Activation of the signal transducers and activators of the transcription 3 pathway in alveolar epithelial cells induces inflammation and adenocarcinomas in mouse lung.

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Cancer Research

• Publication date

  2007-09-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1158/0008-5472.CAN-07-0647PMID 17875688
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Unphosphorylated STAT3 accumulates in response to IL-6 and activates transcription by binding to NFkappaB.

  2007cited by this paper
• Distinct role of macrophages in different tumor microenvironments.

  2006cited by this paper
• Autocrine IL-6-induced Stat3 activation contributes to the pathogenesis of lung adenocarcinoma and malignant pleural effusion

  2006cited by this paper
• Granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor promote malignant growth of cells from head and neck squamous cell carcinomas in vivo.

  2006cited by this paper
• IL-6 trans-signaling via STAT3 directs T cell infiltration in acute inflammation.

  2005cited by this paper
• Neutral lipids and peroxisome proliferator-activated receptor-{gamma} control pulmonary gene expression and inflammation-triggered pathogenesis in lysosomal acid lipase knockout mice.

  2005cited by this paper
• Activated Epidermal Growth Factor Receptor–Stat-3 Signaling Promotes Tumor Survival In vivo in Non–Small Cell Lung Cancer

  2005cited by this paper
• Overexpression of Stat3C in Pulmonary Epithelium Protects against Hyperoxic Lung Injury1

  2005cited by this paper
• Macrophage migration and gene expression in response to tumor hypoxia

  2005cited by this paper
• Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity

  2005cited by this paper
• Stat3 regulates genes common to both wound healing and cancer

  2005cited by this paper
• Targeting STAT3 affects melanoma on multiple fronts

  2005cited by this paper
• IL-6 induces neuroendocrine dedifferentiation and cell proliferation in non-small cell lung cancer cells.

  2005cited by this paper
• Sonic hedgehog signaling regulates Gli3 processing, mesenchymal proliferation, and differentiation during mouse lung organogenesis.

  2004cited by this paper
• Role of Sonic hedgehog in patterning of tracheal–bronchial cartilage and the peripheral lung

  2004cited by this paper
• Lysosomal acid lipase deficiency causes respiratory inflammation and destruction in the lung.

  2004cited by this paper
• Synergy between signal transducer and activator of transcription 3 and retinoic acid receptor-alpha in regulation of the surfactant protein B gene in the lung.

  2004cited by this paper
• Depletion of CXCR2 Inhibits Tumor Growth and Angiogenesis in a Murine Model of Lung Cancer1

  2004cited by this paper
• Non-small-cell lung cancer molecular signatures recapitulate lung developmental pathways.

  2003cited by this paper
• Activation of Stat3 by receptor tyrosine kinases and cytokines regulates survival in human non-small cell carcinoma cells

  2003cited by this paper
• Expression of epidermal growth factor receptor (EGFR) and downstream-activated peptides in surgically excised non-small-cell lung cancer (NSCLC).

  2003cited by this paper
• Transcriptional Stimulation of the Surfactant Protein B Gene by STAT3 in Respiratory Epithelial Cells*

  2002cited by this paper
• Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis

  2002cited by this paper
• Temporal/spatial expression of nuclear receptor coactivators in the mouse lung.

  2000cited by this paper
• More surprises in the Hedgehog signaling pathway.

  2000cited by this paper
• The sonic hedgehog-patched-gli pathway in human development and disease.

  2000cited by this paper
• Stat3 as an oncogene.

  1999cited by this paper
• Jaks and STATs: biological implications.

  1998cited by this paper
• Sonic hedgehog regulates branching morphogenesis in the mammalian lung.

  1998cited by this paper
• Sonic hedgehog is essential to foregut development

  1998cited by this paper
• Stat3 activation is responsible for IL-6-dependent T cell proliferation through preventing apoptosis: generation and characterization of T cell-specific Stat3-deficient mice.

  1998cited by this paper
• Gp130 and the interleukin-6 family of cytokines.

  1997cited by this paper
• Involvement of Sonic hedgehog (Shh) in mouse embryonic lung growth and morphogenesis.

  1997cited by this paper
• Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality.

  1997cited by this paper
• The T/ebp null mouse: thyroid-specific enhancer-binding protein is essential for the organogenesis of the thyroid, lung, ventral forebrain, and pituitary.

  1996cited by this paper
• Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6.

  1994cited by this paper
• Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway.

  1994influential reference
• The interleukin-6-activated acute-phase response factor is antigenically and functionally related to members of the signal transducer and activator of transcription (STAT) family

  1994influential reference
• Identification of nine tissue-specific transcription factors of the hepatocyte nuclear factor 3/forkhead DNA-binding-domain family.

