Pyrimidine pathways in health and disease.

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Trends in Molecular Medicine

• Publication date

  2005-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/J.MOLMED.2005.07.003PMID 16098809
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Uridine adenosine tetraphosphate: a novel endothelium- derived vasoconstrictive factor

  2005cited by this paper
• Functional analysis of pyrimidine 5'-nucleotidase mutants causing nonspherocytic hemolytic anemia.

  2005cited by this paper
• Hydroxyurea exerts a cytostatic but not immunosuppressive effect on T lymphocytes

  2005cited by this paper
• Novel mutations in the thymidine kinase 2 gene (TK2) associated with fatal mitochondrial myopathy and mitochondrial DNA depletion.

  2005cited by this paper
• A novel thymidine phosphorylase mutation in a Spanish MNGIE patient.

  2005cited by this paper
• Molecular insight into mitochondrial DNA depletion syndrome in two patients with novel mutations in the deoxyguanosine kinase and thymidine kinase 2 genes.

  2005cited by this paper
• New insights in dihydropyrimidine dehydrogenase deficiency: a pivotal role for beta-aminoisobutyric acid?

  2004cited by this paper
• Analysis of pyrimidine synthesis "de novo" intermediates in urine and dried urine filter- paper strips with HPLC-electrospray tandem mass spectrometry.

  2004cited by this paper
• Psychiatric genetics: methods and reviews

  2004cited by this paper
• beta-Ureidopropionase deficiency: an inborn error of pyrimidine degradation associated with neurological abnormalities.

  2004cited by this paper
• Role of platelet-derived endothelial cell growth factor/thymidine phosphorylase in fluoropyrimidine sensitivity

  2003cited by this paper
• Identification of a novel human uridine phosphorylase.

  2003cited by this paper
• Mammalian 5′-Nucleotidases*

  2003cited by this paper
• NUCLEOSIDES, NUCLEOTIDES & NUCLEIC ACIDS

  2003cited by this paper
• Deoxyuridine accumulation in urine in thymidine phosphorylase deficiency (MNGIE)

  2002cited by this paper
• Inhibitors of de novo nucleotide biosynthesis as drugs.

  2002cited by this paper
• Cyclopentenyl cytosine increases the phosphorylation and incorporation into DNA of 1‐β‐D‐arabinofuranosyl cytosine in a human T‐lymphoblastic cell line

  2002cited by this paper
• Detection and location of the enzymes of de novo pyrimidine biosynthesis in mammalian spermatozoa.

  2002cited by this paper
• Defects of pyrimidine degradation: clinical, molecular and diagnostic aspects.

  2002cited by this paper
• Homeostatic control of uridine and the role of uridine phosphorylase: a biological and clinical update.

  2002cited by this paper
• Mutant mitochondrial thymidine kinase in mitochondrial DNA depletion myopathy

  2001cited by this paper
• Multiple inhibitor analysis of the brequinar and leflunomide binding sites on human dihydroorotate dehydrogenase.

  2001cited by this paper
• Fluorouracil modulation in colorectal cancer: lack of improvement with N -phosphonoacetyl- l -aspartic acid or oral leucovorin or interferon, but enhanced therapeutic index with weekly 24-hour infusion schedule--an Eastern Cooperative Oncology Group/Cancer and Leukemia Group B Study.

  2001cited by this paper
• Genetic basis of hemolytic anemia caused by pyrimidine 5' nucleotidase deficiency.

  2001cited by this paper
• Controlled Protein Degradation Regulates Ribonucleotide Reductase Activity in Proliferating Mammalian Cells during the Normal Cell Cycle and in Response to DNA Damage and Replication Blocks*

  2000cited by this paper
• Defects of pyrimidine degradation: clinical, molecular and diagnostic aspects.

  2000cited by this paper
• Nifedipine and Nimodipine Competitively Inhibit Uridine Kinase and Orotidine-Phosphate Decarboxylase: Theoretical Relevance to Poor Outcome in Stroke

  2000cited by this paper
• Urea cycle disorders.

  2000cited by this paper
• Regulation of carbamoyl phosphate synthetase by MAP kinase

  2000cited by this paper
• Kinetics of inhibition of human and rat dihydroorotate dehydrogenase by atovaquone, lawsone derivatives, brequinar sodium and polyporic acid.

  2000cited by this paper
• Thymidine phosphorylase gene mutations in MNGIE, a human mitochondrial disorder.

