HIV-1 Maturation Inhibitor Bevirimat Stabilizes the Immature Gag Lattice

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Journal of Virology

• Publication date

  2010-11-24

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1128/JVI.01926-10PMID 21106735PMCID PMC3028903
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Polymorphisms in Gag spacer peptide 1 confer varying levels of resistance to the HIV- 1maturation inhibitor bevirimat

  2010cited by this paper
• The capsid-spacer peptide 1 Gag processing intermediate is a dominant-negative inhibitor of HIV-1 maturation.

  2010cited by this paper
• X-ray structures of the hexameric building block of the HIV capsid.

  2009cited by this paper
• Structure and assembly of immature HIV

  2009influential reference
• Visualization of a Missing Link in Retrovirus Capsid Assembly

  2009cited by this paper
• Impact of Human Immunodeficiency Virus Type 1 Resistance to Protease Inhibitors on Evolution of Resistance to the Maturation Inhibitor Bevirimat (PA-457)

  2009cited by this paper
• Virus maturation as a new HIV-1 therapeutic target

  2009cited by this paper
• Three-dimensional analysis of budding sites and released virus suggests a revised model for HIV-1 morphogenesis.

  2008cited by this paper
• Irregular and Semi-Regular Polyhedral Models for Rous Sarcoma Virus Cores.

  2008cited by this paper
• RSV capsid polymorphism correlates with polymerization efficiency and envelope glycoprotein content: implications that nucleation controls morphogenesis.

  2008cited by this paper
• Computational resources for cryo-electron tomography in Bsoft.

  2008cited by this paper
• The inhibition of assembly of HIV-1 virus-like particles by 3-O-(3',3'-dimethylsuccinyl) betulinic acid (DSB) is counteracted by Vif and requires its Zinc-binding domain

  2008cited by this paper
• Structure of B-MLV capsid amino-terminal domain reveals key features of viral tropism, gag assembly and core formation.

  2008cited by this paper
• Recent progress in antiretrovirals--lessons from resistance.

  2008cited by this paper
• Electron cryotomography of immature HIV‐1 virions reveals the structure of the CA and SP1 Gag shells

  2007influential reference
• Human immunodeficiency virus type 1 assembly, release, and maturation.

  2007influential reference
• Structure of full-length HIV-1 CA: a model for the mature capsid lattice.

  2007cited by this paper
• Human Immunodeficiency Virus Type 1 Resistance to the Small Molecule Maturation Inhibitor 3-O-(3′,3′-Dimethylsuccinyl)-Betulinic Acid Is Conferred by a Variety of Single Amino Acid Substitutions at the CA-SP1 Cleavage Site in Gag

  2006cited by this paper
• 3-O-(3′,3′-Dimethysuccinyl) Betulinic Acid Inhibits Maturation of the Human Immunodeficiency Virus Type 1 Gag Precursor Assembled In Vitro

  2006cited by this paper
• In Vitro Resistance to the Human Immunodeficiency Virus Type 1 Maturation Inhibitor PA-457 (Bevirimat)

  2006influential reference
• Determinants of activity of the HIV-1 maturation inhibitor PA-457.

  2006cited by this paper
• Influenza virus pleiomorphy characterized by cryoelectron tomography

  2006cited by this paper
• The mechanism of HIV-1 core assembly: insights from three-dimensional reconstructions of authentic virions.

  2006cited by this paper
• Inhibition of HIV-1 Maturation via Drug Association with the Viral Gag Protein in Immature HIV-1 Particles*

  2005cited by this paper
• Automated electron microscope tomography using robust prediction of specimen movements.

  2005cited by this paper
• A resolution criterion for electron tomography based on cross-validation.

  2005cited by this paper
• Betulinic acid derivatives as HIV-1 antivirals.

  2005cited by this paper
• Three-dimensional structure of HIV-1 virus-like particles by electron cryotomography.

  2005cited by this paper
• Association of Human Immunodeficiency Virus Type 1 Gag with Membrane Does Not Require Highly Basic Sequences in the Nucleocapsid: Use of a Novel Gag Multimerization Assay

  2005cited by this paper
• Small-Molecule Inhibition of Human Immunodeficiency Virus Type 1 Replication by Specific Targeting of the Final Step of Virion Maturation

  2004cited by this paper
• The stoichiometry of Gag protein in HIV-1

  2004cited by this paper
• The sequence of the CA-SP1 junction accounts for the differential sensitivity of HIV-1 and SIV to the small molecule maturation inhibitor 3-O-{3',3'-dimethylsuccinyl}-betulinic acid

  2004cited by this paper
• Key interactions in HIV-1 maturation identified by hydrogen-deuterium exchange

  2004cited by this paper
• Retrovirus budding.

