The influence of inflammatory cytokines in physiopathology of suicidal behavior.

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Journal of Affective Disorders

• Publication date

  2015-02-01

• Fields of study

  Medicine, Psychology

• Identifiers
  DOI 10.1016/j.jad.2014.09.057PMID 25451421
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A role for inflammatory metabolites as modulators of the glutamate N-methyl-D-aspartate receptor in depression and suicidality.

  2015influential reference
• SUICIDAL IDEATION IS ASSOCIATED WITH ELEVATED INFLAMMATION IN PATIENTS WITH MAJOR DEPRESSIVE DISORDER

  2013influential reference
• Oxidative stress and inflammatory markers are associated with depression and nicotine dependence.

  2013influential reference
• The neuroprogressive nature of major depressive disorder: pathways to disease evolution and resistance, and therapeutic implications

  2013cited by this paper
• Concomitant Interferon Alpha Stimulation and TLR3 Activation Induces Neuronal Expression of Depression-Related Genes That Are Elevated in the Brain of Suicidal Persons

  2013influential reference
• Pharmacological properties of glutamatergic drugs targeting NMDA receptors and their application in major depression.

  2013influential reference
• The role of inflammatory cytokines in suicidal behavior: a systematic review.

  2013influential reference
• he role of microRNAs in synaptic plasticity , major affective disorders and uicidal behavior

  2012cited by this paper
• Cyclothymic-depressive-anxious temperament pattern is related to suicide risk in 346 patients with major mood disorders.

  2012cited by this paper
• Psychoneuroimmunology Meets Neuropsychopharmacology: Translational Implications of the Impact of Inflammation on Behavior

  2012cited by this paper
• Biochemical markers of depressive disorders – a new concept of the diagnostic significance of its response to acute stress

  2012influential reference
• Vascular endothelial growth factor (VEGF) and its role in the central nervous system: A new element in the neurotrophic hypothesis of antidepressant drug action

  2012cited by this paper
• Regular exercise cures depression-like behavior via VEGF-Flk-1 signaling in chronically stressed mice.

  2012cited by this paper
• VEGF regulates antidepressant effects of lamotrigine.

  2012cited by this paper
• Electroconvulsive seizures stimulate the vegf pathway via mTORC1

  2012cited by this paper
• Mechanistic explanations how cell-mediated immune activation, inflammation and oxidative and nitrosative stress pathways and their sequels and concomitants play a role in the pathophysiology of unipolar depression.

  2012cited by this paper
• Low vascular endothelial growth factor and interleukin-8 in cerebrospinal fluid of suicide attempters

  2012influential reference
• 5-HT(1A) receptor and apoptosis contribute to interferon-α-induced "depressive-like" behavior in mice.

  2012cited by this paper
• Association of smoking and nicotine dependence with severity and course of symptoms in patients with depressive or anxiety disorder.

  2012cited by this paper
• Neurobiology of suicidal behaviour.

  2012cited by this paper
• Temperaments mediate suicide risk and psychopathology among patients with bipolar disorders.

  2012cited by this paper
• Constant Darkness Induces IL-6-Dependent Depression-Like Behavior through the NF-κB Signaling Pathway

  2011cited by this paper
• Interferon alpha regulates MAPK and STAT1 pathways in human hepatoma cells

  2011cited by this paper
• Suicide risk in first episode psychosis: a selective review of the current literature.

  2011cited by this paper
• Cytokine levels in the blood may distinguish suicide attempters from depressed patients.

  2011influential reference
• Psychometric properties of the Gotland Scale for Depression in Italian psychiatric inpatients and its utility in the prediction of suicide risk.

  2011cited by this paper
• Affective temperamental profiles are associated with white matter hyperintensity and suicidal risk in patients with mood disorders.

  2011cited by this paper
• Circumstantial evidence for a role of glutamine-synthetase in suicide.

  2011influential reference
• Depression is an inflammatory disease, but cell-mediated immune activation is the key component of depression.

  2011cited by this paper
• Exploration of new molecular mechanisms for antidepressant actions of electroconvulsive seizure.

  2011cited by this paper
• Plasma kynurenine levels are elevated in suicide attempters with major depressive disorder.

