Mechanisms and Function of DUOX in Epithelia of the Lung

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Antioxidants and Redox Signaling

• Publication date

  2009-09-18

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1089/ars.2009.2558PMID 19358684PMCID PMC2823369
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Cell number and cell characteristics of the normal human lung.

  2015cited by this paper
• Activation of Dual Oxidases Duox1 and Duox2

  2009influential reference
• Duox maturation factors form cell surface complexes with Duox affecting the specificity of reactive oxygen species generation

  2009cited by this paper
• The Pseudomonas Toxin Pyocyanin Inhibits the Dual Oxidase-Based Antimicrobial System as It Imposes Oxidative Stress on Airway Epithelial Cells1

  2008cited by this paper
• INHIBITORY ACTION OF NOXA1 ON DUOX ACTIVITY IN AIRWAY CELLS

  2008influential reference
• NADPH oxidases in lung biology and pathology: host defense enzymes, and more.

  2008cited by this paper
• Oxidative stress caused by pyocyanin impairs CFTR Cl(-) transport in human bronchial epithelial cells.

  2008cited by this paper
• Inhibitory Action of NoxA1 on Dual Oxidase Activity in Airway Cells*

  2008cited by this paper
• Silencing of DUOX NADPH oxidases by promoter hypermethylation in lung cancer.

  2008cited by this paper
• NADPH oxidases in lung biology and pathology: host defense enzymes, and more.

  2008cited by this paper
• The lactoperoxidase system links anion transport to host defense in cystic fibrosis

  2007influential reference
• Exhaled breath condensate pH and hydrogen peroxide as non-invasive markers for asthma.

  2007cited by this paper
• A novel host defense system of airways is defective in cystic fibrosis.

  2007influential reference
• Thiocyanate Transport in Resting and IL-4-Stimulated Human Bronchial Epithelial Cells: Role of Pendrin and Anion Channels1

  2007cited by this paper
• Acinar origin of CFTR-dependent airway submucosal gland fluid secretion.

  2007cited by this paper
• Organelle redox of CF and CFTR-corrected airway epithelia.

  2007cited by this paper
• Unconventional Roles of the NADPH Oxidase: Signaling, Ion Homeostasis, and Cell Death

  2007cited by this paper
• Airway Epithelial Cell Migration and Wound Repair by ATP-mediated Activation of Dual Oxidase 1*

  2007cited by this paper
• Developmental regulation of DUOX1 expression and function in human fetal lung epithelial cells.

  2007influential reference
• Duox2 exhibits potent heme peroxidase activity in human respiratory tract epithelium

  2006cited by this paper
• Mechanisms of Acid and Base Secretion by the Airway Epithelium

  2006influential reference
• Identification of the Maturation Factor for Dual Oxidase

  2006cited by this paper
• Role of Nox Family NADPH Oxidases in Host Defense

  2006cited by this paper
• Oxidative changes of bronchoalveolar proteins in cystic fibrosis.

  2006influential reference
• Hyperacidity of secreted fluid from submucosal glands in early cystic fibrosis.

  2006cited by this paper
• Dual Oxidase-2 Has an Intrinsic Ca2+-dependent H2O2-generating Activity*

  2005cited by this paper
• Differential regulation of dual NADPH oxidases/peroxidases, Duox1 and Duox2, by Th1 and Th2 cytokines in respiratory tract epithelium

  2005influential reference
• Identification of a Novel Partner of Duox

  2005cited by this paper
• Dual oxidases

  2005cited by this paper
• Dual oxidase 1-dependent MUC5AC mucin expression in cultured human airway epithelial cells.

  2005cited by this paper
• Freshly isolated rat alveolar type I cells, type II cells, and cultured type II cells have distinct molecular phenotypes.

  2005influential reference
• Regulated hydrogen peroxide production by Duox in human airway epithelial cells.

  2005cited by this paper
• [Exhaled hydrogen peroxide (H2O2) in allergic and non-allergic stable mild asthmatic children].

