors and clinical consequences. A cohort study in septic patients

  2001cited by this paper
• Muscular contractile failure in septic patients: role of the inducible nitric oxide synthase pathway.

  2000cited by this paper
• Analysis of muscle proteins in acute quadriplegic myopathy

  2000cited by this paper
• Acute quadriplegia and loss of muscle myosin in patients treated with nondepolarizing neuromuscular blocking agents and corticosteroids: Mechanisms at the cellular and molecular levels

  2000cited by this paper
• Muscle fibre atrophy in critically ill patients is associated with the loss of myosin filaments and the presence of lysosomal enzymes and ubiquitin

  1998cited by this paper
• Sepsis is associated with increased mRNAs of the ubiquitin-proteasome proteolytic pathway in human skeletal muscle.

  1997cited by this paper
• Direct muscle stimulation in acute quadriplegic myopathy

  1997cited by this paper
• Energy-ubiquitin-dependent muscle proteolysis during sepsis in rats is regulated by glucocorticoids.

  1996cited by this paper
• Increased mRNA levels for components of the lysosomal, Ca2+-activated, and ATP-ubiquitin-dependent proteolytic pathways in skeletal muscle from head trauma patients.

  1996cited by this paper
• Neurological complications of severe illness and prolonged mechanical ventilation.

  1995cited by this paper
• Maximum velocity of shortening in relation to myosin isoform composition in single fibres from human skeletal muscles.

  1993cited by this paper
• Insulin action on protein metabolism.

  1993cited by this paper
• [Critical illness polyneuropathy].

  1990cited by this paper
• Critical illness polyneuropathy. A complication of sepsis and multiple organ failure.

  1987cited by this paper
• Critically ill polyneuropathy: electrophysiological studies and differentiation from Guillain-Barré syndrome.

  1986cited by this paper

• Metabolic and Muscular Determinants of Weaning Failure: The Role of BUN/Creatinine Ratio and Rectus Femoris Thickness

  2026cites this paper
• Integrated Single-Fiber Multi-Omics Links an Inflammatory-Associated Myofiber State to Altered Myosin Dynamics in Patients with ICU-acquired weakness

  2026cites this paper
• Effect of early intensive physical therapy on NLRP3 inflammasome activation and muscle atrophy in critical illness myopathy (PT-NLRP3-CIM): a two-centre randomized open-label study protocol.

  2026cites this paper
• Clinical risk factors of intensive care unit acquired weakness predicted by human muscle microtissue response to humoral factors

  2025cites this paper
• Serum from patients with MuSK antibody-positive myasthenia gravis triggers transcriptomic changes leading to muscle atrophy and weakness in human myotube cells.

  2025cites this paper
• Muscle weakness after critical illness: unravelling biological mechanisms and clinical hurdles

  2025cites this paper
• Altered muscle transcriptome as molecular basis of long-term muscle weakness in survivors from critical illness

  2025cites this paper
• Neurophysiology and muscle histopathology in ICU-acquired muscle weakness: Lessons learned from COVID-19

  2025cites this paper
• An exploratory prospective observational study of muscle cross-sectional area changes and energy balance in critically ill children: avoiding negative energy balance is necessary but not sufficient to maintain muscle mass in critically ill children

  2025cites this paper
• The flux of energy in critical illness and the obesity paradox.

  2025cites this paper
• Predicting early diagnosis of intensive care unit-acquired weakness in septic patients using critical ultrasound and biological markers

  2025cites this paper
• Clinical characteristics and predictive biomarkers of intensive care unit-acquired weakness in patients with cardiogenic shock requiring mechanical circulatory support

  2025cites this paper
• Early urea-to-creatinine ratio to predict rapid muscle loss in critically ill patients with sepsis: a single-center retrospective observational study

  2025cites this paper
• Prior GLP-1 agonist use is not associated with adverse inpatient critical care outcomes: A propensity-matched analysis.

  2025cites this paper
• The Current Research Status of ICU-Acquired Muscle Weakness

  2024cites this paper
• Clinical effect of pulmonary rehabilitation in patients with mechanical ventilation: A meta-analysis

  2024cites this paper
• Research Progress of ICU-Acquired Weakness

  2024cites this paper
• Diagnosis of “intensive care unit-acquired weakness” and “critical illness myopathy”: Do the diagnostic criteria need to be revised?

