Functional characterization of the P2X4 receptor orthologues

No abstract is available for this paper.

• Publication year

  2000

• Venue

  British Journal of Pharmacology

• Publication date

  2000-01-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1038/sj.bjp.0703059PMID 10694247PMCID PMC1571843
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Molecular cloning, functional characterization and possible cooperativity between the murine P2X4 and P2X4a receptors.

  1999influential reference
• The anticonvulsant effects of the enantiomers of losigamone

  1999cited by this paper
• Co-Expression of P 2 X 1 and P 2 X 5 Receptor Subunits Reveals a Novel ATP-Gated Ion Channel

  1998cited by this paper
• The human P2X4 receptor gene is alternatively spliced.

  1998cited by this paper
• Effects of antagonists at the human recombinant P2X7 receptor

  1998cited by this paper
• Central P2X4 and P2X6 Channel Subunits Coassemble into a Novel Heteromeric ATP Receptor

  1998influential reference
• Ca2+ Signals Mediated by P2X-Type Purinoceptors in Cultured Cerebellar Purkinje Cells

  1998cited by this paper
• Co-expression of P2X1 and P2X5 receptor subunits reveals a novel ATP-gated ion channel.

  1998cited by this paper
• Cibacron blue allosterically modulates the rat P2X4 receptor.

  1998cited by this paper
• Characterization of recombinant human P2X4 receptor reveals pharmacological differences to the rat homologue.

  1997influential reference
• ATP, a partial agonist for the P2Z receptor of human lymphocytes

  1997cited by this paper
• The isoquinoline derivative KN‐62 a potent antagonist of the P2Z‐receptor of human lymphocytes

  1997cited by this paper
• Properties of the pore‐forming P2X7 purinoceptor in mouse NTW8 microglial cells

  1997cited by this paper
• Presence of epsilon-adenosine tetraphosphate in chromaffin granules after transport of epsilon-ATP.

  1996cited by this paper
• An antagonist‐insensitive P2X receptor expressed in epithelia and brain.

  1996influential reference
• Presence of ε‐adenosine tetraphosphate in chromaffin granules after transport of ε‐ATP

  1996cited by this paper
• A novel neuronal P2x ATP receptor ion channel with widespread distribution in the brain

  1996influential reference
• The Cytolytic P2Z Receptor for Extracellular ATP Identified as a P2X Receptor (P2X7)

  1996cited by this paper
• Cloning OF P2X5 and P2X6 receptors and the distribution and properties of an extended family of ATP-gated ion channels

  1996influential reference
• Extracellular purine metabolism

  1996influential reference
• P2X4: an ATP-activated ionotropic receptor cloned from rat brain.

  1996cited by this paper
• A P2X purinoceptor cDNA conferring a novel pharmacological profile

  1995cited by this paper
• Inhibition of [3H]CGP 39653 binding to NMDA receptors by a P2 antagonist, suramin

  1995cited by this paper
• Coexpression of P2X2 and P2X3 receptor subunits can account for ATP-gated currents in sensory neurons

  1995cited by this paper
• A P2X purinoceptor expressed by a subset of sensory neurons

  1995cited by this paper
• A new class of ligand-gated ion channel defined by P2X receptor for extracellular ATP

  1994cited by this paper
• New structural motif for ligand-gated ion channels defined by an ionotropic ATP receptor

  1994cited by this paper
• A patch‐clamp study of bovine chromaffin cells and of their sensitivity to acetylcholine.

  1982cited by this paper
• Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

  1981cited by this paper
• Studies on the occurrence and biosynthesis of adenosine tetraphosphate.

  1966cited by this paper

• Species Differences of P2X4 Receptor Modulators.

