Diverse regulation of protein function by O-GlcNAc: a nuclear and cytoplasmic carbohydrate post-translational modification.

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Current Opinion in Chemical Biology

• Publication date

  2002-12-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/S1367-5931(02)00384-8PMID 12470741
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Alloxan is an inhibitor of the enzyme O-linked N-acetylglucosamine transferase.

  2002cited by this paper
• Elevated nucleocytoplasmic glycosylation by O-GlcNAc results in insulin resistance associated with defects in Akt activation in 3T3-L1 adipocytes

  2002cited by this paper
• How do 14‐3‐3 proteins work? – Gatekeeper phosphorylation and the molecular anvil hypothesis

  2002cited by this paper
• Cellular adaptation to hypoxia: O2‐sensing protein hydroxylases, hypoxia‐inducible transcription factors, and O2‐regulated gene expression

  2002cited by this paper
• Recruitment of O-GlcNAc transferase to promoters by corepressor mSin3A: coupling protein O-GlcNAcylation to transcriptional repression.

  2002cited by this paper
• Enhanced O-GlcNAc protein modification is associated with insulin resistance in GLUT1-overexpressing muscles.

  2002cited by this paper
• Flux through the hexosamine pathway is a determinant of nuclear factor kappaB- dependent promoter activation.

  2002cited by this paper
• Mapping Sites of O-GlcNAc Modification Using Affinity Tags for Serine and Threonine Post-translational Modifications*

  2002cited by this paper
• Dynamic interplay between O-glycosylation and O-phosphorylation of nucleocytoplasmic proteins: alternative glycosylation/phosphorylation of THR-58, a known mutational hot spot of c-Myc in lymphomas, is regulated by mitogens.

  2002cited by this paper
• Interactions between Protein Kinase CK2 and Pin1

  2002cited by this paper
• Hexosamines as mediators of nutrient sensing and regulation in diabetes.

  2002cited by this paper
• Phosphoprotein isotope-coded affinity tags: application to the enrichment and identification of low-abundance phosphoproteins.

  2002cited by this paper
• Altered glycan-dependent signaling induces insulin resistance and hyperleptinemia

  2002cited by this paper
• O‐glycosylation of the nuclear forms of Pax‐6 products in quail neuroretina cells

  2002cited by this paper
• Insulin-Dependent Activation of Endothelial Nitric Oxide Synthase Is Impaired by O-Linked Glycosylation Modification of Signaling Proteins in Human Coronary Endothelial Cells

  2002cited by this paper
• Dynamic O-Glycosylation of Nuclear and Cytosolic Proteins

  2002cited by this paper
• The sequence of the human genome (abstract only)

  2001cited by this paper
• Identification of N-acetyl-d-glucosamine-specific lectins from rat liver cytosolic and nuclear compartments as heat-shock proteins.

  2001cited by this paper
• Hyperglycemia and the O-GlcNAc transferase in rat aortic smooth muscle cells: elevated expression and altered patterns of O-GlcNAcylation.

  2001cited by this paper
• Excessive Hexosamines Block the Neuroprotective Effect of Insulin and Induce Apoptosis in Retinal Neurons*

  2001cited by this paper
• Activation of the Hexosamine Pathway Leads to Deterioration of Pancreatic β-Cell Function through the Induction of Oxidative Stress*

  2001cited by this paper
• Glycosylation of Nucleocytoplasmic Proteins: Signal Transduction and O-GlcNAc

  2001cited by this paper
• Hyperglycemia activates p53 and p53-regulated genes leading to myocyte cell death.

  2001cited by this paper
• Alternative O-glycosylation/O-phosphorylation of serine-16 in murine estrogen receptor beta: post-translational regulation of turnover and transactivation activity.

  2001cited by this paper
• The potential mechanism of the diabetogenic action of streptozotocin: inhibition of pancreatic beta-cell O-GlcNAc-selective N-acetyl-beta-D-glucosaminidase.

  2001cited by this paper
• Glycan‐dependent signaling: O‐linked N‐acetylglucosamine

  2001cited by this paper
• Hyperglycemia inhibits endothelial nitric oxide synthase activity by posttranslational modification at the Akt site.

  2001cited by this paper
• State of the arg: protein methylation at arginine comes of age.

  2001cited by this paper
• Identification of GlcNAcylation sites of peptides and alpha-crystallin using Q-TOF mass spectrometry.

  2001cited by this paper
• Increased N-acetyl-beta-glucosaminidase activity in primary breast carcinomas corresponds to a decrease in N-acetylglucosamine containing proteins.