  2024cites this paper
• Risk Factors and Electromyographic Characteristics of Acquired Weakness in Critically Ill Patients: A Retrospective Study

  2024cites this paper
• Extracellular Matrix Alterations in Human Soleus Muscle under Conditions of Chronic Disorder of Consciousness

  2024cites this paper
• Loss of ZBED6 Protects Against Sepsis‐Induced Muscle Atrophy by Upregulating DOCK3‐Mediated RAC1/PI3K/AKT Signaling Pathway in Pigs

  2023cites this paper
• Skeletal Muscle Myokine Expression in Critical Illness, Association With Outcome and Impact of Therapeutic Interventions

  2023cites this paper
• Characterization of muscle mass, strength and mobility of critically ill patients with SARS-CoV-2 pneumonia: Distribution by sex, age, days on mechanical ventilation, and muscle weakness

  2023cites this paper
• Early Mobilization and Rehabilitation of Critically-Ill Patients

  2023cites this paper
• Intensive Care Unit-Acquired Weakness after Liver Transplantation: Analysis of Seven Cases and a Literature Review

  2023cites this paper
• Early detection and assessment of intensive care unit-acquired weakness: a comprehensive review

  2023cites this paper
• Overview of Pharmaceutical Aspects of Artificial Nutrition: Simple Review

  2023cites this paper
• Importance of Asprosin for Changes of M. Rectus Femoris Area during the Acute Phase of Medical Critical Illness: A Prospective Observational Study

  2023cites this paper
• Quantitative muscle MRI displays clinically relevant myostructural abnormalities in long-term ICU-survivors: a case–control study

  2023cites this paper
• Intensive care unit‐acquired weakness and the COVID‐19 pandemic: A clinical review

  2022cites this paper
• Using a multiomics approach to unravel a septic shock specific signature in skeletal muscle

  2022cites this paper
• Early and final outcome of patients suffered from muscle weakness aquired in COVID Intensive Care Unit – How precise we can be about eary and final outcome of patients at the time of the end of mechanical ventilation?

  2022cites this paper
• Variability in Skeletal Muscle Protein Synthesis Rates in Critically Ill Patients

  2022cites this paper
• The role of nutrition rehabilitation in the recovery of survivors of critical illness: underrecognized and underappreciated

  2022cites this paper
• Intensive care unit-acquired weakness: A review from molecular mechanisms to its impact in COVID-2019

  2022cites this paper
• n-3 PUFA dietary lipid replacement normalizes muscle mitochondrial function and oxidative stress through enhanced tissue mitophagy and protects from muscle wasting in experimental kidney disease.

  2022cites this paper
• Disuse-induced skeletal muscle atrophy in disease and non-disease states in humans: mechanisms, prevention, and recovery strategies.

  2022cites this paper
• Development and early diagnosis of critical illness myopathy in COVID‐19 associated acute respiratory distress syndrome

  2022cites this paper
• Hind-limb unloading in rodents: Current evidence and perspectives

  2022cites this paper
• Intensive care unit-acquired weakness: Questions the clinician should ask.

  2022cites this paper
• Could Exogenous Insulin Ameliorate the Metabolic Dysfunction Induced by Glucocorticoids and COVID-19?

  2021cites this paper
• Inspiratory muscle capacity with abdominal support: a prospective observational study in critically ill patients

  2021cites this paper
• Prognostic value of serum albumin and urea nitrogen excretion in COVID-19 ICU patients: a single-center, prospective, cohort study

  2021cites this paper
• Impact of prolonged sepsis on neural and muscular components of muscle contractions in a mouse model

  2021cites this paper
• Critical illness myopathy precedes hyperglycaemia and high glucose variability.

  2021cites this paper
• Molecular mechanisms of postintensive care syndrome

  2021cites this paper
• Proteasome- and Calpain-Mediated Proteolysis, but Not Autophagy, Is Required for Leucine-Induced Protein Synthesis in C2C12 Myotubes

  2021cites this paper
• Prognostic value of serum albumin and urea nitrogen excretion in COVID-19 ICU patients: a single-center, prospective, cohort study

  2021cites this paper
• Structural and Metabolic Changes in Skeletal Muscles of Patients with Chronic Disorders of Consciousness—To the Issue of Critical Illness Polyneuromyopathies (a PET/CT Pathomorphological Study)

  2021cites this paper
• Physical Rehabilitation in the ICU: A Systematic Review and Meta-Analysis*

  2021cites this paper
• Association Between SARS-CoV-2 Infection and Immune-Mediated Myopathy in Patients Who Have Died.

  2021cites this paper
• Mitoquinone Mesylate (MitoQ) Prevents Sepsis Induced Diaphragm Dysfunction.

  2021cites this paper
• Changes in Respiratory Muscle Thickness during Mechanical Ventilation: Focus on Expiratory Muscles

  2020cites this paper
• ICU-acquired weakness

  2020influential citation
• Relationship between intensive care unit-acquired weakness, fatigability and fatigue: What role for the central nervous system?

  2020cites this paper
• Respiratory Neuropathy as an Important Component of Critical Illness Polyneuromyopathy

  2020cites this paper
• Breath-synchronized electrical stimulation of the expiratory muscles in mechanically ventilated patients: a randomized controlled feasibility study and pooled analysis

  2020cites this paper
• Intensive Care Unit-Acquired Weakness: Not Just Another Muscle Atrophying Condition

  2020cites this paper
• Muscular weakness and muscle wasting in the critically ill

  2020cites this paper
• Hydrocortisone mitigates ICU-AW by fine-tuning of muscle atrophic and hypertrophic signaling pathways in a sepsis model with limb immobilization.

