Charge replacement near the phosphorylatable serine of the myosin regulatory light chain mimics aspects of phosphorylation.

No abstract is available for this paper.

• Publication year

  1994

• Venue

  Proceedings of the National Academy of Sciences of the United States of America

• Publication date

  1994-02-15

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1073/PNAS.91.4.1490PMID 8108436PMCID PMC43185
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Chimeric regulatory light chains as probes of smooth muscle myosin function.

  1993cited by this paper
• Effects of phosphorylation by myosin light chain kinase on the structure of Limulus thick filaments

  1991cited by this paper
• Smooth muscle myosin cross-bridge interactions modulate actin filament sliding velocity in vitro

  1990cited by this paper
• Alteration of cross-bridge kinetics by myosin light chain phosphorylation in rabbit skeletal muscle: implications for regulation of actin-myosin interaction.

  1990cited by this paper
• Peptides and Protein Phosphorylation

  1990cited by this paper
• Characterization and differential expression of human vascular smooth muscle myosin light chain 2 isoform in nonmuscle cells.

  1989cited by this paper
• Filamentous smooth muscle myosin is regulated by phosphorylation

  1989cited by this paper
• Variations in cross-bridge attachment rate and tension with phosphorylation of myosin in mammalian skinned skeletal muscle fibers. Implications for twitch potentiation in intact muscle

  1989cited by this paper
• The regulatory light chain is required for folding of smooth muscle myosin.

  1988cited by this paper
• Characterization of regulatory light chain-a myosin kinase from smooth muscle of scallop, Patinopecten yessoensis.

  1987cited by this paper
• Structural changes accompanying phosphorylation of tarantula muscle myosin filaments

  1987cited by this paper
• Phosphorylation of myosin in permeabilized mammalian cardiac and skeletal muscle cells.

  1986cited by this paper
• Light chain phosphorylation regulates the movement of smooth muscle myosin on actin filaments

  1985cited by this paper
• A mechanical study of regulation in the striated adductor muscle of the scallop.

  1985cited by this paper
• The effect of myosin phosphorylation on the contractile properties of skinned rabbit skeletal muscle fibers.

  1985cited by this paper
• The function of myosin and myosin light chain kinase phosphorylation in smooth muscle.

  1985cited by this paper
• Rapid and efficient site-specific mutagenesis without phenotypic selection.

  1985cited by this paper
• Conformational states of smooth muscle myosin. Effects of light chain phosphorylation and ionic strength.

  1984cited by this paper
• Correlation of enzymatic properties and conformation of smooth muscle myosin.

  1983cited by this paper
• Calcium-independent myosin light chain kinase of smooth muscle. Preparation by limited chymotryptic digestion of the calcium ion dependent enzyme, purification, and characterization.

  1982cited by this paper
• Electron microscopic studies of myosin molecules from chicken gizzard muscle I: the formation of the intramolecular loop in the myosin tail.

  1982cited by this paper
• Phosphorylation-dependent regulation of Limulus myosin.

  1981cited by this paper
• Reversible phosphorylation of smooth muscle myosin, heavy meromyosin, and platelet myosin.

  1981cited by this paper
• Control of tension development in scallop muscle fibres with foreign regulatory light chains

  1980cited by this paper
• Phosphorylation-dephosphorylation of the 18,000-dalton light chain of myosin during the contraction-relaxation cycle of frog muscle.

  1979cited by this paper
• Structure and function of chicken gizzard myosin.

  1978cited by this paper
• Regulatory light chains in myosins.

  1976cited by this paper
• A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

  1976cited by this paper

• Mechanisms of myosin II force generation. Insights from novel experimental techniques and approaches.

  2024cites this paper
• Post‐translational modifications of vertebrate striated muscle myosin heavy chains

  2024cites this paper
• Phosphorylation of myosin regulatory light chain at Ser17 regulates actomyosin dissociation.

