Thyroid hormone in the regulation of hepatocellular carcinoma and its microenvironment.

No abstract is available for this paper.

• Publication year

  2018

• Venue

  Cancer Letters

• Publication date

  2018-04-10

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1016/j.canlet.2018.01.055PMID 29414304
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Thyroid hormone inhibits growth of hepatoma cells through induction of miR-214

  2017cited by this paper
• HIF-1 α as a Key Factor in Bile Duct Ligation-Induced Liver Fibrosis in Rats

  2017cited by this paper
• Prevalence of Liver Fibrosis and its Association with Non-invasive Fibrosis and Metabolic Markers in Morbidly Obese Patients with Vitamin D Deficiency

  2016cited by this paper
• T3/TRs axis in hepatocellular carcinoma: new concepts for an old pair.

  2016cited by this paper
• Thyroid hormones inhibit TGF-β signaling and attenuate fibrotic responses

  2016influential reference
• Role of Hedgehog Signaling Pathway in NASH

  2016cited by this paper
• Thyroid Hormone Receptor β Agonist Induces β-Catenin-Dependent Hepatocyte Proliferation in Mice: Implications in Hepatic Regeneration.

  2016cited by this paper
• Hypothyroidism Induces a Moderate Steatohepatitis Accompanied by Liver Regeneration, Mast Cells Infiltration, and Changes in the Expression of the Farnesoid X Receptor.

  2016cited by this paper
• Chemical Hybridization of Glucagon and Thyroid Hormone Optimizes Therapeutic Impact for Metabolic Disease.

  2016cited by this paper
• Hepatic macrophages in homeostasis and liver diseases: from pathogenesis to novel therapeutic strategies

  2016cited by this paper
• Thyroid Function and the Risk of Nonalcoholic Fatty Liver Disease: The Rotterdam Study.

  2016influential reference
• Thyroid hormone suppresses expression of stathmin and associated tumor growth in hepatocellular carcinoma

  2016cited by this paper
• Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets

  2015cited by this paper
• Non-Canonical Wnt Predominates in Activated Rat Hepatic Stellate Cells, Influencing HSC Survival and Paracrine Stimulation of Kupffer Cells

  2015cited by this paper
• Wnt-/-β-catenin pathway signaling in human hepatocellular carcinoma.

  2015cited by this paper
• Global cancer statistics, 2012

  2015cited by this paper
• Local hypothyroidism favors the progression of preneoplastic lesions to hepatocellular carcinoma in rats

  2015cited by this paper
• Subclinical and clinical hypothyroidism and non-alcoholic fatty liver disease: a cross-sectional study of a random population sample aged 18 to 65 years

  2015cited by this paper
• Signaling in Fibrosis: TGF-β, WNT, and YAP/TAZ Converge

  2015cited by this paper
• The Amelioration of Hepatic Steatosis by Thyroid Hormone Receptor Agonists Is Insufficient to Restore Insulin Sensitivity in Ob/Ob Mice

  2015cited by this paper
• Impact of hypothyroidism on the development of non-alcoholic fatty liver disease: A 4-year retrospective cohort study

  2015cited by this paper
• Targeting the tumor stroma in hepatocellular carcinoma.

  2015cited by this paper
• β-catenin is overexpressed in hepatic fibrosis and blockage of Wnt/β-catenin signaling inhibits hepatic stellate cell activation

  2014cited by this paper
• Tri‐iodothyronine induces hepatocyte proliferation by protein kinase a‐dependent β‐catenin activation in rodents

  2014cited by this paper
• Thyroid hormone regulation of metabolism.

  2014cited by this paper
• Vitamin D counteracts fibrogenic TGF-β signalling in human hepatic stellate cells both receptor-dependently and independently

  2014cited by this paper
• Genomic portrait of resectable hepatocellular carcinomas: Implications of RB1 and FGF19 aberrations for patient stratification

  2014cited by this paper
• Repair-Related Activation of Hedgehog Signaling in Stromal Cells Promotes Intrahepatic Hypothyroidism

  2014cited by this paper
• Mice with hepatocyte-specific deficiency of type 3 deiodinase have intact liver regeneration and accelerated recovery from nonthyroidal illness after toxin-induced hepatonecrosis.

