Mammalian Target of Rapamycin (mTOR): Conducting the Cellular Signaling Symphony*

The mammalian target of rapamycin (mTOR) protein kinase responds to diverse environmental cues to control a plethora of cellular processes. mTOR forms the catalytic core of at least two distinct signaling complexes known as mTOR complexes 1 and 2. Differing sensitivities to the mTOR inhibitor rapamycin, unique partner proteins, distinct substrates, and unique cellular functions distinguish the complexes. Here, we review recent progress in our understanding of the regulation and function of mTOR signaling networks in cellular physiology.

• Publication year

  2010

• Venue

  Journal of Biological Chemistry

• Publication date

  2010-03-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1074/jbc.R109.094003PMID 20231296PMCID PMC2863215
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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