  2021cites this paper
• Regulatory Light Chains in Cardiac Development and Disease

  2021cites this paper
• Post‐activation potentiation induced by concentric contractions at three speeds in humans

  2021cites this paper
• Mechanosignaling pathways alter muscle structure and function by post-translational modification of existing sarcomeric proteins to optimize energy usage

  2021cites this paper
• Cryo-EM structure of the inhibited (10S) form of myosin II

  2020cites this paper
• Using the SpyTag SpyCatcher system to label smooth muscle myosin II filaments with a quantum dot on the regulatory light chain

  2019cites this paper
• Quantitative Proteomics and Phosphoproteomics Analysis Revealed Different Regulatory Mechanisms of Halothane and Rendement Napole Genes in Porcine Muscle Metabolism.

  2018cites this paper
• Myosin phosphorylation improves contractile economy of mouse fast skeletal muscle during staircase potentiation

  2018cites this paper
• Activation of ROCK and MLCK tunes regional stress fiber formation and mechanics via preferential myosin light chain phosphorylation

  2017cites this paper
• Mechanisms controlling ureteral motility

  2016cites this paper
• Reduced power output in skeletal muscles devoid of skMLCK: RLC phosphorylation contributes to peak performance

  2016cites this paper
• Study of Spatiotemporal Orientation and Cross Bridge Kinetics in Ventricular and Skeletal Muscles

  2016cites this paper
• Drosophila non-muscle myosin II motor activity determines the rate of tissue folding

  2016cites this paper
• X-ray diffraction analysis of the effects of myosin regulatory light chain phosphorylation and butanedione monoxime on skinned skeletal muscle fibers.

  2016cites this paper
• Modulation of Skeletal Muscle Contraction by Myosin Phosphorylation.

  2016cites this paper
• 1 X-RAY DIFFRACTION ANALYSIS OF THE EFFECTS OF MYOSIN 1 REGULATORY LIGHT CHAIN PHOSPHORYLATION AND BUTANEDIONE 2 MONOXIME ON SKINNED SKELETAL MUSCLE FIBERS 3

  2016cites this paper
• The role of super-relaxed myosin in skeletal and cardiac muscle

  2015cites this paper
• in human skeletal muscle after cast immobilization Changes in inorganic phosphate and force production

  2015cites this paper
• Altered contractile mechanics and Ca2+ handling contribute to cardiomyopathy pathogenesis

  2015cites this paper
• The role of myosin regulatory light chain phosphorylation in cardiac health and disease

  2015cites this paper
• Application of Methods of Inducing Postactivation Potentiation During the Preparation of Rugby Players

  2015cites this paper
• Four things to know about myosin light chains as reporters for non‐muscle myosin‐2 dynamics in live cells

  2015cites this paper
• Rad23 interaction with the proteasome is regulated by phosphorylation of its ubiquitin-like (UbL) domain.

  2014cites this paper
• Mechanisms affecting post-activation potentiation following voluntary isokinetic knee extension

  2014cites this paper
• Phosphorylation of myosin regulatory light chain has minimal effect on kinetics and distribution of orientations of cross bridges of rabbit skeletal muscle.

  2014cites this paper
• Effects of pseudophosphorylation mutants on the structural dynamics of smooth muscle myosin regulatory light chain.

  2014cites this paper
• Myosin light chains: Teaching old dogs new tricks

  2014cites this paper
• Role of the essential light chain in the activation of smooth muscle myosin by regulatory light chain phosphorylation.

  2014influential citation
• Spatiotemporal control of epithelial remodeling by regulated myosin phosphorylation

  2014cites this paper
• Getting the skinny on thick filament regulation in cardiac muscle biology and disease.

  2014cites this paper
• Degree of order and kinetics of phosphorylated (P) and de-P cross-bridges 1 PHOSPHORYLATION OF MYOSIN REGULATORY LIGHT CHAIN HAS MINIMAL EFFECT ON KINETICS AND DISTRIBUTION OF ORIENTATIONS OF CROSS- BRIDGES OF RABBIT SKELETAL MUSCLE

  2013cites this paper
• ATP2B1 and blood pressure: from associations to pathophysiology

  2013cites this paper
• Myosin Regulatory Light Chain (RLC) Phosphorylation Change as a Modulator of Cardiac Muscle Contraction in Disease

  2013cites this paper
• Myosin phosphorylation and force potentiation in skeletal muscle: evidence from animal models

  2013cites this paper
• An aromatic amino acid in the coiled-coil 1 domain plays a crucial role in the auto-inhibitory mechanism of STIM1.

