Yin Yang 1 Promotes Thymocyte Survival by Downregulating p53

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Journal of Immunology

• Publication date

  2016-02-03

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.4049/jimmunol.1501916PMID 26843327PMCID PMC4779672
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A structural hierarchy mediated by multiple nuclear factors establishes IgH locus conformation

  2015cited by this paper
• A discrete chromatin loop in the murine Tcra-Tcrd locus shapes the TCRδ and TCRα repertoires

  2015cited by this paper
• Interleukin-7 co-ordinates proliferation, differentiation and Tcra recombination during thymocyte β-selection

  2015cited by this paper
• Chromatin Dynamics and the Development of the TCRα and TCRδ Repertoires.

  2015cited by this paper
• Developmental gene networks: a triathlon on the course to T cell identity

  2014cited by this paper
• YY1 is indispensable for Lgr5+ intestinal stem cell renewal

  2014cited by this paper
• Yin Yang 1 regulates the transcriptional repression of Survivin.

  2014cited by this paper
• Unifying model for molecular determinants of the preselection Vβ repertoire

  2013cited by this paper
• microRNA-7 is a novel inhibitor of YY1 contributing to colorectal tumorigenesis

  2013cited by this paper
• YY1 controls Igκ repertoire and B‐cell development, and localizes with condensin on the Igκ locus

  2013cited by this paper
• Flexible long-range loops in the VH gene region of the Igh locus facilitate the generation of a diverse antibody repertoire.

  2013cited by this paper
• Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy

  2013influential reference
• Smurf2 suppresses B-cell proliferation and lymphomagenesis by mediating ubiquitination and degradation of YY1

  2013cited by this paper
• Noncoding transcription within the Igh distal VH region at PAIR elements affects the 3D structure of the Igh locus in pro-B cells

  2012cited by this paper
• Transcription factor YY1 is essential for regulation of the Th2 cytokine locus and for Th2 cell differentiation

  2012cited by this paper
• Tcra gene recombination is supported by a Tcra enhancer- and CTCF-dependent chromatin hub

  2012cited by this paper
• Increased Expression of PcG Protein YY1 Negatively Regulates B Cell Development while Allowing Accumulation of Myeloid Cells and LT-HSC Cells

  2012cited by this paper
• p53 opens the mitochondrial permeability transition pore to trigger necrosis.

  2012cited by this paper
• Yin Yang 1 extends the Myc-related transcription factors network in embryonic stem cells

  2011cited by this paper
• Differential regulation of the proapoptotic multidomain protein Bak by p53 and p73 at the promoter level

  2011cited by this paper
• CD28 expression redefines thymocyte development during the pre-T to DP transition.

  2010cited by this paper
• Stress-mediated nuclear stabilization of p53 is regulated by ubiquitination and importin-α3 binding

  2010cited by this paper
• Fine-Scale Staging of T Cell Lineage Commitment in Adult Mouse Thymus

  2010cited by this paper
• Cytoplasmic functions of the tumour suppressor p53

  2009cited by this paper
• BclxL Changes Conformation upon Binding to Wild-type but Not Mutant p53 DNA Binding Domain*

  2009cited by this paper
• The involvement of the transcription factor Yin Yang 1 in cancer development and progression

  2009cited by this paper
• Transcriptional control of human p53-regulated genes

  2008cited by this paper
• Ablation of ribosomal protein L22 selectively impairs alphabeta T cell development by activation of a p53-dependent checkpoint.

  2007cited by this paper
• Yin Yang-1 Inhibits Vascular Smooth Muscle Cell Growth and Intimal Thickening by Repressing p21WAF1/Cip1 Transcription and p21WAF1/Cip1-Cdk4-Cyclin D1 Assembly

  2007cited by this paper
• Yin Yang 1 is a critical regulator of B-cell development.