  2005cited by this paper
• Dual oxidase2 is expressed all along the digestive tract.

  2005cited by this paper
• The pH dependence of NADPH oxidase in human eosinophils

  2005cited by this paper
• Biomarkers of Neutrophilic Inflammation in Exhaled Air of Cystic Fibrosis Children with Bacterial Airway Infections

  2005cited by this paper
• Identification of a Novel Partner of Duox EFP1, A THIOREDOXIN-RELATED PROTEIN*

  2005cited by this paper
• Regulation and termination of NADPH oxidase activity

  2005cited by this paper
• Hydrogen peroxide in expired breath condensate of patients with acute respiratory failure and with ARDS

  2005cited by this paper
• Exhaled breath condensate pH and exhaled nitric oxide in allergic asthma and in cystic fibrosis

  2004cited by this paper
• Elevated exhalation of hydrogen peroxide and thiobarbituric acid reactive substances in patients with community acquired pneumonia.

  2004cited by this paper
• Transcellular thiocyanate transport by human airway epithelia

  2004cited by this paper
• In vivo differentiation potential of tracheal basal cells: evidence for multipotent and unipotent subpopulations.

  2004cited by this paper
• NADPH Oxidase-dependent Acid Production in Airway Epithelial Cells*

  2004influential reference
• Airway surface pH in subjects with cystic fibrosis

  2003cited by this paper
• Dual oxidases represent novel hydrogen peroxide sources supporting mucosal surface host defense

  2003influential reference
• Reassessment of the microbicidal activity of reactive oxygen species and hypochlorous acid with reference to the phagocytic vacuole of the neutrophil granulocyte.

  2003cited by this paper
• The Mitochondrial Barriers Segregate Agonist-induced Calcium-dependent Functions in Human Airway Epithelia

  2003cited by this paper
• Role of airway surface liquid and submucosal glands in cystic fibrosis lung disease.

  2003cited by this paper
• Voltage-gated proton channels and other proton transfer pathways.

  2003cited by this paper
• Lactoperoxidase and human airway host defense.

  2003cited by this paper
• Hydrogen peroxide-scavenging properties of normal human airway secretions.

  2003cited by this paper
• Interactions between NADPH oxidase and voltage‐gated proton channels: why electron transport depends on proton transport

  2003cited by this paper
• Proteins Homologous to p47phox and p67phox Support Superoxide Production by NAD(P)H Oxidase 1 in Colon Epithelial Cells*

  2003cited by this paper
• Abnormal surface liquid pH regulation by cultured cystic fibrosis bronchial epithelium

  2003cited by this paper
• Effects of Inhaled Corticosteroids with Different Lung Deposition on Exhaled Hydrogen Peroxide in Stable COPD Patients

  2003cited by this paper
• β-Defensins in Lung Host Defense

  2002cited by this paper
• Lactoperoxidase and hydrogen peroxide metabolism in the airway.

  2002influential reference
• Cytokines in innate host defense in the lung.

  2002cited by this paper
• Volume of airway surface liquid in health and disease.

  2002cited by this paper
• Airways in cystic fibrosis are acidified: detection by exhaled breath condensate

  2002cited by this paper
• Antimicrobial polypeptides in host defense of the respiratory tract.

  2002cited by this paper
• Characterization of ThOX proteins as components of the thyroid H(2)O(2)-generating system.

  2002cited by this paper
• Variability of Exhaled Hydrogen Peroxide in Stable COPD Patients and Matched Healthy Controls

  2002cited by this paper
• Exhaled H(2)O(2) in steady-state bronchiectasis: relationship with cellular composition in induced sputum, spirometry, and extent and severity of disease.

  2002cited by this paper
• The relationships among hydrogen peroxide in expired breath condensate, airway inflammation, and asthma severity.

  2002cited by this paper
• [beta]-defensins in lung host defense.

  2002cited by this paper
• The pulmonary collectins, SP-A and SP-D, orchestrate innate immunity in the lung.