  2004cited by this paper
• High-resolution structure of a retroviral capsid hexameric amino-terminal domain

  2004cited by this paper
• [Electron tomography].

  2004cited by this paper
• UCSF Chimera—A visualization system for exploratory research and analysis

  2004cited by this paper
• Structural organization of authentic, mature HIV‐1 virions and cores

  2003cited by this paper
• PA-457: A potent HIV inhibitor that disrupts core condensation by targeting a late step in Gag processing

  2003influential reference
• Identification of macromolecular complexes in cryoelectron tomograms of phantom cells

  2002cited by this paper
• Organization of Immature Human Immunodeficiency Virus Type 1

  2001influential reference
• Noise reduction in electron tomographic reconstructions using nonlinear anisotropic diffusion.

  2001cited by this paper
• Solution structure and dynamics of the Rous sarcoma virus capsid protein and comparison with capsid proteins of other retroviruses.

  2000cited by this paper
• Image reconstructions of helical assemblies of the HIV-1 CA protein

  2000cited by this paper
• Model for lentivirus capsid core assembly based on crystal dimers of EIAV p26.

  1999cited by this paper
• Solution structure of the capsid protein from the human T-cell leukemia virus type-I.

  1999cited by this paper
• Sequential Steps in Human Immunodeficiency Virus Particle Maturation Revealed by Alterations of Individual Gag Polyprotein Cleavage Sites

  1998influential reference
• Inhibitors of HIV-1 protease: a major success of structure-assisted drug design.

  1998cited by this paper
• Structure of the carboxyl-terminal dimerization domain of the HIV-1 capsid protein.

  1997cited by this paper
• Proteolytic processing and particle maturation.

  1996cited by this paper
• p6Gag is required for particle production from full-length human immunodeficiency virus type 1 molecular clones expressing protease

  1995cited by this paper
• Single amino acid changes in the human immunodeficiency virus type 1 matrix protein block virus particle production

  1994cited by this paper
• Anti-AIDS agents, 11. Betulinic acid and platanic acid as anti-HIV principles from Syzigium claviflorum, and the anti-HIV activity of structurally related triterpenoids.

  1994cited by this paper
• Evidence for a functional interaction between the V1/V2 and C4 domains of human immunodeficiency virus type 1 envelope glycoprotein gp120

  1994cited by this paper
• Biosynthesis, cleavage, and degradation of the human immunodeficiency virus 1 envelope glycoprotein gp160.

  1988cited by this paper
• Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone

  1986cited by this paper

• A Hybrid Gag Lattice as a Structural Intermediate in HIV-1 Maturation

  2026cites this paper
• Illuminating druggable dark matter in RNA virus replication using in situ cryo-EM.

  2025cites this paper
• Distinct Target Site of Lenacapavir in Immature HIV-1 and Concurrent Binding with the Maturation Inhibitor Bevirimat.

  2025cites this paper
• Structural insights into inhibitor mechanisms on immature HIV-1 Gag lattice revealed by high-resolution in situ single-particle cryo-EM

  2024cites this paper
• Temporal control by co-factors prevents kinetic trapping in retroviral Gag lattice assembly

  2023cites this paper
• Pharmacokinetics and tolerability of the maturation inhibitor GSK3640254 coadministered with darunavir/ritonavir and/or etravirine in healthy adults

  2023cites this paper
• Intrinsic resistance of HIV-2 and SIV to the maturation inhibitor GSK2838232

  2023cites this paper
• The Effect of Inositol Hexakisphosphate on HIV-1 Particle Production and Infectivity can be Modulated by Mutations that Affect the Stability of the Immature Gag Lattice.

  2023cites this paper
• Structure of the HIV immature lattice allows for essential lattice remodeling within budded virions

  2023cites this paper
• Construction of a HIV-1 subtype C 3D model using homology modeling and in-silico docking, molecular dynamics simulation, and MM-GBSA calculation of second-generation HIV-1 maturation inhibitor(s)

  2023cites this paper
• Structural basis of HIV-1 maturation inhibitor binding and activity

  2022cites this paper
• Synthesis, Structure-Activity Relationships, and In Vivo Evaluation of Novel C-17 Amine Derivatives Based on GSK3640254 as HIV-1 Maturation Inhibitors with Broad Spectrum Activity.