  1999cited by this paper
• Uridine and its nucleotides: biological actions, therapeutic potentials.

  1999cited by this paper
• Simultaneous separation by high-performance liquid chromatography of carbamoyl aspartate, carbamoyl phosphate and dihydroorotic acid.

  1999cited by this paper
• Dihydropyrimidinase deficiency: structural organization, chromosomal localization, and mutation analysis of the human dihydropyrimidinase gene.

  1998cited by this paper
• Expression and enzymic activity of ecto 5'-nucleotidase in the human male genital tract.

  1998cited by this paper
• Adenovirus Preterminal Protein Binds to the CAD Enzyme at Active Sites of Viral DNA Replication on the Nuclear Matrix

  1998cited by this paper
• Erythrocyte Cdp-Choline Accumulation in Haemolytic Anaemia and Renal Failure (Rf)

  1998cited by this paper
• Leflunomide Inhibits Pyrimidine de Novo Synthesis in Mitogen-stimulated T-lymphocytes from Healthy Humans*

  1998cited by this paper
• Editorial: Metabolic Supplementation with Orotic Acid and Magnesium Orotate

  1998cited by this paper
• Molecular cloning of the human UMP synthase gene and characterization of point mutations in two hereditary orotic aciduria families.

  1997cited by this paper
• When to investigate for purine and pyrimidine disorders. Introduction and review of clinical and laboratory indications

  1997cited by this paper
• Erythrocyte CDP-choline accumulation in haemolytic anaemia and renal failure (RF).

  1997cited by this paper
• Urinary uracil concentrations are a useful guide to genetic disorders associated with neurological deficits and abnormal pyrimidine metabolism

  1997cited by this paper
• Functional Compartmentation of dCTP Pools

  1995cited by this paper
• Hereditary orotic aciduria and other disorders of pyrimidine metabolism

  1995cited by this paper
• Enzymes of nucleotide biosynthesis: differences between intact and lysed cells as well as between species and tissues can be important.

  1995cited by this paper
• Cyclopentenyl uracil: an effective inhibitor of uridine salvage in vivo.

  1995cited by this paper
• Cytotoxic effects of inhibitors of de novo pyrimidine biosynthesis upon Plasmodium falciparum.

  1994cited by this paper
• Formation and breakdown of uridine in ischemic hearts of rats and humans.

  1993cited by this paper
• Cytoplasmic 5'(3')-nucleotidase from human placenta.

  1990cited by this paper
• Sequence-, time- and dose-dependent synergism of methotrexate and 6-mercaptopurine in malignant human T-lymphoblasts.

  1986cited by this paper
• Selective accumulation of cytosol CDP-choline as an isolated erythrocyte defect in chronic hemolysis.

  1983cited by this paper
• Characteristics of a pyrimidine-specific 5'-nucleotidase in human erythrocytes.

  1975cited by this paper
• Hereditary orotic aciduria: long-term therapy with uridine and a trial of uracil.

  1969cited by this paper

• Cytoophidia: Implications and opportunities for cancer treatment.

  2026cites this paper
• Targeting mitochondrial homeostasis as a cancer treatment strategy: current status and future prospects

  2026cites this paper
• Effects of dietary energy and protein levels during brooding on performance, blood parameters, metabolome and gut microbiota in native chickens

  2026cites this paper
• Structure-based design and computational evaluation of new acrylamide derivatives as potent inhibitors of human dihydroorotate dehydrogenase for the treatment of rheumatoid arthritis

  2026cites this paper
• Exploring metabolite diversity in global rapeseed germplasm: insights into ecotypes, geographical influences, and correlations with diabetes

  2025cites this paper
• NK-A 17E-233I: a novel competitive inhibitor of human dihydroorotate dehydrogenase (DHODH) for cancer therapy

  2025cites this paper
• Molecular insight, rational chemical design and computational assessment of thiazole-based DHODH inhibitors: from structural modelling to binding free energy calculations.

  2025cites this paper
• High tide or low tide: the transport and metabolism of mitochondrial nucleotides

  2025cites this paper
• Accelerating drug discovery targeting dihydroorotate dehydrogenase using machine learning and generative AI approaches

  2025cites this paper
• Novel dose- and time-dependent toxicity biomarkers of fentanyl/carfentanyl: uncovered by urine-plasma metabolomics for forensics

  2025cites this paper
• UMP functions as an endogenous regulator of NR4A1 to control gastric cancer progression.