  2014cited by this paper
• The sonic hedgehog-induced type 3 deiodinase facilitates tumorigenesis of basal cell carcinoma by reducing Gli2 inactivation.

  2014cited by this paper
• Speeding up hepatocyte proliferation: How triiodothyronine and β‐catenin join forces

  2014cited by this paper
• Non-alcoholic fatty liver disease and thyroid dysfunction: a systematic review.

  2014cited by this paper
• Trans-ancestry mutational landscape of hepatocellular carcinoma genomes

  2014cited by this paper
• Role of the microenvironment in the pathogenesis and treatment of hepatocellular carcinoma.

  2013cited by this paper
• Wnt signaling in liver fibrosis: progress, challenges and potential directions.

  2013cited by this paper
• Abstract 4598: Identification of driver genes in hepatocellular carcinoma by exome sequencing.

  2013cited by this paper
• Thyroid hormone receptor inhibits hepatoma cell migration through transcriptional activation of Dickkopf 4.

  2013cited by this paper
• Thyroid Hormones and the Metabolic Syndrome

  2013cited by this paper
• The tumor microenvironment in hepatocellular carcinoma (review).

  2012cited by this paper
• Activation of canonical Wnt signalling is required for TGF-β-mediated fibrosis

  2012cited by this paper
• Mechanisms of thyroid hormone action.

  2012cited by this paper
• Proteomic analysis of extracellular matrix from the hepatic stellate cell line LX-2 identifies CYR61 and Wnt-5a as novel constituents of fibrotic liver

  2012cited by this paper
• Thyroid Function and Obesity

  2012cited by this paper
• Non-alcoholic fatty liver disease across the spectrum of hypothyroidism.

  2012cited by this paper
• Thyroid Function and Obesity

  2012cited by this paper
• The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data.

  2012cited by this paper
• Prevalence of Hypothyroidism in Nonalcoholic Fatty Liver Disease

  2012cited by this paper
• Dickkopf 4 positively regulated by the thyroid hormone receptor suppresses cell invasion in human hepatoma cells

  2012cited by this paper
• Liver regeneration.

  2012cited by this paper
• Thyroid hormone reduces cholesterol via a non-LDL receptor-mediated pathway.

  2012cited by this paper
• Impact of subclinical hypothyroidism on the development of non-alcoholic fatty liver disease: a prospective case-control study.

  2012cited by this paper
• Liver progenitor cells yield functional hepatocytes in response to chronic liver injury in mice.

  2012cited by this paper
• β-Catenin regulates deiodinase levels and thyroid hormone signaling in colon cancer cells.

  2012cited by this paper
• Increased Type 3 Deiodinase Expression in Papillary Thyroid Carcinoma

  2012cited by this paper
• Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma

  2012cited by this paper
• Wnt5a participates in hepatic stellate cell activation observed by gene expression profile and functional assays.

  2012cited by this paper
• Mechanisms of fibrosis: therapeutic translation for fibrotic disease

  2012cited by this paper
• Physiological role and regulation of iodothyronine deiodinases: A 2011 update

  2011cited by this paper
• Global cancer statistics

  2011cited by this paper
• Pathogenesis of liver fibrosis.

  2011cited by this paper
• Mechanisms of hepatic fibrogenesis.

  2011cited by this paper
• The thyroid hormone receptors as tumor suppressors

  2011cited by this paper
• Cooperation between the thyroid hormone receptor TRalpha1 and the WNT pathway in the induction of intestinal tumorigenesis.

  2010cited by this paper
• The quest for liver progenitor cells: a practical point of view.

  2010cited by this paper
• Mechanisms behind the non-thyroidal illness syndrome: an update.

  2010cited by this paper
• TRbeta is the critical thyroid hormone receptor isoform in T3-induced proliferation of hepatocytes and pancreatic acinar cells.

