Localization of human BRCA1 and its loss in high-grade, non-inherited breast carcinomas

No abstract is available for this paper.

• Publication year

  1999

• Venue

  Nature Genetics

• Publication date

  1999-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/6029PMID 9988281
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• CpG methylation within the 5′ regulatory region of the BRCA1 gene is tumor specific and includes a putative CREB binding site

  1998cited by this paper
• Localization of BRCA1 and a splice variant identifies the nuclear localization signal

  1997cited by this paper
• BRCA1 is a cell cycle-regulated nuclear phosphoprotein.

  1997cited by this paper
• Differential subcellular localization, expression and biological toxicity of BRCA1 and the splice variant BRCA1-Δ11b

  1997cited by this paper
• Genomic deletions in the BRCA1, BRCA2 and TP53 regions associate with low expression of the estrogen receptor in sporadic breast carcinoma

  1997cited by this paper
• Association of BRCA1 with Rad51 in mitotic and meiotic cells.

  1997cited by this paper
• Methylation of the BRCA1 gene in sporadic breast cancer.

  1997cited by this paper
• Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage.

  1997cited by this paper
• Differential subcellular localization, expression and biological toxicity of BRCA1 and the splice variant BRCA1-delta11b.

  1997cited by this paper
• BRCA1 is localized in cytoplasmic tube-like invaginations in the nucleus

  1997cited by this paper
• Mutations and Polymorphisms in the familial early‐onset breast cancer (BRCA1) gene

  1996cited by this paper
• Location of BRCA1 in Human Breast and Ovarian Cancer Cells

  1996cited by this paper
• BRCA1 is a 220-kDa nuclear phosphoprotein that is expressed and phosphorylated in a cell cycle-dependent manner.

  1996cited by this paper
• BRCA1 is secreted and exhibits properties of a granin

  1996cited by this paper
• BRCA1 protein products: Antibody specificity…

  1996cited by this paper
• Subcellular Localization and Analysis of Apparent 180-kDa and 220-kDa Proteins of the Breast Cancer Susceptibility Gene, BRCA1*

  1996cited by this paper
• Somatic mutations in the BRCA1 gene in sporadic ovarian tumours

  1995cited by this paper
• A somatic BRCA1 mutation in an ovarian tumour

  1995cited by this paper
• A collaborative survey of 80 mutations in the BRCA1 breast and ovarian cancer susceptibility gene. Implications for presymptomatic testing and screening.

  1995cited by this paper
• Decreased expression of BRCA1 accelerates growth and is often present during sporadic breast cancer progression

  1995cited by this paper
• Aberrant Subcellular Localization of BRCA1 in Breast Cancer

  1995cited by this paper
• A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1.

  1994cited by this paper
• Confirmation of BRCA1 by analysis of germline mutations linked to breast and ovarian cancer in ten families

  1994cited by this paper
• Mutations in the BRCA1 gene in families with early-onset breast and ovarian cancer

  1994cited by this paper
• BRCA1 mutations in primary breast and ovarian carcinomas.

  1994cited by this paper
• Detection of frequent allelic loss on proximal chromosome 17q in sporadic breast carcinoma using microsatellite length polymorphisms.

  1992cited by this paper
• Allele loss from chromosome 17 in ovarian cancer.

  1990cited by this paper
• Identification and characterization of the protein encoded by the human N-myc oncogene.

  1986cited by this paper

• Semi-Quantitative Evaluation of BRCA1 Protein in Breast Tumors Using Anti-BRCA1 Antibodies: Clinical Implications.

  2026cites this paper
• A New Class of BRCA1 Mimetics for ERα-Positive Breast Cancer Therapy: Design, Synthesis, In Silico Screening, In Vitro Assay, and Gene Expression Analysis

  2025cites this paper
• BRCA Mutations—The Achilles Heel of Breast, Ovarian and Other Epithelial Cancers

  2023cites this paper
• Unveiling the vulnerabilities of synthetic lethality in triple-negative breast cancer

  2023cites this paper
• Potential Mechanisms by which Glucocorticoids Induce Breast Carcinogenesis through Nrf2 Inhibition.