  2025cites this paper
• Mass spectrometry analysis of PM2.5 in poultry farms and the cytotoxicity and metabolism perturbation of BEAS-2B cells

  2025cites this paper
• Identification of pyrimidine metabolism-based molecular subtypes and prognostic signature to predict immune landscape and guide clinical treatment in prostate cancer

  2025cites this paper
• PDE7A inhibition suppresses triple-negative breast cancer by attenuating de novo pyrimidine biosynthesis

  2025cites this paper
• Some unanswered questions about the pyrimidine catabolic pathway: The human macrophage perspective.

  2025cites this paper
• DHODH inhibitors: What will it take to get them into the clinic as antivirals?

  2025cites this paper
• mTORC1 regulates the pyrimidine salvage pathway by controlling UCK2 turnover via the CTLH-WDR26 E3 ligase

  2025cites this paper
• Diagnostic and prognostic value of lactate metabolism-related genes in Sepsis

  2025cites this paper
• Roles of nucleotide metabolism in pancreatic cancer

  2025cites this paper
• Glucose metabolism and its direct action in cancer and immune regulation: opportunities and challenges for metabolic targeting

  2025cites this paper
• Mitochondrial DNA signals driving immune responses: Why, How, Where?

  2025cites this paper
• Targeting vulnerability in tumor therapy: Dihydroorotate dehydrogenase.

  2025cites this paper
• A novel UHPLC-MS/MS approach for simultaneous quantification of pyrimidine metabolites in human biofluids.

  2025cites this paper
• Dietary phytochemical indole-3-carbinol regulates metabolic reprogramming in mouse prostate tissue

  2025cites this paper
• Structural and systems characterization of phosphorylation on metabolic enzymes identifies sex-specific metabolic reprogramming in obesity.

  2025cites this paper
• A Novel Mitochondria-Targeting DHODH Inhibitor Induces Robust Ferroptosis and Alleviates Immune Suppression.

  2024cites this paper
• Multi-omic analysis of precocious puberty girls: pathway changes and metabolite validation

  2024cites this paper
• DHODH inhibition represents a therapeutic strategy and improves abiraterone treatment in castration-resistant prostate cancer

  2024cites this paper
• Changes in Plasma, Urine, and Fecal Metabolome after 16 Weeks of Consuming Dairy With Different Food Matrixes - A Randomized Controlled Trial.

  2024cites this paper
• Emerging Drug Targets for Antimalarial Drug Discovery: Validation and Insights into Molecular Mechanisms of Function.

  2024cites this paper
• Liquid chromatography coupled to mass spectrometry metabolomic analysis of cerebrospinal fluid revealed the metabolic characteristics of moyamoya disease

  2024cites this paper
• Discovery of Thiadiazoles as Human Dihydroorotate Dehydrogenase (hDHODH) Inhibitors by Combined Structure‐Based Modelling Methods

  2024cites this paper
• Development of a machine learning‐based target‐specific scoring function for structure‐based binding affinity prediction for human dihydroorotate dehydrogenase inhibitors

  2024cites this paper
• Effects of a liquid and dry Saccharomyces cerevisiae fermentation product (SCFP) feeding program on ruminal fermentation, total tract digestibility, and plasma metabolome of Holstein steers receiving a grain-based diet.

  2024cites this paper
• Structural and systems characterization of phosphorylation on metabolic enzymes identifies sex-specific metabolic reprogramming in obesity

  2024cites this paper
• Mechanisms of S-phase arrest and mitochondrial dysfunction in complex III by DHODH inhibitors in tumorigenic TNBC cells

  2024cites this paper
• Imidazo- and pyrazolopyrimidine scaffolds as anticancer agents

  2024cites this paper
• A mild skeletal phenotype with overlapping features of Miller syndrome and functional characterisation of two new variants of human dihydroorotate dehydrogenase

  2024cites this paper
• Identification of 1-Methylnicotinamide as a specific biomarker for the progression of cirrhosis to hepatocellular carcinoma

  2024cites this paper
• Construction of S100 family members prognosis prediction model and analysis of immune microenvironment landscape at single-cell level in pancreatic adenocarcinoma: a tumor marker prognostic study

  2024cites this paper
• Interplay between mTOR and Purine Metabolism Enzymes and Its Relevant Role in Cancer

  2024cites this paper
• Molecular diagnostic yield of whole-exome sequencing in Saudi autistic children with epilepsy