  1993cited by this paper
• Murine chromosomal location of four hepatocyte-enriched transcription factors: HNf-3α, HNF-3β, HNF-3γ, and HNF-4

  1992cited by this paper
• Murine chromosomal location of four hepatocyte-enriched transcription factors: HNF-3 alpha, HNF-3 beta, HNF-3 gamma, and HNF-4.

  1992cited by this paper
• The transcription factor TTF-1 is expressed at the onset of thyroid and lung morphogenesis and in restricted regions of the foetal brain.

  1991cited by this paper
• Selective attraction of monocytes and T lymphocytes of the memory phenotype by cytokine RANTES

  1990cited by this paper

• In the Process.

  2026cites this paper
• Myeloid-derived suppressor cells in cancer: therapeutic targets to overcome tumor immune evasion

  2024cites this paper
• A Lung Cancer Mouse Model Database

  2024cites this paper
• Exploring Novel Frontiers: Leveraging STAT3 Signaling for Advanced Cancer Therapeutics

  2024cites this paper
• IL-22: A key inflammatory mediator as a biomarker and potential therapeutic target for lung cancer

  2024cites this paper
• Combining STAT3-Targeting Agents with Immune Checkpoint Inhibitors in NSCLC

  2023cites this paper
• Apoptotic activity of genipin in human oral squamous cell carcinoma in vitro by regulating STAT3 signaling

  2023cites this paper
• Characteristics of tumor microenvironment and novel immunotherapeutic strategies for non-small cell lung cancer

  2022cites this paper
• Cell Type-Specific Roles of STAT3 Signaling in the Pathogenesis and Progression of K-ras Mutant Lung Adenocarcinoma

  2022cites this paper
• Proteomics and phosphoproteomics analysis of tissues for the reoccurrence prediction of colorectal cancer

  2022cites this paper
• Oncogenic dependency on STAT3 serine phosphorylation in KRAS mutant lung cancer

  2021cites this paper
• Inflammation-Related Carcinogenesis: Lessons from Animal Models to Clinical Aspects

  2021cites this paper
• The role of myeloid-derived suppressor cells in lung cancer and targeted immunotherapies

  2021cites this paper
• Diffuse large B-cell lymphoma-derived exosomes push macrophage polarization toward M2 phenotype via GP130/STAT3 signaling pathway.

  2021cites this paper
• Multicellular Effects of STAT3 in Non-small Cell Lung Cancer: Mechanistic Insights and Therapeutic Opportunities

  2021cites this paper
• The Fire Within: NF-κB Involvement in Non–Small Cell Lung Cancer

  2020cites this paper
• Myeloid-derived suppressor cells—new and exciting players in lung cancer

  2020cites this paper
• Clinical Characteristics and Outcomes of Severe or Critical COVID-19 Patients Presenting No Respiratory Symptoms or Fever at Onset

  2020cites this paper
• The potential and controversy of targeting STAT family members in cancer.

  2020cites this paper
• STAT3: Versatile Functions in Non-Small Cell Lung Cancer

  2020cites this paper
• Interleukins 6/8 and cyclooxygenase-2 release and expressions are regulated by oxidative stress-JAK2/STAT3 signaling pathway in human bronchial epithelial cells exposed to particulate matter ≤2.5 μm.

  2020cites this paper
• IL-19 Up-Regulates Mucin 5AC Production in Patients With Chronic Rhinosinusitis via STAT3 Pathway

  2019cites this paper
• Development of a Novel STAT3 Inhibitor for the Treatment and Chemoprevention of Lung Cancer

  2019cites this paper
• Transthyretin Stimulates Tumor Growth through Regulation of Tumor, Immune, and Endothelial Cells

  2019influential citation
• Targeting Cancer Stem Cells: A Strategy for Effective Eradication of Cancer

  2019cites this paper
• Alveolar macrophage secretion of vesicular SOCS3 represents a platform for lung cancer therapeutics.

  2019cites this paper
• Integrative Physiology of Pneumonia.

  2018cites this paper
• Sex specific function of epithelial STAT3 signaling in pathogenesis of K-ras mutant lung cancer

  2018cites this paper
• Immunoregulatory Effects of Silymarin on Proliferation and Activation of Th1 Cells Isolated from Newly Diagnosed and IFN-ß1b-Treated MS Patients

  2018cites this paper
• A study of spectrum of pulmonary pathology and expression of thyroid transcription factor-1 during neonatal period

  2018cites this paper
• Two decades of research in discovery of anticancer drugs targeting STAT3, how close are we?

