Structure of a fucose transporter in an outward-open conformation

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Nature

• Publication date

  2010-10-07

• Fields of study

  Biology, Medicine, Materials Science, Chemistry

• Identifiers
  DOI 10.1038/nature09406PMID 20877283
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• CHARMM: The biomolecular simulation program

  2009cited by this paper
• Probing of the rates of alternating access in LacY with Trp fluorescence

  2009cited by this paper
• The sodium-dependent D-glucose transport protein of Helicobacter pylori.

  2009cited by this paper
• Binding of an octylglucoside detergent molecule in the second substrate (S2) site of LeuT establishes an inhibitor-bound conformation

  2009cited by this paper
• Ins and outs of major facilitator superfamily antiporters.

  2008cited by this paper
• Phaser crystallographic software

  2007cited by this paper
• Structural determination of wild-type lactose permease

  2007cited by this paper
• Structure of the Multidrug Transporter EmrD from Escherichia coli

  2006cited by this paper
• Structural evidence for induced fit and a mechanism for sugar/H+ symport in LacY

  2006cited by this paper
• Lessons from lactose permease.

  2006cited by this paper
• Structure and mechanism of the lactose permease.

  2005cited by this paper
• Scalable molecular dynamics with NAMD

  2005cited by this paper
• Coot: model-building tools for molecular graphics.

  2004cited by this paper
• Binding affinity of lactose permease is not altered by the H+ electrochemical gradient.

  2004cited by this paper
• Cloning and Characterization of a Novel Na+-dependent Glucose Transporter (NaGLT1) in Rat Kidney*

  2003cited by this paper
• Regulation of Expression of the 2-Deoxy-d-Ribose Utilization Regulon, deoQKPX, from Salmonella enterica Serovar Typhimurium

  2003cited by this paper
• Structure and Mechanism of the Lactose Permease of Escherichia coli

  2003cited by this paper
• Fucose: biosynthesis and biological function in mammals.

  2003cited by this paper
• Structure and Mechanism of the Glycerol-3-Phosphate Transporter from Escherichia coli

  2003cited by this paper
• Substructure solution with SHELXD.

  2002cited by this paper
• The kamikaze approach to membrane transport

  2001cited by this paper
• Substrate Recognition at the Cytoplasmic and Extracellular Binding Site of the Lactose Transport Protein of Streptococcus thermophilus *

  1999cited by this paper
• Characterization of Glucose-Specific Catabolite Repression-Resistant Mutants of Bacillus subtilis: Identification of a Novel Hexose:H+ Symporter

  1998cited by this paper
• Major Facilitator Superfamily

  1998cited by this paper
• Processing of X-ray diffraction data collected in oscillation mode.

  1997cited by this paper
• Topological analyses of the l‐fucose‐H+ symport protein, FucP, from Escherichia coli

  1995cited by this paper
• The CCP4 suite: programs for protein crystallography.

  1994cited by this paper
• Identification of a novel sugar‐H+ symport protein, FucP, for transport of L‐fucose into Escherichia coli

  1994cited by this paper
• Functional roles of Glu-269 and Glu-325 within the lactose permease of Escherichia coli.

  1994cited by this paper
• Proton-linked L-fucose transport in Escherichia coli.

  1987cited by this paper

• Synthesis and Pd(0)‐Catalyzed Arylation of Naphthalen‐2‐yl 5‐Bromofuran‐2‐Carboxylate Derivatives: Anticonvulsant Evaluation via In Vivo and In Silico Studies

  2026cites this paper
• In silico analysis of pathogenic islands and metabolic pathways for understanding infection biology and lifestyle of Clostridium chauvoei

  2026cites this paper
• Identification and engineering of a new glucose transporter for high-efficiency fatty acid biosynthesis in Schizochytrium

  2026cites this paper
• Structure-based modeling and engineering of Corynebacterium glutamicum LysE transporter for efficient extrusion of L-arginine

  2025cites this paper
• The molecular mechanism underlying the human glucose facilitators inhibition.