  2002cited by this paper
• Elevated concentrations of exhaled hydrogen peroxide in asthmatic patients.

  2001cited by this paper
• Tyrosine cross-linking of extracellular matrix is catalyzed by Duox, a multidomain oxidase/peroxidase with homology to the phagocyte oxidase subunit gp91phox

  2001cited by this paper
• Expression of reduced nicotinamide adenine dinucleotide phosphate oxidase (ThoX, LNOX, Duox) genes and proteins in human thyroid tissues.

  2001cited by this paper
• Long-term administration of N-acetylcysteine decreases hydrogen peroxide exhalation in subjects with chronic obstructive pulmonary disease.

  2001cited by this paper
• Exhalation of H2O2 and thiobarbituric acid reactive substances (TBARs) by healthy subjects.

  2001cited by this paper
• [Ca(2+)](i) oscillations regulate type II cell exocytosis in the pulmonary alveolus.

  2000cited by this paper
• Original Articles: Inhaled glucocorticosteroids decrease hydrogen peroxide level in expired air condensate in asthmatic patients

  2000cited by this paper
• The lactoperoxidase system functions in bacterial clearance of airways.

  2000cited by this paper
• The concentration of hydrogen peroxide in exhaled air depends on expiratory flow rate.

  2000cited by this paper
• Hydrogen peroxide and nitric oxide in exhaled air of children with cystic fibrosis during antibiotic treatment.

  2000cited by this paper
• A comparative study of mammalian tracheal mucous glands

  2000cited by this paper
• Validation of a new technique to assess exhaled hydrogen peroxide: results from normals and COPD patients.

  2000cited by this paper
• Release of hydrogen peroxide by rat type II pneumocytes in the prolonged culture.

  2000cited by this paper
• Cloning of Two Human Thyroid cDNAs Encoding New Members of the NADPH Oxidase Family*

  2000cited by this paper
• Cystic Fibrosis Transmembrane Conductance Regulator: Physical Basis for Lyotropic Anion Selectivity Patterns

  1999cited by this paper
• Cystic Fibrosis Transmembrane Conductance Regulator

  1999cited by this paper
• Increased content of thiobarbituric acid-reactive substances and hydrogen peroxide in the expired breath condensate of patients with stable chronic obstructive pulmonary disease: no significant effect of cigarette smoking.

  1999cited by this paper
• Purification of a Novel Flavoprotein Involved in the Thyroid NADPH Oxidase

  1999cited by this paper
• Anion selectivity of apical membrane conductance of Calu 3 human airway epithelium

  1999cited by this paper
• Expired hydrogen peroxide in breath condensate of cystic fibrosis patients.

  1999cited by this paper
• Differential regulation of centrin genes during ciliogenesis in human tracheal epithelial cells.

  1998cited by this paper
• Elevated levels of expired breath hydrogen peroxide in bronchiectasis.

  1998cited by this paper
• Combined use of exhaled hydrogen peroxide and nitric oxide in monitoring asthma.

  1998cited by this paper
• Differential regulation of centrin genes during ciliogenesis in human tracheal epithelial cells.

  1998cited by this paper
• Involvement of an NAD(P)H oxidase-like enzyme in superoxide anion and hydrogen peroxide generation by rat type II cells.

  1997cited by this paper
• Isolation and characterization of a peroxidase from the airway.

  1997cited by this paper
• Increased hydrogen peroxide and thiobarbituric acid-reactive products in expired breath condensate of asthmatic patients.

  1997cited by this paper
• Permeability of Wild-Type and Mutant Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channels to Polyatomic Anions

  1997cited by this paper
• Increased exhalation of hydrogen peroxide in patients with stable and unstable chronic obstructive pulmonary disease.

  1996cited by this paper
• Extracellular glutathione peroxidase in human lung epithelial lining fluid and in lung cells.

  1996cited by this paper
• Increased content of hydrogen peroxide in the expired breath of cigarette smokers.

