Axotomy‐induced target disconnection promotes an additional death mechanism involved in motoneuron degeneration in amyotrophic lateral sclerosis transgenic mice

No abstract is available for this paper.

• Publication year

  2014

• Venue

  The Journal of comparative neurology

• Publication date

  2014-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/cne.23538PMID 24424947PMCID PMC4046277
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Signal transduction by tumor necrosis factor receptors.

  2012cited by this paper
• Amyotrophic lateral sclerosis.

  2012cited by this paper
• IL-10 within the CNS is necessary for CD4+ T cells to mediate neuroprotection.

  2011cited by this paper
• Hind limb muscle atrophy precedes cerebral neuronal degeneration in G93A-SOD1 mouse model of amyotrophic lateral sclerosis: a longitudinal MRI study.

  2011cited by this paper
• Differential gene expression in the axotomized facial motor nucleus of presymptomatic SOD1 mice

  2011cited by this paper
• Deleterious effects of lymphocytes at the early stage of neurodegeneration in an animal model of amyotrophic lateral sclerosis

  2011cited by this paper
• Molecular basis of amyotrophic lateral sclerosis.

  2011cited by this paper
• Review on the protective effects of PACAP in models of neurodegenerative diseases in vitro and in vivo.

  2011cited by this paper
• The “Dying-Back” Phenomenon of Motor Neurons in ALS

  2011cited by this paper
• Amyotrophic lateral sclerosis - looking for pathogenesis and effective therapy.

  2011cited by this paper
• Neuroinflammation in amyotrophic lateral sclerosis: role of glial activation in motor neuron disease.

  2011cited by this paper
• Electrical stimulation and testosterone differentially enhance expression of regeneration-associated genes.

  2010cited by this paper
• Significance of behavioural tests in a transgenic mouse model of amyotrophic lateral sclerosis (ALS).

  2010cited by this paper
• Activation of TNF receptor 2 in microglia promotes induction of anti-inflammatory pathways.

  2010cited by this paper
• Diagnostic problems and delay of diagnosis in amyotrophic lateral sclerosis.

  2010cited by this paper
• Use of laser microdissection in the investigation of facial motoneuron and neuropil molecular phenotypes after peripheral axotomy.

  2010cited by this paper
• Deficits in axonal transport precede ALS symptoms in vivo

  2010cited by this paper
• Functional recovery and facial motoneuron survival are influenced by immunodeficiency in crush-axotomized mice.

  2010cited by this paper
• Non–cell autonomous toxicity in neurodegenerative disorders: ALS and beyond

  2009cited by this paper
• Amyotrophic lateral sclerosis

  2009cited by this paper
• Effects of facial nerve axotomy on Th2-associated and Th1-associated chemokine mRNA expression in the facial motor nucleus of wild-type and presymptomatic SOD1 mice.

  2009cited by this paper
• Age and founder effect of SOD1 A4V mutation causing ALS

  2009cited by this paper
• Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis

  2008cited by this paper
• UvA-DARE ( Digital Academic Repository ) Cholinergic deficiency and inflammation in cognitive dysfunction

  2008cited by this paper
• Analyzing real-time PCR data by the comparative CT method

  2008cited by this paper
• Axonal lesion-induced microglial proliferation and microglial cluster formation in the mouse.

  2007cited by this paper
• Inaugural Article: Toxicity from different SOD1 mutants dysregulates the complement system and the neuronal regenerative response in ALS motor neurons

  2007cited by this paper
• Fas small interfering RNA reduces motoneuron death in amyotrophic lateral sclerosis mice

  2007cited by this paper
• TNF-alpha inhibition as a treatment strategy for neurodegenerative disorders: new drug candidates and targets.

  2007cited by this paper
• CD4(+) T cell-mediated facial motoneuron survival after injury: Distribution pattern of cell death and rescue throughout the extent of the facial motor nucleus.

  2006cited by this paper
• Amyotrophic lateral sclerosis associated with mutations in the CuZn superoxide dismutase gene

  2006cited by this paper
• In vivo quantification of spinal and bulbar motor neuron degeneration in the G93A-SOD1 transgenic mouse model of ALS by T2 relaxation time and apparent diffusion coefficient.

  2006cited by this paper
• Chronic activation in presymptomatic amyotrophic lateral sclerosis (ALS) mice of a feedback loop involving Fas, Daxx, and FasL.

  2006influential reference
• Control of microglial neurotoxicity by the fractalkine receptor

  2006cited by this paper
• Intracellular signals and events activated by cytokines of the tumor necrosis factor superfamily: From simple paradigms to complex mechanisms.

  2006influential reference
• Microglia as potential contributors to motor neuron injury in amyotrophic lateral sclerosis

  2005cited by this paper
• Motoneuron degeneration after facial nerve avulsion is exacerbated in presymptomatic transgenic rats expressing human mutant Cu/Zn superoxide dismutase

  2005influential reference
• A compensatory subpopulation of motor neurons in a mouse model of amyotrophic lateral sclerosis

  2005cited by this paper
• No widespread induction of cell death genes occurs in pure motoneurons in an amyotrophic lateral sclerosis mouse model.

