Molecular insights into protein synthesis with proline residues

No abstract is available for this paper.

• Publication year

  2016

• Venue

  EMBO Reports

• Publication date

  2016-11-08

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.15252/embr.201642943PMID 27827794PMCID PMC5283605
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Molecular insights into protein synthesis with proline residues

  2016cited by this paper
• Crystal Structure of Hypusine-Containing Translation Factor eIF5A Bound to a Rotated Eukaryotic Ribosome.

  2016influential reference
• Entropic Contribution of Elongation Factor P to Proline Positioning at the Catalytic Center of the Ribosome.

  2015cited by this paper
• Structure of a human translation termination complex

  2015cited by this paper
• Structure of the hypusinylated eukaryotic translation factor eIF-5A bound to the ribosome

  2015cited by this paper
• PolyprOnline: polyproline helix II and secondary structure assignment database

  2014cited by this paper
• Molecular basis for the ribosome functioning as an L-tryptophan sensor.

  2014cited by this paper
• Synthesis of aminoacylated N6,N6-dimethyladenosine solid support for efficient access to hydrolysis-resistant 3′-charged tRNA mimics

  2014cited by this paper
• EF-P Dependent Pauses Integrate Proximal and Distal Signals during Translation

  2014cited by this paper
• Expanding and reprogramming the genetic code of cells and animals.

  2014cited by this paper
• A proton wire to couple aminoacyl-tRNA accommodation and peptide bond formation on the ribosome

  2014cited by this paper
• Arrest peptides: cis-acting modulators of translation.

  2013cited by this paper
• eIF5A promotes translation of polyproline motifs.

  2013cited by this paper
• EF-P Is Essential for Rapid Synthesis of Proteins Containing Consecutive Proline Residues

  2013cited by this paper
• Translation Elongation Factor EF-P Alleviates Ribosome Stalling at Polyproline Stretches

  2013cited by this paper
• Proline: The Distribution, Frequency, Positioning, and Common Functional Roles of Proline and Polyproline Sequences in the Human Proteome

  2013cited by this paper
• Upgrading protein synthesis for synthetic biology.

  2013cited by this paper
• Polyproline-II helix in proteins: structure and function.

  2013influential reference
• Structure of the Eukaryotic Ribosome: Tips and Tricks

  2013cited by this paper
• JLigand: a graphical tool for the CCP4 template-restraint library

  2012cited by this paper
• Optimal fine ϕ-slicing for single-photon-counting pixel detectors

  2011cited by this paper
• Optimal fine u-slicing for single-photon-counting pixel detectors

  2011cited by this paper
• Native chemical ligation of hydrolysis-resistant 3'-peptidyl-tRNA mimics.

  2011cited by this paper
• Functionalized polystyrene supports for solid-phase synthesis of glycyl-, alanyl-, and isoleucyl-RNA conjugates as hydrolysis-resistant mimics of peptidyl-tRNAs

  2011cited by this paper
• The structure of the eukaryotic ribosome at 3.0 A resolution. This entry contains ribosomal RNA and ions of the 40S subunit, ribosome A

  2011influential reference
• pH-sensitivity of the ribosomal peptidyl transfer reaction dependent on the identity of the A-site aminoacyl-tRNA

  2010cited by this paper
• Encoding multiple unnatural amino acids via evolution of a quadruplet-decoding ribosome

  2010cited by this paper
• Crystal Structure of the Eukaryotic Ribosome

  2010cited by this paper
• Efficient access to nonhydrolyzable initiator tRNA based on the synthesis of 3'-azido-3'-deoxyadenosine RNA.

  2010cited by this paper
• Features and development of Coot

  2010cited by this paper
• MolProbity: all-atom structure validation for macromolecular crystallography

  2009cited by this paper
• Slow peptide bond formation by proline and other N-alkylamino acids in translation

  2009cited by this paper
• Non-hydrolyzable RNA-peptide conjugates: a powerful advance in the synthesis of mimics for 3'-peptidyl tRNA termini.

  2009cited by this paper
• Peptidyl-prolyl-tRNA at the ribosomal P-site reacts poorly with puromycin.

  2008cited by this paper
• Modulation of the Rate of Peptidyl Transfer on the Ribosome by the Nature of Substrates*

  2008cited by this paper
• A structural understanding of the dynamic ribosome machine

  2008cited by this paper
• Structural insights into the roles of water and the 2' hydroxyl of the P site tRNA in the peptidyl transferase reaction.

