Brain regeneration in physiology and pathology: the immune signature driving therapeutic plasticity of neural stem cells.

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Physiological Reviews

• Publication date

  2011-10-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1152/physrev.00032.2010PMID 22013212PMCID PMC3552310
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Stem Cell Niche

  2013cited by this paper
• Liver regeneration.

  2012cited by this paper
• Cell-based therapies for Parkinson’s disease

  2011cited by this paper
• Touch gives new life: mechanosensation modulates spinal cord adult neurogenesis

  2011cited by this paper
• The stem cell potential of glia: lessons from reactive gliosis

  2011cited by this paper
• Stem cells in human neurodegenerative disorders--time for clinical translation?

  2010cited by this paper
• Neural stem cell systems: physiological players or in vitro entities?

  2010cited by this paper
• Protective autoimmunity functions by intracranial immunosurveillance to support the mind: The missing link between health and disease

  2010influential reference
• The more you have, the less you get: the functional role of inflammation on neuronal differentiation of endogenous and transplanted neural stem cells in the adult brain

  2010cited by this paper
• CNS-resident glial progenitor/stem cells produce Schwann cells as well as oligodendrocytes during repair of CNS demyelination.

  2010cited by this paper
• Complement and the central nervous system: emerging roles in development, protection and regeneration

  2010cited by this paper
• Proliferation in the human ipsilateral subventricular zone after ischemic stroke

  2010cited by this paper
• IGF‐I stimulates neurogenesis in the hypothalamus of adult rats

  2010cited by this paper
• Dysregulation of kisspeptin and neurogenesis at adolescence link inborn immune deficits to the late onset of abnormal sensorimotor gating in congenital psychological disorders

  2010cited by this paper
• Systemic inflammatory cells fight off neurodegenerative disease

  2010influential reference
• Regulation of learning and memory by meningeal immunity: a key role for IL-4

  2010influential reference
• Signaling in adult neurogenesis.

  2010cited by this paper
• Adult neurogenesis without germinal layers: the "atypical" cerebellum of rabbits.

  2010cited by this paper
• Chordin-induced lineage plasticity of adult SVZ neuroblasts after demyelination

  2010cited by this paper
• Triggering the regeneration and tissue repair programs

  2009cited by this paper
• Behavioral immunization: immunity to self-antigens contributes to psychological stress resilience

  2009cited by this paper
• Human neural stem cells ameliorate autoimmune encephalomyelitis in non‐human primates

  2009cited by this paper
• Neural reconnection in the transected spinal cord of the freshwater turtle Trachemys dorbignyi

  2009cited by this paper
• Transgenic reporter mice as tools for studies of transplantability and connectivity of dopamine neuron precursors in fetal tissue grafts.

  2009cited by this paper
• Multipotent Stromal Cells Are Activated to Reduce Apoptosis in Part by Upregulation and Secretion of Stanniocalcin‐1

  2009cited by this paper
• Signaling in adult neurogenesis.

  2009cited by this paper
• Is there such a thing as a renal stem cell?

  2009cited by this paper
• Adult neural stem cells expressing IL-10 confer potent immunomodulation and remyelination in experimental autoimmune encephalitis.

  2009cited by this paper
• Taking advantage of the systemic immune system to cure brain diseases.

  2009cited by this paper
• Epigenetic reprogramming and induced pluripotency

  2009cited by this paper
• Immune Regulatory Neural Stem/Precursor Cells Protect from Central Nervous System Autoimmunity by Restraining Dendritic Cell Function

  2009influential reference
• Immunology: In the beginning

  2009cited by this paper
• Infiltrating Blood-Derived Macrophages Are Vital Cells Playing an Anti-inflammatory Role in Recovery from Spinal Cord Injury in Mice

  2009cited by this paper
• Immortality and the base of multicellular life: Lessons from cnidarian stem cells.

  2009cited by this paper
• Immune senescence and brain aging: can rejuvenation of immunity reverse memory loss?