  2010cited by this paper
• Mice Lacking Thyroid Hormone Receptor β Show Enhanced Apoptosis and Delayed Liver Commitment for Proliferation after Partial Hepatectomy

  2010cited by this paper
• Hedgehog signaling is critical for normal liver regeneration after partial hepatectomy in mice

  2010cited by this paper
• Large induction of type III deiodinase expression after partial hepatectomy in the regenerating mouse and rat liver.

  2009cited by this paper
• Hypothyroidism Enhances Tumor Invasiveness and Metastasis Development

  2009influential reference
• Hedgehog pathway activation and epithelial-to-mesenchymal transitions during myofibroblastic transformation of rat hepatic cells in culture and cirrhosis.

  2009cited by this paper
• Association between hypothyroidism and hepatocellular carcinoma: A case‐control study in the United States

  2009cited by this paper
• Reduction of hepatic steatosis in rats and mice after treatment with a liver‐targeted thyroid hormone receptor agonist

  2009cited by this paper
• Thyroid hormone receptor (TR) mutants implicated in human hepatocellular carcinoma display an altered target gene repertoire

  2009cited by this paper
• Thyroid hormone receptor beta1 acts as a potent suppressor of tumor invasiveness and metastasis.

  2009cited by this paper
• Thyroid hormone receptor ligands induce regression of rat preneoplastic liver lesions causing their reversion to a differentiated phenotype

  2009cited by this paper
• Liver cirrhosis.

  2008cited by this paper
• Thyroid hormone promotes cell invasion through activation of furin expression in human hepatoma cell lines.

  2008cited by this paper
• Thyroid hormone (T3) and TRβ agonist GC‐1 inhibit/reverse nonalcoholic fatty liver in rats

  2008cited by this paper
• Thyroid dysfunction (TD) among chronic hepatitis C patients with mild and severe hepatic fibrosis.

  2008cited by this paper
• Wnt antagonism inhibits hepatic stellate cell activation and liver fibrosis.

  2008cited by this paper
• Triiodothyronine stimulates hepatocyte proliferation in two models of impaired liver regeneration

  2008cited by this paper
• Canonical Wnt signaling maintains the quiescent stage of hepatic stellate cells.

  2008cited by this paper
• A Mutant Thyroid Hormone Receptor α Antagonizes Peroxisome Proliferator-Activated Receptor α Signaling in Vivo and Impairs Fatty Acid Oxidation

  2007cited by this paper
• Progressive fibrosis in nonalcoholic steatohepatitis: association with altered regeneration and a ductular reaction.

  2007cited by this paper
• Hypothyroidism: a possible risk factor for liver cancer in patients with no known underlying cause of liver disease.

  2007influential reference
• A mutant thyroid hormone receptor alpha antagonizes peroxisome proliferator-activated receptor alpha signaling in vivo and impairs fatty acid oxidation.

  2007cited by this paper
• The influence of hypothyroidism on liver regeneration: an experimental study in rats.

  2007cited by this paper
• Sonic hedgehog-induced type 3 deiodinase blocks thyroid hormone action enhancing proliferation of normal and malignant keratinocytes

  2007cited by this paper
• Activation of the hepatic LDL receptor promoter by thyroid hormone.

  2007cited by this paper
• Tri-Iodothyronine as a Stimulator of Liver Regeneration after Partial and Subtotal Hepatectomy

  2007cited by this paper
• Wnt signaling enhances the activation and survival of human hepatic stellate cells

  2007cited by this paper
• Thyroid hormone receptors mutated in liver cancer function as distorted antimorphs

  2006cited by this paper
• Type 3 deiodinase is critical for the maturation and function of the thyroid axis.

  2006cited by this paper
• Mediation of the inhibitory effect of thyroid hormone on proliferation of hepatoma cells by transforming growth factor-beta.

  2006cited by this paper
• Acting via a cell surface receptor, thyroid hormone is a growth factor for glioma cells.

  2006cited by this paper
• The thyroid hormone receptor-beta agonist GC-1 induces cell proliferation in rat liver and pancreas.

