Cocoa Flavanol Cardiovascular Effects Beyond Blood Pressure Reduction

No abstract is available for this paper.

• Publication year

  2016

• Venue

  The Journal of Clinical Hypertension

• Publication date

  2016-04-01

• Fields of study

  Agricultural and Food Sciences, Medicine

• Identifiers
  DOI 10.1111/jch.12715PMID 26514936PMCID PMC8031944
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Cocoa consumption dose-dependently improves flow-mediated dilation and arterial stiffness decreasing blood pressure in healthy individuals

  2015cited by this paper
• Dietary flavonoids and the development of type 2 diabetes and cardiovascular diseases: review of recent findings

  2013cited by this paper
• Effect of cocoa on blood pressure.

  2013influential reference
• Effect of cocoa on blood pressure.

  2012cited by this paper
• Chronic Ingestion of Flavan-3-ols and Iso fl avones Improves Insulin Sensitivity and Lipoprotein Status and Attenuates Estimated 10-Year CVD Risk in Medicated Postmenopausal Women With Type 2 Diabetes A 1-year, double-blind, randomized, controlled trial

  2012cited by this paper
• Chronic Ingestion of Flavan-3-ols and Isoflavones Improves Insulin Sensitivity and Lipoprotein Status and Attenuates Estimated 10-Year CVD Risk in Medicated Postmenopausal Women With Type 2 Diabetes

  2012cited by this paper
• Flavonoid intake and cardiovascular disease mortality in a prospective cohort of US adults.

  2012cited by this paper
• Flavonols intake and the risk of coronary heart disease: a meta-analysis of cohort studies.

  2012cited by this paper
• Benefits in Cognitive Function, Blood Pressure, and Insulin Resistance Through Cocoa Flavanol Consumption in Elderly Subjects With Mild Cognitive Impairment: The Cocoa, Cognition, and Aging (CoCoA) Study

  2012cited by this paper
• Dietary Flavonoids and Risk of Stroke in Women

  2012cited by this paper
• Effects of chocolate, cocoa, and flavan-3-ols on cardiovascular health: a systematic review and meta-analysis of randomized trials.

  2012influential reference
• Cardiovascular effects of flavanol-rich chocolate in patients with heart failure.

  2012cited by this paper
• Effect of fruit and vegetable concentrates on endothelial function in metabolic syndrome: A randomized controlled trial

  2011cited by this paper
• Effects on Peripheral and Central Blood Pressure of Cocoa With Natural or High-Dose Theobromine: A Randomized, Double-Blind Crossover Trial

  2010cited by this paper
• Consumption of cocoa flavanols results in acute improvements in mood and cognitive performance during sustained mental effort

  2010cited by this paper
• Improvement of endothelial function with dietary flavanols is associated with mobilization of circulating angiogenic cells in patients with coronary artery disease.

  2010cited by this paper
• Chocolate dose may be too much

  2010cited by this paper
• Chocolate consumption in relation to blood pressure and risk of cardiovascular disease in German adults.

  2010cited by this paper
• Chocolate consumption, blood pressure, and cardiovascular risk

  2010cited by this paper
• Dietary flavonol intake may lower stroke risk in men and women.

  2010cited by this paper
• Dose-related effects of flavanol-rich cocoa on blood pressure

  2010cited by this paper
• Acute effect of oral flavonoid-rich dark chocolate intake on coronary circulation, as compared with non-flavonoid white chocolate, by transthoracic Doppler echocardiography in healthy adults.

  2009cited by this paper
• Cocoa and Cardiovascular Health

  2009influential reference
• Chocolate consumption and mortality following a first acute myocardial infarction: the Stockholm Heart Epidemiology Program

  2009cited by this paper
• Effect of cocoa powder on the modulation of inflammatory biomarkers in patients at high risk of cardiovascular disease.

  2009cited by this paper
• A double-blind, placebo-controlled, randomized trial of the effects of dark chocolate and cocoa on variables associated with neuropsychological functioning and cardiovascular health: clinical findings from a sample of healthy, cognitively intact older adults.

  2008cited by this paper
• Blood pressure is reduced and insulin sensitivity increased in glucose-intolerant, hypertensive subjects after 15 days of consuming high-polyphenol dark chocolate.

  2008influential reference
• Sustained benefits in vascular function through flavanol-containing cocoa in medicated diabetic patients a double-masked, randomized, controlled trial.