  2011influential reference
• Inflammation-associated depression: from serotonin to kynurenine.

  2011cited by this paper
• A review on the oxidative and nitrosative stress (O&NS) pathways in major depression and their possible contribution to the (neuro)degenerative processes in that illness.

  2011influential reference
• Inflammatory mechanisms in major depressive disorder

  2011cited by this paper
• Serum anti-inflammatory markers in general population subjects with elevated depressive symptoms.

  2010cited by this paper
• Disturbed sleep: linking allergic rhinitis, mood and suicidal behavior.

  2010influential reference
• Effects of eicosapentaenoic acid and fluoxetine on plasma cortisol, serum interleukin-1beta and interleukin-6 concentrations in patients with major depressive disorder.

  2010cited by this paper
• Impact of tryptophan metabolism on the vulnerability to alcohol-related blackouts and violent impulsive behaviours.

  2010cited by this paper
• Depression and oxidative damage to lipids.

  2010cited by this paper
• Norman Cousins Lecture. Mechanisms of cytokine-induced behavioral changes: psychoneuroimmunology at the translational interface.

  2009cited by this paper
• Role and therapeutic potential of VEGF in the nervous system.

  2009cited by this paper
• Interleukin-6 is elevated in the cerebrospinal fluid of suicide attempters and related to symptom severity.

  2009cited by this paper
• Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression.

  2009cited by this paper
• Lithium and Neuropsychiatric Therapeutics: Neuroplasticity via Glycogen Synthase Kinase-3β, β-Catenin, and Neurotrophin Cascades

  2009cited by this paper
• Vascular Endothelial Growth Factor Signaling is Required for the Behavioral Actions of Antidepressant Treatment: Pharmacological and Cellular Characterization

  2009cited by this paper
• Altered expression of genes involved in ATP biosynthesis and GABAergic neurotransmission in the ventral prefrontal cortex of suicides with and without major depression

  2009cited by this paper
• Lithium and neuropsychiatric therapeutics: neuroplasticity via glycogen synthase kinase-3beta, beta-catenin, and neurotrophin cascades.

  2009cited by this paper
• The effect of tumor necrosis factor antagonists on mood and mental health-associated quality of life: novel hypothesis-driven treatments for bipolar depression?

  2009cited by this paper
• Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2,3-dioxygenase activation in mice

  2009cited by this paper
• The inflammatory & neurodegenerative (I&ND) hypothesis of depression: leads for future research and new drug developments in depression

  2009cited by this paper
• Global Brain Gene Expression Analysis Links Glutamatergic and GABAergic Alterations to Suicide and Major Depression

  2009cited by this paper
• Inflammation and the phenomenology, pathophysiology, comorbidity, and treatment of bipolar disorder: a systematic review of the literature.

  2009cited by this paper
• Elevated cytokine expression in the orbitofrontal cortex of victims of suicide

  2008influential reference
• Differences in cytokines between non-suicidal patients and suicidal patients in major depression.

  2008cited by this paper
• Cinnamon polyphenol extract affects immune responses by regulating anti- and proinflammatory and glucose transporter gene expression in mouse macrophages.

  2008cited by this paper
• VEGF as a potential target for therapeutic intervention in depression.

  2008cited by this paper
• Tobacco smoking as a risk factor for major depressive disorder: population-based study

  2008cited by this paper
• Inflammatory cytokine alterations in schizophrenia: a systematic quantitative review.

  2008cited by this paper
• Impaired E-Cadherin Expression and Glutamine Synthetase Overexpression in Solid Pseudopapillary Neoplasm of the Pancreas

  2008cited by this paper
• Microglia activation in recent-onset schizophrenia: a quantitative (R)-[11C]PK11195 positron emission tomography study.

  2008influential reference
• Canonical Wnt signaling maintains the quiescent stage of hepatic stellate cells.

  2008cited by this paper
• Alteration in kinase activity but not in protein levels of protein kinase B and glycogen synthase kinase-3beta in ventral prefrontal cortex of depressed suicide victims.