  2001cited by this paper
• Characterization of a mouse monoclonal antibody specific for O-linked N-acetylglucosamine.

  2001cited by this paper
• Purification of the O-glycosylated protein p135 and identification as O-GlcNAc transferase.

  2001cited by this paper
• Dynamic O-Glycosylation of Nuclear and Cytosolic Proteins

  2001cited by this paper
• SH2 domains, interaction modules and cellular wiring.

  2001cited by this paper
• Reciprocity between O-GlcNAc and O-phosphate on the carboxyl terminal domain of RNA polymerase II.

  2001cited by this paper
• O-linkage of N-acetylglucosamine to Sp1 activation domain inhibits its transcriptional capability

  2001cited by this paper
• Cytoplasmic O‐glycosylation prevents cell surface transport of E‐cadherin during apoptosis

  2001cited by this paper
• The Sequence of the Human Genome

  2001cited by this paper
• Identification of GlcNAcylation sites of peptides and α-crystallin using Q-TOF mass spectrometry

  2001cited by this paper
• Glucose stimulates protein modification by O-linked GlcNAc in pancreatic beta cells: linkage of O-linked GlcNAc to beta cell death.

  2000cited by this paper
• Glucose stimulates protein modification by O-linked GlcNAc in pancreatic β cells: Linkage of O-linked GlcNAc to β cell death

  2000cited by this paper
• Glucose and streptozotocin stimulate p135 O-glycosylation in pancreatic islets.

  2000cited by this paper
• Decreased UDP‐GlcNAc levels abrogate proliferation control in EMeg32‐deficient cells

  2000cited by this paper
• The O-GlcNAc transferase gene resides on the X chromosome and is essential for embryonic stem cell viability and mouse ontogeny.

  2000cited by this paper
• Streptozotocin-induced beta-cell death is independent of its inhibition of O-GlcNAcase in pancreatic Min6 cells.

  2000cited by this paper
• Acetylation: a regulatory modification to rival phosphorylation?

  2000cited by this paper
• Elevated O-linked N-acetylglucosamine metabolism in pancreatic beta-cells.

  1999cited by this paper
• Regulation of a Cytosolic and Nuclear O-GlcNAc Transferase

  1999cited by this paper
• Crystal structures of two H-2Db/glycopeptide complexes suggest a molecular basis for CTL cross-reactivity.

  1999cited by this paper
• Elevated O-LinkedN-Acetylglucosamine Metabolism in Pancreatic β-Cells

  1999cited by this paper
• Modulation of O-LinkedN-Acetylglucosamine Levels on Nuclear and Cytoplasmic Proteins in Vivo Using the PeptideO-GlcNAc-β-N-acetylglucosaminidase InhibitorO-(2-Acetamido-2-deoxy-dglucopyranosylidene)amino-N-phenylcarbamate*

  1998cited by this paper
• Insulin and glucosamine infusions increase O-linked N-acetyl-glucosamine in skeletal muscle proteins in vivo.

  1998cited by this paper
• O-Linked GlcNAc Transferase Is a Conserved Nucleocytoplasmic Protein Containing Tetratricopeptide Repeats*

  1997cited by this paper
• Role of the glucosamine pathway in fat-induced insulin resistance.

  1997cited by this paper
• Dynamic O-linked glycosylation of nuclear and cytoskeletal proteins.

  1997cited by this paper
• O glycosylation of an Sp1-derived peptide blocks known Sp1 protein interactions

  1997cited by this paper
• Reduced O glycosylation of Sp1 is associated with increased proteasome susceptibility

  1997cited by this paper
• Dynamic Glycosylation of Nuclear and Cytosolic Proteins

  1997cited by this paper
• Benzyl-N-acetyl-α-d-galactosaminide inhibits the sialylation and the secretion of mucins by a mucin secreting HT-29 cell subpopulation

  1996cited by this paper
• O-GlcNAcylation of key nuclear and cytoskeletal proteins: reciprocity with O-phosphorylation and putative roles in protein multimerization.

  1996cited by this paper
• BETA‐CELL APOPTOSIS IS RESPONSIBLE FOR THE DEVELOPMENT OF IDDM IN THE MULTIPLE LOW‐DOSE STREPTOZOTOCIN MODEL

  1996cited by this paper
• Apoptotic Cell Death Triggered by Nitric Oxide in Pancreatic β-Cells

  1995cited by this paper
• Apoptotic cell death triggered by nitric oxide in pancreatic beta-cells.

  1995cited by this paper
• Characterization of mucins and proteoglycans synthesized by a mucin-secreting HT-29 cell subpopulation.