  2022cites this paper
• Targeting the Virus Capsid as a Tool to Fight RNA Viruses

  2022cites this paper
• Equilibrium dynamics of the pre- and post-cleavage regions of SP1 are separately shifted by the HIV-1 maturation inhibitor Bevirimat

  2022cites this paper
• Defects in the HIV immature lattice support essential lattice remodeling within budded virions

  2022cites this paper
• A single G10T polymorphism in HIV-1 subtype C Gag-SP1 regulates sensitivity to maturation inhibitors

  2021cites this paper
• Structural Analysis of Retrovirus Assembly and Maturation

  2021cites this paper
• Stephan Oroszlan and the Proteolytic Processing of Retroviral Proteins: Following A Pro

  2021cites this paper
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  2021cites this paper
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  2021cites this paper
• When in Need of an ESCRT: The Nature of Virus Assembly Sites Suggests Mechanistic Parallels between Nuclear Virus Egress and Retroviral Budding

  2021cites this paper
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  2021cites this paper
• Effects of an HIV-1 maturation inhibitor on the structure and dynamics of CA-SP1 junction helices in virus-like particles

  2020cites this paper
• The HIV-1 maturation inhibitor, EP39, interferes with the dynamic helix-coil equilibrium of the CA-SP1 junction of Gag.

  2020cites this paper
• Viral structural proteins as targets for antivirals.

  2020cites this paper
• High resolution electron tomography and segmentation‐by‐modeling interpretation in Bsoft

  2020cites this paper
• HIV-1 Maturation: Lessons Learned from Inhibitors

  2020cites this paper
• Resistance profile of the HIV-1 maturation inhibitor GSK3532795 in vitro and in a clinical study

  2019cites this paper
• Maturation of retroviruses.

  2019cites this paper
• Multiple Roles of HIV-1 Capsid during the Virus Replication Cycle

  2019cites this paper
• Reviewing HIV-1 Gag Mutations in Protease Inhibitors Resistance: Insights for Possible Novel Gag Inhibitor Designs

  2019cites this paper
• Insight into the mechanism of action of EP‐39, a bevirimat derivative that inhibits HIV‐1 maturation

  2019cites this paper
• STRUCTURE DETERMINATION OF HETEROGENEOUS BIOLOGICAL SPECIMENS IN CROWDED ENVIRONMENTS

  2019cites this paper
• Recent Achievements in Medicinal and Supramolecular Chemistry of Betulinic Acid and Its Derivatives

  2019cites this paper
• Dominant Negative MA-CA Fusion Protein Is Incorporated into HIV-1 Cores and Inhibits Nuclear Entry of Viral Preintegration Complexes

  2019cites this paper
• Structural analysis of pleomorphic and asymmetric viruses using cryo-electron tomography and subtomogram averaging.

  2019cites this paper
• Review of Current Cell-Penetrating Antibody Developments for HIV-1 Therapy

  2018cites this paper
• Recent advances in retroviruses via cryo-electron microscopy

  2018cites this paper
• The KT Jeang Retrovirology prize 2018: Eric Freed

  2018cites this paper
• Resistance to Second-Generation HIV-1 Maturation Inhibitors

  2018cites this paper
• Identification of a Structural Element in HIV-1 Gag Required for Virus Particle Assembly and Maturation

  2018cites this paper
• High-resolution structures of HIV-1 Gag cleavage mutants determine structural switch for virus maturation

  2018cites this paper
• Inositol phosphates are assembly co-factors for HIV-1

  2018cites this paper
• Maturation inhibitors facilitate virus assembly and release of HIV-1 capsid P224 mutant.

  2018cites this paper
• MicroED Structure of the CTD-SP1 fragment of HIV-1 Gag with bound maturation inhibitor Bevirimat.

  2018cites this paper
• Molecular mechanisms by which HERV-K Gag interferes with HIV-1 Gag assembly and particle infectivity

  2017cites this paper
• Functional insights into pathogen biology from 3D electron microscopy

  2017cites this paper
• Inhibition of HIV-1 Maturation via Small-Molecule Targeting of the Amino-Terminal Domain in the Viral Capsid Protein

  2017cites this paper
• Insights into the activity of maturation inhibitor PF-46396 on HIV-1 clade C

  2017cites this paper
• Quenching protein dynamics interferes with HIV capsid maturation

  2017cites this paper
• MicroED structures of HIV-1 Gag CTD-SP1 reveal binding interactions with the maturation inhibitor bevirimat

  2017cites this paper
• Structure-Activity Relationships of the Human Immunodeficiency Virus Type 1 Maturation Inhibitor PF-46396

  2016cites this paper
• HIV-1 Capsid Inhibitors as Antiretroviral Agents.

  2016cites this paper
• Crystal structure of an HIV assembly and maturation switch

  2016cites this paper
• Identification of potent maturation inhibitors against HIV-1 clade C

  2016cites this paper
• HIV-1 Capsid as a Target for Antiviral Therapy

  2016cites this paper
• In vitro protease cleavage and computer simulations reveal the HIV-1 capsid maturation pathway

  2016cites this paper
• Helical Conformation in the CA-SP1 Junction of the Immature HIV-1 Lattice Determined from Solid-State NMR of Virus-like Particles.

