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Flexible Transient Optical Waveguides and Surface‐Wave Biosensors Constructed from Monocrystalline Silicon

Wubin Bai,Hong Yang,Yinji Ma,Hao Chen,Jiho Shin,Yonghao Liu,Quansan Yang,I. Kandela,Zhonghe Liu,Seung‐Kyun Kang,Chen Wei,C. Haney,Anlil Brikha,X. Ge,Xue Feng,P. Braun,Yonggang Huang,Weidong Zhou,J. Rogers

Published 2018 in Advances in Materials

ABSTRACT

Optical technologies offer important capabilities in both biological research and clinical care. Recent interest is in implantable devices that provide intimate optical coupling to biological tissues for a finite time period and then undergo full bioresorption into benign products, thereby serving as temporary implants for diagnosis and/or therapy. The results presented here establish a silicon‐based, bioresorbable photonic platform that relies on thin filaments of monocrystalline silicon encapsulated by polymers as flexible, transient optical waveguides for accurate light delivery and sensing at targeted sites in biological systems. Comprehensive studies of the mechanical and optical properties associated with bending and unfurling the waveguides from wafer‐scale sources of materials establish general guidelines in fabrication and design. Monitoring biochemical species such as glucose and tracking physiological parameters such as oxygen saturation using near‐infrared spectroscopic methods demonstrate modes of utility in biomedicine. These concepts provide versatile capabilities in biomedical diagnosis, therapy, deep‐tissue imaging, and surgery, and suggest a broad range of opportunities for silicon photonics in bioresorbable technologies.

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