Hedgehog signaling is critical for normal liver regeneration after partial hepatectomy in mice

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Hepatology

• Publication date

  2010-05-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/hep.23525PMID 20432255PMCID PMC2920129
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Liver regeneration.

  2012cited by this paper
• Hedgehog-mediated epithelial-to-mesenchymal transition and fibrogenic repair in nonalcoholic fatty liver disease.

  2009cited by this paper
• Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease.

  2009cited by this paper
• Hedgehog pathway activation and epithelial-to-mesenchymal transitions during myofibroblastic transformation of rat hepatic cells in culture and cirrhosis.

  2009cited by this paper
• Stem cells and liver regeneration.

  2009cited by this paper
• Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer

  2009cited by this paper
• Hedgehog signal activation coordinates proliferation and differentiation of fetal liver progenitor cells.

  2009cited by this paper
• Paracrine Hedgehog signaling in stomach and intestine: new roles for hedgehog in gastrointestinal patterning.

  2009cited by this paper
• Sonic hedgehog is an autocrine viability factor for myofibroblastic hepatic stellate cells.

  2008cited by this paper
• Mechanisms of hepatic fibrogenesis.

  2008cited by this paper
• Accumulation of hedgehog-responsive progenitors parallels alcoholic liver disease severity in mice and humans.

  2008cited by this paper
• Hedgehog signaling regulates epithelial-mesenchymal transition during biliary fibrosis in rodents and humans.

  2008influential reference
• The adventures of sonic hedgehog in development and repair. II. Sonic hedgehog and liver development, inflammation, and cancer.

  2008influential reference
• Integrative genomic analyses on GLI2: mechanism of Hedgehog priming through basal GLI2 expression, and interaction map of stem cell signaling network with P53.

  2008cited by this paper
• Back and forth between cell fate specification and movement during vertebrate gastrulation.

  2008cited by this paper
• Dose- and route-dependent teratogenicity, toxicity, and pharmacokinetic profiles of the hedgehog signaling antagonist cyclopamine in the mouse.

  2008cited by this paper
• Identification of adult hepatic progenitor cells capable of repopulating injured rat liver

  2007cited by this paper
• Bile ductules and stromal cells express hedgehog ligands and/or hedgehog target genes in primary biliary cirrhosis

  2007cited by this paper
• Mesenchymal to Epithelial Transition in Development and Disease

  2007cited by this paper
• Novel hepatic progenitor cell surface markers in the adult rat liver

  2007cited by this paper
• Cancer metastasis facilitated by developmental pathways: Sonic hedgehog, Notch, and bone morphogenic proteins

  2007cited by this paper
• Hedgehog signaling maintains resident hepatic progenitors throughout life.

  2006cited by this paper
• Liver regeneration

  2006cited by this paper
• Dysregulation of the Hedgehog pathway in human hepatocarcinogenesis.

  2006cited by this paper
• Suppressing Wnt Signaling by the Hedgehog Pathway through sFRP-1*

  2006cited by this paper
• TWEAK, via its receptor Fn14, is a novel regulator of mesenchymal progenitor cells and skeletal muscle regeneration

  2006cited by this paper
• Isolation of multipotent progenitor cells from human fetal liver capable of differentiating into liver and mesenchymal lineages.

  2006cited by this paper
• TWEAK induces liver progenitor cell proliferation.

  2005cited by this paper
• Role for Hedgehog signaling in hepatic stellate cell activation and viability

  2005cited by this paper
• Epithelial Cell Plasticity in Development and Tumor Progression

  2004cited by this paper
• Uncoupling protein‐2 deficiency promotes oxidant stress and delays liver regeneration in mice

  2004cited by this paper
• Liver regeneration and repair: Hepatocytes, progenitor cells, and stem cells

  2004cited by this paper
• Epithelial-mesenchymal transitions in development and pathologies.

  2003cited by this paper
• Gene Expression Profiling Reveals the Mechanism and Pathophysiology of Mouse Liver Regeneration*

  2003cited by this paper
• Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened.

  2002cited by this paper
• [Mechanisms of hepatic fibrogenesis].

  2002cited by this paper
• The Fn14 immediate-early response gene is induced during liver regeneration and highly expressed in both human and murine hepatocellular carcinomas.

