Strand specificity for mutations induced by (+)-anti BPDE in the hprt gene in human T-lymphocytes.

No abstract is available for this paper.

• Publication year

  1992

• Venue

  Mutation research

• Publication date

  1992-09-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1016/0027-5107(92)90168-2PMID 1381465
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Mutations causing defective splicing in the human hprt gene

  1992cited by this paper
• Molecular analysis of mutation in the human gene for hypoxanthine phosphoribosyltransferase.

  1992cited by this paper
• Alternative Dideoxy Sequencing of Double-Stranded DNA by Cyclic Reactions Using Taq Polymerase

  1991cited by this paper
• Strand specificity for UV-induced DNA repair and mutations in the Chinese hamster HPRT gene.

  1991cited by this paper
• Cell cycle-dependent strand bias for UV-induced mutations in the transcribed strand of excision repair-proficient human fibroblasts but not in repair-deficient cells

  1991cited by this paper
• Strand-specific mutation spectra in repair-proficient and repair-deficient hamster cells.

  1991cited by this paper
• In vivo benzo[a]pyrene diol epoxide-induced alkali-labile sites are not apurinic sites.

  1991cited by this paper
• Mutations induced by benzo[a]pyrene diolepoxide at the hprt locus in human T-lymphocytes in vitro.

  1990cited by this paper
• DNA base changes in benzo[a]pyrene diol epoxide-induced dihydrofolate reductase mutants of Chinese hamster ovary cells.

  1990cited by this paper
• Effect of excision repair by diploid human fibroblasts on the kinds and locations of mutations induced by (+/-)-7 beta,8 alpha-dihydroxy-9 alpha,10 alpha-epoxy-7,8,9,10- tetrahydrobenzo[a]pyrene in the coding region of the HPRT gene.

  1990cited by this paper
• Frameshift mutation: determinants of specificity.

  1990cited by this paper
• Induction of specific frameshift and base substitution events by benzo[a]pyrene diol epoxide in excision-repair-deficient Escherichia coli.

  1990cited by this paper
• Molecular analysis of hprt mutants induced by 2-cyanoethylene oxide in human lymphoblastoid cells.

  1990cited by this paper
• Gut reaction. “Intestinal Metabolism of Xenobiotics,” A.Sj. Koster, E. Richter, F. Lauterbach, and F. Hartmann (eds). New York: Gustav Fischer Verlag, 1989, 338 pp, $96.50

  1990cited by this paper
• Mutations affecting RNA splicing in man are detected more frequently in somatic than in germ cells.

  1990cited by this paper
• Automated DNA sequencing of the human HPRT locus.

  1990cited by this paper
• Splicing mutations in the CHO DHFR gene preferentially induced by (+/-)-3 alpha,4 beta-dihydroxy-1 alpha,2 alpha-epoxy-1,2,3,4- tetrahydrobenzo[c]phenanthrene.

  1990cited by this paper
• DNA sequence analysis of in vivo hprt mutation in human T lymphocytes.

  1990cited by this paper
• Crystal structure and stability of a DNA duplex containing A(anti).G(syn) base-pairs.

  1989cited by this paper
• DNA–carcinogen interaction: covalent DNA-adducts of benzo(a)pyrene 7, 8-dihydrodiol 9, 10-epoxides studied by biochemical and biophysical techniques

  1989cited by this paper
• DNA strand specificity for UV-induced mutations in mammalian cells

  1989cited by this paper
• NMR and computational characterization of the N-(deoxyguanosin-8-yl)aminofluorene adduct [(AF)G] opposite adenosine in DNA: (AF)G[syn].A[anti] pair formation and its pH dependence.

  1989cited by this paper
• Generation of single-stranded DNA by the polymerase chain reaction and its application to direct sequencing of the HLA-DQA locus.

  1988cited by this paper
• Mapping and characterization of mutations induced by benzo[a]pyrene diol epoxide at dihydrofolate reductase locus in CHO cells

  1988cited by this paper
• Sequence specificity of mutations induced by benzo[a]pyrene-7,8-diol-9,10-epoxide at endogenousaprt gene in CHO cells

  1988cited by this paper
• Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase.