  2018cites this paper
• Targeting the IL-6/JAK/STAT3 signalling axis in cancer

  2018cites this paper
• STAT3: a multifaceted oncoprotein

  2018influential citation
• Comparative mRNA and miRNA transcriptome analysis of a mouse model of IGFIR-driven lung cancer

  2018cites this paper
• STATs in Lung Development: Distinct Early and Late Expression, Growth Modulation and Signaling Dysregulation in Congenital Diaphragmatic Hernia

  2017cites this paper
• Exploring the role of Interleukin-6 and other host-associated factors in tumor progression and metastasis development

  2017cites this paper
• Role of STAT3 in Pancreatic Cancer: A target for therapy

  2017cites this paper
• Autotaxin-Lysophosphatidic Acid: From Inflammation to Cancer Development

  2017cites this paper
• Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) as a Target for Concurrent Management of Diabetes and Obesity-Related Cancer.

  2017cites this paper
• Novel Synthetic bisindolylmaleimide alkaloids inhibit STAT3 activation by binding to the SH2 domain and suppress breast xenograft tumor growth

  2017cites this paper
• Hdac7 promotes lung tumorigenesis by inhibiting Stat3 activation

  2017cites this paper
• Sex-specific IL-6-associated signaling activation in ozone-induced lung inflammation

  2016cites this paper
• The Role of Tumour Necrosis Factor in Pulmonary Viral Infections

  2016cites this paper
• Lysosomal acid lipase in mesenchymal stem cell stimulation of tumor growth and metastasis

  2016cites this paper
• Quercetin inhibits multiple pathways involved in interleukin 6 secretion from human lung fibroblasts and activity in bronchial epithelial cell transformation induced by benzo[a]pyrene diol epoxide

  2016cites this paper
• Lung Epithelial Cell-Specific Expression of Human Lysosomal Acid Lipase Ameliorates Lung Inflammation and Tumor Metastasis in Lipa(-/-) Mice.

  2016cites this paper
• The sonic hedgehog signaling pathway contributes to the development of salivary gland neoplasms regardless of perineural infiltration

  2016cites this paper
• inflammation from emphysema in gp130 mutant mice Deregulated Stat3 signaling dissociates pulmonary

  2016cites this paper
• Oral administration of aflatoxin G₁ induces chronic alveolar inflammation associated with lung tumorigenesis.

  2015cites this paper
• Translational Research in Acute Lung Injury and Pulmonary Fibrosis Inflammatory impact of IFN-in CD 8 T cell-mediated lung injury is mediated by both Stat 1-dependent and-independent pathways

  2015cites this paper
• CALL PAPERS Translational Research in Acute Lung Injury and Pulmonary Fibrosis Inflammatory impact of IFN- (cid:2) in CD8 (cid:3) T cell-mediated lung injury is mediated by both Stat1-dependent and -independent pathways

  2015cites this paper
• Stat3‐siRNA inhibits the growth of gastric cancer in vitro and in vivo

  2015cites this paper
• Die Bedeutung von Socs3 im in-vivo -Modell der pankreatischen Karzinogenese

  2015cites this paper
• Critical role of PPARγ in myeloid-derived suppressor cell-stimulated cancer cell proliferation and metastasis

  2015cites this paper
• The association with COPD

  2015cites this paper
• HDAC Inhibition Overcomes Acute Resistance to MEK Inhibition in BRAF-Mutant Colorectal Cancer by Downregulation of c-FLIPL

  2015cites this paper
• Enhanced Phenotypic Alterations of Alveolar Type II Cells in Response to Aflatoxin G1‐Induced Lung Inflammation

  2015cites this paper
• Modulation of tumorigenesis by the pro-inflammatory microRNA miR-301a in mouse models of lung cancer and colorectal cancer

  2015cites this paper
• Avalle L, Regis G, Poli V. Universal and Specific Functions of STAT3in Solid Tumours

  2015cites this paper
• Isolation of epithelial, endothelial, and immune cells from lungs of transgenic mice with oncogene-induced lung adenocarcinomas.

  2015cites this paper
• ReviewStat 3 : linking inflammation to epithelial cancer-more than a " gut " feeling ?

  2015cites this paper
• Smoking, inflammation and small cell lung cancer: recent developments

  2015cites this paper
• Dynamics of lung defense in pneumonia: resistance, resilience, and remodeling.

  2015cites this paper
• Inflammatory impact of IFN-γ in CD8+ T cell-mediated lung injury is mediated by both Stat1-dependent and -independent pathways.