  2005cited by this paper
• Adult Motor Neuron Apoptosis Is Mediated by Nitric Oxide and Fas Death Receptor Linked by DNA Damage and p53 Activation

  2005cited by this paper
• Microarray analysis identifies an aberrant expression of apoptosis and DNA damage-regulatory genes in multiple sclerosis.

  2005cited by this paper
• The facial nerve axotomy model.

  2004cited by this paper
• Amyotrophic lateral sclerosis is a distal axonopathy: evidence in mice and man.

  2004influential reference
• Pituitary adenylate cyclase activating polypeptide: a potential neuroprotective peptide.

  2004cited by this paper
• Temporal gene expression patterns in G93A/SOD1 mouse

  2004cited by this paper
• Displacement of synaptic terminals from regenerating motoneurons by microglial cells

  2004cited by this paper
• Tumor Necrosis Factor (TNF)-mediated Neuroprotection against Glutamate-induced Excitotoxicity Is Enhanced by N-Methyl-D-aspartate Receptor Activation

  2004cited by this paper
• Spinal cord molecular profiling provides a better understanding of amyotrophic lateral sclerosis pathogenesis.

  2004cited by this paper
• Reactive Astrocytes Protect Tissue and Preserve Function after Spinal Cord Injury

  2004cited by this paper
• Evidence of widespread cerebral microglial activation in amyotrophic lateral sclerosis: an [11C](R)-PK11195 positron emission tomography study.

  2004cited by this paper
• Wild-Type Nonneuronal Cells Extend Survival of SOD1 Mutant Motor Neurons in ALS Mice

  2003cited by this paper
• Inflammatory neurodegeneration mediated by nitric oxide, glutamate, and mitochondria

  2003cited by this paper
• Role of SODD in Regulation of Tumor Necrosis Factor Responses

  2003cited by this paper
• Protein kinase and protein phosphatase expression in the central nervous system of G93A mSOD over‐expressing mice

  2003cited by this paper
• Cytotoxic potential of proinflammatory cytokines: combined deletion of TNF receptors TNFR1 and TNFR2 prevents motoneuron cell death after facial axotomy in adult mouse.

  2002cited by this paper
• Altered reaction of facial motoneurons to axonal damage in the presymptomatic phase of a murine model of familial amyotrophic lateral sclerosis.

  2002influential reference
• Motoneuron death triggered by a specific pathway downstream of Fas. potentiation by ALS-linked SOD1 mutations.

  2002influential reference
• TNF-R1 Signaling: A Beautiful Pathway

  2002cited by this paper
• Temporal patterns of cytokine and apoptosis-related gene expression in spinal cords of the G93A-SOD1 mouse model of amyotrophic lateral sclerosis.

  2002influential reference
• Temporal patterns of cytokine and apoptosis‐related gene expression in spinal cords of the G93A‐SOD1 mouse model of amyotrophic lateral sclerosis

  2002influential reference
• Differential expression of inflammation‐ and apoptosis‐related genes in spinal cords of a mutant SOD1 transgenic mouse 
model of familial amyotrophic lateral sclerosis

  2002cited by this paper
• Differential vulnerability of cranial motoneurons in mouse models with motor neuron degeneration.

  2002cited by this paper
• Transgenic mouse model for familial amyotrophic lateral sclerosis with superoxide dismutase‐1 mutation

  2001cited by this paper
• Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.

  2001cited by this paper
• Neuron-Specific Expression of Mutant Superoxide Dismutase 1 in Transgenic Mice Does Not Lead to Motor Impairment

  2001cited by this paper
• Immunohistochemical localization of group I and II metabotropic glutamate receptors in control and amyotrophic lateral sclerosis human spinal cord: upregulation in reactive astrocytes.

  2001cited by this paper
• SODD‐Silencer of Death Domains

  2000cited by this paper
• Axonal Damage Induced by Invading T Cells in Organotypic Central Nervous System Tissue in vitro: Involvement of Microglial Cells

  2000cited by this paper
• Pituitary adenylate cyclase-activating polypeptide and its receptors: from structure to functions.

  2000cited by this paper
• In vitro induction of neuronal apoptosis by anti-Fas antibody-containing sera from amyotrophic lateral sclerosis patients.

  2000cited by this paper
• Differential vulnerability of oculomotor, facial, and hypoglossal nuclei in G86R superoxide dismutase transgenic mice

  2000cited by this paper
• Functional role of caspase-1 and caspase-3 in an ALS transgenic mouse model.