  1996cited by this paper
• Membrane-restricted regulation of Ca2+ release and influx in polarized epithelia

  1995cited by this paper

• Mucosal Immunity: Lessons from the Lower Respiratory and Small Intestinal Epithelia

  2025cites this paper
• NADPH Oxidases: Redox Regulation of Cell Homeostasis & Disease.

  2025cites this paper
• Amphibian mast cells serve as barriers to chytrid fungus infections

  2024cites this paper
• Famotidine increases cellular phospho-tyrosine levels.

  2024cites this paper
• NOX proteins and ROS generation: role in invadopodia formation and cancer cell invasion

  2024cites this paper
• Amphibian mast cells: barriers to chytrid fungus infections

  2024cites this paper
• CFTR dysfunction leads to defective bacterial eradication on cystic fibrosis airways.

  2024cites this paper
• Amphibian mast cells: barriers to deadly chytrid fungus infections

  2023cites this paper
• Cystic Fibrosis Reprograms Airway Epithelial IL-33 Release and Licenses IL-33 Dependent Inflammation.

  2023cites this paper
• Assessment of total peroxidase activity and its relationship with vitamin D in Iraqi rheumatoid arthritis patients

  2023cites this paper
• Modulation of innate immunity in airway epithelium for host-directed therapy

  2023cites this paper
• Neutrophil Defect and Lung Pathogen Selection in Cystic Fibrosis.

  2023cites this paper
• (Poly)phenols and the regulation of NADPH oxidases

  2023cites this paper
• Early mechanisms of neutrophil activation and transmigration in acute lung injury

  2022cites this paper
• ScholarWorks at WMU ScholarWorks at WMU The Flavoprotein RCLA is a Hypothiocyanous Acid Reductase The Flavoprotein RCLA is a Hypothiocyanous Acid Reductase

  2022cites this paper
• Atmospheric Reactive Oxygen Species and Some Aspects of the Antiviral Protection at the Respiratory Epithelium

  2022cites this paper
• NOX as a Therapeutic Target in Liver Disease

  2022cites this paper
• Electric Field Induced Biomimetic Transmembrane Electron Transport using Carbon Nanotube Porins as Bipolar Electrodes

  2021cites this paper
• Oxidative Stress and Endoplasmic Reticulum Stress in Rare Respiratory Diseases

  2021cites this paper
• The double-edged roles of ROS in cancer prevention and therapy

  2021cites this paper
• Cyclic nucleotide phosphodiesterase inhibitors as therapeutic interventions for cystic fibrosis.

  2021cites this paper
• DUOX1 in mammalian disease pathophysiology

  2021cites this paper
• Intestinal IL-17R signaling controls SIgA and oxidase balance in C. rodentium infection

  2021cites this paper
• Excess iodine exposure acutely increases salivary iodide and antimicrobial hypoiodous acid concentrations in humans

  2021cites this paper
• Transcriptomics of single dose and repeated carbon black and ozone inhalation co-exposure highlight progressive pulmonary mitochondrial dysfunction

  2021cites this paper
• Dry Hydrogen Peroxide for Viral Inactivation

  2021cites this paper
• [Atmospheric reactive oxygen species and some aspects of the antiviral protection of the respiratory epithelium].

  2021cites this paper
• Nlrx1-Regulated Defense and Metabolic Responses to Aspergillus fumigatus Are Morphotype and Cell Type Specific

  2021cites this paper
• Electric Field Induced Biomimetic Transmembrane Electron Transport Using Carbon Nanotube Porins.

  2021cites this paper
• Intestinal IL-17R Signaling Controls Secretory IgA and Oxidase Balance in Citrobacter rodentium Infection

  2021cites this paper
• Efficacy of sodium iodide for prevention of respiratory disease in preweaned dairy calves.

  2020cites this paper
• Effectiveness of Dry Hydrogen Peroxide on Reducing Environmental Microbial Bioburden Risk in a Pediatric Oncology Intensive Care Unit.