  2005influential reference
• An induced-fit mechanism to promote peptide bond formation and exclude hydrolysis of peptidyl-tRNA

  2005cited by this paper
• About the authors

  2004cited by this paper
• Retrieval of Crystallographically-Derived Molecular Geometry Information

  2004cited by this paper
• Polyproline II structure in proteins: identification by chiroptical spectroscopies, stability, and functions.

  2002cited by this paper
• Structural insights into peptide bond formation

  2002influential reference
• Facile synthesis of puromycin-tethered oligonucleotides at the 3′-end

  1998cited by this paper
• Effect of proline residues on protein folding.

  1981cited by this paper
• Electronic Reprint Biological Crystallography Phenix : a Comprehensive Python-based System for Macromolecular Structure Solution

  year unknowncited by this paper
• Figures and Figure Supplements Mechanisms of Ribosome Stalling by Secm at Multiple Elongation Steps

  year unknowncited by this paper

• Quality control and signaling pathways at stalled ribosomes

  2026cites this paper
• Clinical efficacy of collagen-based dressings in wound management: a focus on their interactive role in wound healing

  2026cites this paper
• Co-Translational Incorporation of (R)- and (S)-β2-Hydroxy Acids In Vitro: A Structural and Biochemical Study on the E. coli Ribosome.

  2026cites this paper
• Structural modification of oxazolidinone antibiotics alters nascent peptide stalling preference and peptide trajectory through the ribosome

  2026cites this paper
• Exploration of Novel Antimicrobial Peptides from Gut Probiotics Enterococcus spp. Against Extensively drug-resistant Pathogens Through cutting-edge Computational Discovery.

  2026cites this paper
• Functional characterization of two protein C variants causing type I deficiency via cellular degradation or retention

  2025cites this paper
• Warburg-Cinotti disease variant p.Tyr740Cys enhances catalytic activity of DDR2 kinase

  2025cites this paper
• Emerging Roles of De Novo Proline Biosynthesis in Human Diseases

  2025cites this paper
• Single nucleotide switches confer bacteriophage resistance to Pseudomonas protegens

  2025cites this paper
• Metabolomics analysis reveals the formation mechanism of Cordyceps militaris fruiting bodies in liquid culture.

  2025cites this paper
• Substrate Specificity and Peptide Motif Preferences of β-Lytic and L5 Proteases from Lysobacter spp. Revealed by LC–MS/MS Analysis

  2025cites this paper
• Directed evolution-based discovery of ligands for in vivo restimulation of chimeric antigen receptor T cells.

  2025cites this paper
• Evaluation of SLC6A8 species conservation and the effect of pathogenic variants on creatine transport

  2025cites this paper
• Protein and Peptide Therapeutics: Stability Challenges, Regulatory Demands, and Innovative Formulation Solutions for Enhanced Clinical Effectiveness.

  2025cites this paper
• Directed evolution and modular integration of a high-affinity ICOS-L variant for potent T cell–mediated tumor elimination

  2025cites this paper
• Synergistic Ciprofloxacin-RWn Peptide Therapy Overcomes Drug Resistance in Gram-Negative Bacteria

  2025cites this paper
• Multiple strategies were adopted to optimize the enzymatic characteristics and improve the expression of bovine chymosin BtChy in Kluyveromyces lactis for cheese production

  2025cites this paper
• Microneedle Innovations in Oral Therapeutics: Transforming Protein and Peptide Delivery

  2025cites this paper
• Conserved specificity of extracellular wastewater peptidases revealed by multiplex substrate profiling by mass spectrometry

  2025cites this paper
• Emerging mechanisms of human mitochondrial translation regulation.

  2025cites this paper
• Arginine: at the crossroads of nitrogen metabolism

  2025cites this paper
• Nutritional and functional assessment of fortified bread with psychrotolerant and mesophilic microalgae

  2025cites this paper
• Amino Acids Frequency and Interaction Trends: Comprehensive Analysis of Experimentally Validated Viral Antigen–Antibody Complexes

  2025cites this paper
• Characterization of peptides released from frozen-then-aged beef after digestion in an in vitro infant gastrointestinal model.

  2024cites this paper
• Impact of missense mutations on the structure-function relationship of human succinyl-CoA synthetase using in silico analysis.

