Tom40, the import channel of the mitochondrial outer membrane, plays an active role in sorting imported proteins

No abstract is available for this paper.

• Publication year

  2003

• Venue

  EMBO Journal

• Publication date

  2003-05-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1093/emboj/cdg229PMID 12743032PMCID PMC155987
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The protein import motor of mitochondria

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• The dimensions of the protein import channels in the outer and inner mitochondrial membranes.

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• How membrane proteins travel across the mitochondrial intermembrane space.

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• The Tom Core Complex

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• Biogenesis of Tim proteins of the mitochondrial carrier import pathway: differential targeting mechanisms and crossing over with the main import pathway.

  1999cited by this paper
• Distribution of Binding Sequences for the Mitochondrial Import Receptors Tom20, Tom22, and Tom70 in a Presequence-carrying Preprotein and a Non-cleavable Preprotein*

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• Functional Staging of ADP/ATP Carrier Translocation across the Outer Mitochondrial Membrane*

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• Transport of the ADP/ATP carrier of mitochondria from the TOM complex to the TIM22·54 complex

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• The aromatic residues Trp and Phe have different effects on the positioning of a transmembrane helix in the microsomal membrane.

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• Interaction of mitochondrial targeting signals with acidic receptor domains along the protein import pathway: evidence for the ‘acid chain’ hypothesis

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• The yeast nascent polypeptide-associated complex initiates protein targeting to mitochondria in vivo.

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• Tom40 forms the hydrophilic channel of the mitochondrial import pore for preproteins

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• Positively and negatively charged residues have different effects on the position in the membrane of a model transmembrane helix.

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• Import of mitochondrial carriers mediated by essential proteins of the intermembrane space.

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• A Toxic Fusion Protein Accumulating between the Mitochondrial Membranes Inhibits Protein Assembly in Vivo *

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• The Import Route of ADP/ATP Carrier into Mitochondria Separates from the General Import Pathway of Cleavable Preproteins at thetrans Side of the Outer Membrane*

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• cis and trans Sites of the TOM Complex of Mitochondria in Unfolding and Initial Translocation of Preproteins*

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• Mitochondrial Protein Import

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• Probing the environment along the protein import pathways in yeast mitochondria by site-specific photocrosslinking.

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• Identification of a mitochondrial receptor complex required for recognition and membrane insertion of precursor proteins

  1990cited by this paper
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  1989cited by this paper
• Import of proteins into mitochondria.

  1988cited by this paper
• Disruption of the outer membrane restores protein import to trypsin‐treated yeast mitochondria.

  1987cited by this paper
• Mitochondrial protein import: involvement of the mature part of a cleavable precursor protein in the binding to receptor sites.

  1987cited by this paper
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  1982cited by this paper
• Federal Republic of Germany SUMMARY

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