  2025cites this paper
• Facile Synthesis of Thiophen‐2‐ylmethyl 5‐Phenylfuran‐2‐Carboxylates Through SMC Reaction: Assessing Their Anti‐Seizure Potential and Molecular Docking Studies

  2025cites this paper
• Multidrug resistance and major facilitator superfamily antimicrobial efflux pumps of the ESKAPEE pathogen Staphylococcus aureus

  2025cites this paper
• Structural and functional insights of AmpG in muropeptide transport and multiple β-lactam antibiotics resistance

  2025cites this paper
• Major facilitator superfamily efflux pumps in human pathogens: Role in multidrug resistance and beyond

  2024cites this paper
• Transport mechanism of DgoT, a bacterial homolog of SLC17 organic anion transporters

  2024influential citation
• Cryo-EM characterization of the anydromuropeptide permease AmpG central to bacterial fitness and β-lactam antibiotic resistance

  2024influential citation
• Synthesis of N, N-Bis([1,1′-Biphenyl]-4-ylmethyl)-4-morpholinoaniline derivatives via SMC reaction: Assessing their anti-seizure potential through electroencephalogram evaluation and molecular docking studies

  2024cites this paper
• Cultivation of SAR202 Bacteria from the Ocean

  2023cites this paper
• E � ux pump in genomic island GIM 202 a mediates transfer of Polymyxin B resistance in Pandoraea pnomenusa M 202

  2023cites this paper
• An efflux pump in genomic island GI-M202a mediates the transfer of polymyxin B resistance in Pandoraea pnomenusa M202

  2023cites this paper
• Macrophytes and their wrack as a habitat for faecal indicator bacteria and Vibrio in coastal marine environments.

  2023cites this paper
• Cultivation of marine bacteria of the SAR202 clade

  2023cites this paper
• Enhanced internal ionic interaction of MFS efflux pump MdfA contributes to its elevated antibiotic export.

  2022cites this paper
• Distantly Related Homologue of UhpT in Pseudomonas aeruginosa

  2022cites this paper
• Structures of ferroportin in complex with its specific inhibitor vamifeport

  2022cites this paper
• Identification of a major facilitator superfamily protein that is beneficial to L-lactic acid production by Bacillus coagulans at low pH

  2022cites this paper
• Mutagenesis and functional analysis of SotB: A multidrug transporter of the major facilitator superfamily from Escherichia coli

  2022cites this paper
• Substrate-binding guides individual melibiose permeases MelB to structurally soften and to destabilize cytoplasmic middle-loop C3.

  2022cites this paper
• Structural basis of organic cation transporter-3 inhibition

  2022cites this paper
• An overview of the Plasmodium falciparum hexose transporter and its therapeutic interventions

  2022cites this paper
• X-ray crystallography reveals molecular recognition mechanism for sugar binding in a melibiose transporter MelB

  2021cites this paper
• FucP promotes the pathogenicity of Edwardsiella piscicida to infect zebrafish

  2021cites this paper
• Efficient Production of 2'-Fucosyllactose from l-Fucose via Self-Assembling Multienzyme Complexes in Engineered Escherichia coli.

  2021cites this paper
• Cryo-EM structures of Toll-like receptors in complex with UNC93B1

  2021cites this paper
• Impact of natural mutations on the riboflavin transporter 2 and their relevance to human riboflavin transporter deficiency 2

  2021cites this paper
• How do antiporters exchange substrates across the cell membrane? An atomic-level description of the complete exchange cycle in NarK.

  2021cites this paper
• Structures and General Transport Mechanisms by the Major Facilitator Superfamily (MFS)

  2021cites this paper
• Genetic and evolutionary characterization of the Major Facilitator Superfamily transporters of the antibacterial, Pantoea Natural Product 3.