  2007cited by this paper
• Precipitants of adolescent suicide: Possible interaction between allergic inflammation and alcohol intake

  2007influential reference
• The innate immune facet of brain

  2007cited by this paper
• Interferons limit inflammatory responses by induction of tristetraprolin.

  2006cited by this paper
• Increased Serum Levels of 8-Hydroxy-2′-Deoxyguanosine in Clinical Depression

  2006cited by this paper
• Cytokines sing the blues: inflammation and the pathogenesis of depression.

  2006influential reference
• Cytokines as mediators of depression: what can we learn from animal studies?

  2005cited by this paper
• Cytokines and major depression.

  2005cited by this paper
• Inflammatory genes and neural activity: involvement of immune genes in synaptic function and behavior.

  2005cited by this paper
• Depression during pegylated interferon-alpha plus ribavirin therapy: prevalence and prediction.

  2005cited by this paper
• Cytokines as a precipitant of depressive illness: animal and human studies.

  2005cited by this paper
• Smoking and the risk of suicidal behavior: a prospective study of a community sample.

  2005cited by this paper
• Altered cortical glutamatergic and GABAergic signal transmission with glial involvement in depression

  2005cited by this paper
• Cholesterol and lipids in depression: stress, hypothalamo-pituitary-adrenocortical axis, and inflammation/immunity.

  2005cited by this paper
• Tumor necrosis factor alpha, interleukin-1 beta, interleukin-6 and major histocompatibility complex molecules in the normal brain and after peripheral immune challenge

  2005cited by this paper
• Lithium in the prevention of suicidal behavior and all-cause mortality in patients with mood disorders: a systematic review of randomized trials.

  2005cited by this paper
• Expression, purification, and biochemical characterization of the antiinflammatory tristetraprolin: a zinc-dependent mRNA binding protein affected by posttranslational modifications.

  2004cited by this paper
• Psychiatric disorders and stages of smoking.

  2004cited by this paper
• Cytokines: abnormalities in major depression and implications for pharmacological treatment

  2004cited by this paper
• Neurobiology of suicidal behaviour

  2003cited by this paper
• Role of Astrocytes in the Maintenance and Modulation of Glutamatergic and GABAergic Neurotransmission

  2003cited by this paper
• Cytokine-serotonin interaction through IDO: a neurodegeneration hypothesis of depression.

  2003cited by this paper
• Cigarette smoking, suicidal behavior, and serotonin function in major psychiatric disorders.

  2003cited by this paper
• Neurobiology of emotion perception II: Implications for major psychiatric disorders.

  2003cited by this paper
• Lithium treatment and suicide risk in major affective disorders: update and new findings.

  2003cited by this paper
• Tristetraprolin Binds to the 3′-Untranslated Region of Cyclooxygenase-2 mRNA

  2003cited by this paper
• [Lipids, depression and suicide].

  2003influential reference
• Expression and purification of recombinant tristetraprolin that can bind to tumor necrosis factor-alpha mRNA and serve as a substrate for mitogen-activated protein kinases.

  2003influential reference
• Cytokine-induced changes in mood and behaviour: implications for 'depression due to a general medical condition', immunotherapy and antidepressive treatment.

  2002cited by this paper
• The plasma levels of interleukin-12 in schizophrenia, major depression, and bipolar mania: effects of psychotropic drugs

  2002influential reference
• New targets of β-catenin signaling in the liver are involved in the glutamine metabolism

  2002cited by this paper
• Decreased Sensitivity of Tristetraprolin-deficient Cells to p38 Inhibitors Suggests the Involvement of Tristetraprolin in the p38 Signaling Pathway*

  2001cited by this paper
• Changes in the immune system in depression and dementia: causal or co‐incidental effects?

  2001influential reference
• Psychiatric disorder and personality factors associated with suicide in older people: a descriptive and case‐control study

  2001cited by this paper
• Glial cell abnormalities in major psychiatric disorders: the evidence and implications.

  2001cited by this paper
• Free L-tryptophan plasma levels in antisocial violent offenders

  2001cited by this paper
• Evidence that tristetraprolin is a physiological regulator of granulocyte-macrophage colony-stimulating factor messenger RNA deadenylation and stability.

