The Tight Junction-Associated Protein Occludin Is Required for a Postbinding Step in Hepatitis C Virus Entry and Infection

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Journal of Virology

• Publication date

  2009-06-10

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/JVI.00038-09PMID 19515778PMCID PMC2715771
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Human occludin is a hepatitis C virus entry factor required for infection of mouse cells

  2009cited by this paper
• Early steps of the hepatitis C virus life cycle

  2008influential reference
• Tight Junction Proteins Claudin-1 and Occludin Control Hepatitis C Virus Entry and Are Downregulated during Infection To Prevent Superinfection

  2008cited by this paper
• CD81 Is a Central Regulator of Cellular Events Required for Hepatitis C Virus Infection of Human Hepatocytes

  2008cited by this paper
• Hepatitis C virus envelope components alter localization of hepatocyte tight junction–associated proteins and promote occludin retention in the endoplasmic reticulum

  2008cited by this paper
• The tight junction protein complex undergoes rapid and continuous molecular remodeling at steady state

  2008cited by this paper
• Centrifugal enhancement of hepatitis C virus infection of human hepatocytes.

  2008cited by this paper
• Claudin-1 is a hepatitis C virus co-receptor required for a late step in entry

  2007influential reference
• Tight junction targeting and intracellular trafficking of occludin in polarized epithelial cells.

  2007cited by this paper
• Hepatitis C virus cell‐cell transmission in hepatoma cells in the presence of neutralizing antibodies

  2007cited by this paper
• Characterization of Fusion Determinants Points to the Involvement of Three Discrete Regions of Both E1 and E2 Glycoproteins in the Membrane Fusion Process of Hepatitis C Virus

  2007cited by this paper
• Effect of Cell Polarization on Hepatitis C Virus Entry

  2007cited by this paper
• Coxsackievirus entry across epithelial tight junctions requires occludin and the small GTPases Rab34 and Rab5.

  2007cited by this paper
• Time- and Temperature-Dependent Activation of Hepatitis C Virus for Low-pH-Triggered Entry

  2006cited by this paper
• University of Birmingham Time-and Temperature-Dependent Activation of Hepatitis C Virus for Low-pH-Triggered Entry

  2006cited by this paper
• Virus-induced Abl and Fyn kinase signals permit coxsackievirus entry through epithelial tight junctions.

  2006cited by this paper
• Hepatitis C Virus Entry Depends on Clathrin-Mediated Endocytosis

  2006cited by this paper
• Characterization of the Early Steps of Hepatitis C Virus Infection by Using Luciferase Reporter Viruses

  2006cited by this paper
• Hepatitis C Virus Entry Requires a Critical Postinternalization Step and Delivery to Early Endosomes via Clathrin-Coated Vesicles

  2006cited by this paper
• Tight junctions: molecular architecture and function.

  2006influential reference
• Virus Entry: Open Sesame

  2006cited by this paper
• Rab13 Mediates the Continuous Endocytic Recycling of Occludin to the Cell Surface*

  2005cited by this paper
• Production of infectious hepatitis C virus in tissue culture from a cloned viral genome

  2005cited by this paper
• Unravelling hepatitis C virus replication from genome to function

  2005cited by this paper
• Knockdown of occludin expression leads to diverse phenotypic alterations in epithelial cells.

  2005cited by this paper
• Role of clathrin-mediated endocytosis during vesicular stomatitis virus entry into host cells.

  2005cited by this paper
• Viral hepatitis C.

  2004cited by this paper
• Interleukin-1beta and barrier function of retinal pigment epithelial cells (ARPE-19): aberrant expression of junctional complex molecules.

  2003cited by this paper
• Viral hepatitis C.

  2003cited by this paper
• Infectious Hepatitis C Virus Pseudo-particles Containing Functional E1–E2 Envelope Protein Complexes

  2003cited by this paper
• Hepatitis C virus glycoproteins mediate pH-dependent cell entry of pseudotyped retroviral particles

  2003cited by this paper
• Adenovirus fiber disrupts CAR-mediated intercellular adhesion allowing virus escape.

  2002cited by this paper
• Junction adhesion molecule is a receptor for reovirus.

