A positive inotropic effect of ATP in the human cardiac atrium.

No abstract is available for this paper.

• Publication year

  2008

• Venue

  American Journal of Physiology. Heart and Circulatory Physiology

• Publication date

  2008-04-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1152/ajpheart.00945.2007PMID 18263715
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Breakdown of adenine and hypoxanthine nucleotides and nucleosides in human plasma.

  2009cited by this paper
• P2 Purinoceptor-Mediated Cardioprotection in Ischemic-Reperfused Mouse Heart

  2007cited by this paper
• Inhibition of human and mouse plasma membrane bound NTPDases by P2 receptor antagonists.

  2007cited by this paper
• Ca2+‐dependent ATP release from A549 cells involves synergistic autocrine stimulation by coreleased uridine nucleotides

  2007cited by this paper
• Positive Inotropic Effects by Uridine Triphosphate (UTP) and Uridine Diphosphate (UDP) via P2Y2 and P2Y6 Receptors on Cardiomyocytes and Release of UTP in Man During Myocardial Infarction

  2006cited by this paper
• Pharmacological profiles of cloned mammalian P2Y-receptor subtypes

  2006influential reference
• A C-terminal Lysine That Controls Human P2X4 Receptor Desensitization*

  2006cited by this paper
• Extracellular ATP‐stimulated current in wild‐type and P2X4 receptor transgenic mouse ventricular myocytes: implications for a cardiac physiologic role of P2X4 receptors

  2006cited by this paper
• Pharmacological profiles of cloned mammalian P2Y-receptor subtypes.

  2006cited by this paper
• International Union of Pharmacology LVIII: Update on the P2Y G Protein-Coupled Nucleotide Receptors: From Molecular Mechanisms and Pathophysiology to Therapy

  2006cited by this paper
• P2 receptors in human heart: upregulation of P2X6 in patients undergoing heart transplantation, interaction with TNFalpha and potential role in myocardial cell death.

  2005cited by this paper
• P2X Receptors: Targets for Novel Analgesics?

  2005cited by this paper
• A beneficial role of cardiac P2X4 receptors in heart failure: rescue of the calsequestrin overexpression model of cardiomyopathy.

  2004cited by this paper
• Role of ATP‐conductive anion channel in ATP release from neonatal rat cardiomyocytes in ischaemic or hypoxic conditions

  2004cited by this paper
• International Union of Pharmacology: Approaches to the Nomenclature of Voltage-Gated Ion Channels

  2003cited by this paper
• P2X4, P2Y1 and P2Y2 receptors on rat alveolar macrophages

  2003cited by this paper
• Altered function in atrium of transgenic mice overexpressing triadin 1.

  2002cited by this paper
• Volume-regulated Anion Channels Serve as an Auto/Paracrine Nucleotide Release Pathway in Aortic Endothelial Cells

  2002cited by this paper
• International union of pharmacology. XXIV. Current status of the nomenclature and properties of P2X receptors and their subunits.

  2001cited by this paper
• Adenosine 5'-triphosphate: a P2-purinergic agonist in the myocardium.

  2001cited by this paper
• A novel contractile phenotype with cardiac transgenic expression of the human P2X4 receptor

  2001cited by this paper
• P2 purinergic receptor activation enhances cardiac contractility in isolated rat and mouse hearts.

  2001cited by this paper
• ATP Crossing the Cell Plasma Membrane Generates an Ionic Current in Xenopus Oocytes*

  2000cited by this paper
• Adenosine A(2a)-receptor activation increases contractility in isolated perfused hearts.

  2000cited by this paper
• Cardiovascular and pulmonary response to oral administration of ATP in rabbits.

  2000cited by this paper
• Inotropic effects of diadenosine monophosphate (AP1A) in isolated human cardiac preparations.

  2000cited by this paper
• ATP, an agonist at the rat P2Y(4) receptor, is an antagonist at the human P2Y(4) receptor.

  2000cited by this paper
• Permittivity of a multiphase and isotropic lattice of spheres at low frequency

  2000cited by this paper
• Hypotonic stress-induced dual Ca(2+) responses in bovine aortic endothelial cells.