  2024cites this paper
• Effects of Mutation in Myostatin Exon 3 on Growth and Carcass Characteristics of Savak Akkaraman Sheep

  2024cites this paper
• A Universal Support for the Solid‐Phase Synthesis of Peptidyl‐tRNA Mimics

  2024cites this paper
• Mechanical unfolding of RNA molecules using a knowledge-based model.

  2024cites this paper
• Interpreting protein abundance in Saccharomyces cerevisiae through relational learning

  2024cites this paper
• The pivotal role of histidine 976 in human histone deacetylase 4 for enzyme function and ligand recognition.

  2024cites this paper
• Atomistic simulations reveal impacts of missense mutations on the structure and function of SynGAP1

  2024cites this paper
• In-Silico Method for Predicting Pathogenic Missense Variants Using Online Tools: AURKA Gene as a Model

  2024cites this paper
• Metabolomics to investigate the effect of preconditioned mesenchymal stem cells with crocin on pulmonary epithelial cells exposed to 2-chloroethyl ethyl sulfide.

  2024cites this paper
• CheckMyMetal (CMM): validating metal-binding sites in X-ray and cryo-EM data

  2024cites this paper
• Tuning tRNAs for improved translation

  2024cites this paper
• Degradation pathways of amino acids during thermal utilization of biomass: a review

  2024cites this paper
• Proline substitutions in the ASIC1 β11-12 linker slow desensitization

  2024cites this paper
• Deep mutational scanning of hepatitis B virus reveals a mechanism for cis-preferential reverse transcription.

  2024cites this paper
• Engineering tRNAs for the Ribosomal Translation of Non-proteinogenic Monomers

  2024cites this paper
• Directed evolution-based discovery of ligands for in vivo restimulation of CAR-T cells

  2024cites this paper
• Progressive alterations in polysomal architecture and activation of ribosome stalling relief factors in a mouse model of Huntington’s disease

  2024cites this paper
• mRNA-based In Silico Vaccine Design using Epstein-Barr Virus'Envelope Glycoprotein GP350 and Glycoprotein BDLF3 through Immunoinformatics Approaches

  2023cites this paper
• Aminobenzoic Acid Derivatives Obstruct Induced Fit in the Catalytic Center of the Ribosome

  2023cites this paper
• Anticodon sequence determines the impact of mistranslating tRNAAla variants

  2023cites this paper
• Isolation, Characterization, Genome Analysis and Host Resistance Development of Two Novel Lastavirus Phages Active against Pandrug-Resistant Klebsiella pneumoniae

  2023cites this paper
• Practical Synthesis of N-Formylmethionylated Peptidyl-tRNA Mimics

  2023cites this paper
• The integrated stress response effector GADD34 is repurposed by neurons to promote stimulus-induced translation

  2023cites this paper
• Genetic analysis of TMPRSS6 catalytic domain variants in Mexican patients with iron treatment refractoriness.

  2023cites this paper
• Synthesis of Peptidyl-tRNA Mimics for Structural Biology Applications

  2023cites this paper
• Synechococcus elongatus Argonaute reduces natural transformation efficiency and provides immunity against exogenous plasmids

  2023cites this paper
• A simple geometrical model of the electrostatic environment around the catalytic center of the ribosome and its significance for the elongation cycle kinetics

  2023cites this paper
• Concentration and time-dependent amyloidogenic characteristics of intrinsically disordered N-terminal region of Saccharomyces cerevisiae Stm1

  2023cites this paper
• Ultrastructural Abnormalities in Induced Pluripotent Stem Cell-Derived Neural Stem Cells and Neurons of Two Cohen Syndrome Patients

  2023cites this paper
• Insights into Superinfection Immunity Regulation of Xanthomonas axonopodis Filamentous Bacteriophage cf

  2023cites this paper
• Insights into Network of Hot Spots of Aggregation in Nucleophosmin 1

  2022cites this paper
• Insights into the ribosome function from the structures of non-arrested ribosome–nascent chain complexes

  2022cites this paper
• Synonymous ADAMTS13 variants impact molecular characteristics and contribute to variability in active protein abundance

  2022cites this paper
• Dynamic study of small toxic hydrophobic proteins PepA1 and PepG1 of Staphylococcus aureus.

  2022cites this paper
• Herpesvirus-induced spermidine synthesis and eIF5A hypusination for viral episomal maintenance.

  2022cites this paper
• Omics profiling identifies the regulatory functions of the MAPK/ERK pathway in nephron progenitor metabolism

  2022cites this paper
• Probing the genetic code and impacts of mistranslation using tRNA Ala anticodon variants

  2022cites this paper
• De-novo designed β-lysine derivatives can both augment and diminish the proliferation rates of E. coli through the action of Elongation Factor P.