  2016cites this paper
• Self-assembly of Rous Sarcoma Virus capsid protein, probed by Solid-state NMR and TEM

  2016cites this paper
• An atomic model of HIV-1 capsid-SP1 reveals structures regulating assembly and maturation

  2016cites this paper
• Distribution and Redistribution of HIV-1 Nucleocapsid Protein in Immature, Mature, and Integrase-Inhibited Virions: a Role for Integrase in Maturation

  2015cites this paper
• Pharmacological intervention of HIV-1 maturation

  2015cites this paper
• Retroviral proteases and their roles in virion maturation.

  2015cites this paper
• HIV-1 gag: an emerging target for antiretroviral therapy.

  2015cites this paper
• Maturation of the HIV-1 core by a non-diffusional phase transition

  2015cites this paper
• Morphology and ultrastructure of retrovirus particles

  2015cites this paper
• Allosteric Integrase Inhibitors Reveal a Role for Integrase During HIV-1 Maturation

  2015cites this paper
• The triple threat of HIV-1 protease inhibitors.

  2015cites this paper
• Alkyl Amine Bevirimat Derivatives Are Potent and Broadly Active HIV-1 Maturation Inhibitors

  2015cites this paper
• Identification of an HIV-1 Mutation in Spacer Peptide 1 That Stabilizes the Immature CA-SP1 Lattice

  2015cites this paper
• Three-Dimensional Structural Characterization of HIV-1 Tethered to Human Cells

  2015cites this paper
• Electron cryo-tomography studies of maturing HIV-1 particles reveal the 2 assembly pathway of the viral core 3 4 5

  2014influential citation
• Zernike phase contrast cryo-electron tomography of whole bacterial cells.

  2014cites this paper
• How HIV-1 Gag assembles in cells: Putting together pieces of the puzzle.

  2014influential citation
• Higher-Order Structure of the Rous Sarcoma Virus SP Assembly Domain

  2014cites this paper
• Potential Role for CA-SP in Nucleating Retroviral Capsid Maturation

  2014cites this paper
• Protease-MediatedMaturation of HIV : Inhibitors of Protease and theMaturation Process

  2014influential citation
• Distinct nucleic acid interaction properties of HIV-1 nucleocapsid protein precursor NCp15 explain reduced viral infectivity

  2014cites this paper
• Contribution of Gag and protease to variation in susceptibility to protease inhibitors between different strains of HIV-1

  2014cites this paper
• Electron Cryotomography Studies of Maturing HIV-1 Particles Reveal the Assembly Pathway of the Viral Core

  2014influential citation
• Analysis of Human T-Cell Leukemia Virus Type 1 Particles by Using Cryo-Electron Tomography

  2014cites this paper
• Cryo-electron microscopy of tubular arrays of HIV-1 Gag resolves structures essential for immature virus assembly

  2014cites this paper
• HIV-1 Maturation

  2013influential citation
• A Two-Pronged Structural Analysis of Retroviral Maturation Indicates that Core Formation Proceeds by a Disassembly-Reassembly Pathway Rather than a Displacive Transition

  2013cites this paper
• A sensitive assay using a native protein substrate for screening HIV-1 maturation inhibitors targeting the protease cleavage site between the matrix and capsid.

  2013cites this paper
• Immunogenicity of sequences around HIV-1 protease cleavage sites: potential targets and population coverage analysis for a HIV vaccine targeting protease cleavage sites.

  2013cites this paper
• Synthesis and biological evaluation of a new derivative of bevirimat that targets the Gag CA-SP1 cleavage site.

  2013cites this paper
• Structural Biology of HIV Assembly

  2013cites this paper
• Virus Assembly as a Target for Antiretroviral Therapy

  2013cites this paper
• Characterization of Human Lysyl-tRNA Synthetase- and Retroviral Nucleocapsid Protein- Nucleic Acid Interactions

  2013cites this paper
• Structural biology in situ--the potential of subtomogram averaging.

  2013cites this paper
• Capturing Enveloped Viruses on Affinity Grids for Downstream Cryo-Electron Microscopy Applications

  2013cites this paper
• Assembly and architecture of HIV.

  2012influential citation
• Étude de la résistance des sous-types non-B du VIH-1 aux antirétroviraux au Mali

  2012cites this paper
• The Choreography of HIV-1 Proteolytic Processing and Virion Assembly*

  2012cites this paper
• Limiting factors in single particle cryo electron tomography

  2012cites this paper
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  2012cites this paper
• Human Immunodeficiency Virus gag and protease: partners in resistance

  2012cites this paper
• Protease Cleavage Leads to Formation of Mature Trimer Interface in HIV-1 Capsid

  2012cites this paper
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  2012influential citation