  2024cites this paper
• In Silico Virtual Screening Studies Using Molecular Docking of Isoflavonoid Compounds as Potential Antimalarials on the Plasmodium Falciparum Dihydroorotate Dehydrogenase (PfDHODH) Enzyme

  2023cites this paper
• Human uridine 5′-monophosphate synthase stores metabolic potential in inactive biomolecular condensates

  2023cites this paper
• Synthesis and Cytotoxicity Assay of Aniline Substituted Thienopyrimidines for Anti-Colorectal Cancer Activity

  2023cites this paper
• Design and Synthesis of Isobavachalcone Derivatives as Potential Dihydroorotate Dehydrogenase Inhibitors

  2023cites this paper
• Retinoblastoma vulnerability to combined de novo and salvage pyrimidine ribonucleotide synthesis pharmacologic blockage

  2023cites this paper
• Discovery and Optimization of Novel hDHODH Inhibitors for the Treatment of Inflammatory Bowel Disease.

  2023cites this paper
• Intermediate metabolites and molecular correlates of one‑carbon and nutrient metabolism differ in tissues from Holstein fetuses.

  2023cites this paper
• The pyrimidinosome is cancer’s Achilles’ heel

  2023cites this paper
• Recent advances on patents of Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) inhibitors as antimalarial agents

  2023cites this paper
• The evolving landscape of involvement of DTYMK enzymes in cancer

  2023cites this paper
• A patent review of human dihydroorotate dehydrogenase (hDHODH) inhibitors as anticancer agents and their other therapeutic applications (1999-2022).

  2023cites this paper
• Medicinal chemistry approaches for the discovery of Plasmodium falciparum dihydroorotate dehydrogenase inhibitors as antimalarial agents.

  2023cites this paper
• Bok: real killer or bystander with non-apoptotic roles?

  2023cites this paper
• An enzyme-coupled microplate assay for activity and inhibition of hmdUMP hydrolysis by DNPH1.

  2023cites this paper
• Non-canonical role of UCKL1 on ferroptosis defence in colorectal cancer

  2023cites this paper
• Effect of 5-hydroxypyrimidine derivatives and reference drug Aerius on systemic anaphylaxis, concentration of immunoglobulin E and cytokines tested in Balb/c mice

  2023cites this paper
• Caesium carbonate promoted regioselective O-functionalization of 4,6-diphenylpyrimidin-2(1H)-ones under mild conditions and mechanistic insight

  2023cites this paper
• Design and Synthesis of 1,3,5-Triazines or Pyrimidines Containing Dithiocarbamate Moiety as PI3Kα Selective Inhibitors.

  2023cites this paper
• Dihydroorotate dehydrogenase promotes cell proliferation and suppresses cell death in esophageal squamous cell carcinoma and colorectal carcinoma

  2023cites this paper
• Targeting nucleotide metabolism: a promising approach to enhance cancer immunotherapy

  2022influential citation
• CPT1A-mediated fatty acid oxidation promotes cell proliferation via nucleoside metabolism in nasopharyngeal carcinoma

  2022cites this paper
• Re-Discovery of Pyrimidine Salvage as Target in Cancer Therapy

  2022influential citation
• New Insights into the Interaction of Class II Dihydroorotate Dehydrogenases with Ubiquinone in Lipid Bilayers as a Function of Lipid Composition

  2022cites this paper
• Metabolomics of bipolar disorder

  2022cites this paper
• The target site of the novel fungicide quinofumelin, Pyricularia oryzae class II dihydroorotate dehydrogenase

  2022cites this paper
• Unveiling the membrane bound dihydroorotate: Quinone oxidoreductase from Staphylococcus aureus.

  2022cites this paper
• Medical Advances in Hepatitis D Therapy: Molecular Targets

  2022cites this paper
• The Microbiome of Suaeda monoica and Delphinium glaucum From Southern Corniche (Saudi Arabia) Reveals Different Recruitment Patterns of Bacteria and Archaea

  2022influential citation
• Discovery of potential natural dihydroorotate dehydrogenase inhibitors and their synergism with brequinar via integrated molecular docking, dynamic simulations and in vitro approach

  2022cites this paper
• Recent advances of human dihydroorotate dehydrogenase inhibitors for cancer therapy: Current development and future perspectives.

  2022cites this paper
• Based on 2-(difluoromethyl)-1-[4,6-di(4-morpholinyl)-1,3,5-triazin-2-yl]-1H-benzimidazole (ZSTK474), design, synthesis and biological evaluation of novel PI3Kα selective inhibitors.