  1988cited by this paper
• Characterization of β-thalassaemia mutations using direct genomic sequencing of amplified single copy DNA

  1987cited by this paper
• Polycyclic aromatic hydrocarbons physically intercalate into duplex regions of denatured DNA.

  1987cited by this paper
• Kinds of mutations formed when a shuttle vector containing adducts of (+/-)-7 beta, 8 alpha-dihydroxy-9 alpha, 10 alpha-epoxy-7,8,9, 10-tetrahydrobenzo[a]pyrene replicates in human cells.

  1987cited by this paper
• Kinds of mutations formed when a shuttle vector containing adducts of benzo[a]pyrene-7,8-diol-9,10-epoxide replicates in COS7 cells

  1987cited by this paper
• Use of T-cell receptor gene probes to quantify the in vivo hprt mutations in human T-lymphocytes.

  1986cited by this paper
• Preferential binding of the carcinogen benzo[a]pyrene to DNA in active chromatin and the nuclear matrix.

  1986cited by this paper
• Is intercalation a critical factor in the covalent binding of mutagenic and tumorigenic polycyclic aromatic diol epoxides to DNA?

  1986cited by this paper
• On the nature of the mutations induced by the diolepoxide of benzo[a]pyrene in mammalian cells.

  1984cited by this paper
• Survival and mutagenesis of bacterial plasmids with localized carcinogen adducts.

  1984cited by this paper
• Measurement of in vivo mutations in human lymphocytes

  1983cited by this paper
• Mutation in mammalian cells by stereoisomers of anti-benzo[a] pyrene-diolepoxide in relation to the extent and nature of the DNA reaction products.

  1982cited by this paper
• The role of DNA polymerase in base substitution mutagenesis on non-instructional templates.

  1982cited by this paper
• T-cell cloning to detect the mutant 6-thioguanine-resistant lymphocytes present in human peripheral blood.

  1982cited by this paper
• Characterization of reversible, physical binding of benzo[a]pyrene derivatives to DNA.

  1982cited by this paper
• Carcinogenic epoxides of benzo[a]pyrene and cyclopenta[cd]pyrene induce base substitutions via specific transversions.

  1982cited by this paper
• Base insertion and deletion mutations induced in an Escherichia coli plasmid by benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide.

  1981cited by this paper
• Benzo(a)pyrene-7,8-dihydrodiol 9,10-oxide adenosine and deoxyadenosine adducts: structure and stereochemistry.

  1979cited by this paper
• Double-stranded DNA stereoselectively binds benzo(a)pyrene diol epoxides

  1979cited by this paper
• Binding of benzo[a]pyrene 7,8-diol-9,10-epoxides to DNA, RNA, and protein of mouse skin occurs with high stereoselectivity.

  1978cited by this paper
• Benzo[a]pyrene diol epoxide covalently binds to deoxyguanosine and deoxyadenosine in DNA

  1977cited by this paper
• Structures of benzo(a)pyrene–nucleic acid adducts formed in human and bovine bronchial explants

  1977cited by this paper
• Mutagenicity of polycyclic aromatic hydrocarbons.

  1977cited by this paper
• Benzo[a]pyrene diol epoxides: mechanism of enzymatic formation and optically active intermediates.

  1977cited by this paper
• (+/-)-7alpha,8beta-dihydroxy-9beta,10beta-epoxy-7,8,9,10-tetrahydrobenzo(a)-pyrene is an intermediate in the metabolism and binding to DNA of benzo(a)pyrene.

  1976cited by this paper
• Benzo(a)pyrene diol epoxides as intermediates in nucleic acid binding in vitro and in vivo.

  1976cited by this paper
• Complementary base pairing and the origin of substitution mutations

  1976cited by this paper

• Mutagenicity monitoring following battlefield exposures: Molecular analysis of HPRT mutations in gulf war i veterans exposed to depleted uranium

  2015cites this paper
• The human T-cell cloning assay: identifying genotypes susceptible to drug toxicity and somatic mutation.

  2014cites this paper
• In Vivo Genotoxicity and Selection Associated with Thiopurine Treatment in Subjects with Inflammatory Bowel Disease

  2008cites this paper
• Formation of lysine 63-linked poly-ubiquitin chains protects human lung cells against benzo[a]pyrene-diol-epoxide-induced mutagenicity.