  2000cited by this paper
• Caspase‐3 is activated following axotomy of neonatal facial motoneurons and caspase‐3 gene deletion delays axotomy‐induced cell death in rodents

  2000cited by this paper
• Fractalkine Cleavage from Neuronal Membranes Represents an Acute Event in the Inflammatory Response to Excitotoxic Brain Damage

  2000cited by this paper
• El Escorial revisited: Revised criteria for the diagnosis of amyotrophic lateral sclerosis

  2000cited by this paper
• Lack of involvement of neuronal nitric oxide synthase in the pathogenesis of a transgenic mouse model of familial amyotrophic lateral sclerosis.

  1999cited by this paper
• Proliferation of microglia and astrocytes in the dentate gyrus following entorhinal cortex lesion: a quantitative bromodeoxyuridine‐labelling study

  1999cited by this paper
• Exacerbation of Facial Motoneuron Loss after Facial Nerve Transection in Severe Combined Immunodeficient (scid) Mice

  1999cited by this paper
• Differential regulation of cytoskeletal gene expression in hamster facial motoneurons: Effects of axotomy and testosterone treatment

  1999cited by this paper
• Axotomy‐induced changes in pituitary adenylate cyclase activating polypeptide (PACAP) and PACAP receptor gene expression in the adult rat facial motor nucleus

  1999cited by this paper
• Primary structure of GAP‐43 mRNA expressed in the spinal cord of ALS patients

  1998cited by this paper
• Immune Surveillance in the Injured Nervous System: T-Lymphocytes Invade the Axotomized Mouse Facial Motor Nucleus and Aggregate around Sites of Neuronal Degeneration

  1998cited by this paper
• The cellular and molecular basis of peripheral nerve regeneration

  1997cited by this paper
• Alterations in Glial Fibrillary Acidic Protein (GFAP) mRNA Levels in the Hamster Facial Motor Nucleus: Effects of Axotomy and Testosterone

  1997cited by this paper
• Entrapment of motor nerves in motor neuron disease: does double crush occur?

  1997cited by this paper
• Transcriptional and post-transcriptional mechanisms regulating neurofilament and tubulin gene expression during normal development of the rat brain.

  1995cited by this paper
• Age-dependent penetrance of disease in a transgenic mouse model of familial amyotrophic lateral sclerosis.

  1995cited by this paper
• Androgenic regulation of tubulin gene expression in axotomized hamster facial motoneurons

  1994cited by this paper
• Surveillance, intervention and cytotoxicity: is there a protective role of microglia?

  1994cited by this paper
• Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation.

  1994cited by this paper
• Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis.

  1993cited by this paper
• Molecular cloning of CD68, a human macrophage marker related to lysosomal glycoproteins.

  1993cited by this paper
• GAP‐43 immunoreactivity is detected in the nerve terminals of patients with amyotrophic lateral sclerosis

  1993cited by this paper
• Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

  1993cited by this paper
• GAP‐43 gene expression is increased in anterior horn cells of amyotrophic lateral sclerosis

  1992cited by this paper
• A consideration of neural counting methods.

  1992influential reference
• Response of facial and rubrospinal neurons to axotomy: changes in mRNA expression for cytoskeletal proteins and GAP-43

  1991cited by this paper
• New expression of myelomonocytic antigens by microglia and perivascular cells following lethal motor neuron injury.

  1990influential reference
• Response of endogenous glial cells to motor neuron degeneration induced by toxic ricin

  1988cited by this paper
• Microglial cells but not astrocytes undergo mitosis following rat facial nerve axotomy.

  1988cited by this paper

• Axonal regeneration and sprouting as a potential therapeutic target for nervous system disorders

  2021cites this paper
• CD4+ T cell expression of the IL-10 receptor is necessary for facial motoneuron survival after axotomy

  2020cites this paper
• Impact of peripheral immune status on central molecular responses to facial nerve axotomy.

  2018cites this paper
• Identification of a resilient mouse facial motoneuron population following target disconnection by injury or disease

  2018cites this paper
• Modeling Environmentally-Induced Motor Neuron Degeneration in Zebrafish

  2018cites this paper
• Immunoregulation of the central response to peripheral nerve injury: motoneuron survival and relevance to ALS

  2017influential citation
• Locomotor analysis identifies early compensatory changes during disease progression and subgroup classification in a mouse model of amyotrophic lateral sclerosis

  2017cites this paper
• Necroptosis in amyotrophic lateral sclerosis and other neurological disorders.

  2017cites this paper
• The role of ALS associated genes and c-Jun in neurodegeneration

  2016cites this paper
• Facial nerve axotomy in mice: a model to study motoneuron response to injury.

  2015cites this paper
• CD4 + T Cells and Neuroprotection: Relevance to Motoneuron Injury and Disease

  2015cites this paper
• Identification of B6SJL mSOD1G93A mouse subgroups with different disease progression rates

  2015influential citation
• Amyotrophic lateral sclerosis as a spatiotemporal mislocalization disease: location, location, location.

  2015cites this paper
• SOD1(G93A) transgenic mouse CD4(+) T cells mediate neuroprotection after facial nerve axotomy when removed from a suppressive peripheral microenvironment.

  2014cites this paper