Hypoxia-induced protein CAIX is associated with somatic loss of BRCA1 protein and pathway activity in triple negative breast cancer

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Breast Cancer Research and Treatment

• Publication date

  2012-09-14

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s10549-012-2232-0PMID 22976806
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2010cited by this paper
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  2009cited by this paper
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  2009cited by this paper
• Immunohistochemical detection of changes in tumor hypoxia.

  2009cited by this paper
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  2008cited by this paper
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  2002influential reference
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  2002cited by this paper
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  1999cited by this paper
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  1997cited by this paper
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  1997cited by this paper
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