  2007cites this paper
• Analysis of global gene expression in complex biological systems using microarray technology

  2006cites this paper
• Methods for Detecting Somatic Mutations In Vitro

  2005cites this paper
• Differences between the mutational consequences of replication of cis- and trans-opened benzo[a]pyrene 7,8-diol 9,10-epoxide-deoxyguanosine adducts in M13mp7L2 constructs.

  2001cites this paper
• Mutational spectrum induced by acetaldehyde in the HPRT gene of human T lymphocytes resembles that in the p53 gene of esophageal cancers.

  2001cites this paper
• Mutational spectra at the hypoxanthine-guanine phosphoribosyltransferase (HPRT) locus in T-lymphocytes of nonsmoking and smoking lung cancer patients.

  2000cites this paper
• Identification of in vivo mutations in exon 5 of the human HPRT gene in a set of pooled T-cell mutants by constant denaturant capillary electrophoresis (CDCE).

  2000cites this paper
• Influence of sex, smoking and age on human hprt mutation frequencies and spectra.

  1999cites this paper
• A comparison of mutational specificity of mutations induced by S9-activated B[a]P and benzo[a]pyrene-7,8-diol-9,10-epoxide at the endogenous aprt gene in CHO cells.

  1999cites this paper
• Dose-dependent mutation profile in the c-Ha-ras proto-oncogene of skin tumors in mice initiated with benzo[a]pyrene.

  1999cites this paper
• Influence of DNA sequence context on O⁶-methylguanine mutagenicity in Escherichia coli

  1999cites this paper
• Influence of smoking and donor age on the spectrum of in vivo mutation at the HPRT-locus in T lymphocytes of healthy adults.

  1999cites this paper
• Different somatic and germline HPRT1 mutations promote use of a common, cryptic intron 1 splice site

  1999influential citation
• Genetic instability in human T-lymphocytes.

  1998cites this paper
• Mutations that alter RNA splicing of the human HPRT gene: a review of the spectrum.

  1998cites this paper
• The association of nonsense codons with exon skipping.

  1998cites this paper
• Splicing mutations at the HPRT locus in human T‐lymphocytes in vivo

  1998cites this paper
• Spectrum of point mutations in the coding region of the hypoxanthine-guanine phosphoribosyltransferase (hprt) gene in human T-lymphocytes in vivo.

  1998cites this paper
• Transcription coupled repair and its impact on mutagenesis.

  1998cites this paper
• Nitrogen mustard-mediated mutagenesis in human T-lymphocytes in vitro

  1997cites this paper
• Molecular analysis of styrene oxide-induced hprt mutation in human T-lymphocytes.

  1996cites this paper
• Somatic mutation detection in human biomonitoring.

  1996cites this paper
• Molecular characterization of mutation and comparison of mutation profiles in the hprt gene of Chinese hamster ovary cells treated with benzo[a]pyrene trans‐7,8‐diol‐anti‐9,10‐epoxide, 1‐nitrobenzo[a]pyrene trans‐7,8‐diol‐anti‐9,10‐epoxide, and 3‐nitrobenzo[a]pyrene trans‐7,8‐diol‐anti‐9,10‐epoxide

  1996cites this paper
• H- and K-ras mutational profiles in chemically induced liver tumors from B6C3F1 and CD-1 mice.

  1996cites this paper
• Reduced proliferation rate of hypoxanthine‐phosphoribosyl transferase mutant human T‐lymphocytes in vitro

  1996cites this paper
• Dose-dependent differences in the mutational profiles of (-)-(1R,2S,3S,4R)-3,4-dihydroxy-1, 2-epoxy-1,2,3,4-tetrahydrobenzo[c]phenanthrene and its less carcinogenic enantiomer.