  2020cites this paper
• DGP-Empfehlungen zur pneumologischen Rehabilitation bei COVID-19

  2020cites this paper
• From skeletal muscle weakness to functional outcomes following critical illness: a translational biology perspective

  2019cites this paper
• Changes in Skeletal Muscle Mass and Contractile Function

  2019cites this paper
• Die Rolle des angeborenen Immunsystems in der inflammations-vermittelten Kardiomyopathie

  2019cites this paper
• Adipose tissue protects against sepsis-induced muscle weakness in mice: from lipolysis to ketones

  2019cites this paper
• Long-term Cognitive and Functional Impairments After Critical Illness

  2019cites this paper
• Critical Illness Neuromyopathy: Clinical, Electrophysiological, and Histological Diagnosis

  2019cites this paper
• Anabolic response to amino acid supplementation in critical illness

  2019cites this paper
• Protein recycling and limb muscle recovery after critical illness in slow- and fast-twitch limb muscle.

  2019influential citation
• Neuromyopathy: Histological and Molecular Findings

  2019cites this paper
• Pérdida de masa muscular en el paciente críticamente enfermo: ¿Caquexia, sarcopenia y/o atrofia? Impacto en la respuesta terapéutica y la supervivencia

  2018cites this paper
• Critical Care Management of Stress-Induced Hyperglycemia

  2018cites this paper
• Pulmonary inflammation-induced loss and subsequent recovery of skeletal muscle mass require functional poly-ubiquitin conjugation

  2018cites this paper
• Early nutritional inadequacy is associated with psoas muscle deterioration and worse clinical outcomes in critically ill surgical patients

  2018cites this paper
• Weak by the machines: muscle motor protein dysfunction – a side effect of intensive care unit treatment

  2018cites this paper
• Nursing diagnoses of the activity / rest domain in people living with AIDS : a transversal study

  2018influential citation
• Amino acid supplements in critically ill patients

  2017cites this paper
• The ICM research agenda on intensive care unit-acquired weakness

  2017cites this paper
• Intensive care unit-acquired weakness.

  2017cites this paper
• [Validity of scales for the functional assessment of critically ill patients].

  2017cites this paper
• Skeletal Muscle Dysfunction in Critical Illness

  2017cites this paper
• Early Mobilization and Rehabilitation in the ICU: Moving Back to the Future

  2016cites this paper
• Impaired Ca2+ release contributes to muscle weakness in a rat model of critical illness myopathy

  2016cites this paper
• Post-intensive Care Syndrome (PICS)

  2016cites this paper
• ICU-Acquired Weakness: A Rehabilitation Perspective of Diagnosis, Treatment, and Functional Management.

  2016cites this paper
• Intensive Care Unit Outcomes in Older Adults

  2016cites this paper
• EFFECTS OF CORTICOSTEROID TREATMENT ON RESPIRATORY MUSCLES FUNCTION IN PATIENTS WITH SEVERE OBSTRUCTIVE LUNG DISEASE

  2016influential citation
• Premorbid obesity, but not nutrition, prevents critical illness‐induced muscle wasting and weakness

  2016cites this paper
• Pharmacological Therapy for the Prevention and Treatment of Weakness After Critical Illness: A Systematic Review*

  2016cites this paper
• Targeting Heat Shock Proteins Mitigates Ventilator Induced Diaphragm Muscle Dysfunction in an Age-Dependent Manner

  2016cites this paper
• Mechanisms of Chronic Muscle Wasting and Dysfunction after an Intensive Care Unit Stay. A Pilot Study.

  2016cites this paper
• Neuromuscular Blocking Agents and Neuromuscular Dysfunction Acquired in Critical Illness: A Systematic Review and Meta-Analysis

  2016cites this paper
• Myopathic characteristics in septic mechanically ventilated patients

  2015influential citation
• Physical rehabilitation for critical illness myopathy and neuropathy.

  2015cites this paper
• Baseline Characteristics of Patients With and Without Myofiber Necrosis

  2015cites this paper
• The Sick and the Weak: Neuropathies/Myopathies in the Critically Ill.

  2015influential citation
• Clinical review: intensive care unit acquired weakness

  2015cites this paper
• The impact of extended bed rest on the musculoskeletal system in the critical care environment

  2015cites this paper
• Sustained elevation of circulating GDF-15 and a dynamic imbalance in mediators of muscle homeostasis is associated with the development of acute muscle wasting following cardiac surgery

  2015cites this paper
• Muscle weakness, molecular mechanisms and nutrition during critical illness

  2015cites this paper