  2007cited by this paper
• Essential Dosage-Dependent Functions of the Transcription Factor Yin Yang 1 in Late Embryonic Development and Cell Cycle Progression

  2006cited by this paper
• Developmental and molecular characterization of emerging beta- and gammadelta-selected pre-T cells in the adult mouse thymus.

  2006cited by this paper
• The p53–Bcl-2 connection

  2006cited by this paper
• The transcriptional targets of p53 in apoptosis control.

  2005cited by this paper
• Notch promotes survival of pre–T cells at the β-selection checkpoint by regulating cellular metabolism

  2005cited by this paper
• Direct Activation of Bax by p53 Mediates Mitochondrial Membrane Permeabilization and Apoptosis

  2004influential reference
• Obligatory Role for Cooperative Signaling by Pre-TCR and Notch during Thymocyte Differentiation1

  2004cited by this paper
• Yin Yang 1 is a negative regulator of p53.

  2004cited by this paper
• YY1 inhibits the activation of the p53 tumor suppressor in response to genotoxic stress.

  2004influential reference
• Mitochondrial p53 activates Bak and causes disruption of a Bak–Mcl1 complex

  2004cited by this paper
• p53- and Drug-Induced Apoptotic Responses Mediated by BH3-Only Proteins Puma and Noxa

  2003cited by this paper
• Transgenic mice with hematopoietic and lymphoid specific expression of Cre

  2003cited by this paper
• p53 has a direct apoptogenic role at the mitochondria.

  2003influential reference
• Live or let die: the cell's response to p53

  2002cited by this paper
• Human survivin is negatively regulated by wild-type p53 and participates in p53-dependent apoptotic pathway

  2002cited by this paper
• Regulation of the TCRalpha repertoire by the survival window of CD4(+)CD8(+) thymocytes.

  2002cited by this paper
• Induction of T cell development from hematopoietic progenitor cells by delta-like-1 in vitro.

  2002cited by this paper
• Regulation of the TCRα repertoire by the survival window of CD4+CD8+ thymocytes

  2002cited by this paper
• Regulation of thymocyte differentiation: pre-TCR signals and beta-selection.

  2002cited by this paper
• PUMA induces the rapid apoptosis of colorectal cancer cells.

  2001cited by this paper
• The Role of Recombination Activating Gene (RAG) Reinduction in Thymocyte Development in Vivo

  2001cited by this paper
• PUMA, a novel proapoptotic gene, is induced by p53.

  2001cited by this paper
• A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival.

  2001cited by this paper
• The Central Role of Phosphatidylserine in the Phagocytosis of Apoptotic Thymocytes

  2000cited by this paper
• Requirement for RORgamma in thymocyte survival and lymphoid organ development.

  2000cited by this paper
• A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy.

  1999cited by this paper
• Characterization of TCR gene rearrangements during adult murine T cell development.

  1999cited by this paper
• Pre-TCR signaling and inactivation of p53 induces crucial cell survival pathways in pre-T cells.

  1999cited by this paper
• Kinetics of T cell receptor beta, gamma, and delta rearrangements during adult thymic development: T cell receptor rearrangements are present in CD44(+)CD25(+) Pro-T thymocytes.

  1998cited by this paper
• Kinetics of T cell receptor β, γ, and δ rearrangements during adult thymic development: T cell receptor rearrangements are present in CD44+CD25+ Pro-T thymocytes

  1998cited by this paper
• Everything you have ever wanted to know about Yin Yang 1......

  1997cited by this paper
• Regulation of p53 stability by Mdm2

  1997cited by this paper
• p53 prevents maturation to the CD4+CD8+ stage of thymocyte differentiation in the absence of T cell receptor rearrangement

  1996cited by this paper
• V(D)J recombination activates a p53-dependent DNA damage checkpoint in scid lymphocyte precursors.

  1996cited by this paper
• T-cell-specific deletion of a polypeptide N-acetylgalactosaminyl-transferase gene by site-directed recombination.