  2001influential reference
• The Hepatitis B Virus X Protein Induces HIV-1 Replication and Transcription in Synergy with T-cell Activation Signals

  2001cited by this paper
• Biogenesis of tight junctions: the C-terminal domain of occludin mediates basolateral targeting.

  1998influential reference
• Clathrin and adaptors.

  1998cited by this paper
• Vpr is required for efficient replication of human immunodeficiency virus type-1 in mononuclear phagocytes.

  1995cited by this paper
• Human immunodeficiency virus type 1 viral protein R (Vpr) arrests cells in the G2 phase of the cell cycle by inhibiting p34cdc2 activity

  1995cited by this paper
• Structural integrity of hepatocyte tight junctions

  1983cited by this paper

• Architecture, permeability, disruption dynamics and remodeling of tight junction proteins: Implications for performance, health, and welfare of the broiler chicken

  2025cites this paper
• Pathogenic breaches: how viruses compromise blood-tissue barriers

  2025cites this paper
• Epitope-focused immunogens targeting the hepatitis C virus glycoproteins induce broadly neutralizing antibodies

  2024cites this paper
• Hepatitis B virus entry, assembly, and egress

  2024cites this paper
• Tight Junction Proteins as Therapeutic Targets to Treat Liver Fibrosis and Hepatocellular Carcinoma

  2024cites this paper
• Hepatic cell junctions: Pulling a double‐duty

  2024cites this paper
• Structural insights into hepatitis C virus neutralization.

  2023cites this paper
• Genetic and pharmacological perturbation of hepatitis-C virus entry.

  2023cites this paper
• Preventing occludin tight-junction disruption via inhibition of microRNA-193b-5p attenuates viral load and influenza-induced lung injury

  2023cites this paper
• The Early Secretory Pathway Is Crucial for Multiple Aspects of the Hepatitis C Virus Life Cycle

  2023cites this paper
• Micronutrient Improvement of Epithelial Barrier Function in Various Disease States: A Case for Adjuvant Therapy

  2022cites this paper
• Occludin stalls HCV particle dynamics apart from hepatocyte tight junctions, promoting virion internalization

  2022cites this paper
• Sites of vulnerability in HCV E1E2 identified by comprehensive functional screening.

  2022cites this paper
• ORIGINAL RESEARCH Loss of Claudin-3 Impairs Hepatic Metabolism, Biliary Barrier Function, and Cell Proliferation in the Murine Liver Q1 Claudin-3 knockout

  2021cites this paper
• Loss of Claudin-3 Impairs Hepatic Metabolism, Biliary Barrier Function, and Cell Proliferation in the Murine Liver

  2021cites this paper
• Zika Virus Requires the Expression of Claudin-7 for Optimal Replication in Human Endothelial Cells

  2021cites this paper
• Hepatitis C virus infects and perturbs liver stem cells

  2021cites this paper
• HCV Virology

  2021cites this paper
• Hepatitis C Virus Entry: An Intriguingly Complex and Highly Regulated Process

  2020cites this paper
• Umbilical cord derived MSC-administration modulates the angiogenic response after TBI and rescues vascular dysfunction

  2020cites this paper
• Role of Impedance Based Cellular Assays in the Hepatology Research

  2020cites this paper
• Blood-Bile Barrier: Morphology, Regulation, and Pathophysiology.

  2019cites this paper
• M Cells: Intelligent Engineering of Mucosal Immune Surveillance

  2019cites this paper
• Gut microbiota dysbiosis increases the risk of visceral gout in goslings through translocation of gut-derived lipopolysaccharide.

  2019cites this paper
• Hepatitis C Virus Entry: Protein Interactions and Fusion Determinants Governing Productive Hepatocyte Invasion.

  2019cites this paper
• Application of Impedance-Based Techniques in Hepatology Research

  2019cites this paper
• Chapter 3 HCV Lymphotropism and Its Pathogenic Significance

  2018cites this paper
• Hepatitis C Virus Entry into Macrophages/Monocytes Mainly Depends on the Phagocytosis of Macrophages

  2018cites this paper
• Dengue virus enters and exits epithelial cells through both apical and basolateral surfaces and perturbs the apical junctional complex.