  2022cites this paper
• Untargeted Metabolomics Sensitively Differentiates Gut Bacterial Species in Single Culture and Co-Culture Systems

  2022cites this paper
• Dual contribution of the mTOR pathway and of the metabolism of amino acids in prostate cancer

  2022cites this paper
• Progressive alterations in polysomal architecture in a mouse model of Huntington’s disease

  2022cites this paper
• A "spindle and thread" mechanism unblocks p53 translation by modulating N-terminal disorder.

  2022cites this paper
• In silico characterization of the GH5-cellulase family from uncultured microorganisms: physicochemical and structural studies

  2021cites this paper
• Progressive alterations of striatal polysomal architecture in a mouse model of Huntington’s disease

  2021cites this paper
• Peptidyl transferase center decompaction and structural constraints during early protein elongation on the ribosome

  2021cites this paper
• The landscape of translational stall sites in bacteria revealed by monosome and disome profiling

  2021cites this paper
• Progressive alterations in polysomal architecture and activation of ribosome stalling relief factors in a mouse model of Huntington’s disease

  2021cites this paper
• Overexpression of Karrikins Receptor Gene Sapium sebiferum KAI2 Promotes the Cold Stress Tolerance via Regulating the Redox Homeostasis in Arabidopsis thaliana

  2021cites this paper
• Scaffold Hopping Transformations Using Auxiliary Restraints for Calculating Accurate Relative Binding Free Energies.

  2021cites this paper
• Impaired eIF5A function causes a Mendelian disorder that is partially rescued in model systems by spermidine

  2021cites this paper
• Alternative human eIF5A protein isoform plays a critical role in mitochondria

  2021cites this paper
• Amine‐to‐Azide Conversion on Native RNA via Metal‐Free Diazotransfer Opens New Avenues for RNA Manipulations

  2021cites this paper
• in vitro yeast reconstituted translation system reveals function of eIF5A for synthesis of long polypeptide.

  2020cites this paper
• A systematic analysis of the beta hairpin motif in the Protein Data Bank

  2020cites this paper
• Phosphorothioate Modification of mRNA Accelerates Rate of Translation Initiation Providing More Efficient Protein Synthesis.

  2020cites this paper
• A novel phage display vector for selection of target-specific peptides.

  2020cites this paper
• Templates direct the sequence-specific anchoring of the C-terminus of peptido RNAs

  2020cites this paper
• Genome-wide Survey of Ribosome Collision.

  2020cites this paper
• A short translational ramp determines the efficiency of protein synthesis

  2019cites this paper
• Strategies for in vitro engineering of the translation machinery

  2019cites this paper
• Genome-wide survey of ribosome collision

  2019cites this paper
• Short translational ramp determines efficiency of protein synthesis

  2019cites this paper
• Ribosome pausing, a dangerous necessity for co-translational events

  2019cites this paper
• Dynamics of transcription–translation coordination tune bacterial indole signaling

  2019cites this paper
• Complex Structure of Pseudomonas aeruginosa Arginine Rhamnosyltransferase EarP with Its Acceptor Elongation Factor P

  2019cites this paper
• How mRNA and nascent chain sequences regulate translation elongation

  2019cites this paper
• Optimization of secretion and surface localization of heterologous OVA protein in mycobacteria by using LipY as a carrier

  2019cites this paper
• Switching the Post-translational Modification of Translation Elongation Factor EF-P

  2019cites this paper
• Flexizyme-catalyzed synthesis of 3′-aminoacyl-NH-tRNAs

  2019cites this paper
• The polyproline‐motif of S6K2: eIF5A translational dependence and importance for protein‐protein interactions

  2018cites this paper
• How Messenger RNA and Nascent Chain Sequences Regulate Translation Elongation.

  2018cites this paper
• A metastable rRNA junction essential for bacterial 30S biogenesis

  2018cites this paper
• Translation Elongation and Recoding in Eukaryotes.

  2018cites this paper
• Engineered Ribosomes for Basic Science and Synthetic Biology.

  2018cites this paper
• Design of Novel Putative Peptide fragments derived from exons of p53 isoform g and p53 promoter region ORF sequence targeting HDM2/MDM2-p53 interaction

  2018cites this paper
• Mechanistic insights into the slow peptide bond formation with D-amino acids in the ribosomal active site

  2018cites this paper