  1995cited by this paper
• Purification and characterization of an O-GlcNAc selective N-acetyl-beta-D-glucosaminidase from rat spleen cytosol.

  1994cited by this paper
• Discovery of a metabolic pathway mediating glucose-induced desensitization of the glucose transport system. Role of hexosamine biosynthesis in the induction of insulin resistance.

  1991cited by this paper
• Glycosylation of chromosomal proteins: localization of O-linked N-acetylglucosamine in Drosophila chromatin.

  1989cited by this paper

• Keratinocyte-specific deletion of O-GlcNAc transferase reduces the subcutaneous adipocyte layer in mice.

  2025cites this paper
• Presence and Interactions of Entamoeba histolytica Lectin and p53 Protein in Colorectal Cancer

  2025cites this paper
• Aerobic glycolysis of vascular endothelial cells: a novel perspective in cancer therapy

  2024cites this paper
• Extracellular vesicles are dynamic regulators of maternal glucose homeostasis during pregnancy

  2023cites this paper
• Silver Nanoparticles Promote the Osteogenic Differentiation of Human Bone Marrow Mesenchymal Stem Cells by Modulating the O-GlcNAcylation of RUNX1

  2023cites this paper
• O-GlcNAcylation of NLRP3 Contributes to Lipopolysaccharide-Induced Pyroptosis of Human Gingival Fibroblasts

  2023cites this paper
• Enhancement of O-GlcNAcylation on Mitochondrial Proteins with 2-(4-Methoxyphenyl)ethyl-2-acetamido-2-deoxy-β-d-pyranoside, Contributes to the Mitochondrial Network, Cellular Bioenergetics and Stress Response in Neuronal Cells under Ischemic-like Conditions

  2021cites this paper
• Relationships among the Hexosamine Biosynthetic Pathway, Sleep Disturbance, and Cognition in Obstructive Sleep Apnea

  2021cites this paper
• O-GlcNAcylation in early stages of chronic lymphocytic leukemia: Protocol development for flow cytometry

  2021cites this paper
• Naegleria fowleri Induces Jurkat T Cell Death via O-deGlcNAcylation

  2021influential citation
• Numerous severely twisted N‐acetylglucosamine conformations found in the protein databank

  2020cites this paper
• Chemical individuality in T cells: A Garrodian view of immunometabolism

  2020cites this paper
• O‐GlcNAcylation Mediates Glucose‐Induced Alterations in Endothelial Cell Phenotype in Human Diabetes Mellitus

  2020cites this paper
• Identification of Conserved Proteomic Networks in Neurodegenerative Dementia

  2019cites this paper
• Metabolic Pathways Fueling the Endothelial Cell Drive.

  2019cites this paper
• The Role of O-GlcNAcylation for Protection against Ischemia-Reperfusion Injury

  2019cites this paper
• The Road to Pathogenesis: Charting the Development of LSCs and Pre-LSCs

  2019cites this paper
• O-GlcNAcylation Regulates Primary Ciliary Length by Promoting Microtubule Disassembly

  2019cites this paper
• Protein Glycosylation and Tumor Microenvironment Alterations Driving Cancer Hallmarks

  2019cites this paper
• Arginine-GlcNAcylation of death domain and NleB/SseK proteins is crucial for bacteria pathogenesis by regulating host cell death

  2019influential citation
• Model-based in silico analysis of the PI3K/Akt pathway: the elucidation of cross-talk between diabetes and breast cancer

  2018cites this paper
• O-deGlcNAcylation is required for Entamoeba histolytica-induced HepG2 cell death.

  2018cites this paper
• O-GlcNAcylation regulates integrin-mediated cell adhesion and migration via formation of focal adhesion complexes

  2018cites this paper
• Conditions Inducing Excessive O-GlcNAcylation Inhibit BMP2-Induced Osteogenic Differentiation of C2C12 Cells

  2018cites this paper
• ‘O-GlcNAc Code’ Mediated Biological Functions of Downstream Proteins

  2018cites this paper
• O-GlcNAcylation of boundary element associated factor (BEAF 32) in Drosophila melanogaster correlates with active histone marks at the promoters of its target genes

  2017cites this paper
• Recognition of a glycosylation substrate by the O-GlcNAc transferase TPR repeats

  2017cites this paper
• Regulation of the Hippo-YAP Pathway by Glucose Sensor O-GlcNAcylation.