  2025cites this paper
• The vasoconstrictor adenosine 5′-tetraphosphate is a danger signal that induces IL-1β

  2025cites this paper
• A Bioelectric Therapy for Glioblastoma: Stimulating Purinergic Signaling via Pulsed Electric Fields

  2025cites this paper
• ATP release mediated by pannexin-3 is required for plasma cell survival via P2X4 receptors in bone marrow

  2024cites this paper
• Pharmacological differences between human and mouse P2X4 receptor explored using old and new tools

  2024cites this paper
• Extracellular ATP Release Triggered by 131I-Trastuzumab Mitigates Radiation-Induced Reduction in Cell Viability through the P2Y6 Receptor in SKOV3 Cells.

  2024cites this paper
• Structural insights into the orthosteric inhibition of P2X receptors by non-ATP analog antagonists

  2024cites this paper
• Bone marrow plasma cells require P2RX4 to sense extracellular ATP

  2024cites this paper
• Migraine signaling pathways: purine metabolites that regulate migraine and predispose migraineurs to headache

  2023cites this paper
• The P2X4 Receptor: Cellular and Molecular Characteristics of a Promising Neuroinflammatory Target

  2022cites this paper
• Taspine is a natural product that suppresses P2X4 receptor activity via phosphoinositide 3‐kinase inhibition

  2021cites this paper
• Dissection of P2X4 and P2X7 Receptor Current Components in BV-2 Microglia

  2020cites this paper
• Pharmacological and genetic characterisation of the canine P2X4 receptor

  2020cites this paper
• “ESTUDIO DE LA GENERACIÓN DE ESTEREOCILIOS EN PRECURSORES DE LAS CÉLULAS CILIADAS”

  2020cites this paper
• P2 Receptors in Cardiac Myocyte Pathophysiology and Mechanotransduction

  2020cites this paper
• P2Y2 and P2X4 Receptors Mediate Ca2+ Mobilization in DH82 Canine Macrophage Cells

  2020cites this paper
• Resolving the Ionotropic P2X4 Receptor Mystery Points towards a New Therapeutic Target for Cardiovascular Diseases

  2020cites this paper
• The Ionotropic P2X4 Receptor has Unique Properties in the Heart by Mediating the Negative Chronotropic Effect of ATP While Increasing the Ventricular Inotropy

  2019cites this paper
• An Allosteric Inhibitory Site Conserved in the Ectodomain of P2X Receptor Channels

  2019cites this paper
• Rôle des récepteurs P2X4 dans la dégradation d’ApoE : implication dans la maladie d’Alzheimer

  2019cites this paper
• Antibodies binding the head domain of P2X4 inhibit channel function and reverse neuropathic pain.

  2019cites this paper
• Characterization of purinergic receptor expression in ARPKD cystic epithelia

  2018cites this paper
• Eosinophil depletion suppresses radiation-induced small intestinal fibrosis

  2018cites this paper
• Identification and structure activity relationship of small molecule antagonists of the human P2X4 receptor

  2018cites this paper
• The molecular basis of antagonism by PPADS at the human P2X1 receptor

  2018cites this paper
• Osthole alleviated diabetic neuropathic pain mediated by the P2X4 receptor in dorsal root ganglia.

  2018cites this paper
• P2X4 Receptor Function in the Nervous System and Current Breakthroughs in Pharmacology

  2017influential citation
• Characterization of P2X4 receptor agonists and antagonists by calcium influx and radioligand binding studies

  2017cites this paper
• ATP evokes Ca2+ signals in cultured foetal human cortical astrocytes entirely through G protein‐coupled P2Y receptors

  2017cites this paper
• P2X4 receptor in human macrophages : role in ATP-evoked calcium responses and cytokine production

  2017cites this paper
• Conductance of P2X4 purinergic receptor is determined by conformational equilibrium in the transmembrane region

  2016cites this paper
• Leptin suppresses adenosine triphosphate‐induced impairment of spinal cord astrocytes

  2016cites this paper
• P2X4 Receptor Reporter Mice: Sparse Brain Expression and Feeding-Related Presynaptic Facilitation in the Arcuate Nucleus

  2016cites this paper
• Mitochondrial Dysfunction, Depleted Purinergic Signaling, and Defective T Cell Vigilance and Immune Defense.