  2000cited by this paper
• Agonists and antagonists acting at P2X receptors: selectivity profiles and functional implications

  2000cited by this paper
• Functional characterization of the P2X4 receptor orthologues

  2000cited by this paper
• Purinergic Inhibition of Glucose Transport in Cardiomyocytes*

  1999cited by this paper
• Inotropic effects of diadenosine tetraphosphate (AP4A) in human and animal cardiac preparations.

  1999cited by this paper
• Effects of CGS 21680, a selective A2A adenosine receptor agonist, on cardiac output and vascular resistance in acute heart failure in the anaesthetized rat

  1998cited by this paper
• Rat gastroduodenal motility in vivo: involvement of NO and ATP in spontaneous motor activity.

  1998cited by this paper
• Receptors for purines and pyrimidines.

  1998cited by this paper
• Connexins regulate calcium signaling by controlling ATP release.

  1998cited by this paper
• Interstitial ATP level and degradation in control and postmyocardial infarcted rats.

  1998cited by this paper
• CFTR Cl− channel and CFTR‐associated ATP channel: distinct pores regulated by common gates

  1998cited by this paper
• Interstitial ATP level and degradation in control and postmyocardial infarcted rats.

  1998cited by this paper
• A novel phospholipase C- and cAMP-independent positive inotropic mechanism via a P2 purinoceptor.

  1997cited by this paper
• A novel phospholipase Cand cAMP-independent positive inotropic mechanism via a P 2 purinoceptor

  1997cited by this paper
• A novel phospholipase C- and cAMP-independent positive inotropic mechanism via a P2 purinoceptor.

  1997cited by this paper
• Adenosine and adenosine receptors in the cardiovascular system: biochemistry, physiology, and pharmacology.

  1997cited by this paper
• Differential A1 adenosine receptor reserve for two actions of adenosine on guinea pig atrial myocytes.

  1997cited by this paper
• Evidence that adenosine triphosphate or a related nucleotide is the transmitter substance released by non‐adrenergic inhibitory nerves in the gut

  1997cited by this paper
• PURINES AND THE NUCLEUS TRACTUS SOLITARIUS: EFFECTS ON CARDIOVASCULAR AND RESPIRATORY FUNCTION

  1997cited by this paper
• Adenosine effectively controls pulmonary hypertension after cardiac operations.

  1996cited by this paper
• Extracellular ATP inhibits adrenergic agonist-induced hypertrophy of neonatal cardiac myocytes.

  1996cited by this paper
• Relative contribution of P2U‐ and P2Y‐purinoceptors to endothelium‐dependent vasodilatation in the golden hamster isolated mesenteric arterial bed

  1996cited by this paper
• Development and perspectives of the purinoceptor concept.

  1996cited by this paper
• Transport mechanisms of nucleosides and the derivative, 6-mercaptopurine riboside across rate intestinal brush-border membranes.

  1996cited by this paper
• Cloning OF P2X5 and P2X6 receptors and the distribution and properties of an extended family of ATP-gated ion channels

  1996cited by this paper
• Negative chronotropic and inotropic effects exerted by diadenosine hexaphosphate (AP6A) via A1‐adenosine receptors

  1996cited by this paper
• A P2X purinoceptor cDNA conferring a novel pharmacological profile

  1995cited by this paper
• Adenosine, antioxidant enzymes and cytoprotection.

  1995cited by this paper
• Dual effect of ATP and UTP on rat atria: which types of receptors are involved?

  1994influential reference
• Characterization of adenosine receptors in the rat isolated aorta.

  1994cited by this paper
• Nomenclature and classification of purinoceptors.

  1994cited by this paper
• Ecto‐enzymes and metabolism of extracellular ATP

  1994cited by this paper
• Physiological concentrations of purines and pyrimidines

  1994cited by this paper
• Determination of plasma adenosine by high-performance liquid chromatography with column switching and fluorometric detection.

  1994cited by this paper
• Dietary nucleotides: cellular immune, intestinal and hepatic system effects.

  1994cited by this paper
• Cardiovascular effects of adenosine and its analogs in anaesthetized rats.

  1993cited by this paper
• Physiological and pathological roles of purines: An update

  1993cited by this paper
• Alpha 1-adrenoceptor and purinoceptor agonists modulate Na-H antiport in single cardiac cells.

