Light, heat, action: neural control of fruit fly behaviour

The fruit fly Drosophila melanogaster has emerged as a popular model to investigate fundamental principles of neural circuit operation. The sophisticated genetics and small brain permit a cellular resolution understanding of innate and learned behavioural processes. Relatively recent genetic and technical advances provide the means to specifically and reproducibly manipulate the function of many fly neurons with temporal resolution. The same cellular precision can also be exploited to express genetically encoded reporters of neural activity and cell-signalling pathways. Combining these approaches in living behaving animals has great potential to generate a holistic view of behavioural control that transcends the usual molecular, cellular and systems boundaries. In this review, we discuss these approaches with particular emphasis on the pioneering studies and those involving learning and memory.

• Publication year

  2015

• Venue

  Philosophical Transactions of the Royal Society B: Biological Sciences

• Publication date

  2015-09-19

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1098/rstb.2014.0211PMID 26240426PMCID 4528823
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2012influential reference
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  2007cited by this paper
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  2007cited by this paper
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  2007cited by this paper

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