  2009cited by this paper
• The stem cell niche

  2009cited by this paper
• Effector T cell interactions with meningeal vascular structures in nascent autoimmune CNS lesions

  2009cited by this paper
• CD4-Positive T Lymphocytes Provide a Neuroimmunological Link in the Control of Adult Hippocampal Neurogenesis1

  2009cited by this paper
• Cell-based therapies in Parkinson’s disease

  2009cited by this paper
• Endothelin-1 Regulates Oligodendrocyte Development

  2009cited by this paper
• Locating the stem cell niche and tracing hepatocyte lineages in human liver

  2009cited by this paper
• Considering the evolution of regeneration in the central nervous system

  2009cited by this paper
• Attenuation of AD‐like neuropathology by harnessing peripheral immune cells: local elevation of IL‐10 and MMP‐9

  2009cited by this paper
• Persistent inflammation alters the function of the endogenous brain stem cell compartment

  2009cited by this paper
• Stem cells and liver repair.

  2009cited by this paper
• The glial nature of embryonic and adult neural stem cells.

  2009influential reference
• Polydendrocytes (NG2 cells): multifunctional cells with lineage plasticity

  2009cited by this paper
• The bright side of the glial scar in CNS repair

  2009influential reference
• Alternative activation of macrophages: an immunologic functional perspective.

  2009cited by this paper
• Evolution and regeneration of the planarian central nervous system

  2009cited by this paper
• Delayed post-ischaemic neuroprotection following systemic neural stem cell transplantation involves multiple mechanisms.

  2009cited by this paper
• Toll-like receptors in the CNS: implications for neurodegeneration and repair.

  2009cited by this paper
• Vaccination as a novel approach for treating depressive behavior.

  2009cited by this paper
• Two Faces of Chondroitin Sulfate Proteoglycan in Spinal Cord Repair: A Role in Microglia/Macrophage Activation

  2008cited by this paper
• Stem cells and niches: mechanisms that promote stem cell maintenance throughout life.

  2008cited by this paper
• Proliferation, neurogenesis and regeneration in the non-mammalian vertebrate brain

  2008cited by this paper
• Stem cells, the molecular circuitry of pluripotency and nuclear reprogramming.

  2008cited by this paper
• Age-Dependent Spatial Memory Loss Can Be Partially Restored by Immune Activation

  2008cited by this paper
• Slicing across kingdoms: regeneration in plants and animals.

  2008cited by this paper
• Toll-like receptor 4 restricts retinal progenitor cell proliferation

  2008cited by this paper
• A specialized vascular niche for adult neural stem cells.

  2008cited by this paper
• Derive and conquer: sourcing and differentiating stem cells for therapeutic applications

  2008cited by this paper
• Estrogen and adult neurogenesis in the amygdala and hypothalamus.

  2008cited by this paper
• Novel and immortalization-based protocols for the generation of neural CNS stem cell lines for gene therapy approaches.

  2008cited by this paper
• Genesis of Neuronal and Glial Progenitors in the Cerebellar Cortex of Peripuberal and Adult Rabbits

  2008cited by this paper
• Comparative aspects of animal regeneration.

  2008cited by this paper
• Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation

  2008cited by this paper
• Neural precursor cells inhibit multiple inflammatory signals.

  2008cited by this paper
• Orchestrating brain-cell renewal: the role of immune cells in adult neurogenesis in health and disease.

  2008cited by this paper
• Lewy body–like pathology in long-term embryonic nigral transplants in Parkinson's disease

  2008cited by this paper
• T lymphocytes potentiate endogenous neuroprotective inflammation in a mouse model of ALS

  2008cited by this paper
• Pericytes: pluripotent cells of the blood brain barrier.

  2008cited by this paper
• Adult zebrafish as a model for successful central nervous system regeneration

  2008cited by this paper
• Persistent inflammation alters the function of the endogenous brain stem cell compartment

  2008cited by this paper
• Molecular Mechanism of Systemic Delivery of Neural Precursor Cells to the Brain: Assembly of Brain Endothelial Apical Cups and Control of Transmigration by CD44

  2008cited by this paper
• Neural stem cells confer unique pinwheel architecture to the ventricular surface in neurogenic regions of the adult brain.