  2017cites this paper
• O-GlcNAcylation of SKN-1 modulates the lifespan and oxidative stress resistance in Caenorhabditis elegans

  2017cites this paper
• Regulation of the Hippo-Y AP Pathway by Glucose Sensor O-GlcNAcylation Graphical Abstract Highlights

  2017cites this paper
• Glycolysis and the Hexosamine Biosynthetic Pathway as Novel Targets for Upper and Lower Airway Inflammation

  2017cites this paper
• O-GlcNAc transferase regulates transcriptional activity of human Oct4

  2017cites this paper
• DNMT3A and TET2 in the Pre-Leukemic Phase of Hematopoietic Disorders

  2016cites this paper
• TET family proteins: oxidation activity, interacting molecules, and functions in diseases.

  2015cites this paper
• Overexpression of Zinc‐Finger Protein 777 (ZNF777) Inhibits Proliferation at Low Cell Density Through Down‐Regulation of FAM129A

  2015cites this paper
• Regulation and clinical significance of O-GlcNAc transferase in cancer

  2015cites this paper
• Regulation of keratinocyte differentiation by O-GlcNAcylation.

  2014cites this paper
• Immunohistochemical Study of O-GlcNAcylation in Human Skin Tumors

  2014cites this paper
• Connections between TET proteins and aberrant DNA modification in cancer.

  2014cites this paper
• The N-glycan profile of placental membrane glycoproteins alters during gestation and aging.

  2014cites this paper
• Investigating the role of O-GlcNAc in the regulation of human Oct4

  2014cites this paper
• RETRACTED: Identification of Nitric Oxide as an Endogenous Inhibitor of 26S Proteasomes in Vascular Endothelial Cells

  2014cites this paper
• Discovery and Confirmation of O-GlcNAcylated Proteins in Rat Liver Mitochondria by Combination of Mass Spectrometry and Immunological Methods

  2013cites this paper
• Investigating breast cancer O-linked glycosylation changes and their immunotherapeutic potential

  2013cites this paper
• Lactobacillus plantarum WCFS1 O-linked protein glycosylation: an extended spectrum of target proteins and modification sites detected by mass spectrometry.

  2013cites this paper
• Regulation Of Stim1 By O-Glcnacylation In Cardiomyocytes

  2013cites this paper
• Regulation of vascular smooth muscle cell phenotype

  2012cites this paper
• Wnt/β‐catenin signaling pathway and thioredoxin‐interacting protein (TXNIP) mediate the “glucose sensor” mechanism in metastatic breast cancer‐derived cells MDA‐MB‐231

  2012cites this paper
• Enhanced epimerization of glycosylated amino acids during solid-phase peptide synthesis.

  2012cites this paper
• Regulation of the Proteasome by AMPK in Endothelial Cells: The Role of O-GlcNAc Transferase (OGT)

  2012cites this paper
• TET2 promotes histone O-GlcNAcylation during gene transcription

  2012cites this paper
• The Increase in O-Linked N-Acetylglucosamine Protein Modification Stimulates Chondrogenic Differentiation Both in Vitro and in Vivo*

  2012cites this paper
• Advances in N‐ and O‐Glycopeptide Synthesis – A Tool to Study Glycosylation and Develop New Therapeutics

  2011cites this paper
• Glutamine is cardioprotective in patients with ischemic heart disease following cardiopulmonary bypass.

  2011cites this paper
• Interplay of Glycosylation and Phosphorylation in Murine Oct-2 Regulates its POU Domain Binding

  2011cites this paper
• A versatile method for analysis of serine/threonine posttranslational modifications by β-elimination in the presence of pyrazolone analogues.

  2011cites this paper
• Regulation of mitochondrial morphology and function by O-GlcNAcylation in neonatal cardiac myocytes.

  2011cites this paper
• Development and validation of a LC-MS/MS method for the pharmacokinetic study of thiamet-G and its analogues in rat

  2010cites this paper
• Enrichment of O-GlcNAc modified proteins by the periodate oxidation-hydrazide resin capture approach.

  2010cites this paper
• Glucosamine Treatment-mediated O-GlcNAc Modification of Paxillin Depends on Adhesion State of Rat Insulinoma INS-1 Cells*

  2010cites this paper
• The effects of oral glucosamine on joint health: is a change in research approach needed?

  2010cites this paper
• The Role of the O-GlcNAc Modification in Regulating Eukaryotic Gene Expression.

  2010cites this paper
• The role of O-linked GlcNAc modification on the glucose response of ChREBP.

