Energy-ubiquitin-dependent muscle proteolysis during sepsis in rats is regulated by glucocorticoids.

No abstract is available for this paper.

• Publication year

  1996

• Venue

  Journal of Clinical Investigation

• Publication date

  1996-01-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1172/JCI118421PMID 8567953PMCID PMC507023
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Functions of the proteasome: the lysis at the end of the tunnel.

  1995cited by this paper
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  1995cited by this paper
• Ubiquitin gene expression is increased in skeletal muscle of tumour‐bearing rats

  1994cited by this paper
• Acidosis and glucocorticoids concomitantly increase ubiquitin and proteasome subunit mRNAs in rat muscle.

  1994influential reference
• Sepsis stimulates nonlysosomal, energy-dependent proteolysis and increases ubiquitin mRNA levels in rat skeletal muscle.

  1994influential reference
• Nucleotide sequence and expression of the rat polyubiquitin mRNA.

  1994cited by this paper
• Metabolic acidosis stimulates muscle protein degradation by activating the adenosine triphosphate-dependent pathway involving ubiquitin and proteasomes.

  1994cited by this paper
• Antioxidant: a new role for RU-486 and related compounds.

  1994cited by this paper
• Glucocorticoids activate the ATP-ubiquitin-dependent proteolytic system in skeletal muscle during fasting.

  1993influential reference
• The ubiquitin system for protein degradation.

  1992cited by this paper
• ATP depletion stimulates calcium-dependent protein breakdown in chick skeletal muscle.

  1992cited by this paper
• Effect of the glucocorticoid receptor antagonist RU 38486 on muscle protein breakdown in sepsis.

  1991influential reference
• Influence of sepsis in rats on muscle protein turnover in vivo and in tissue incubated under different in vitro conditions.

  1991cited by this paper
• Role of different proteolytic systems in the degradation of muscle proteins during denervation atrophy.

  1990cited by this paper
• Regulation of total and myofibrillar protein breakdown in rat extensor digitorum longus and soleus muscle incubated flaccid or at resting length.

  1990cited by this paper
• Corticosterone alone does not explain increased muscle proteolysis in septic rats.

  1990cited by this paper
• Properties of glutamine release from muscle and its importance for the immune system.

  1990cited by this paper
• Total and myofibrillar protein breakdown in different types of rat skeletal muscle: effects of sepsis and regulation by insulin.

  1989influential reference
• Hemodynamic and metabolic alterations during experimental sepsis in young and adult rats.

  1989cited by this paper
• UbiA, the major polyubiquitin locus in Caenorhabditis elegans, has unusual structural features and is constitutively expressed

  1989cited by this paper
• Unequal crossover generates variation in ubiquitin coding unit number at the human UbC polyubiquitin locus.

  1989cited by this paper
• The effect of sepsis in rats on skeletal muscle protein synthesis in vivo and in periphery and central core of incubated muscle preparations in vitro.

  1988cited by this paper
• Increased synthesis of secreted hepatic proteins during abdominal sepsis.

  1988cited by this paper
• Physiological hypercortisolemia increases proteolysis, glutamine, and alanine production.

  1988cited by this paper
• Sensitivity of myofibrillar proteins to glucocorticoid-induced muscle proteolysis.

  1987influential reference
• Protein damage and degradation by oxygen radicals. I. general aspects.

  1987cited by this paper
• Maintenance of normal length improves protein balance and energy status in isolated rat skeletal muscles.

  1986cited by this paper
• Inhibited Muscle Amino Acid Uptake in Sepsis

  1986cited by this paper
• Blockade of glucocorticoid receptor binding and inhibition of dexamethasone-induced muscle atrophy in the rat by RU38486, a potent glucocorticoid antagonist.

  1986influential reference
• The human ubiquitin multigene family: some genes contain multiple directly repeated ubiquitin coding sequences.

  1985influential reference
• RU 38486: An Original Multifaceted Antihormone in Vivo

  1984cited by this paper
• Muscle proteolysis induced by a circulating peptide in patients with sepsis or trauma.

  1983cited by this paper
• The role of oxygen free radicals in human disease processes.

  1983cited by this paper
• The role of oxygen free radicals in human disease processes.

  1983cited by this paper
• Cortisol and corticotrophin in burned patients.

  1982cited by this paper
• The differing responses of four muscle types to dexamethasone treatment in the rat.

  1982influential reference
• Respiratory fuels and nitrogen metabolism in vivo in small intestine of fed rats. Quantitative importance of glutamine, glutamate, and aspartate.

  1980cited by this paper
• Effect of sepsis on tissue adenine nucleotide levels.

  1979cited by this paper
• Ntau-methylhistidine (3-methylhistidine) and muscle protein turnover: an overview.

  1978cited by this paper
• Ntau-methylhistidine (3-methylhistidine) and muscle protein turnover: an overview.

  1978cited by this paper
• Compositional studies of myofibrils from rabbit striated muscle

  1976cited by this paper
• In vitro preparations of the diaphragm and other skeletal muscles.

  1975cited by this paper
• Protein measurement with the Folin phenol reagent.

  1951cited by this paper

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