  2015cites this paper
• A Small Molecule Compound Targeting STAT3 DNA-Binding Domain Inhibits Cancer Cell Proliferation, Migration, and Invasion

  2014cites this paper
• The Role of STAT3 in Non-Small Cell Lung Cancer

  2014cites this paper
• Delayed Neutralization of Interleukin 6 Reduces Organ Injury, Selectively Suppresses Inflammatory Mediator, and Partially Normalizes Immune Dysfunction Following Trauma and Hemorrhagic Shock

  2014cites this paper
• The Stat3 paradox: a killer and an oncogene.

  2014cites this paper
• Genetic Interactions of STAT3 and Anticancer Drug Development

  2014cites this paper
• Cucurbitacin I Induces Protective Autophagy in Glioblastoma in Vitro and in Vivo*

  2014cites this paper
• Differential roles of STAT3 in the initiation and growth of lung cancer

  2014cites this paper
• Role of STAT3 in lung cancer.

  2014cites this paper
• Bufadienolides Overcome TRAIL Resistance in Breast Cancer Cells via JAK-STAT Pathway

  2014cites this paper
• Targeting the STAT3 signaling pathway in cancer: role of synthetic and natural inhibitors.

  2014cites this paper
• STAT3 as a therapeutic target for Epstein-Barr virus (EBV): associated nasopharyngeal carcinoma.

  2013cites this paper
• Targeting the tumor microenvironment

  2013cites this paper
• Exposing a deadly alliance: novel insights into the biological links between COPD and lung cancer.

  2013cites this paper
• Stat3 Downstream Gene Product Chitinase 3-Like 1 Is a Potential Biomarker of Inflammation-induced Lung Cancer in Multiple Mouse Lung Tumor Models and Humans

  2013cites this paper
• Antitumor activity of IL-32β through the activation of lymphocytes, and the inactivation of NF-κB and STAT3 signals

  2013cites this paper
• STAT1 and STAT3 in Tumorigenesis: Two Sides of the Same Coin?

  2013cites this paper
• Defining the mechanism of prostaglandin E2- Enhanced hematopoietic stem and progenitor cell homing

  2013cites this paper
• Reactive Oxygen Species, Kinase Signaling, and Redox Regulation of Epigenetics

  2013cites this paper
• Transcriptional Signaling Hubs in Epithelial Cells During Pneumonia

  2013cites this paper
• From tissue invasion to glucose metabolism: the many aspects of signal transducer and activator of transcription 3 pro-oncogenic activities

  2012cites this paper
• Tobacco, inflammation, and respiratory tract cancer.

  2012cites this paper
• Deregulated Stat3 signaling dissociates pulmonary inflammation from emphysema in gp130 mutant mice.

  2012cites this paper
• Emerging avenues linking inflammation and cancer.

  2012cites this paper
• Curcumin: a novel Stat3 pathway inhibitor for chemoprevention of lung cancer

  2012cites this paper
• Universal and Specific Functions of STAT3 in Solid Tumours

  2012cites this paper
• Inhibitory roles of signal transducer and activator of transcription 3 in antitumor immunity during carcinogen-induced lung tumorigenesis.

  2012cites this paper
• Inhibition of PPARγ in myeloid-lineage cells induces systemic inflammation, immunosuppression, and tumorigenesis.

  2012cites this paper
• Targeting the interleukin-6/Jak/stat pathway in human malignancies.

  2012cites this paper
• Multifaceted link between cancer and inflammation.

  2012cites this paper
• STAT3 activation and aberrant ligand-dependent sonic hedgehog signaling in human pulmonary adenocarcinoma.

  2012cites this paper
• Deregulated Stat 3 signaling dissociates pulmonary inflammation from emphysema in gp 130 mutant mice

  2012cites this paper
• Differential Transcriptomic Analysis of Spontaneous Lung Tumors in B6C3F1 Mice: Comparison to Human Non–Small Cell Lung Cancer

  2012influential citation
• Gene Profile of Myeloid-Derived Suppressive Cells from the Bone Marrow of Lysosomal Acid Lipase Knock-Out Mice

  2012cites this paper
• Silibinin modulates TNF‐α and IFN‐γ mediated signaling to regulate COX2 and iNOS expression in tumorigenic mouse lung epithelial LM2 cells

  2012cites this paper
• Lung Tumorigenesis Transcription 3 in Antitumor Immunity during Carcinogen-Induced Inhibitory Roles of Signal Transducer and Activator of

  2012cites this paper
• Serum hepatocyte growth factor and interleukin-6 are effective prognostic markers for non-small cell lung cancer.

  2012cites this paper