  2000cited by this paper
• Plasma levels of interleukin-6, interleukin-10, and interleukin-1 receptor antagonist in depression: comparison between the acute state and after remission.

  2000cited by this paper
• Major depression and activation of the inflammatory response system.

  1999influential reference

• Interleukins in Major Depressive Disorder: Lessons From Autoimmune Diseases and Pathways to Clinical Translation

  2026cites this paper
• Plasma proteomic profiles linked to suicidal behaviors

  2026cites this paper
• Early life stress-induced depression reveals distinct region-specific modulation of unfolded protein response genes in the prefrontal cortex and hippocampus of rats

  2026cites this paper
• Suicidality in patients with skin diseases: What dermatologists need to know?

  2025cites this paper
• Pro-inflammatory cytokines level in depressed patients with suicidal behaviour: a systematic review and meta-analysis

  2025cites this paper
• Extreme ("20") self-shocks during the Self-Aggression Paradigm and lifetime suicide attempt history: Potential use in suicide research.

  2025cites this paper
• CD4 + T lymphocyte and cytokine profiles in depressive disorders

  2025cites this paper
• Epidemiological aspects and inflammatory cytokine profiles associated with Toxoplasma gondii infection in suicide attempters in Iran

  2025cites this paper
• Completed suicide in patients with skin disease: A systematic review and meta‐analysis

  2025cites this paper
• The role of cytokines in predicting the therapeutic effect of non-suicidal self-injury in adolescents: a longitudinal study

  2025cites this paper
• Association Between Riboflavin Intake and Suicidal Ideation: A Nationwide Study in Korea

  2025cites this paper
• Associations of pro-inflammatory factors and IL-10 levels with degree of suicide risk in adolescents with depression

  2025cites this paper
• Evaluation of peripheral inflammatory parameters of cases with suicide attempts.

  2024cites this paper
• Proinflammatory cytokine levels, cognitive function, and suicidal symptoms of adolescents and young adults with major depressive disorder

  2024cites this paper
• Association between dementia risk and ulcerative colitis, with and without colectomy: a Swedish population-based register study

  2023cites this paper
• Depicting the molecular features of suicidal behavior: a review from an "omics" perspective.

  2023cites this paper
• Association of interleukin-6 with suicidal ideation in veterans: a longitudinal perspective

  2023cites this paper
• Unlocking the Secrets: Exploring the Biochemical Correlates of Suicidal Thoughts and Behaviors in Adults with Autism Spectrum Conditions

  2023cites this paper
• Increased risk of suicidality in patients with psoriasis: A Nationwide cohort study in Korea

  2022cites this paper
• Risk for incident suicidality among psoriasis patients: a systematic review and meta-analysis

  2022cites this paper
• Hyper/neuroinflammation in COVID-19 and suicide etiopathogenesis: Hypothesis for a nefarious collision?

  2022cites this paper
• Hyperinflammation in COVID-19 and suicide etiopathogenesis_ Hypothesis for a nefarious collision?

  2022cites this paper
• Association of Atopic Dermatitis with Depression and Suicide: A Two-Sample Mendelian Randomization Study

  2022cites this paper
• İNTİHAR GİRİŞİMİ OLAN ERGENLERDE PERİFERİK İNFLAMASYON PARAMETRELERİNİN DEĞERLENDİRİLMESİ

  2022cites this paper
• Hyper/neuroinflammation in COVID-19 and suicide etiopathogenesis: Hypothesis for a nefarious collision?

  2022cites this paper
• Inflammation in Major Depressive Disorder Patients with and without Attempted Suicide

  2022cites this paper
• Relationship between the early repolarization pattern and a history of suicide attempts among drug‐free psychiatric patients

  2022cites this paper
• Investigating Predictive Factors of Suicidal Re-attempts in Adolescents and Young Adults After a First Suicide Attempt, a Prospective Cohort Study. Study Protocol of the SURAYA Project

  2022cites this paper
• Inflamed Mind: Multiple Genetic Variants of IL6 Influence Suicide Risk Phenotypes in Interaction With Early and Recent Adversities in a Linkage Disequilibrium-Based Clumping Analysis

  2021cites this paper
• Severe Suicidality in Athletes with Chronic Traumatic Encephalopathy: A Case Series and Overview on Putative Ethiopathogenetic Mechanisms

  2021cites this paper
• Neutrophilic Leukocytosis in Nonfatal Suicidal Hanging: A Case Series.