  1995influential reference
• CD3ε-mediated signals rescue the development of CD4+CD8+ thymocytes in RAG-2−/− mice in the absence of TCR β chain expression

  1994influential reference
• CD3 epsilon-mediated signals rescue the development of CD4+CD8+ thymocytes in RAG-2-/- mice in the absence of TCR beta chain expression.

  1994cited by this paper
• RAG-1-deficient mice have no mature B and T lymphocytes.

  1992cited by this paper

• A bridge between embryonic development and disease: The converging regulatory roles of RKIP and YY1.

  2026cites this paper
• YY1 in four dimensions: From context-dependent transcription factor to spatiotemporal gene regulator.

  2026cites this paper
• The roles and perspectives of YY1 in immune central tolerance establishment.

  2025cites this paper
• CD4+CD8+ double-positive T cells in immune disorders and cancer: Prospects and hurdles in immunotherapy.

  2025cites this paper
• Yin Yang 1 regulates cohesin complex protein SMC3 in mouse hematopoietic stem cells

  2024cites this paper
• Transcriptional Regulation of Early T-Lymphocyte Development in Thymus

  2022cites this paper
• 3D Genome Organization as an Epigenetic Determinant of Transcription Regulation in T Cells

  2022cites this paper
• Astrocytic Yin Yang 1 is critical for murine brain development and protection against apoptosis, oxidative stress, and inflammation

  2022cites this paper
• Loss of Zfp335 triggers cGAS/STING-dependent apoptosis of post-β selection thymocytes

  2022cites this paper
• Chromatin organizer SATB1 controls the cell identity of CD4+ CD8+ double-positive thymocytes by regulating the activity of super-enhancers

  2022cites this paper
• The Transcription Factor YY-1 Is an Essential Regulator of T Follicular Helper Cell Differentiation

  2022cites this paper
• A lineage-specific requirement for YY1 polycomb group protein function in early T cell development.

  2021cites this paper
• Expression of YY1 in pro-B and T phenotypes correlation with poor survival in pediatric acute lymphoblastic leukemia

  2021cites this paper
• Chromatin organizer SATB1 controls the cell identity of CD4+ CD8+ double-positive thymocytes by compacting super-enhancers

  2021cites this paper
• Loss of Zfp335 triggers cGAS/STING-dependent apoptosis of post-β selection pre-T cells

  2021cites this paper
• YY1lo NKT cells are dedicated IL-10 producers

  2020cites this paper
• Mitochondrial Pyruvate Carrier 1 Promotes Peripheral T Cell Homeostasis through Metabolic Regulation of Thymic Development.

  2020cites this paper
• Yin Yang 1 is critical for mid-hindbrain neuroepithelium development and involved in cerebellar agenesis

  2020cites this paper
• Yin Yang 1 sustains biosynthetic demands during brain development in a stage-specific manner

  2019cites this paper
• An integrated transcriptional switch at the β-selection checkpoint determines T cell survival, development and leukaemogenesis.

  2019cites this paper
• Transcription factor YY1 is essential for iNKT cell development

  2019cites this paper
• Coexpression of YY1 Is Required to Elaborate the Effector Functions Controlled by PLZF in NKT Cells

  2019influential citation
• Polycomb Group Protein YY1 Is an Essential Regulator of Hematopoietic Stem Cell Quiescence

  2018cites this paper
• Diversification of the TCR β Locus Vβ Repertoire by CTCF

  2018cites this paper
• Liver-directed microRNA-7a depletion induces nonalcoholic fatty liver disease by stabilizing YY1-mediated lipogenic pathways in zebrafish.

  2018cites this paper
• EZH2 Regulates the Developmental Timing of Effectors of the Pre–Antigen Receptor Checkpoints

  2017cites this paper
• The SMURF2-YY1-C-MYC Axis in the Germinal Center Reaction and Diffuse Large B Cell Lymphoma: A Dissertation

  2016cites this paper
• YY1 plays an essential role at all stages of B-cell differentiation

  2016cites this paper