  1993cited by this paper
• Effects of selective A1 and A2 adenosine receptor agonists on cardiovascular tissues

  1993cited by this paper
• Comparison of adenosine and muscarinic receptor-mediated effects on protein phosphatase inhibitor-1 activity in the heart.

  1993cited by this paper
• Blockade of adenosine receptors unmasks a stimulatory effect of ATP on cardiac contractility

  1993influential reference
• A1-adenosine receptor-mediated inhibition of isoproterenol-stimulated protein phosphorylation in ventricular myocytes. Evidence against a cAMP-dependent effect.

  1993cited by this paper
• The multidrug resistance (mdr1) gene product functions as an ATP channel.

  1993cited by this paper
• Adenosine Triphosphate and Adenosine Increase the Pulmonary Blood Flow to Postnatal Levels in Fetal Lambs

  1992cited by this paper
• A nucleoside transporter is functionally linked to ectonucleotidases in rat liver canalicular membrane.

  1992cited by this paper
• Activation by extracellular nucleotides of chloride secretion in the airway epithelia of patients with cystic fibrosis.

  1991cited by this paper
• Arachidonic acid induced increase in intracellular free calcium in guinea-pig hepatocytes.

  1991cited by this paper
• Gastrointestinal implications in pigs of wheat and oat fractions

  1991cited by this paper
• Adenine nucleotide release from isolated perfused guinea pig hearts and extracellular formation of adenosine.

  1991cited by this paper
• Physiological and pharmacological properties of adenosine: therapeutic implications.

  1991cited by this paper
• Effects of purines and pyrimidines on the rat mesenteric arterial bed.

  1991cited by this paper
• The mechanism of positive inotropy induced by adenosine triphosphate in rat heart.

  1990cited by this paper
• Selective enhancement of intratumoral blood flow in malignant gliomas using intra-arterial adenosine triphosphate.

  1990cited by this paper
• Differential antagonism by 1,3-dipropylxanthine-8-cyclopentylxanthine and 9-chloro-2-(2-furanyl)-5,6-dihydro-1,2,4-triazolo(1,5-c)quinazolin-5-im ine of the effects of adenosine derivatives in the presence of isoprenaline on contractile response and cyclic AMP content in cardiomyocytes. Evidence for

  1990cited by this paper
• Effects of adenosine analogues on contractile response and CAMP content in guinea-pig isolated ventricular myocytes

  1989cited by this paper
• Characterization of Ax Adenosine Receptors in Atrial and Ventricular Myocardium From Diseased Human Hearts

  1989cited by this paper
• ATP and other adenine compounds increase mechanical activity and inositol trisphosphate production in rat heart.

  1988cited by this paper
• Experimental cancer therapy in mice by adenine nucleotides.

  1988cited by this paper
• Affinities of barbiturates for the GABA-receptor complex and A1 adenosine receptors: a possible explanation of their excitatory effects

  1987cited by this paper
• The structure-activity relationships of ectonucleotidases and of excitatory P2-purinoceptors: evidence that dephosphorylation of ATP analogues reduces pharmacological potency.

  1987cited by this paper
• Role of guanine nucleotide-binding protein in the regulation by adenosine of cardiac potassium conductance and force of contraction. Evaluation with pertussis toxin

  1986cited by this paper
• Treatment of paroxysmal supraventricular tachycardia with intravenous injection of adenosine triphosphate.

  1986cited by this paper
• Accumulation and salvage of adenosine and inosine by isolated mature cardiac myocytes.

  1985cited by this paper
• DISTRIBUTION OF P1 AND P2‐PURINOCEPTORS IN THE GUINEA‐PIG AND FROG HEART

  1981cited by this paper
• Effects of pH on the myofilaments and the sarcoplasmic reticulum of skinned cells from cardiace and skeletal muscles.

  1978cited by this paper
• Purinergic Nerves

  1977cited by this paper
• Utilization of dietary nucleic acid purines for nucleotide and nucleic acid synthesis in the mouse.

  1976cited by this paper
• Stimulation of Prostaglandin Biosynthesis by Adenine Nucleotides: Profile of Prostaglandin Release by Perfused Organs

  1974cited by this paper
• Purinergic nerves.