  2016cites this paper
• High-frequency voltage oscillations in cultured astrocytes

  2015cites this paper
• Medicinal chemistry of P2X receptors: agonists and orthosteric antagonists.

  2015cites this paper
• Using fruit fly eyes as membrane protein factories: Expression of rat P2X2 and pannexin-1 in Drosophila melanogaster

  2015cites this paper
• Purinergic receptors in tubulointerstitial inflammatory cells: a pathophysiological mechanism of salt‐sensitive hypertension

  2015cites this paper
• Identification and Characterization of a Selective Allosteric Antagonist of Human P2X4 Receptor Channels

  2015cites this paper
• Pyridoxal-5'-phosphate (MC-1), a vitamin B6 derivative, inhibits expressed P2X receptors.

  2014cites this paper
• Measurement of ATP-Induced Membrane Potential Changes in IVD Cells

  2014cites this paper
• Imaging P2X4 receptor subcellular distribution, trafficking, and regulation using P2X4-pHluorin

  2014cites this paper
• Purinergic P2X receptors: structural and functional features depicted by X-ray and molecular modelling studies.

  2014cites this paper
• The effects of ATP and adenosine on the extracellular Matrix biosynthesis via purinergic pathways

  2014cites this paper
• Sensitization of cutaneous neuronal purinergic receptors contributes to endothelin‐1‐induced mechanical hypersensitivity

  2014influential citation
• Inhibition of P2X4 function by P2Y6 UDP receptors in microglia

  2013cites this paper
• P2X and P2Y nucleotide receptors as targets in cardiovascular disease.

  2013cites this paper
• Heteromeric assembly of P2X subunits

  2013cites this paper
• Mise au point d'outils optogénétiques pour la photorégulation de l'activité des récepteurs canaux P2X

  2013cites this paper
• Die durch exogenes ATP gesteuerte Modulation von exzitatorischen synaptischen Signalen in striatalen Neuronen der Ratte

  2013cites this paper
• P2X4 subunits are part of P2X native channels in murine myenteric neurons.

  2013cites this paper
• Hemodynamics - New Diagnostic and Therapeutic Approaches

  2012cites this paper
• Fluvastatin suppresses native and recombinant human P2X4 receptor function

  2012cites this paper
• N-substituted phenoxazine and acridone derivatives: structure-activity relationships of potent P2X4 receptor antagonists.

  2012cites this paper
• Molecular and functional properties of P2X receptors—recent progress and persisting challenges

  2012cites this paper
• Pharmacology of P2X receptors

  2012cites this paper
• Regulation of Renal Hemodyamics by Purinergic Receptors in Angiotensin II -Induced Hypertension

  2012cites this paper
• Contribution of renal purinergic receptors to renal vasoconstriction in angiotensin II-induced hypertensive rats.

  2011cites this paper
• Activation of P2X receptors induces apoptosis in human retinal pigment epithelium.

  2011cites this paper
• Renal Hemodynamics Contribution of renal purinergic receptors to renal vasoconstriction in angiotensin II-induced hypertensive rats

  2011cites this paper
• Purinergic P2Y2 receptors mediate rapid Ca(2+) mobilization, membrane hyperpolarization and nitric oxide production in human vascular endothelial cells.