  2006cited by this paper
• The Thyroid Hormone Receptor-β Agonist GC-1 Induces Cell Proliferation in Rat Liver and Pancreas

  2006cited by this paper
• An Unliganded Thyroid Hormone β Receptor Activates the Cyclin D1/Cyclin-Dependent Kinase/Retinoblastoma/E2F Pathway and Induces Pituitary Tumorigenesis

  2005cited by this paper
• Thyroid Status Affects Rat Liver Regeneration After Partial Hepatectomy by Regulating Cell Cycle and Apoptosis

  2005cited by this paper

• Integrative multiomics dissection of LSM7 as a prognostic biomarker and therapeutic target in hepatocellular carcinoma

  2026cites this paper
• Sex disparities in hepatocellular carcinoma immunotherapy: hormonal and genetic influences on treatment efficacy

  2025cites this paper
• Clinical biomarkers for thyroid immune-related adverse events in patients with stage III and IV gastrointestinal tumors

  2024cites this paper
• Interleukin‐17A educated hepatic stellate cells promote hepatocellular carcinoma occurrence through fibroblast activation protein expression

  2024cites this paper
• Prognostic microRNA signature for estimating survival in patients with hepatocellular carcinoma.

  2023cites this paper
• An 8-gene predicting survival model of hepatocellular carcinoma (HCC) related to pyroptosis and cuproptosis

  2023cites this paper
• Targeting Thyroid Hormone/Thyroid Hormone Receptor Axis: An Attractive Therapy Strategy in Liver Diseases

  2022cites this paper
• A successful case of transarterial chemoembolization for hyperprogressive disease induced by immunotherapy in a patient with unresectable hepatocellular carcinoma

  2022cites this paper
• Research progress on the correlation between metabolic-associated fatty liver disease and metabolic diseases

  2022cites this paper
• Thyroid stimulating hormone levels are associated with genetically predicted nonalcoholic fatty liver disease.

  2022cites this paper
• Thyroid hormone and androgen signals mutually interplay and enhance inflammation and tumorigenic activation of tumor microenvironment in prostate cancer.

  2022cites this paper
• Ferroptosis-related gene signature predicts the prognosis of papillary thyroid carcinoma

  2021cites this paper
• Hepatocellular Carcinoma in Cirrhotic Versus Non-Cirrhotic Patients: A Retrospective Study of 483 Patients

  2021cites this paper
• Exploring the Mechanisms of Arsenic Trioxide (Pishuang) in Hepatocellular Carcinoma Based on Network Pharmacology

  2021cites this paper
• AATF and SMARCA2 are associated with thyroid volume in Hashimoto’s thyroiditis patients

  2020cites this paper
• Integrated Analysis of an lncRNA-Associated ceRNA Network Reveals Potential Biomarkers for Hepatocellular Carcinoma

  2020cites this paper
• Exploration of Sorafenib Influences on Gene Expression of Hepatocellular Carcinoma

  2020cites this paper
• Systematically Exploring the Antitumor Mechanisms of Core Chinese Herbs on Hepatocellular Carcinoma: A Computational Study

  2020cites this paper
• Hypothyroidism-Induced Nonalcoholic Fatty Liver Disease (HIN): Mechanisms and Emerging Therapeutic Options

  2020cites this paper
• Can network pharmacology identify the anti-virus and anti- inflammatory activities of Shuanghuanglian oral liquid used in Chinese medicine for respiratory tract infection?

  2020cites this paper
• LNA Inhibitor in microRNA miR-23b as a Potential Anti-proliferative Option in Human Hepatocellular Carcinoma

  2019cites this paper
• Roles of Thyroid Hormone-Associated microRNAs Affecting Oxidative Stress in Human Hepatocellular Carcinoma

  2019cites this paper
• The Role of Thyroid Hormones in Hepatocyte Proliferation and Liver Cancer

  2019cites this paper
• Exposure to nitrite alters thyroid hormone levels and morphology in Takifugu rubripes.

  2019cites this paper
• Maternal Hyperthyroidism and Developing Thyroid Cancer: What is the Next?

  2018cites this paper