  2013cites this paper
• Mouse and computational models link Mlc2v dephosphorylation to altered myosin kinetics in early cardiac disease.

  2012cites this paper
• Phosphorylated smooth muscle heavy meromyosin shows an open conformation linked to activation.

  2012cites this paper
• Pathogenic Role of Store-Operated and Receptor-Operated Ca2+ Channels in Pulmonary Arterial Hypertension

  2012cites this paper
• 4.14 Smooth Muscle and Myosin Regulation

  2012cites this paper
• The effect of skeletal myosin light chain kinase gene ablation on the fatigability of mouse fast muscle

  2011cites this paper
• Myosin light chain kinase and the role of myosin light chain phosphorylation in skeletal muscle.

  2011cites this paper
• Role of the tail in the regulated state of myosin 2.

  2011cites this paper
• Myosin light-chain phosphorylation and potentiation of dynamic function in mouse fast muscle

  2011cites this paper
• The effect of work cycle frequency on the potentiation of dynamic force in mouse fast twitch skeletal muscle

  2011cites this paper
• Vascular smooth muscle myosin light chain diphosphorylation: Mechanism, function, and pathological implications

  2011cites this paper
• Phosphorylation of human calsequestrin: implications for calcium regulation

  2011cites this paper
• The role of nonmuscle Myosin IIA in endothelial cell

  2010cites this paper
• Regulatory light chains modulate in vitro actin motility driven by skeletal heavy meromyosin.

  2010cites this paper
• Differential roles of regulatory light chain and myosin binding protein‐C phosphorylations in the modulation of cardiac force development

  2010influential citation
• The Ubiquitin-Proteasome System Regulates the Accumulation of Turnip yellow mosaic virus RNA-Dependent RNA Polymerase during Viral Infection[W]

  2010cites this paper
• CAMDI, a Novel Disrupted in Schizophrenia 1 (DISC1)-binding Protein, Is Required for Radial Migration*

  2010cites this paper
• Locomotion versus spawning: escape responses during and after spawning in the scallop Argopecten purpuratus

  2009cites this paper
• Increased CRMP2 phosphorylation is observed in Alzheimer's disease; does this tell us anything about disease development?

  2009cites this paper
• Phosphorylation-induced structural changes in smooth muscle myosin regulatory light chain

  2009cites this paper
• Three-dimensional reconstruction of tarantula myosin filaments suggests how phosphorylation may regulate myosin activity.

  2008cites this paper
• Thermodynamic and structural basis of phosphorylation-induced disorder-to-order transition in the regulatory light chain of smooth muscle myosin.

  2008cites this paper
• Skeletal muscle fatigue: cellular mechanisms.

  2008cites this paper
• Invertebrate muscles: thin and thick filament structure; molecular basis of contraction and its regulation, catch and asynchronous muscle.

  2008cites this paper
• Investigation of the N-terminal interactions of cardiac Myosin-Binding Protein C (cMyBPC) under defined phosphorylation states

  2008cites this paper
• Phosphorylation of CKBBP2/CRIF1 by protein kinase CKII promotes cell proliferation.

  2007cites this paper
• Molecular dynamics simulations reveal a disorder-to-order transition on phosphorylation of smooth muscle myosin.

  2007cites this paper
• An investigation of NAADP-dependent Ca²⁺ signalling mechanisms in arterial smooth muscle

  2007cites this paper
• Ectopic expression of caveolin-1 restores physiological contractile response of aged colonic smooth muscle.

  2007influential citation
• Acceleration of Stretch Activation in Murine Myocardium due to Phosphorylation of Myosin Regulatory Light Chain

  2006cites this paper
• Phosphorylation of Viral RNA-dependent RNA Polymerase and Its Role in Replication of a Plus-strand RNA Virus*

  2006cites this paper
• Phosphorylation of a single head of smooth muscle myosin activates the whole molecule.