  2020cites this paper
• Molecular Physiology and Pharmacology of the Cystic Fibrosis Transmembrane Conductance Regulator

  2020cites this paper
• Dual Oxidase Maturation Factor 1 Positively Regulates RANKL-Induced Osteoclastogenesis via Activating Reactive Oxygen Species and TRAF6-Mediated Signaling

  2020cites this paper
• Epithelial Sodium Channels (ENaC)

  2020cites this paper
• Dual Role of Hydrogen Peroxide as an Oxidant in Pneumococcal Pneumonia

  2020cites this paper
• Response of Pseudomonas aeruginosa to the Innate Immune System-Derived Oxidants Hypochlorous Acid and Hypothiocyanous Acid

  2020cites this paper
• Airway Redox Homeostasis and Inflammation Gone Awry: From Molecular Pathogenesis to Emerging Therapeutics in Respiratory Pathology

  2020cites this paper
• Oxidative Stress in Pulmonary Fibrosis.

  2020cites this paper
• NADPH oxidase DUOX1 sustains TGF-β1 signalling and promotes lung fibrosis

  2020cites this paper
• NOX Inhibitors: From Bench to Naxibs to Bedside.

  2020cites this paper
• Proton channel blockers inhibit Duox activity independent of Hv1 effects

  2019cites this paper
• Oxidative stress pathway gene transcription after bovine respiratory syncytial virus infection in vitro and ex vivo.

  2019cites this paper
• Hydrogen peroxide-producing NADPH oxidases and the promotion of migratory phenotypes in cancer.

  2019cites this paper
• Cystic Fibrosis and Pseudomonas aeruginosa: the Host-Microbe Interface

  2019cites this paper
• Pros and Cons of Use of Mitochondria-Targeted Antioxidants

  2019cites this paper
• Hydrogen peroxide in neutrophil inflammation: Lesson from the zebrafish.

  2019cites this paper
• Agonists that stimulate secretion promote the recruitment of CFTR into membrane lipid microdomains

  2019influential citation
• Reactive Oxygen Species: Friends or Foes of Lung Cancer?

  2019cites this paper
• Title Efficacy of Oral Administration of Sodium Iodide to Prevent Bovine Respiratory Disease Complex Permalink

  2018cites this paper
• Duox2-induced innate immune responses in the respiratory epithelium and intranasal delivery of Duox2 DNA using polymer that mediates immunization

  2018cites this paper
• Immune Responses in the Upper Respiratory Tract in Health and Disease

  2018cites this paper
• Therapeutic Interventions to Block Oxidative Stress-Associated Pathologies

  2018cites this paper
• Role of Hypothiocyanous Acid on the Cytokine Production in Airway Epithelial Cells

  2018cites this paper
• Inducible Lung Epithelial Resistance Requires Multisource Reactive Oxygen Species Generation To Protect against Viral Infections

  2018cites this paper
• Bone Marrow-Derived Mononuclear Cell Therapy in Papain-Induced Experimental Pulmonary Emphysema

  2018cites this paper
• Efficacy of Oral Administration of Sodium Iodide to Prevent Bovine Respiratory Disease Complex

  2018cites this paper
• HOCl and the control of oncogenesis.

  2018cites this paper
• Cerium oxide and barium sulfate nanoparticle inhalation affects gene expression in alveolar epithelial cells type II

  2018cites this paper
• Dual oxidase: a novel therapeutic target in allergic disease

  2018cites this paper
• Hypothiocyanous Acid Suppresses PolyI:C-Induced Antiviral Responses by Modulating IRF3 Phosphorylation in Human Airway Epithelial Cells.

  2018cites this paper
• CrossTalk proposal: mucosal acidification drives early progressive lung disease in cystic fibrosis

  2018cites this paper
• Slippery When Wet: Airway Surface Liquid Homeostasis and Mucus Hydration.