  2011cites this paper
• Purine receptor‐mediated endocannabinoid production and retrograde synaptic signalling in the cerebellar cortex

  2011cites this paper
• Activation and Regulation of Purinergic P2X Receptor Channels

  2011influential citation
• Activation of P 2 X Receptors Induces Apoptosis in Human Retinal Pigment Epithelium

  2011cites this paper
• Characterization of three diaminopyrimidines as potent and selective antagonists of P2X3 and P2X2/3 receptors with in vivo efficacy in a pain model

  2011cites this paper
• The carbon monoxide donor, CORM-2, is an antagonist of ATP-gated, human P2X4 receptors

  2011cites this paper
• Structural interpretation of P2X receptor mutagenesis studies on drug action

  2010cites this paper
• Damage-induced cell–cell communication in different cochlear cell types via two distinct ATP-dependent Ca2+ waves

  2010cites this paper
• P2X4 receptors in activated C8-B4 cells of cerebellar microglial origin

  2010influential citation
• Excitotoxic ATP and Glutamate Signalling during Central Nervous System Ischaemia

  2010cites this paper
• Amitriptyline does not block the action of ATP at human P2X4 receptor

  2010cites this paper
• Purinergic receptor expression in neuronal, bladder smooth muscle and urothelial cells : characterization and inhibition by low molecular weight antagonists

  2009influential citation
• Antidepressants inhibit P2X4 receptor function: a possible involvement in neuropathic pain relief

  2009cites this paper
• Alpha,Beta Methylene ATP

  2008cites this paper
• A positive inotropic effect of ATP in the human cardiac atrium.

  2008cites this paper
• P2X3 receptors and sensory transduction

  2008cites this paper
• PPADS, a purinergic antagonist reduces Fos expression at spinal cord level in a mouse model of mononeuropathy.

  2008cites this paper
• Dorsal root ganglion neurons innervating skeletal muscle respond to physiological combinations of protons, ATP, and lactate mediated by ASIC, P2X, and TRPV1.

  2008influential citation
• Role of aromatic and charged ectodomain residues in the P2X4 receptor functions

  2007cites this paper
• Functional expression of ionotropic purinergic receptors on mouse taste bud cells

  2007influential citation
• Quantal Release of ATP in Mouse Cortex

  2007cites this paper
• P2X1 and P2X4 receptor currents in mouse macrophages

  2007cites this paper
• Extracellular ATP has stimulatory effects on the expression and release of IL-6 via purinergic receptors in normal human epidermal keratinocytes.

  2007cites this paper
• Functional Properties of Internalization-Deficient P2X4 Receptors Reveal a Novel Mechanism of Ligand-Gated Channel Facilitation by Ivermectin

  2006cites this paper
• Pharmacology of P2X channels

  2006cites this paper
• Pore properties and pharmacological features of the P2X receptor channel in airway ciliated cells

  2006cites this paper
• Nucleotide receptor P2x4

  2006cites this paper
• Identification of P2X4 receptor-specific residues contributing to the ivermectin effects on channel deactivation.

  2006cites this paper
• Antagoniste du recepteur p2x4antagoniste du recepteur p2x4antagoniste du recepteur p2x4

  2006cites this paper
• Extracellular ATP‐stimulated current in wild‐type and P2X4 receptor transgenic mouse ventricular myocytes: implications for a cardiac physiologic role of P2X4 receptors

  2006cites this paper
• P2X receptors in mouse Leydig cells.

  2006cites this paper
• The cytokine IL‐1β transiently enhances P2X7 receptor expression and function in human astrocytes

  2005influential citation
• Stimulation of P2X receptors enhances lipooligosaccharide‐mediated apoptosis of endothelial cells

  2005cites this paper
• P2X Receptors: Targets for Novel Analgesics?

  2005cites this paper
• P2X7-like receptor subunits enhance excitatory synaptic transmission at central synapses by presynaptic mechanisms.

  2004cites this paper
• Functional Characterization of a P2X Receptor from Schistosoma mansoni*

  2004cites this paper
• Role of extracellular histidines in antagonist sensitivity of the rat P2X4 receptor.

  2004cites this paper
• Multiple actions of extracellular ATP and adenosine on calcium currents mediated by various purinoceptors in neurons of nucleus tractus solitarius.

  2004cites this paper
• Characterisation of P2 receptors in mouse superior cervical ganglia

  2003cites this paper
• Expression and function of P2X purinoceptors in rat histaminergic neurons

  2003cites this paper