  1972cited by this paper
• Inhibition by lanthanum ions of ADP-induced platelet aggregation

  1971cited by this paper
• Concepts of the blood platelet release reaction.

  1971cited by this paper
• Evidence that adenosine triphosphate or a related nucleotide is the transmitter substance released by non‐adrenergic inhibitory nerves in the gut

  1970cited by this paper

• Further investigations on the influence of protein phosphatases on the signaling of muscarinic receptors in the atria of mouse hearts

  2024cites this paper
• Adenosine Triphosphate Stress Myocardial Strain in Ischemic Heart Disease: An Animal Study with Histological Validation.

  2023cites this paper
• The role of PP5 and PP2C in cardiac health and disease.

  2021cites this paper
• Cerebral conditioning: mechanisms and potential clinical implications

  2021cites this paper
• Distinct shear-induced Ca2+ signaling in the left and right atrial myocytes: Role of P2 receptor context.

  2020cites this paper
• P2 Receptors in Cardiac Myocyte Pathophysiology and Mechanotransduction

  2020influential citation
• Evidence for Arrhythmogenic Effects of A2A-Adenosine Receptors

  2019cites this paper
• Mineralocorticoid receptor antagonists lead to increased adenosine bioavailability and modulate contractile cardiac parameters

  2019cites this paper
• The Ionotropic P2X4 Receptor has Unique Properties in the Heart by Mediating the Negative Chronotropic Effect of ATP While Increasing the Ventricular Inotropy

  2019cites this paper
• On inotropic effects of UTP in the human heart

  2019cites this paper
• Mechanism underlying the contractile activity of UTP in the mammalian heart

  2018cites this paper
• Increased Gi protein signaling potentiates the negative chronotropic effect of adenosine in the SHR right atrium

  2018cites this paper
• Cardiac Effects of Purinergic P2X Channel Activation

  2017cites this paper
• Association of Plasma Nucleotide levels with severity of Coronary Arterial lesion and left ventricular systolic Function in Acute Myocardial infarction

  2015cites this paper
• Short report Open Access

  2015cites this paper
• Chronic treatment with red wine modulates the purinergic neurotransmission and decreases blood pressure in hypertensive SHR and diabetic-STZ rats

  2015cites this paper
• Inositol 1,4,5-trisphosphate receptors and electromechanical coupling in cardiomyocytes

  2015influential citation
• Differential regulation of atrial contraction by P1 and P2 purinoceptors in normotensive and spontaneously hypertensive rats

  2014cites this paper
• Novel Protective Role of Endogenous Cardiac Myocyte P2X4 Receptors in Heart Failure

  2014cites this paper
• Purinoceptors exert negative inotropic effects on the heart in all major groups of reptiles.

  2014cites this paper
• A positive inotropic effect of UTP in the human cardiac atrium.

  2014cites this paper
• Cardiac purinergic signalling in health and disease

  2014cites this paper
• Inositol 1 , 4 , 5-Triphosphate Receptors and Human Left Ventricular Myocytes

  2013influential citation
• The Therapeutic Effect of 2-Cyclohexylthio-AMP in Heart Failure

  2013cites this paper
• Adenosine-5'-triphosphate (ATP) supplementation improves low peak muscle torque and torque fatigue during repeated high intensity exercise sets

  2012cites this paper
• Alteration of Purinergic Neurotransmission in Isolated Atria of Streptozotocin-induced Diabetic Rats

  2012cites this paper
• Involvement of P2Y receptors in pyridoxal‐5′‐phosphate‐induced cardiac preconditioning

  2009cites this paper
• P2 purinergic receptor mRNA in rat and human sinoatrial node and other heart regions

  2009influential citation
• A positive inotropic effect of adenosine in cardiac preparations of right atria from diseased human hearts

  2009influential citation
• Role of P2X purinergic receptors in the rescue of ischemic heart failure.

  2008cites this paper
• Role of P 2 X purinergic receptors in the rescue of ischemic heart failure

  2008cites this paper
• , Kenneth A . heart failure Role of P 2 X purinergic receptors in the rescue of ischemic

  2008cites this paper