  2008cited by this paper
• Origin and progeny of reactive gliosis: A source of multipotent cells in the injured brain

  2008cited by this paper
• c-Myc is dispensable for direct reprogramming of mouse fibroblasts.

  2008cited by this paper
• Reducing post-traumatic anxiety by immunization.

  2008cited by this paper
• Anti-inflammatory mechanism of intravascular neural stem cell transplantation in haemorrhagic stroke.

  2008cited by this paper
• Spinal Cord Injury Reveals Multilineage Differentiation of Ependymal Cells

  2008influential reference
• Prospects of Cell Therapy for Disorders of Myelin

  2008cited by this paper
• Adaptive Immune Neuroprotection in G93A-SOD1 Amyotrophic Lateral Sclerosis Mice

  2008cited by this paper
• Neuroprotective Effect of Transplanted Human Embryonic Stem Cell-Derived Neural Precursors in an Animal Model of Multiple Sclerosis

  2008cited by this paper
• Immunity to self and self-maintenance: what can tumor immunology teach us about ALS and Alzheimer's disease?

  2008cited by this paper
• Immune-based regulation of adult neurogenesis: implications for learning and memory.

  2008cited by this paper
• Neural Stem/Progenitor Cells Initiate the Formation of Cellular Networks That Provide Neuroprotection by Growth Factor‐Modulated Antioxidant Expression

  2008cited by this paper
• CD4+ T cells support glial neuroprotection, slow disease progression, and modify glial morphology in an animal model of inherited ALS

  2008cited by this paper
• Research in motion: the enigma of Parkinson's disease pathology spread

  2008cited by this paper
• Adult SVZ stem cells lie in a vascular niche: a quantitative analysis of niche cell-cell interactions.

  2008cited by this paper
• Remyelination in the CNS: from biology to therapy

  2008cited by this paper
• The Skin: A Home to Multiple Classes of Epithelial Progenitor Cells

  2008cited by this paper
• IL-1β is an essential mediator of the antineurogenic and anhedonic effects of stress

  2008cited by this paper
• Neonatal chimerization with human glial progenitor cells can both remyelinate and rescue the otherwise lethally hypomyelinated shiverer mouse.

  2008cited by this paper
• Mesenchymal stem cell-mediated immunosuppression occurs via concerted action of chemokines and nitric oxide.

  2008cited by this paper
• [Mammalian neural stem cells].

  2008influential reference
• Response to Comment on "Human Neuroblasts Migrate to the Olfactory Bulb via a Lateral Ventricular Extension"

  2007cited by this paper
• Long-Term Neuroblast Migration Along Blood Vessels in an Area With Transient Angiogenesis and Increased Vascularization After Stroke

  2007cited by this paper
• Generation of germline-competent induced pluripotent stem cells

  2007cited by this paper
• Cellular and molecular processes of regeneration, with special emphasis on fish fins

  2007cited by this paper

• CG-RecNet: a gated and attention-fused deep learning framework for label-free classification of neural stem cell differentiation via imaging flow cytometry.

  2026cites this paper
• 4-Chlorobenzylamine Containing Maleic Acid Derivatives: Synthesis, In Silico Studies, and Anti-Alzheimer's Activity.

  2026cites this paper
• Exosome-derived microRNAs from stem cells from human exfoliated deciduous teeth (SHED): Emerging therapeutics for neurodegenerative disorders.

  2026cites this paper
• Spatial distribution-based progression of spinal cord injury pathology: a key role for neuroimmune cells

  2025cites this paper
• Brain structural plasticity in large-brained mammals: Not only narrowing roads

  2025cites this paper
• Sustaining Brain Youth by Neural Stem Cells: Physiological and Therapeutic Perspectives

  2025influential citation
• Augmentation of neural stem cell proliferation and enhanced differentiation toward neural and oligodendroglia lineages through sonic hedgehog pathway: Cross-activation of Notch1 and SOX10.