  2022cites this paper
• Heterozygotic Brca1 mutation initiates mouse genome instability at embryonic stage

  2022cites this paper
• Biomarkers in Breast Carcinomas

  2022cites this paper
• High BRCA1 gene expression increases the risk of early distant metastasis in ER+ breast cancers

  2022cites this paper
• Exceptional behavior of breast cancer-associated type 1 gene in breast invasive carcinoma

  2022cites this paper
• BMI‐1 promotes breast cancer proliferation and metastasis through different mechanisms in different subtypes

  2022cites this paper
• FMNL1 promotes growth and metastasis of breast cancer by inhibiting BRCA1 via upregulation of HMGA1

  2022cites this paper
• BRCA1 Antibodies Matter

  2021cites this paper
• The fellowship of the RING: BRCA1, its partner BARD1 and their liaison in DNA repair and cancer.

  2021cites this paper
• Targeted Therapeutic Strategies for Triple-Negative Breast Cancer

  2021cites this paper
• Metabolomic Identification of Anticancer Metabolites of Australian Propolis and Proteomic Elucidation of Its Synergistic Mechanisms with Doxorubicin in the MCF7 Cells

  2021cites this paper
• Predicting Ovarian/Breast Cancer Pathogenic Risks of Human BRCA1 Gene Variants of Unknown Significance

  2021cites this paper
• TP53 Mutation in Saudi Breast Cancer Patients: Correlations with Cancer Stem Cell Markers Expression and Clinicopathological Variables

  2020cites this paper
• Predicting ovarian/breast cancer pathogenic risks of BRCA1 gene variants of unknown significance

  2020cites this paper
• Histone H2A ubiquitination resulting from Brap loss of function connects multiple aging hallmarks and accelerates neurodegeneration

  2020cites this paper
• Molecular docking analysis of the BRCA1 protein with compounds from Justica adhatoda L

  2020cites this paper
• Bioinformatics and Molecular Analysis of the Breast Cancer Susceptibility Gene BRCA1 in Breast Cancer

  2020cites this paper
• Expresión tumoral de BRCA1 y resultados clínicos en pacientes uruguayas diagnosticadas de cáncer de mama antes de los 40 años

  2020cites this paper
• BRCA1-No Matter How You Splice It.

  2019influential citation
• Testing equality of means in partially paired data with incompleteness in single response

  2019cites this paper
• Utility of evaluation of P53 and BRCA1 in invasive breast cancers: An immunohistochemical study

  2019cites this paper
• The effects of BRCA1 expression on the chemosensitivity of gastric cancer cells to platinum agents

  2019cites this paper
• Capturing heterogeneity of covariate effects in hidden subpopulations in the presence of censoring and large number of covariates

  2019cites this paper
• Functional Impacts of the BRCA1-mTORC2 Interaction in Breast Cancer

  2019cites this paper
• Elucidating the novel BRCA1 function as a non-genomic metabolic restraint in ER-positive breast cancer cell lines

  2018cites this paper
• Synergistic anticancer action of quercetin and curcumin against triple‐negative breast cancer cell lines

  2018cites this paper
• Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma

  2018cites this paper
• Frequency of BRCA 1 Mutations in B & H Breast and Ovarian Cancer Patients

  2018cites this paper
• Development of Natural Cyclic Peptide Inhibitors of XRCC4/XLF Interaction for Radio-Sensitization of Breast Tumor Cells

  2018cites this paper
• BRCA0 Immunohistochemical Study of Serous Ovarian Cancer

  2018cites this paper
• BRCA1 and BRCA2 expression patterns and prognostic significance in digestive system cancers.

  2018cites this paper
• Expression of Brca1 in a Group of Iraqi Patients with Breast Cancer

  2018cites this paper
• 12 Potential Tumor Biomarkers for Ovarian Cancer

  2018cites this paper
• BRCA1 protein expression and subcellular localization in primary breast cancer: Automated digital microscopy analysis of tissue microarrays

  2017cites this paper
• BRCA1 expression, proliferative and apoptotic activities in ovarian epithelial inclusions

  2017cites this paper
• Impact of Etoposide on BRCA1 Expression in Various Breast Cancer Cell Lines

  2017cites this paper
• A novel Ubc9 -dependent pathway regulates SIRT1- ER-α Axis and BRCA1-associated TNBC lung metastasis.