  2008cited by this paper
• Cocoa consumption for 2 wk enhances insulin-mediated vasodilatation without improving blood pressure or insulin resistance in essential hypertension.

  2008cited by this paper
• Effect of cocoa flavanols and exercise on cardiometabolic risk factors in overweight and obese subjects

  2008cited by this paper
• Flavanol and flavonol contents of cocoa powder products: influence of the manufacturing process.

  2008cited by this paper
• Dark Chocolate Improves Coronary Vasomotion and Reduces Platelet Reactivity

  2007cited by this paper
• Quercetin reduces blood pressure in hypertensive subjects.

  2007cited by this paper
• Flavonoid intake and cardiovascular disease mortality: a prospective study in postmenopausal women.

  2007cited by this paper
• Effects of low habitual cocoa intake on blood pressure and bioactive nitric oxide: a randomized controlled trial.

  2007cited by this paper
• Does Flavanol Intake Influence Mortality from Nitric Oxide-Dependent Processes? Ischemic Heart Disease, Stroke, Diabetes Mellitus, and Cancer in Panama

  2007cited by this paper
• Milk Does Not Affect the Bioavailability of Cocoa Powder Flavonoid in Healthy Human

  2007cited by this paper
• (-)-Epicatechin mediates beneficial effects of flavanol-rich cocoa on vascular function in humans.

  2006cited by this paper
• Cocoa intake, blood pressure, and cardiovascular mortality: the Zutphen Elderly Study.

  2006cited by this paper
• Acute and chronic effects of flavanol-rich cocoa on vascular function in subjects with coronary artery disease: a randomized double-blind placebo-controlled study.

  2006cited by this paper
• Chronic Consumption of Flavanol-rich Cocoa Improves Endothelial Function and Decreases Vascular Cell Adhesion Molecule in Hypercholesterolemic Postmenopausal Women

  2006cited by this paper
• Polyphenols and disease risk in epidemiologic studies.

  2005cited by this paper
• Dark chocolate improves endothelial and platelet function

  2005cited by this paper
• Cocoa antioxidants and cardiovascular health.

  2005cited by this paper
• Acute consumption of flavanol-rich cocoa and the reversal of endothelial dysfunction in smokers.

  2005cited by this paper
• Cocoa Reduces Blood Pressure and Insulin Resistance and Improves Endothelium-Dependent Vasodilation in Hypertensives

  2005influential reference
• Regular Consumption of a Flavanol-rich Chocolate can Improve Oxidant Stress in Young Soccer Players

  2005cited by this paper
• Relationship between procyanidin and flavor contents of cocoa liquors from different origins.

  2004cited by this paper
• Polyphenols: food sources and bioavailability.

  2004cited by this paper
• Flavonoid-Rich Dark Chocolate Improves Endothelial Function and Increases Plasma Epicatechin Concentrations in Healthy Adults

  2004cited by this paper
• Plasma antioxidants from chocolate

  2003cited by this paper
• Dietary flavanols and procyanidin oligomers from cocoa (Theobroma cacao) inhibit platelet function.

  2003cited by this paper
• Chocolate and blood pressure in elderly individuals with isolated systolic hypertension.

  2003cited by this paper
• Flavanol-rich cocoa induces nitric-oxide-dependent vasodilation in healthy humans

  2003cited by this paper
• Vascular effects of cocoa rich in flavan-3-ols.

  2003influential reference
• Nutrition: Milk and absorption of dietary flavanols

  2003cited by this paper
• Milk and absorption of dietary flavanols

  2003cited by this paper
• Uptake and metabolism of epicatechin and its access to the brain after oral ingestion.

  2002cited by this paper
• Prognostic impact of coronary vasodilator dysfunction on adverse long-term outcome of coronary heart disease.

  2000cited by this paper
• Catechin contents of foods commonly consumed in The Netherlands. 1. Fruits, vegetables, staple foods, and processed foods.

  2000cited by this paper
• Long-term follow-up of patients with mild coronary artery disease and endothelial dysfunction.

  2000cited by this paper
• Effects of cocoa extracts on endothelium-dependent relaxation.

  2000cited by this paper
• Roles for insulin receptor, PI3-kinase, and Akt in insulin-signaling pathways related to production of nitric oxide in human vascular endothelial cells.