  2000influential reference
• Coexpression of C‐myc and transforming growth factor alfa in the liver promotes early replicative senescence and diminishes regenerative capacity after partial hepatectomy in transgenic mice

  1997cited by this paper
• Appearance of oval cells in the liver of rats after long‐term exposure to ethanol

  1996cited by this paper
• Hepatic collagen synthesis and degradation during liver regeneration after partial hepatectomy

  1995cited by this paper
• Immunohistochemical detection of proliferating lipocytes in regenerating rat liver

  1990cited by this paper
• In situ cellular analysis of α‐fetoprotein gene expression in regenerating rat liver after partial hepatectomy

  1988cited by this paper
• alpha-Fetoprotein and albumin mRNA levels in liver regeneration and carcinogenesis.

  1983cited by this paper
• The elevation of alpha-fetoprotein messenger RNA in regenerating rat liver.

  1981cited by this paper
• The elevation of α-fetoprotein messenger RNA in regenerating rat liver

  1981cited by this paper
• [On the manner of proliferation of the liver parenchyma after partial hepatectomy. Autoradiography studies using 3H-thymidine].

  1965cited by this paper
• THE RATE OF INCORPORATION OF LABELED THYMIDINE INTO THE DEOXYRIBONUCLEIC ACID OF REGENERATING RAT LIVER IN RELATION TO THE AMOUNT OF LIVER EXCISED.

  1964cited by this paper
• A morphologic study of deoxyribonucleic acid synthesis and cell proliferation in regenerating rat liver; autoradiography with thymidine-H3.

  1962cited by this paper
• Experimental pathology of the liver

  1931influential reference

• Anti-aging effect of Hedgehog signaling.

  2026cites this paper
• Triggering Mechanisms of Hepatocyte Repopulation during Liver Regeneration

  2025cites this paper
• Cell differentiation-related signaling pathways in hepatocellular carcinoma metastasis.

  2025cites this paper
• TGF-β1/SMAD3-mediated Non-canonical Hedgehog Signaling Promotes Pancreatic Stellate Cell Activation and Fibrosis in Chronic Pancreatitis

  2025cites this paper
• Liver Progenitor Cells: Cellular Origins, Plasticity, and Signaling Pathways in Liver Regeneration

  2025cites this paper
• Regeneração hepática: Revisão de literatura

  2025cites this paper
• Involvement of the hedgehog signaling pathway in liver diseases.

  2025cites this paper
• Liver regeneration: unraveling the molecular mechanisms and clinical application

  2025cites this paper
• Liver regeneration: Literature review.

  2025cites this paper
• Ring expansion of bicyclo[1.1.0]butyl ketones to bicyclo[2.1.1]hexenes using ketone as both activating and reacting groups

  2025cites this paper
• Zonation, Zonation, Zonation: The Real Estate of the Liver.

  2025cites this paper
• The role of chondroitin sulphate as a potential biomaterial for hepatic tissue regeneration: A comprehensive review.

  2024cites this paper
• Hepatic progenitor cell-originated ductular reaction facilitates liver fibrosis through activation of hedgehog signaling

  2024cites this paper
• Molecular Pathways Governing the Termination of Liver Regeneration

  2024cites this paper
• Characterization of a model of liver regeneration: Role of hedgehog signaling in experimental hepatic amoebiasis.

  2024cites this paper
• The senescence-associated secretome of Hedgehog-deficient hepatocytes drives MASLD progression

  2024cites this paper
• Unveiling the power of microenvironment in liver regeneration: an in-depth overview

  2023cites this paper
• Non-Parenchymal Cells and the Extracellular Matrix in Hepatocellular Carcinoma in Non-Alcoholic Fatty Liver Disease

  2023cites this paper
• Magnesium and Liver Metabolism Through the Lifespan

  2023cites this paper
• Structural and Functional Impact of Posttranslational Modification of Glypican-3 on Liver Carcinogenesis

  2023cites this paper
• Hepatic stellate cells maintain liver homeostasis through paracrine neurotrophin-3 signaling

  2023cites this paper
• Indian Hedgehog release from TNF-activated renal epithelia drives local and remote organ fibrosis

  2023cites this paper
• The functions and roles of C2H2 zinc finger proteins in hepatocellular carcinoma

  2023cites this paper
• Liver histology and hepatic progenitor cell activity in pediatric acute liver failure: Implications for clinical outcome

