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Phytochemicals as emerging therapeutic agents for alopecia treatment

A. Premanand,V. B. Ancy,J. Jeevanandam,B. Rajkumari,Michael Danquah

Published 2020 in Phytochemicals as Lead Compounds for New Drug Discovery

ABSTRACT

Abstract Alopecia or hair loss is a worldwide unisex dermatological problem which affects aesthetic lifestyle qualities in humans. In recent years, drug discovery for hair loss has gained significant pharmaceutical research attention. Synthetic drugs such as minoxidil, oral finasteride, anthralin cream, and ketoconazole-based antifungal shampoos are some of the commercially available product formulations for hair loss treatment. As these products are mostly chemically derived, their long-term exposure to the skin could result in various side effects and skin disorders. As traditional medicine relies on herbs to treat alopecia, in recent times, different species of herbs are being extracted to generate functional bioactive chemicals as active ingredients to treat hair loss. These biologically derived phytochemicals may offer improved long-term biocompatibility with the skin. This chapter presents an overview of various phytochemicals with antialopecia properties and discusses their modes of action. Additionally, the efficiency of flavonoids, which is a major phytochemical constituent of several herbs and a potential 5α-reductase enzyme inhibitor, as a potential drug for alopecia treatment is also discussed.

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