  2000cited by this paper
• HPLC method for the quantification of procyanidins in cocoa and chocolate samples and correlation to total antioxidant capacity.

  1999cited by this paper
• Aging, acculturation, salt intake, and hypertension in the Kuna of Panama.

  1997cited by this paper
• Dietary Flavonoids, Antioxidant Vitamins, and Incidence of Stroke: The Zutphen Study

  1996cited by this paper
• Dietary flavonoids, antioxidant vitamins, and incidence of stroke: the Zutphen study.

  1996cited by this paper
• Close relation of endothelial function in the human coronary and peripheral circulations.

  1995cited by this paper
• Endothelium-dependent dilation in the systemic arteries of asymptomatic subjects relates to coronary risk factors and their interaction.

  1994cited by this paper

• Cocoa Flavonoids: A Natural Approach to Regulating Metabolic Health and Combating Metabolic Syndrome

  2025cites this paper
• Bioactive compounds in fermented foods: a systematic narrative review

  2025cites this paper
• The Modulatory Role of Bioactive Compounds in Functional Foods on Inflammation and Metabolic Pathways in Chronic Diseases

  2025cites this paper
• Dietary Flavonoids Consumption and Health: An Umbrella Review.

  2024cites this paper
• Changes in coffee and caffeine intake during the pandemic in women smokers and non-smokers: a future challenge for cardiovascular prevention

  2023cites this paper
• The effects of flavonoids in experimental sepsis: A systematic review and meta‐analysis

  2023cites this paper
• Inflammation, atherosclerosis and hypertension: the impact of depression and stress on their complex relationship.

  2023cites this paper
• Bioactive compounds for human and planetary health

  2023cites this paper
• A comprehensive insight into the molecular effect of theobromine on cardiovascular‐related risk factors: A systematic review of in vitro and in vivo studies

  2023cites this paper
• Role of gut microbiota in the immunopathology of atherosclerosis: Focus on immune cells

  2022cites this paper
• Effect of polyphenol secondary metabolites on oxidative stress and inflammatory responses associated with aging diseases

  2022cites this paper
• Natural Bioactive Compounds Useful in Clinical Management of Metabolic Syndrome

  2021cites this paper
• Novel insights in the relationship of gut microbiota and coronary artery diseases

  2021cites this paper
• Ageing, Age-Related Cardiovascular Risk and the Beneficial Role of Natural Components Intake

  2021cites this paper
• Assessment of the Effects of Cocoa Powder on Blood Pressure in Humans – A Preliminary Study in Osogbo

  2020cites this paper
• The sweet side of dark chocolate for chronic kidney disease patients.

  2020cites this paper
• The Effect of a Single Dose of Dark Chocolate on Cardiovascular Parameters and Their Reactivity to Mental Stress

  2019cites this paper
• The gut microbiome and atherosclerosis: current knowledge and clinical potential.

  2019cites this paper
• The gut microbiome and cardiovascular disease: current knowledge and clinical potential

  2019cites this paper
• Habitudes alimentaires : évolution, caractéristiques, impact sur la santé et génétique nutritionnelle

  2018cites this paper
• Cardioprotection by Cocoa Polyphenols and ω-3 Fatty Acids: A Disease-Prevention Perspective on Aging-Associated Cardiovascular Risk

  2018cites this paper
• Flavonoids as Functional Food

  2018cites this paper
• Oxidative Stress in Cerebral Small Vessel Disease Dizziness Patients, Basally and After Polyphenol Compound Supplementation

  2018cites this paper
• Neuronutrition: An Emerging Concept

  2017cites this paper
• (–)-Epicatechin Suppresses Angiotensin II-induced Cardiac Hypertrophy via the Activation of the SP1/SIRT1 Signaling Pathway

  2017cites this paper
• Cocoa, Blood Pressure, and Vascular Function

  2017cites this paper
• The role of polyphenols in modern nutrition

  2017cites this paper
• Bioactive polyphenols and cardiovascular disease: chemical antagonists, pharmacological agents or xenobiotics that drive an adaptive response?

  2017cites this paper
• A dietary strategy for the management of artemether-lumefantrine-induced cardiovascular and renal toxicity

  2016cites this paper
• Chocolate, Air Pollution and Children's Neuroprotection: What Cognition Tools should be at Hand to Evaluate Interventions?

  2016influential citation