  2023cites this paper
• Genome of the sea anemone Exaiptasia pallida and transcriptome profiles during tentacle regeneration

  2022cites this paper
• miR-182-5p promotes hepatocyte-stellate cell crosstalk to facilitate liver regeneration

  2022cites this paper
• Aging reduces liver resiliency by dysregulating Hedgehog signaling

  2022cites this paper
• Hepatocyte β‐catenin loss is compensated by Insulin‐mTORC1 activation to promote liver regeneration

  2022cites this paper
• Inhibition of Hedgehog Delays Liver Regeneration through Disrupting the Cell Cycle

  2022cites this paper
• Hedgehog Signaling: Linking Embryonic Lung Development and Asthmatic Airway Remodeling

  2022cites this paper
• Hepatic stellate cell activation by TGFβ induces hedgehog signaling and endoplasmic reticulum stress simultaneously.

  2022cites this paper
• YAP regulates the liver size during the fasting-refeeding transition in mice

  2022cites this paper
• Gypenosides ameliorate ductular reaction and liver fibrosis via inhibition of hedgehog signaling

  2022cites this paper
• Hedgehog signaling activates a mammalian heterochronic gene regulatory network controlling differentiation timing across lineages.

  2022cites this paper
• Molecular Mechanisms Linking Nonalcoholic Steatohepatitis to Cancer

  2021cites this paper
• Relationship between lipid metabolism and Hedgehog signaling pathway.

  2021cites this paper
• Decellularized extracellular matrix mediates tissue construction and regeneration

  2021cites this paper
• Tissues & Organs | Biochemistry of Liver Regeneration

  2021cites this paper
• Liver regeneration biology: Implications for liver tumour therapies

  2021cites this paper
• Δ9-tetrahydrocannabinol inhibits Hedgehog-dependent patterning during development

  2021cites this paper
• Aging-related upregulation of the homeobox gene caudal represses intestinal stem cell differentiation in Drosophila

  2021cites this paper
• Hepatic stellate cells – from past till present: morphology, human markers, human cell lines, behavior in normal and liver pathology

  2021cites this paper
• Sonic Hedgehog signalling in the regulation of barrier tissue homeostasis and inflammation

  2021cites this paper
• Molecular pathways of liver regeneration: A comprehensive review

  2021cites this paper
• Genetic and Cellular Contributions to Liver Regeneration.

  2021cites this paper
• Biomaterial-based cell delivery strategies to promote liver regeneration

  2021cites this paper
• Liver Regeneration

  2020cites this paper
• Cellular and molecular basis of liver regeneration.

  2020cites this paper
• Maladaptive regeneration — the reawakening of developmental pathways in NASH and fibrosis

  2020cites this paper
• Hedgehog signaling activates a heterochronic gene regulatory network to control differentiation timing across lineages

  2020cites this paper
• Liver regeneration: biological and pathological mechanisms and implications

  2020cites this paper
• La plasticidad del hepatocito y su relevancia en la fisiología y la patología hepática

  2020cites this paper
• Liver regeneration and liver metastasis.

  2020cites this paper
• The Hepatic Sinusoid in Aging and Disease: Update and Advances From the 20th Liver Sinusoid Meeting

  2020cites this paper
• Liver stem cells

  2020cites this paper
• Hedgehog signaling pathway regulates hexavalent chromium-induced liver fibrosis by activation of hepatic stellate cells.

  2019cites this paper
• Exploration of the Transcriptional Landscape of ALPPS Reveals the Pathways of Accelerated Liver Regeneration

  2019cites this paper
• Wnt Signaling Pathway Linked to Intestinal Regeneration via Evolutionary Patterns and Gene Expression in the Sea Cucumber Apostichopus japonicus

  2019cites this paper
• The roles of signaling pathways in liver repair and regeneration

  2019influential citation
• Transforming growth factor‐β signaling confers hepatic stellate cells progenitor features after partial hepatectomy

  2019cites this paper
• Recent Insight into the Role of Fibrosis in Nonalcoholic Steatohepatitis-Related Hepatocellular Carcinoma

  2019cites this paper
• Régénération hépatique

  2019cites this paper
• Gant61 ameliorates CCl4-induced liver fibrosis by inhibition of Hedgehog signaling activity.