  2017cites this paper
• Defects in recombination activity caused by somatic and germline mutations in the multimerization/BRCA2 binding region of human RAD51 protein.

  2017cites this paper
• MATHEMATICAL DEGRADATION MODEL FOR TRANSCRIPTIONAL REGULATION OF BRCA1

  2017cites this paper
• MicroRNA deregulation in triple negative breast cancer reveals a role of miR-498 in regulating BRCA1 expression

  2016cites this paper
• Study of the DNA sensor IFI16 in cancer and herpes simplex virus type 1 infection

  2016cites this paper
• Yeast cells reveal the misfolding and the cellular mislocalization of the human BRCA1 protein

  2016cites this paper
• Epigenetics of breast cancer: Modifying role of environmental and bioactive food compounds.

  2016cites this paper
• Indole-3-Carbinol and Its Role in Chronic Diseases.

  2016cites this paper
• Differential effects of HTLV-1 Tax oncoprotein on the different estrogen-induced-ER α-mediated transcriptional activities

  2016cites this paper
• Epigenetic regulation of BRCA1 expression and its role inbreast cancer stem cell development

  2016cites this paper
• BRCA1 positively regulates FOXO3 expression by restricting FOXO3 gene methylation and epigenetic silencing through targeting EZH2 in breast cancer

  2016cites this paper
• The long range regulation of breast cancer associated genes

  2016influential citation
• In vitro model for DNA double‐strand break repair analysis in breast cancer reveals cell type–specific associations with age and prognosis

  2016cites this paper
• RAD51 variant proteins from human lung and kidney tumors exhibit DNA strand exchange defects.

  2016cites this paper
• Levels of DNA Methylation Vary at CpG Sites across the BRCA1 Promoter, and Differ According to Triple Negative and “BRCA-Like” Status, in Both Blood and Tumour DNA

  2016cites this paper
• pre-mRNAs containing multiple intervening sequences?

  2016cites this paper
• Title BRCA 1 positively regulates FOXO 3 expression by restricting FOXO 3 gene methylation and epigenetic silencing through targeting EZH 2 in breast cancer

  2016cites this paper
• Increased ID4 expression, accompanied by mutant p53 accumulation and loss of BRCA1/2 proteins in triple‐negative breast cancer, adversely affects survival

  2016cites this paper
• Prevalence of BRCA1 Oncogen Expression in Breast Cancer Specimens of Patients with Positive Family History

  2015cites this paper
• KPNA2 is a nuclear export protein that contributes to aberrant localisation of key proteins and poor prognosis of breast cancer

  2015cites this paper
• RNF126 promotes homologous recombination via regulation of E2F1-mediated BRCA1 expression

  2015cites this paper
• Epigenetic Reduction of DNA Repair in Progression to Cancer

  2015cites this paper
• BRCA1 Alternative splicing landscape in breast tissue samples

  2015cites this paper
• BRCA1 alterations are associated with endometriosis, but BRCA2 alterations show no detectable endometriosis risk: a study in Indian population

  2015cites this paper
• BRCA1 mislocalization associated with breast carcinogenesis and poor prognosis in Taiwanese women

  2015influential citation
• Folic acid supplementation in vitro induces cell type-specific changes in BRCA1 and BRCA 2 mRNA expression, but does not alter DNA methylation of their promoters or DNA repair.

  2015cites this paper
• BRCA1 and 2

  2015cites this paper
• Expression of BRCA1 and BRCA2 proteins and their correlation with clinical staging in breast cancer.