  2022cites this paper
• Cerebrospinal fluid metabolic profiling reveals divergent modulation of pentose phosphate pathway by midazolam, propofol and dexmedetomidine in patients with subarachnoid hemorrhage: a cohort study

  2022cites this paper
• Emvododstat, a Potent Dihydroorotate Dehydrogenase Inhibitor, Is Effective in Preclinical Models of Acute Myeloid Leukemia

  2022cites this paper
• Protein production, kinetic and biophysical characterization of three human dihydroorotate dehydrogenase mutants associated with Miller syndrome

  2022influential citation
• A Three-mRNA Signature Associated with Pyrimidine Metabolism for Prognosis of BRCA

  2022cites this paper
• Electron Acceptor, Excitation Energies, Oscillatory Strength, Spectroscopic and Solvent Effects on 5-Amino-4,6-Dichloro-2-(Propylthio) Pyrimidine- Anticancer Agent

  2022cites this paper
• Teriflunomide Loaded SPION Nanoparticles Induced Apoptosis in MDA-MB-231 Breast Cancer Cells

  2022cites this paper
• Prognosis stratification in breast cancer and characterization of immunosuppressive microenvironment through a pyrimidine metabolism-related signature

  2022cites this paper
• Metabonomics Study of the Hematopoietic Effect of Medicinal Wine Maoji Jiu on a Blood Deficiency Rat Model by Ultra-High-Performance Liquid Chromatography Coupled to Quadrupole Time-of-Flight Mass Spectrometry and a Pattern Recognition Approach

  2022cites this paper
• Inborn errors of purine and pyrimidine metabolism: A guide to diagnosis.

  2022cites this paper
• A Broad Antiviral Strategy: Inhibitors of Human DHODH Pave the Way for Host-Targeting Antivirals against Emerging and Re-Emerging Viruses

  2022cites this paper
• De novo nucleotide biosynthetic pathway and cancer

  2022cites this paper
• Identification of novel Plasmodium falciparum dihydroorotate dehydrogenase inhibitors for malaria using in silico studies

  2022cites this paper
• Development and evaluation of a simultaneous strategy for pyrimidine metabolome quantification in multiple biological samples.

  2021cites this paper
• Genome-Scale Metabolic Model of Infection with SARS-CoV-2 Mutants Confirms Guanylate Kinase as Robust Potential Antiviral Target

  2021cites this paper
• DHODH and cancer: promising prospects to be explored

  2021influential citation
• A cross-phase reaction coordinate in the formation of a simple copper (II) orotate complex; lability of crystals of a Jahn-Teller active intermediate

  2021cites this paper
• RNA-seq and nuclear proteomics provide insights into the lactation regulation mechanism of goat transfected IGF-I and GH recombinant vectors.

  2021cites this paper
• Exploring the potentials of selected bioactive compounds isolated from Piper guineense Schumach. & Thonn. leaf toward identification of novel pfDHFR and pfDHODH inhibitors as antimalaria agents

  2021cites this paper
• Selection of human single domain antibodies (sdAb) against thymidine kinase 1 and their incorporation into sdAb-Fc antibody constructs for potential use in cancer therapy

  2021cites this paper
• Recent contributions of quinolines to antimalarial and anticancer drug discovery research.

  2021cites this paper
• Design, synthesis, and biological evaluation of N-(3-cyano-1H-indol-5/6-yl)-6-oxo-1,6-dihydropyrimidine-4-carboxamides and 5-(6-oxo-1,6-dihydropyrimidin-2-yl)-1H-indole-3-carbonitriles as novel xanthine oxidase inhibitors.

  2021cites this paper
• Targeting Pyrimidine Metabolism in the Era of Precision Cancer Medicine

  2021cites this paper
• Multi-omics analysis identifies essential regulators of mitochondrial stress response in two wild-type C. elegans strains

  2021cites this paper
• Metabolomic analysis of plasma and intramuscular adipose tissue between Wagyu and Holstein cattle

  2021cites this paper
• Perturbation of serum metabolome in relation to type 2 diabetes mellitus and urinary levels of phthalate metabolites and bisphenols.

  2021cites this paper
• The clinical impact of maternal weight on offspring health: lights and shadows in breast milk metabolome

  2021cites this paper
• Thymidylate synthase is essential for efficient HIV-1 replication in macrophages.

  2021cites this paper