  2021cites this paper
• Data-Driven Ensemble Docking to Map Molecular Interactions of Steroid Analogs with Hepatic Organic Anion Transporting Polypeptides

  2021cites this paper
• Investigation of sugar binding kinetics of the E. coli sugar/H+ symporter XylE using solid-supported membrane-based electrophysiology

  2021cites this paper
• Energy Metabolism | Glucose/Sugar Transport in Bacteria

  2021cites this paper
• In-Silico Study of Immune System Associated Genes in Case of Type-2 Diabetes With Insulin Action and Resistance, and/or Obesity

  2021cites this paper
• Functional and Structural Roles of the Major Facilitator Superfamily Bacterial Multidrug Efflux Pumps

  2020cites this paper
• Cloning and Molecular Characterization of CcNRT2.1/CcNAR2, a Putative Inducible High Affinity Nitrate Transport System in Capsicum chinense Jacq. Roots

  2020cites this paper
• Molecular recognition of sugar binding in a melibiose transporter MelB by X-ray crystallography

  2020cites this paper
• Asp22 drives the protonation state of the Staphylococcus epidermidis glucose/H+ symporter

  2020cites this paper
• Dynamical Behavior of the Human Ferroportin Homologue from Bdellovibrio bacteriovorus: Insight into the Ligand Recognition Mechanism

  2020cites this paper
• Multiomics Study of Gut Bacteria and Host Metabolism in Irritable Bowel Syndrome and Depression Patients

  2020cites this paper
• A non‐helical region in transmembrane helix 6 of hydrophobic amino acid transporter MhsT mediates substrate recognition

  2020cites this paper
• Role of transmembrane helix 6 in substrate recognition of the amino acid transporter MhsT

  2020cites this paper
• Structural Insights into the Atomistic Mechanisms of Uric Acid Recognition and Translocation of Human Urate Anion Transporter 1

  2020cites this paper
• Toward a Molecular Basis of Cellular Nucleoside Transport in Humans.

  2020cites this paper
• How antiporters exchange substrates across the cell membrane? An atomic-level description of the complete exchange cycle in NarK

  2020cites this paper
• Expression, purification and crystallization of an SLC16 monocarboxylate transporter family homologue specific for l-lactate.

  2020cites this paper
• Visualizing the nonlinear changes of a drug-proton antiporter from inward-open to occluded state.

  2020cites this paper
• Organic Cation Transporters in Health and Disease

  2020cites this paper
• It takes two to tango: The dance of the permease

  2019cites this paper
• Variation of a major facilitator superfamily gene contributes to differential cadmium accumulation between rice subspecies

  2019cites this paper
• smFRET Probing Reveals Substrate-Dependent Conformational Dynamics of E. coli Multidrug MdfA.

  2019cites this paper
• Thyroid hormone transporters.

  2019cites this paper
• Enhanced production of 2'-fucosyllactose from fucose by elimination of rhamnose isomerase and arabinose isomerase in engineered Escherichia coli.

  2019cites this paper
• The proton electrochemical gradient induces a kinetic asymmetry in the symport cycle of LacY

  2019cites this paper
• Towards understanding the mechanisms of proton pumps in Complex-I of the respiratory chain

  2019cites this paper
• An Optimized Screen Reduces the Number of GA Transporters and Provides Insights Into Nitrate Transporter 1/Peptide Transporter Family Substrate Determinants

  2019cites this paper
• Crystal structure of a bacterial homolog to human lysosomal transporter, spinster.

  2019cites this paper
• Conformational Transition Pathways in Major Facilitator Superfamily Transporters

  2019cites this paper
• Exploring Conformational Transitions and Free Energy Profiles of Proton Coupled Oligopeptide Transporters

  2019cites this paper
• An Optimized Screen Reduces the Number of GA Transporters and provides Insights into NPF Substrate Determinants

  2019cites this paper
• Secondary Active Transporters.