  1996cites this paper
• System Issues: Mutagenic response of the endogenous hprt gene and lacl transgene in benzo[a]pyrene‐treated Big Blue™ B6C3F1 mice

  1996cites this paper
• Spectroscopic Studies of Oligonucleotide Adducts and Base Sequence Preference of Adducts Formed by the Stereoisomers of 7,8-Dihydroxy-9,10-epoxy-7,8,9,10-Tetrahydrobenzo[a]pyrene

  1996cites this paper
• The Effect of Chromium Compounds on the Mutagenic Rate of Benzo[A]Pyrenediolepoxide in Human Fibroblasts

  1996cites this paper
• Methylglyoxal induces hprt mutation and DNA adducts in human T‐lymphocytes in vitro

  1995cites this paper
• Inhibition of poly(ADP-ribose) polymerase increases (+/-)-anti-benzo [a]pyrene diolepoxide-induced micronuclei formation and p53 accumulation in isolated human peripheral blood lymphocytes.

  1995cites this paper
• Characterization of hprt splicing mutations induced by the ultimate carcinogenic metabolite of benzo[a]pyrene in Chinese hamster V-79 cells.

  1995cites this paper
• Genomic DNA sequencing of mRNA splicing mutants in the hprt gene of chinese hamster ovary cells

  1995cites this paper
• Analysis of mutation at the hprt locus in human T lymphocytes.

  1995cites this paper
• Molecular analysis of hprt gene mutations in skin fibroblasts of rats exposed in vivo to N-methyl-N-nitrosourea or N-ethyl-N-nitrosourea.

  1994cites this paper
• Molecular analysis of the retinoblastoma gene in primary ovarian cancer cells

  1994cites this paper
• Mutagenic selectivity at the HPRT locus in V-79 cells: comparison of mutations caused by bay-region benzo[a]pyrene 7,8-diol-9,-10-epoxide enantiomers with high and low carcinogenic activity.

  1994cites this paper
• Analysis of 4-nitroquinoline-1-oxide induced mutations at the hprt locus in mammalian cells: possible involvement of preferential DNA repair.

  1994cites this paper
• Strand bias in mutation involving 5-methylcytosine deamination in the human hprt gene.

  1994cites this paper
• Spectrum of somatic mutation at the hypoxanthine phosphoribosyltransferase (hprt) gene of healthy people.

  1994cites this paper
• Mutations induced in the hypoxanthine phosphoribosyl transferase gene by three urban air pollutants: acetaldehyde, benzo[a]pyrene diolepoxide, and ethylene oxide.

  1994cites this paper
• Effect of dose and dose rate on benzo[a]pyrene induced mutational spectra in human cells

  1994cites this paper
• Covalent binding of benzo[a]pyrene 7,8-dihydrodiol 9,10-epoxides to DNA: molecular structures, induced mutations and biological consequences.

  1994cites this paper
• Defective splicing induced by 4NQO in the hamster hprt gene.

  1994cites this paper
• Spectroscopic studies of the trans adducts derived from (+)- and (-)-anti-benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide and the oligonucleotide 5'-d(CCTATAGATATCC).

  1994cites this paper
• Novel types of mutation identified at the hprt locus of human T-lymphocytes.

  1994cites this paper
• Multiplex PCR analysis of in vivo‐arising deletion mutations in the hprt gene of human T‐lymphocytes

  1994cites this paper
• Molecular analysis of ethylene oxide-induced mutations at the HPRT locus in human diploid fibroblasts.

  1993cites this paper
• Hprt activities and RNA phenotypes in 6-thioguanine resistant human T-lymphocytes.

  1993cites this paper
• Chronic lymphocytic leukemia cells with allelic deletions at 13q14 commonly have one intact RB1 gene: evidence for a role of an adjacent locus.

  1993cites this paper
• 8 – Mechanisms by Which Aflatoxins and Other Bulky Carcinogens Induce Mutations

  1993cites this paper
• A missense mutation in the hypoxanthine phosphoribosyltransferase gene in a pediatric patient with hyperuricemia

  1993cites this paper
• Molecular spectrum of background mutation at the hprt locus in human T-lymphocytes.

  1993cites this paper
• Molecular analysis of DNA adducts and hprt mutations produced by 6-nitrosochrysene in Chinese hamster ovary cells.

  1993cites this paper
• Dose-dependent differences in the profile of mutations induced by (+)-7R,8S-dihydroxy-9S,10R-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene in the coding region of the hypoxanthine (guanine) phosphoribosyltransferase gene in Chinese hamster V-79 cells.

  1993influential citation
• Mutations causing defective splicing in the human hprt gene

  1992cites this paper