  2025cites this paper
• Traumatic Brain Injury Promotes Neurogenesis and Oligodendrogenesis in Subcortical Brain Regions of Mice

  2025cites this paper
• DCX+ cells cripple systemic spleen immunity and promote tumor progression.

  2025cites this paper
• "Cell climbing stones" - varying the surfaces of electrospun nanofibers with protrusions as secondary structures to manipulate neural cell behaviors.

  2025cites this paper
• Molecular signatures of social fear learning with regenerative medicine

  2025cites this paper
• Therapeutic Potential of Third Molar-Derived Dental Pulp Stem Cells in Alzheimer's disease: Current Evidence and Future Directions.

  2025cites this paper
• Melatonin and its physiological and therapeutic effects: A review

  2024cites this paper
• Clickable Granular Hydrogel Scaffolds for Delivery of Neural Progenitor Cells to Sites of Spinal Cord Injury

  2024cites this paper
• Oxygen‐Releasing Hydrogels for Tissue Regeneration

  2024cites this paper
• Deciphering Tuberculous Meningitis: From Clinical Challenges to Novel Models and Pathogenic Pathways.

  2024cites this paper
• Harnessing the Stem Cell Niche in Regenerative Medicine: Innovative Avenue to Combat Neurodegenerative Diseases

  2024influential citation
• The role of small extracellular vesicles and microRNA as their cargo in the spinal cord injury pathophysiology and therapy

  2024cites this paper
• A longitudinal study investigating the effects of noise exposure on behavioural, electrophysiological and self-report measures of hearing in musicians with normal audiometric thresholds.

  2024cites this paper
• Macrophage Polarization-Based Biomaterials for Repairing Spinal Cord Injury

  2024cites this paper
• Characteristic changes in astrocyte properties during astrocyte-to-neuron conversion induced by NeuroD1/Ascl1/Dlx2

  2024cites this paper
• Endogenous neural stem cells characterization using omics approaches: Current knowledge in health and disease

  2023cites this paper
• Modulating axonal growth and neural stem cell migration with the use of uniaxially aligned nanofiber yarns welded with NGF-loaded microparticles

  2023cites this paper
• Adult neurogenesis and “immature” neurons in mammals: an evolutionary trade-off in plasticity?

  2023cites this paper
• Regulation of microglia function by neural stem cells

  2023cites this paper
• Immunomodulatory and Anti-inflammatory effect of Neural Stem/Progenitor Cells in the Central Nervous System

  2023cites this paper
• Adult human neurogenesis: A view from two schools of thought

  2023cites this paper
• Relapse‐associated worsening in a real‐life multiple sclerosis cohort: the role of age and pyramidal phenotype

  2023cites this paper
• Tau and Alzheimer's disease: Past, present and future

  2023cites this paper
• Electroconductive and mechano-competent PUCL@CNT nanohybrid scaffolds guiding neuronal specification of neural stem/progenitor cells

  2023cites this paper
• A Century of Brain Regeneration Phenomena and Neuromorphological Research Advances, 1890s–1990s—Examining the Practical Implications of Theory Dynamics in Modern Biomedicine

  2022cites this paper
• Wnt Signaling Pathways: A Role in Pain Processing

  2022cites this paper
• Prevalence of low dietary zinc intake in women and pregnant women in Ireland

  2022cites this paper
• Using dual polarities of transcranial direct current stimulation in global cerebral ischemia and its following reperfusion period attenuates neuronal injury

  2022cites this paper
• Distinct characteristics of microglia from neurogenic and non-neurogenic regions of the human brain in patients with Mesial Temporal Lobe Epilepsy

  2022cites this paper
• Mapping the acute time course of immune cell infiltration into an ECM hydrogel in a rat model of stroke using 19F MRI.