  2019cites this paper
• Crystal structure of a MFS transporter with Ligand at 2.69 Angstroem resolution

  2019cites this paper
• Essential Oils as an Intervention Strategy to Reduce Campylobacter in Poultry Production: A Review

  2019cites this paper
• Mechanistic basis of L-lactate transport in the SLC16 solute carrier family

  2019cites this paper
• Uptake dynamics in the Lactose permease (LacY) membrane protein transporter

  2018cites this paper
• The role of regulator FucP in Edwardsiella tarda pathogenesis and the inflammatory cytokine response in tilapia

  2018cites this paper
• Free Energy Landscape of the Complete Transport Cycle in a Key Bacterial Transporter

  2018cites this paper
• Functional Characterization of the Saccharomyces cerevisiae Equilibrative Nucleoside Transporter 1 (ScENT1)

  2018cites this paper
• Natural variation OsCd 1 V 449 contributes to reducing cadmium accumulation in rice grain 1

  2018cites this paper
• Advances in Bayesian Modeling of Protein Structure Evolution

  2018cites this paper
• Conformational transitions of uracil transporter UraA from Escherichia coli: a molecular simulation study

  2018cites this paper
• Perturbations of Native Membrane Protein Structure in Alkyl Phosphocholine Detergents: A Critical Assessment of NMR and Biophysical Studies

  2018cites this paper
• Thermodynamic secrets of multidrug resistance: A new take on transport mechanisms of secondary active antiporters

  2018cites this paper
• Study of the relative domain stability of a two-domain E. coli MFS transporter, GlpT

  2018cites this paper
• Understanding Human Erythrocyte Glucose Transporter (GLUT1) Mediated Glucose Transport Phenomena Through Structural Analysis

  2018cites this paper
• Key amino acid residues of the AGT1 permease required for maltotriose consumption and fermentation by Saccharomyces cerevisiae

  2018influential citation
• Interplay between the electrostatic membrane potential and conformational changes in membrane proteins

  2018cites this paper
• Outward open conformation of a Major Facilitator Superfamily multidrug/H+ antiporter provides insights into switching mechanism

  2018cites this paper
• Homology modelling and in silico substrate-binding analysis of a Rhizobium sp. RC1 haloalkanoic acid permease

  2018cites this paper
• Molecular characterization of central cytoplasmic loop in Aspergillus nidulans AstA transporter.

  2018cites this paper
• An improved structural model of the human iron exporter ferroportin. Insight into the role of pathogenic mutations in hereditary hemochromatosis type 4

  2017cites this paper
• MSDC-0160 and MSDC-0602 Binding with Human Mitochondrial Pyruvate Carrier (MPC) 1 and 2 Heterodimer: PPARγ Activating and Sparing TZDs as Therapeutics

  2017cites this paper
• pKa of Glu 325 in LacY

  2017cites this paper
• Design of self-assembling transmembrane helical bundles to elucidate principles required for membrane protein folding and ion transport

  2017cites this paper
• Expression in Sf9 insect cells, purification and functional reconstitution of the human proton-coupled folate transporter (PCFT, SLC46A1)

  2017cites this paper
• Thermodynamic cooperativity of cosubstrate binding and cation selectivity of Salmonella typhimurium MelB

  2017cites this paper
• An in silico pan-genomic probe for the molecular traits behind Lactobacillus ruminis gut autochthony

  2017cites this paper
• A Loose Relationship: Incomplete H+/Sugar Coupling in the MFS Sugar Transporter GlcP

  2017cites this paper
• Functional Roles of Highly Conserved Amino Acid Sequence Motifs A and C in Solute Transporters of the Major Facilitator Superfamily

  2017cites this paper
• Dimeric structure of the uracil:proton symporter UraA provides mechanistic insights into the SLC4/23/26 transporters

  2017cites this paper
• Chapter 2 Functional Properties of Organic Cation Transporter OCT 1 , Binding of Substrates and Inhibitors , and Presumed Transport Mechanism

  2017cites this paper
• Identification of Key Residues for Urate Specific Transport in Human Glucose Transporter 9 (hSLC2A9)

  2017cites this paper
• Glycoscience@Synchrotron: Synchrotron radiation applied to structural glycoscience

  2017cites this paper
• Trans reentrant loop structures in secondary transporters

  2017cites this paper
• Membrane-traversing mechanism of thyroid hormone transport by monocarboxylate transporter 8

  2017influential citation
• Mycobacterium tuberculosis Major Facilitator Superfamily Transporters

  2017cites this paper
• pKa of Glu325 in LacY

  2017cites this paper