  2021cites this paper
• Repurposing Ketamine in Depression and Related Disorders: Can This Enigmatic Drug Achieve Success?

  2021cites this paper
• Affective temperament, depressive symptoms and interleukins in patients with psoriasis

  2021cites this paper
• Neutrophil‐to‐lymphocyte ratio and C‐reactive protein in non‐fatal suicidal attempts: A cross‐sectional pilot study in Bangladesh

  2021cites this paper
• Neutrophil/lymphocyte, platelet/lymphocyte and monocyte/lymphocyte ratios in mood disorders.

  2021cites this paper
• The role of microglia in neuropsychiatric disorders and suicide

  2021cites this paper
• Periodontal pathogens and neuropsychiatric health.

  2020cites this paper
• Suicidality in Patients with Brain Tumors: A Brief Literature Review with Clinical Exemplar

  2020cites this paper
• Predictive inflammatory biomarkers for change in suicidal ideation in major depressive disorder and panic disorder: A 12-week follow-up study.

  2020cites this paper
• The role of gene polymorphisms, and analysis of peripheral and central levels of interleukins in suicidal behavior: A systematic review.

  2020cites this paper
• Inflammation and behavioral symptoms in preoperational glioma patients: Is depression, anxiety, and cognitive impairment related to markers of systemic inflammation?

  2020cites this paper
• An increase in IL-6 levels at 6-month follow-up visit is associated with SSRI-emergent suicidality in high-risk children and adolescents treated with fluoxetine.

  2020cites this paper
• Early Repolarization Pattern and Suicidal Risks: A Single Center Case-Control Study.

  2020cites this paper
• An inflammatory profile linked to increased suicide risk.

  2019cites this paper
• Increased circulatory IL-6 during 8-week fluoxetine treatment is a risk factor for suicidal behaviors in youth.

  2019cites this paper
• Risk for Suicidal Behavior Among Psoriasis Patients: A Nationwide Cohort Study

  2019cites this paper
• The Role of BDNF in the Neuroimmune Axis Regulation of Mood Disorders

  2019cites this paper
• Ethanol induces interferon expression in neurons via TRAIL: role of astrocyte-to-neuron signaling

  2019cites this paper
• Life Trajectories of Suicide Attempt Survivors

  2019cites this paper
• Association of defecation disorders with suicidal ideation in young adult with chronic abdominal discomfort.

  2019cites this paper
• Estimation of IL-6, INFγ, and Lipid Profile in Suicidal and Nonsuicidal Adults with Major Depressive Disorder

  2019cites this paper
• Interleukin-6 and Interleukin-10 in mood disorders: A population-based study.

  2019cites this paper
• Infections, Anti-infective Agents, and Risk of Deliberate Self-harm and Suicide in a Young Cohort: A Nationwide Study.

  2019cites this paper
• suicide and lyme and associated diseases

  2018cites this paper
• Suicide and Lyme and associated diseases

  2017cites this paper
• Risk of Suicidality in People with Psoriasis: A Systematic Review and Meta-Analysis of Cohort Studies

  2017cites this paper
• [Dyslipidemia and suicidal risk in patients with psychiatric disorders].

  2017cites this paper
• A Nationwide Cohort Study of the Association Between Hospitalization With Infection and Risk of Death by Suicide.

  2016cites this paper
• Neutrophil-to-lymphocyte ratio predicting suicide risk in euthymic patients with bipolar disorder: Moderatory effect of family history.

  2016influential citation
• Risk of self‐harm and nonfatal suicide attempts, and completed suicide in patients with psoriasis: a population‐based cohort study

  2016cites this paper
• Antidepressants normalize elevated Toll-like receptor profile in major depressive disorder

  2015cites this paper
• Suicidal ideation and associated factors in adults: population-based study from Brazil Ideação suicida e fatores associados: estudo de base populacional do Brasil Ideación suicida y factores asociados en adultos: estudio de base poblacional en Brasil

  year unknowncites this paper