  2010cites this paper
• Glucosamine exerts a neuroprotective effect via suppression of inflammation in rat brain ischemia/reperfusion injury

  2010cites this paper
• Genomic methods for studying the post-translational regulation of transcription factors

  2010cites this paper
• Increased Enzymatic O-GlcNAcylation of Mitochondrial Proteins Impairs Mitochondrial Function in Cardiac Myocytes Exposed to High Glucose*

  2009cites this paper
• In Vivo Modulation of O-GlcNAc Levels Regulates Hippocampal Synaptic Plasticity through Interplay with Phosphorylation*

  2009cites this paper
• Characterization of novel CDG-I defects : new insights in dolichol cycle regulation and ER quality control

  2009cites this paper
• Phosphorylation Modification of Wheat Lectin VER2 Is Associated with Vernalization-Induced O-GlcNAc Signaling and Intracellular Motility

  2009cites this paper
• Non-canonical glycosyltransferase modulates post-hypoxic cardiac myocyte death and mitochondrial permeability transition.

  2008cites this paper
• Protein ubiquitination is modulated by O‐GlcNAc glycosylation

  2008cites this paper
• O-GlcNAc modulation at Akt1 Ser473 correlates with apoptosis of murine pancreatic beta cells.

  2008cites this paper
• Glucose induces an autocrine activation of the Wnt/beta-catenin pathway in macrophage cell lines.

  2008cites this paper
• Chapter 15 O-GlcNAc Proteomics: Mass Spectrometric Analysis of O-GlcNAc Modifications on Proteins

  2008cites this paper
• Effects of hexosamine biosynthesis on an in vitro model of cardiac ischemia

  2008cites this paper
• Increased protein O-GlcNAc modification inhibits inflammatory and neointimal responses to acute endoluminal arterial injury.

  2008cites this paper
• Prevention of incipient diabetic cardiomyopathy by high-dose thiamine.

  2008cites this paper
• Sp1 modulates ncOGT activity to alter target recognition and enhanced thermotolerance in E. coli.

  2008cites this paper
• Aging leads to increased levels of protein O-linked N-acetylglucosamine in heart, aorta, brain and skeletal muscle in Brown-Norway rats

  2008cites this paper
• Defining the regulated secreted proteome of rodent adipocytes upon the induction of insulin resistance.

  2008cites this paper
• Chemical approaches to mapping the function of post‐translational modifications

  2008cites this paper
• Modification of topoisomerase I activity by glucose and by O-GlcNAcylation of the enzyme protein.

  2007influential citation
• Glucosamine protects neonatal cardiomyocytes from ischemia-reperfusion injury via increased protein-associated O-GlcNAc.

  2007cites this paper
• Glutamine-induced protection of isolated rat heart from ischemia/reperfusion injury is mediated via the hexosamine biosynthesis pathway and increased protein O-GlcNAc levels.

  2007cites this paper
• Glucose Mediates the Translocation of NeuroD1 by O-Linked Glycosylation*

  2007cites this paper
• Defective Glycosylation and Muscular Dystrophies

  2007cites this paper
• Expanding the diversity of chemical protein modification allows post-translational mimicry

  2007cites this paper
• Dementia: The Significance of Cerebral Metabolic Disturbances in Alzheimer's Disease. Relation to Parkinson's Disease

  2007cites this paper
• Effects of hyperglycaemia in primary human macrophages

  2007cites this paper
• O-GlcNAc modification modulates the expression of osteocalcin via OSE2 and Runx2.

  2007cites this paper
• O-Linked N-Acetylglucosamine Proteomics of Postsynaptic Density Preparations Using Lectin Weak Affinity Chromatography and Mass Spectrometry*S

  2006cites this paper
• Glucosamine inhibits angiotensin II-induced cytoplasmic Ca2+ elevation in neonatal cardiomyocytes via protein-associated O-linked N-acetylglucosamine.

  2006cites this paper
• GLUCOSAMINE ADMINISTRATION DURING RESUSCITATION IMPROVES ORGAN FUNCTION AFTER TRAUMA HEMORRHAGE

  2006cites this paper
• Post‐translational modification by O‐GlcNAc: Another way to change protein function

  2006influential citation
• Cause of death: suicide.

  2006cites this paper
• The use of mass spectrometry for the proteomic analysis of glycosylation

  2006cites this paper
• Increased hexosamine biosynthesis and protein O-GlcNAc levels associated with myocardial protection against calcium paradox and ischemia.

  2006cites this paper
• Mapping of two O‐GlcNAc modification sites in the capsid protein of the potyvirus Plum pox virus

  2006cites this paper
• Alternative O-GlcNAcylation/O-phosphorylation of Ser16 induce different conformational disturbances to the N terminus of murine estrogen receptor beta.

  2006cites this paper
• Pemphigus antibody induced phosphorylation of keratinocyte proteins

  2006cites this paper