  2006cites this paper
• GSK-3β Regulates Phosphorylation of CRMP-2 and Neuronal Polarity

  2005cites this paper
• Changes in inorganic phosphate and force production in human skeletal muscle after cast immobilization.

  2005cites this paper
• Rho mediates endocytosis of epidermal growth factor receptor through phosphorylation of endophilin A1 by Rho‐kinase

  2005cites this paper
• Site-directed spin labeling reveals a conformational switch in the phosphorylation domain of smooth muscle myosin.

  2005cites this paper
• Prediction of secondary ionization of the phosphate group in phosphotyrosine peptides.

  2003cites this paper
• Phosphorylation of myosin II regulatory light chain is necessary for migration of HeLa cells but not for localization of myosin II at the leading edge.

  2003cites this paper
• Phosphorylation of Threonine 10 on CKBBP1/SAG/ROC2/Rbx2 by Protein Kinase CKII Promotes the Degradation of IκBα and p27Kip1*

  2003cites this paper
• Genetic analysis in hypertrophic cardiomyopathy : missense mutations in the ventricular myosin regulatory light chain gene

  2002cites this paper
• Novel peptide inhibitors of Leishmania gp63 based on the cleavage site of MARCKS (myristoylated alanine-rich C kinase substrate)-related protein.

  2002cites this paper
• The Thick Filament of Vertebrate Striated Muscle

  2002cites this paper
• A "wringing" endorsement for myosin phosphorylation in the heart.

  2002cites this paper
• Effects of pH on the length-dependent twitch potentiation in skeletal muscle.

  2002cites this paper
• Influence of length on force and activation-dependent changes in troponin c structure in skinned cardiac and fast skeletal muscle.

  2001cites this paper
• Diphosphorylated MRLC is required for organization of stress fibers in interphase cells and the contractile ring in dividing cells.

  2001cites this paper
• Protein variants of skeletal muscle regulatory myosin light chain isoforms: prevalence in mammals, generation and transitions during muscle remodelling

  2001cites this paper
• Effects of Aging on Contraction and Ca 2+ Mobilization in Smooth Muscle Cells of the Rat Coronary Artery

  2001cites this paper
• Regulation of smooth muscle contraction

  2000cites this paper
• Regulation of contraction in striated muscle.

  2000cites this paper
• Two distinct mechanisms for regulation of nonmuscle myosin assembly via the heavy chain: phosphorylation for MIIB and mts 1 binding for MIIA.

  2000cites this paper
• Myosin light chain kinase mediates sarcomere organization during cardiac hypertrophy in vitro

  2000cites this paper
• Phosphorylation of Myosin-Binding Subunit (Mbs) of Myosin Phosphatase by Rho-Kinase in Vivo

  1999cites this paper
• Phosphorylation of Adducin by Rho-Kinase Plays a Crucial Role in Cell Motility

  1999cites this paper
• Dynamic modulation of the regulatory domain of myosin heads by pH, ionic strength, and RLC phosphorylation in synthetic myosin filaments.

  1999cites this paper
• The COOH Terminus of Rho-kinase Negatively Regulates Rho-kinase Activity*

  1999cites this paper
• Myofibrillar protein structure and assembly during idiopathic dilated cardiomyopathy

  1999cites this paper
• Abnormal Cardiac Structure and Function in Mice Expressing Nonphosphorylatable Cardiac Regulatory Myosin Light Chain 2*

  1999cites this paper
• Lever arm model of force generation by actin-myosin-ATP.

  1999cites this paper
• Registration of the rod is not critical for the phosphorylation-dependent regulation of smooth muscle myosin.

  1999cites this paper
• Cell adhesion and Rho small GTPases.

  1999cites this paper
• Phosphorylation of Heterochromatin Protein 1 by Casein Kinase II Is Required for Efficient Heterochromatin Binding inDrosophila *

  1999cites this paper
• Regulation of the cytoskeleton and cell adhesion by the Rho family GTPases in mammalian cells.

  1999cites this paper
• Regulation of cross-bridge cycling by Ca2+ in smooth muscle.

  1999cites this paper