  2018cites this paper
• Peroxidase Activity of Human Hemoproteins: Keeping the Fire under Control

  2018influential citation
• The Plasma Membrane: A Platform for Intra- and Intercellular Redox Signaling

  2018cites this paper
• The Chaperone and Redox Properties of CnoX Chaperedoxins Are Tailored to the Proteostatic Needs of Bacterial Species

  2018cites this paper
• Inducible lung epithelial resistance requires multisource reactive oxygen species generation to protect against bacterial infections

  2018cites this paper
• Exercise and Reactive Oxygen Species

  2017cites this paper
• Lung epithelial cells: therapeutically inducible effectors of antimicrobial defense

  2017cites this paper
• Functional and Mechanistic Consequences of Dual Oxidase 1 Suppression in Lung Cancer

  2017cites this paper
• Trans-Plasma Membrane Electron Transport and Ascorbate Efflux by Skeletal Muscle

  2017cites this paper
• Paradoxical roles of dual oxidases in cancer biology.

  2017cites this paper
• The use of sodium iodide for the management of bovine respiratory disease

  2017influential citation
• CysLT1 Receptor Is Protective against Oxidative Stress in a Model of Irritant-Induced Asthma

  2016cites this paper
• Association between NADPH oxidase (NOX) and lung cancer: a systematic review and meta-analysis.

  2016cites this paper
• Dual oxidase 1: A predictive tool for the prognosis of hepatocellular carcinoma patients

  2016cites this paper
• The combination of three molecular markers can be a valuable predictive tool for the prognosis of hepatocellular carcinoma patients

  2016cites this paper
• Air pollution-related metals induce differential cytokine responses in bronchial epithelial cells.

  2016cites this paper
• Effect of Combination of Acapella Device and Breathing Exercises on Treatment of Pulmonary Complications After Upper Abdominal Surgeries

  2016cites this paper
• Overexpression of Interleukin-4 in the Thyroid of Transgenic Mice Upregulates the Expression of Duox1 and the Anion Transporter Pendrin

  2016influential citation
• DUOX1 silencing in lung cancer promotes EMT, cancer stem cell characteristics and invasive properties

  2016cites this paper
• Pulmonary Oxidant–Antioxidant Dysregulation in Asthma

  2016cites this paper
• Epithelial Anion Transport as Modulator of Chemokine Signaling

  2016cites this paper
• Chapter 2 Thyroid Hormone Synthesis And Secretion

  2015cites this paper
• Proteinase activated receptor‐2‐mediated dual oxidase‐2 up‐regulation is involved in enhanced airway reactivity and inflammation in a mouse model of allergic asthma

  2015cites this paper
• NADPH oxidases and cancer.

  2015cites this paper
• Lung epithelial NOX/DUOX and respiratory virus infections.

  2015cites this paper
• Dual oxidase 2 generated reactive oxygen species selectively mediate the induction of mucins by epidermal growth factor in enterocytes.

  2015cites this paper
• Reactive oxygen species, nutrition, hypoxia and diseases: Problems solved?

  2015cites this paper
• Cystic Fibrosis-Related Oxidative Stress and Intestinal Lipid Disorders

  2015cites this paper
• TROPICAL PARASITIC LUNG DISEASES

  2015cites this paper
• Estudio de la estimulación de la respuesta innata en mucosas inducida por agonistas en la protección contra pertussis , una enfermedad considerada resurgente

  2015influential citation
• Chronic rhinosinusitis pathogenesis.

  2015cites this paper
• NOX Modifiers—Just a Step Away from Application in the Therapy of Airway Inflammation?

  2015influential citation
• Antenna for Lung Cancer Detection Using Electric Properties of Lung Tissues

  2015cites this paper
• The dual oxidase gene BdDuox regulates the intestinal bacterial community homeostasis of Bactrocera dorsalis

  2015cites this paper
• Rates of Hydroxyl Radical Production from Transition Metals and Quinones in a Surrogate Lung Fluid.

  2015cites this paper
• NADPH oxidases and inflammatory bowel disease.

  2015cites this paper
• Prostaglandin pathways in duodenal chemosensing

  2014cites this paper
• The Role of Reactive Oxygen Species in Microvascular Remodeling

  2014cites this paper