  2022cites this paper
• SWALLOWING ACTIVATION USING SENSORY STIMULATION IN PATIENTS WITH SEVERE DISORDERS OF CONSCIOUSNESS

  2022influential citation
• The Augmented Cochlear Implant: a Convergence of Drugs and Cochlear Implantation for the Treatment of Hearing Loss

  2022cites this paper
• Disparate progenitor cell populations contribute to maintenance and repair neurogenesis in the zebrafish olfactory epithelium

  2022cites this paper
• The impact of acupuncture on neuroplasticity after ischemic stroke: a literature review and perspectives

  2022cites this paper
• Multi-target cell therapy using a magnetoelectric microscale biorobot for targeted delivery and selective differentiation of SH-SY5Y cells via magnetically driven cell stamping

  2022cites this paper
• Toll-like receptors 2 and 4 differentially regulate the self-renewal and differentiation of spinal cord neural precursor cells

  2021cites this paper
• Biomimetic 3D bacterial cellulose-graphene foam hybrid scaffold regulates neural stem cell proliferation and differentiation.

  2021cites this paper
• KAP1 phosphorylation promotes the survival of neural stem cells after ischemia/reperfusion by maintaining the stability of PCNA

  2021cites this paper
• Dynamics of morphological changes in neural cell culture with a model of neurotrauma in vitro under the influence of conditioned media of the rat fetal brain neurogenic cells

  2021cites this paper
• The PSA-NCAM-Positive “Immature” Neurons: An Old Discovery Providing New Vistas on Brain Structural Plasticity

  2021cites this paper
• Brain Plasticity in Humans and Model Systems: Advances, Challenges, and Future Directions

  2021cites this paper
• Stimulation of the Migration and Expansion of Adult Mouse Neural Stem Cells by the FPR2-Specific Peptide WKYMVm

  2021cites this paper
• The protective effects of neural stem cells and neural stem cells-conditioned medium against inflammation-induced prenatal brain injury.

  2021cites this paper
• Neurogenesis after Spinal Cord Injury: State of the Art

  2021cites this paper
• Endogenous neural stem cells modulate microglia and protect against demyelination

  2021cites this paper
• Modeling Neuroregeneration and Neurorepair in an Aging Context: The Power of a Teleost Model

  2021cites this paper
• Cancer metastasis as a non-healing wound

  2021cites this paper
• Non-invasive, non-pharmacological/bio-technological interventions towards neurorestoration upshot after ischemic stroke, in adults-systematic, synthetic, literature review.

  2021cites this paper
• Therapeutic potential of stem cells for preterm infant brain damage: can we move from the heterogeneity of preclinical and clinical studies to established therapeutics?

  2021cites this paper
• The potential roles of circular RNAs as modulators in traumatic spinal cord injury.

  2021cites this paper
• Low vitamin D levels and the long‐term functional outcome of stroke up to 5 years

  2021cites this paper
• Structurally different anabolic androgenic steroids reduce neurite outgrowth and neuronal viability in primary rat cortical cell cultures.

  2021cites this paper
• The therapeutic potential of exogenous adult stem cells for the injured central nervous system

  2020cites this paper
• Meningeal lymphoid structures are activated under acute and chronic spinal cord pathologies

  2020cites this paper
• Neurodegenerative Diseases and Cell Reprogramming

  2020cites this paper
• Substrate stiffness induced mechanotransduction regulates temporal evolution of human fetal neural progenitor cell phenotype, differentiation, and biomechanics.

  2020cites this paper
• Application of Nanotechnology in Stem-Cell-Based Therapy of Neurodegenerative Diseases

  2020cites this paper
• Phylogenetic variation in cortical layer II immature neuron reservoir of mammals

  2020cites this paper
• Harnessing the Neural Stem Cell Secretome for Regenerative Neuroimmunology

  2020cites this paper
• Exosomes derived from neural progenitor cells preserve photoreceptors during retinal degeneration by inactivating microglia

  2020cites this paper
• The impact of hyperpolarization-activated cyclic nucleotide-gated (HCN) and voltage-gated potassium KCNQ/Kv7 channels on primary microglia function

  2020cites this paper
• Promises and Limitations of Neural Stem Cell Therapies for Progressive Multiple Sclerosis.