  2015cites this paper
• A new class of small molecule estrogen receptor-alpha antagonists that overcome anti-estrogen resistance

  2015cites this paper
• RAD9A Stabilization and Destabilization Processes in Checkpoint Maintenance and Checkpoint Recovery

  2015cites this paper
• Gestational Exposure as Epigenetic Modifier of Breast Cancer Risk

  2015cites this paper
• Effect of aflatoxin B1 on BRCA1 and BRCA2 genes expression under in vitro cultured cell line of normal Human Mammary Epithelial Cells (HMEC)

  2015cites this paper
• Title Tumor-associated mutations in a conserved structural motif alter physical and biochemical properties of human RAD 51 recombinase Permalink

  2015cites this paper
• The PARP inhibitor AZD2281 (Olaparib) induces autophagy/mitophagy in BRCA1 and BRCA2 mutant breast cancer cells

  2015cites this paper
• Constitutive expression of AhR and BRCA-1 promoter CpG hypermethylation as biomarkers of ERα-negative breast tumorigenesis

  2015cites this paper
• Depletion of eIF2.GTP.Met-tRNAi translation initiation complex up-regulates BRCA1 expression in vitro and in vivo

  2015cites this paper
• Epigenetic Inactivation of BRCA1 Through Promoter Hypermethylation and Its Clinical Importance in Triple-Negative Breast Cancer.

  2015cites this paper
• Protein mislocalization: mechanisms, functions and clinical applications in cancer.

  2014cites this paper
• A germline mutation in the BRCA1 3’UTR predicts Stage IV breast cancer

  2014cites this paper
• miR-185 Suppresses Tumor Proliferation by Directly Targeting E2F6 and DNMT1 and Indirectly Upregulating BRCA1 in Triple-Negative Breast Cancer

  2014cites this paper
• BRCA1 deficiency induces protective autophagy to mitigate stress and provides a mechanism for BRCA1 haploinsufficiency in tumorigenesis.

  2014cites this paper
• Small-molecule "BRCA1-mimetics" are antagonists of estrogen receptor-α.

  2014cites this paper
• Epigenetics of BRCA-1–Related Breast Tumorigenesis and Dietary Prevention

  2014cites this paper
• BRCA1 and Oxidative Stress

  2014cites this paper
• Tumor-associated mutations in a conserved structural motif alter physical and biochemical properties of human RAD51 recombinase

  2014cites this paper
• The Anti-Carcinogenic Effect of Indole-3-Carbinol and 3, 3'-Diindolylmethane and their Mechanism of Action

  2014cites this paper
• Companion Diagnostics and Cancer Biomarkers miR-185 Suppresses Tumor Proliferation by Directly Targeting E 2 F 6 and DNMT 1 and Indirectly Upregulating BRCA 1 in Triple-Negative Breast Cancer

  2014cites this paper
• 53BP1 expression in sporadic and inherited ovarian carcinoma: Relationship to genetic status and clinical outcomes.

  2013cites this paper
• BRCA1 in the DNA damage response and at telomeres

  2013influential citation
• Differing effects of adjuvant chemotherapy according to BRCA1 nuclear expression in gastric cancer

  2013cites this paper
• Hypoxia and Human Genome Stability: Downregulation of BRCA2 Expression in Breast Cancer Cell Lines

  2013cites this paper
• Molecular and Cellular Pathobiology TNRC 9 Downregulates BRCA 1 Expression and Promotes Breast Cancer Aggressiveness

  2013cites this paper
• ROLE OF ESTROGEN IN FAMILIAL BREAST CANCER

  2013cites this paper
• BRCA1 and BRCA2 Gene Mutations Screening In Sporadic Breast Cancer Patients In Kazakhstan

  2013cites this paper
• MammaPrint for Individualized Recurrence Risk Assessment and Treatment Recommendations for Early-Stage Breast Cancer Patients

  2013cites this paper
• Derailed estrogen signaling and breast cancer: an authentic couple.

  2013cites this paper
• Prediction of BRCA 1 GermLine Mutation Status in Patients with Breast Cancer Using Histoprognosis Grade , MS 110 , Lys 27 H 3 , Vimentin , and KI 67

  2013cites this paper
• MYC overexpression and poor prognosis in sporadic breast cancer with BRCA1 deficiency

  2013cites this paper
• Prediction of BRCA1 Germ-Line Mutation Status in Patients with Breast Cancer Using Histoprognosis Grade, MS110, Lys27H3, Vimentin, and KI67

  2013cites this paper
• Localization of BRCA1 protein in breast cancer tissue and cell lines with mutations

  2013cites this paper