  2018cites this paper
• Tight junction proteins in gastrointestinal and liver disease

  2018cites this paper
• Epigenetic Regulations in the Pathogenesis of HCC and the Clinical Application

  2018cites this paper
• Upsetting the Balance: When Viruses Manipulate Cell Polarity Control

  2018cites this paper
• Sortida del virus de l’hepatitis a dels hepatòcits: implicacions en la selecció d’antivirals

  2018cites this paper
• HCV Lymphotropism and Its Pathogenic Significance

  2018cites this paper
• Attachment and Postattachment Receptors Important for Hepatitis C Virus Infection and Cell-to-Cell Transmission

  2017cites this paper
• Molecular Responses of Human Retinal Cells to Infection with Dengue Virus

  2017cites this paper
• Regulated Entry of Hepatitis C Virus into Hepatocytes

  2017cites this paper
• Human embryonic stem cell–derived hepatoblasts are an optimal lineage stage for hepatitis C virus infection

  2017cites this paper
• Ectopic delivery of miR-200c diminishes hepatitis C virus infectivity through transcriptional and translational repression of Occludin

  2017cites this paper
• Correction to: Ectopic delivery of miR-200c diminishes hepatitis C virus infectivity through transcriptional and translational repression of Occludin

  2017cites this paper
• Hepatitis C virus infection causes apoptosis and pyroptosis in both infected and bystander cells

  2017cites this paper
• Impact de la cinétique de décroissance de la charge virale du virus de l'hépatite C sous antiviraux d'action directe : étude chez les transplantés hépatiques au CHU de Rennes

  2016cites this paper
• Recent advances in understanding hepatitis C

  2016cites this paper
• Occludin-Knockout Human Hepatic Huh7.5.1-8-Derived Cells Are Completely Resistant to Hepatitis C Virus Infection.

  2016cites this paper
• DETERMINANTS OF NEUTRALIZATION IN ENVELOPE PROTEINS OF HEPATITIS C VIRUS

  2016cites this paper
• Hepatitis C Virus (HCV) infection: molecular study of immune response mediators

  2016cites this paper
• B Cell Responses and Control of HCV Infection

  2016cites this paper
• Design, synthesis, assessment, and molecular docking of novel pyrrolopyrimidine (7-deazapurine) derivatives as non-nucleoside hepatitis C virus NS5B polymerase inhibitors.

  2016cites this paper
• New perspectives for preventing hepatitis C virus liver graft infection

  2016cites this paper
• Hepatitis C virus cell entry: a target for novel antiviral strategies to address limitations of direct acting antivirals

  2016cites this paper
• Bacterial induction of Snail 1 contributes to blood-brain barrier disruption

  2016cites this paper
• Interaction of Human Tumor Viruses with Host Cell Surface Receptors and Cell Entry

  2015cites this paper
• Monoclonal antibodies: Principles and applications of immmunodiagnosis and immunotherapy for hepatitis C virus.

  2015cites this paper
• Bacterial induction of Snail1 contributes to blood-brain barrier disruption.

  2015cites this paper
• The bystander effect in hepatitis C virus infection: cellular interactions between infected cells and uninfected cells

  2015cites this paper
• Claudin-6 and Occludin Natural Variants Found in a Patient Highly Exposed but Not Infected with Hepatitis C Virus (HCV) Do Not Confer HCV Resistance In Vitro

  2015cites this paper
• Targeting Viral Entry for Treatment of Hepatitis B and C Virus Infections.

  2015cites this paper
• Cellular Response of the Blood Brain Barrier to Bacterial Meningeal Pathogens

  2015cites this paper
• AP-2-Associated Protein Kinase 1 and Cyclin G-Associated Kinase Regulate Hepatitis C Virus Entry and Are Potential Drug Targets

  2015cites this paper
• Apolipoprotein E, but Not Apolipoprotein B, Is Essential for Efficient Cell-to-Cell Transmission of Hepatitis C Virus

  2015cites this paper
• Alternative endocytosis pathway for productive entry of hepatitis C virus.