  2020cites this paper
• Immunization with neural‐derived peptides increases neurogenesis in rats with chronic spinal cord injury

  2020cites this paper
• Highlight article: Neural stem cell-derived exosomes facilitate spinal cord functional recovery after injury by promoting angiogenesis

  2020cites this paper
• Endogenous neural stem cells modulate microglia and protect from demyelination

  2020cites this paper
• Silencing of circular RNA HIPK2 in neural stem cells enhances functional recovery following ischaemic stroke

  2020cites this paper
• Dynamics of morphological changes in neural cell culture with a model of neurotrauma under the influence of conditioned media of the rat fetal brain neurogenic cells

  2020cites this paper
• Investigating the effects of noise exposure on self-report, behavioral and electrophysiological indices of hearing damage in musicians with normal audiometric thresholds.

  2020cites this paper
• Transplantation of M2-Deviated Microglia Promotes Recovery of Motor Function after Spinal Cord Injury in Mice.

  2020cites this paper
• Newly Generated and Non-Newly Generated “Immature” Neurons in the Mammalian Brain: A Possible Reservoir of Young Cells to Prevent Brain Aging and Disease?

  2019cites this paper
• What physicians and patients should know about different designs of cochlear implant electrodes?

  2019cites this paper
• Endogenous neural precursor cells in health and disease.

  2019cites this paper
• The neural stem cell secretome and its role in brain repair.

  2019cites this paper
• In utero transplantation of neural stem cells ameliorates maternal inflammation‐induced prenatal white matter injury

  2019cites this paper
• Functions of subventricular zone neural precursor cells in stroke recovery.

  2019cites this paper
• Brain Plasticity in Mammals: An Example for the Role of Comparative Medicine in the Neurosciences

  2018influential citation
• Selective killing of spinal cord neural stem cells impairs locomotor recovery in a mouse model of spinal cord injury

  2018cites this paper
• Brain stem cells and IGF-I: implications in development, regeneration and cancer therapeutics

  2018cites this paper
• Resident brain neural precursor cells develop age-dependent loss of therapeutic functions in Alzheimer's mice.

  2018cites this paper
• Brain precursor cells' failure in neurodegeneration

  2018cites this paper
• On the Viability and Potential Value of Stem Cells for Repair and Treatment of Central Neurotrauma: Overview and Speculations

  2018cites this paper
• The plasticity of primary microglia and their multifaceted effects on endogenous neural stem cells in vitro and in vivo

  2018cites this paper
• GDF11 induces differentiation and apoptosis and inhibits migration of C17.2 neural stem cells via modulating MAPK signaling pathway

  2018cites this paper
• Developmental roles of microglia: A window into mechanisms of disease

  2018cites this paper
• Brain Plasticity: Limitations and Possibilities

  2018cites this paper
• Do large brains of long-living mammals prefer non-newly generated, immature neurons?

  2018cites this paper
• Mechanisms of Neural Network Structures Recovery in Brain Trauma

  2018cites this paper
• TrkB receptor antagonism inhibits stab injury induced proliferative response in adult zebrafish (Danio rerio) brain.

  2018cites this paper
• Past, Present and Future of Cell-Based Therapy in Progressive Multiple Sclerosis

  2018cites this paper
• Sensors of Succinate: Neural Stem Cell Grafts Fight Neuroinflammation.

  2018cites this paper
• Neuroplasticity in stroke recovery. The role of microglia in engaging and modifying synapses and networks

  2018cites this paper
• Aggregation‐Induced Emission Luminogens: Union Is Strength, Gathering Illuminates Healthcare

  2018cites this paper
• Microglia Polarization, Gene-Environment Interactions and Wnt/β-Catenin Signaling: Emerging Roles of Glia-Neuron and Glia-Stem/Neuroprogenitor Crosstalk for Dopaminergic Neurorestoration in Aged Parkinsonian Brain

  2018cites this paper
• Evaluation of RGD functionalization in hybrid hydrogels as 3D neural stem cell culture systems.

  2018cites this paper