  2019cites this paper
• Dysregulated activation of fetal liver programme in acute liver failure

  2019cites this paper
• Nonalcoholic Steatohepatitis: Histopathology Basics Within a Broader Context.

  2018cites this paper
• Understanding Liver Regeneration: From Mechanisms to Regenerative Medicine.

  2018cites this paper
• The hedgehog pathway in nonalcoholic fatty liver disease

  2018cites this paper
• The roles of signaling pathways in bone repair and regeneration

  2018cites this paper
• Thyroid hormone in the regulation of hepatocellular carcinoma and its microenvironment.

  2018cites this paper
• Cellular Dedifferentiation and Regenerative Medicine

  2018cites this paper
• Dedifferentiation and Organ Regeneration

  2018cites this paper
• Patched Domain-containing 4 (PTCH53) Identified in Li-Fraumeni Syndrome Patient-derived Cells

  2018cites this paper
• Partial hepatectomy promotes implanted mouse hepatic tumor growth by activating hedgehog signaling.

  2018cites this paper
• MicroRNA-378 is involved in hedgehog-driven epithelial-to-mesenchymal transition in hepatocytes of regenerating liver

  2018cites this paper
• Identification and characterization of long noncoding RNAs and mRNAs expression profiles related to postnatal liver maturation of breeder roosters using Ribo-zero RNA sequencing

  2018cites this paper
• Novel molecular insights and new therapeutic strategies in osteosarcoma

  2018cites this paper
• Developmental Morphogens & Recovery from Alcoholic Liver Disease.

  2018cites this paper
• Adult Hepatocytes Are Hedgehog-Responsive Cells in the Setting of Liver Injury: Evidence for Smoothened-Mediated Activation of NF-κB/Epidermal Growth Factor Receptor/Akt in Hepatocytes that Counteract Fas-Induced Apoptosis.

  2018cites this paper
• Role of canonical Hedgehog signaling pathway in liver

  2018cites this paper
• Hedgehog Signaling in Cancer: A Prospective Therapeutic Target for Eradicating Cancer Stem Cells

  2018cites this paper
• MicroRNAs in the pathogenesis and treatment of progressive liver injury in NAFLD and liver fibrosis.

  2018cites this paper
• JNK1 induces hedgehog signaling from stellate cells to accelerate liver regeneration in mice.

  2018cites this paper
• Targeting GLI Transcription Factors in Cancer

  2018cites this paper
• The Injury-Related Activation of Hedgehog Signaling Pathway Modulates the Repair-Associated Inflammation in Liver Fibrosis

  2017cites this paper
• The Hedgehog Signaling Pathway Emerges as a Pathogenic Target

  2017cites this paper
• Hedgehog Signaling: From Basic Biology to Cancer Therapy.

  2017cites this paper
• Hepatotoxicity with Vismodegib: An MD Anderson Cancer Center and Research on Adverse Drug Events and Reports Project

  2017cites this paper
• Hepatostat: Liver regeneration and normal liver tissue maintenance

  2017cites this paper
• Hedgehog signaling pathway regulates liver regeneration in the Fah-/- knockout mice model xenografted by human hepatocytes.

  2017cites this paper
• Lentivirus-mediated silencing of the PTC1 and PTC2 genes promotes recovery from spinal cord injury by activating the Hedgehog signaling pathway in a rat model

  2017cites this paper
• Hedgehog signalling in liver pathophysiology.

  2017cites this paper
• The healthy biliary tree - cellular and immune-biology

  2017cites this paper
• Nonalcoholic Steatohepatitis.

  2017cites this paper
• Implication of the Hedgehog pathway in hepatocellular carcinoma

  2017cites this paper
• Radiation-Induced Liver Toxicity.

  2017cites this paper
• The diversity and plasticity of adult hepatic progenitor cells and their niche

  2017cites this paper
• Systems physiology and nutrition in dairy cattle: applications of omics and bioinformatics to better understand the hepatic metabolomics and transcriptomics adaptations in transition dairy cows

  2017cites this paper
• The progenitor cell dilemma: Cellular and functional heterogeneity in assistance or escalation of liver injury.

  2017cites this paper
• Hepatic Progenitor Cells: An Update.

  2017cites this paper
• Enhanced oral bioavailability of [6]-Gingerol-SMEDDS: Preparation, in vitro and in vivo evaluation

  2016cites this paper