  2014cites this paper
• Framework selection can influence pharmacokinetics of a humanized therapeutic antibody through differences in molecule charge

  2014cites this paper
• Hepatitis C Virus Life Cycle and Lipid Metabolism

  2014cites this paper
• The role of epithelial tight junctions involved in pathogen infections

  2014cites this paper
• Natural Killer Cell Function and Dysfunction in Hepatitis C Virus Infection

  2014cites this paper
• The expression of HCV-associated host factors is dependent on the hepatoma cell line used in HCV studies

  2014cites this paper
• Degradation of AIMP1/p43 Induced by Hepatitis C Virus E2 Leads to Upregulation of TGF-β Signaling and Increase in Surface Expression of gp96

  2014cites this paper
• Role of N-linked glycans in the interactions of recombinant HCV envelope glycoproteins with cellular receptors.

  2014cites this paper
• Immunohistological characterization of intercellular junction proteins in rhesus macaque intestine.

  2014cites this paper
• Virology and cell biology of the hepatitis C virus life cycle: an update.

  2014cites this paper
• Therapeutic vaccines against hepatitis C virus.

  2014cites this paper
• CD81 and Hepatitis C Virus (HCV) Infection

  2014cites this paper
• Biology and Regulation of Blood-Tissue Barriers

  2014cites this paper
• Immune Escape whereas Apolipoprotein E3 Mediates Viral Ficolin-2 Inhibits Hepatitis C Virus Infection,

  2014cites this paper
• Investigating mechanisms of Hepatitis C virus endocytosis

  2014cites this paper
• Cell Polarity: A Key Defence Mechanism Against Infection and Cancer Cell Invasion?

  2014cites this paper
• Recent advances in HCV entry

  2014cites this paper
• How viruses use the immune system to promote infection of polarized cells

  2014cites this paper
• Characterization of hepatitis C virus infection of hepatocytes and astrocytes

  2014influential citation
• THE REGULATION OF THE EIGHT-EXON ISOFORM OF THE COXSACKIEVIRUS AND ADENOVIRUS RECEPTOR (CAR EX8 ) AND ITS BIOLOGICAL RELEVANCE

  2014cites this paper
• Ficolin-2 Inhibits Hepatitis C Virus Infection, whereas Apolipoprotein E3 Mediates Viral Immune Escape

  2014cites this paper
• Scalable spheroid model of human hepatocytes for hepatitis C infection and replication.

  2014cites this paper
• Hepatitis C virus entry.

  2013cites this paper
• Tetraspanins

  2013cites this paper
• Phosphatidylinositol 4 -Kinases de type III hépatiques : implication au cours de l'infection par le virus de l'hépatite C et lien avec le carcinome hépatocellulaire

  2013cites this paper
• Differential Expression of Candidate Virus Receptors in Human T Lymphocytes Prone or Resistant to Infection with Patient-Derived Hepatitis C Virus

  2013cites this paper
• Structural and Antigenic Definition of Hepatitis C Virus E2 Glycoprotein Epitopes Targeted by Monoclonal Antibodies

  2013cites this paper
• Hepatitis C Virus–Infected Cells Downregulate NKp30 and Inhibit Ex Vivo NK Cell Functions

  2013cites this paper
• The Role of CD81 in HCV and Plasmodium Infection

  2013cites this paper
• Glycan shifting on hepatitis C virus (HCV) E2 glycoprotein is a mechanism for escape from broadly neutralizing antibodies.

  2013cites this paper
• 5-HT2 Receptors Facilitate JC Polyomavirus Entry

  2013cites this paper
• Temporal Analysis of Hepatitis C Virus Cell Entry with Occludin Directed Blocking Antibodies

  2013cites this paper
• The interaction between claudin-1 and dengue viral prM/M protein for its entry.

  2013influential citation
• Transport of folic acid across Caco-2 cells is more effective than 5-methyltetrahydrofolate following the in vitro digestion of fortified bread

  2013cites this paper
• Understanding the biological context of NS5A-host interactions in HCV infection: a network-based approach.

  2013cites this paper
• Cell-Cell Contact-Mediated Hepatitis C Virus (HCV) Transfer, Productive Infection, and Replication and Their Requirement for HCV Receptors

  2013cites this paper
• Structure and Molecular Virology

  2013cites this paper
• Active RNA Replication of Hepatitis C Virus Downregulates CD81 Expression

  2013influential citation
• Biología molecular aplicada del virus de la hepatitis C

  2013cites this paper
• Expression of tricellulin in epithelial cells and non-epithelial cells.

  2013cites this paper