The Atg8 and Atg12 ubiquitin‐like conjugation systems in macroautophagy

No abstract is available for this paper.

• Publication year

  2008

• Venue

  EMBO Reports

• Publication date

  2008-09-01

• Fields of study

  Biology, Medicine, Computer Science

• Identifiers
  DOI 10.1038/embor.2008.163PMID 18704115PMCID PMC2529362
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Quantitative analysis of autophagy-related protein stoichiometry by fluorescence microscopy

  2008cited by this paper
• Atg8 controls phagophore expansion during autophagosome formation.

  2008cited by this paper
• The Atg16L complex specifies the site of LC3 lipidation for membrane biogenesis in autophagy.

  2008cited by this paper
• Autophagosome formation: core machinery and adaptations

  2007cited by this paper
• Atg8, a ubiquitin-like protein required for autophagosome formation, mediates membrane tethering and hemifusion.

  2007cited by this paper
• The Atg12-Atg5 Conjugate Has a Novel E3-like Activity for Protein Lipidation in Autophagy*

  2007cited by this paper
• Selective degradation of mitochondria by mitophagy.

  2007cited by this paper
• p62/SQSTM1 Binds Directly to Atg8/LC3 to Facilitate Degradation of Ubiquitinated Protein Aggregates by Autophagy*

  2007cited by this paper
• Autophagy and Human Disease

  2007cited by this paper
• Hierarchy of Atg proteins in pre‐autophagosomal structure organization

  2007cited by this paper
• The Crystal Structure of Atg3, an Autophagy-related Ubiquitin Carrier Protein (E2) Enzyme that Mediates Atg8 Lipidation*

  2007cited by this paper
• Atg8L/Apg8L is the fourth mammalian modifier of mammalian Atg8 conjugation mediated by human Atg4B, Atg7 and Atg3

  2006cited by this paper
• Starvation and ULK1-dependent cycling of mammalian Atg9 between the TGN and endosomes

  2006cited by this paper
• Pexophagy: autophagic degradation of peroxisomes.

  2006cited by this paper
• Modification of proteins by ubiquitin and ubiquitin-like proteins.

  2006cited by this paper
• The Crystal Structure of Plant ATG12 and its Biological Implication in Autophagy

  2005cited by this paper
• A new progressive-iterative algorithm for multiple structure alignment

  2005cited by this paper
• Molecular Mechanisms and Regulation of Specific and Nonspecific Autophagy Pathways in Yeast*

  2005cited by this paper
• Autophagy in Health and Disease: A Double-Edged Sword

  2004cited by this paper
• Autophagy Defends Cells Against Invading Group A Streptococcus

  2004cited by this paper
• The crystal structure of microtubule‐associated protein light chain 3, a mammalian homologue of Saccharomyces cerevisiae Atg8

  2004cited by this paper
• LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation

  2004cited by this paper
• GATE-16 and GABARAP are authentic modifiers mediated by Apg7 and Apg3.

  2003cited by this paper
• Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugate

  2003cited by this paper
• In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker.

  2003cited by this paper
• A unified nomenclature for yeast autophagy-related genes.

  2003cited by this paper
• Mouse Apg10 as an Apg12‐conjugating enzyme: analysis by the conjugation‐mediated yeast two‐hybrid method

  2002cited by this paper
• Mechanism of cargo selection in the cytoplasm to vacuole targeting pathway.

  2002cited by this paper
• Convergence of Multiple Autophagy and Cytoplasm to Vacuole Targeting Components to a Perivacuolar Membrane Compartment Prior tode Novo Vesicle Formation*

  2002cited by this paper
• Formation of the approximately 350-kDa Apg12-Apg5.Apg16 multimeric complex, mediated by Apg16 oligomerization, is essential for autophagy in yeast.

  2002cited by this paper
• Human Apg3p/Aut1p Homologue Is an Authentic E2 Enzyme for Multiple Substrates, GATE-16, GABARAP, and MAP-LC3, and Facilitates the Conjugation of hApg12p to hApg5p*

  2002cited by this paper
• Formation of the ∼350-kDa Apg12-Apg5·Apg16 Multimeric Complex, Mediated by Apg16 Oligomerization, Is Essential for Autophagy in Yeast*

  2002cited by this paper
• Cvt19 is a receptor for the cytoplasm-to-vacuole targeting pathway.

  2001cited by this paper
• The C-terminal Region of an Apg7p/Cvt2p Is Required for Homodimerization and Is Essential for Its E1 Activity and E1-E2 Complex Formation*

  2001cited by this paper
• The Human Homolog of Saccharomyces cerevisiae Apg7p Is a Protein-activating Enzyme for Multiple Substrates Including Human Apg12p, GATE-16, GABARAP, and MAP-LC3*

  2001cited by this paper
• The pre‐autophagosomal structure organized by concerted functions of APG genes is essential for autophagosome formation

  2001cited by this paper
• Dissection of Autophagosome Formation Using Apg5-Deficient Mouse Embryonic Stem Cells

  2001cited by this paper
• LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

  2000cited by this paper
• The Itinerary of a Vesicle Component, Aut7p/Cvt5p, Terminates in the Yeast Vacuole via the Autophagy/Cvt Pathways*

  2000influential reference
• A ubiquitin-like system mediates protein lipidation

  2000cited by this paper
• The Reversible Modification Regulates the Membrane-Binding State of Apg8/Aut7 Essential for Autophagy and the Cytoplasm to Vacuole Targeting Pathway

  2000cited by this paper
• Apg10p, a novel protein‐conjugating enzyme essential for autophagy in yeast

  1999cited by this paper
• Formation Process of Autophagosome Is Traced with Apg8/Aut7p in Yeast

  1999cited by this paper
• Apg16p is required for the function of the Apg12p–Apg5p conjugate in the yeast autophagy pathway

  1999cited by this paper
• Apg7p/Cvt2p: A novel protein-activating enzyme essential for autophagy.

  1999cited by this paper
• A protein conjugation system essential for autophagy

  1998cited by this paper
• A New Protein Conjugation System in Human

  1998cited by this paper
• Structure of ubiquitin refined at 1.8 A resolution.

  1987cited by this paper

• GlRac Regulates a Noncanonical, ATG8-Independent Autophagy-Like Pathway in Giardia lamblia

  2026cites this paper
• Lipid metabolic dysregulation: A novel developmental toxicity pathway of aged nanoplastics via inhibition of lipophagy in zebrafish.

  2026cites this paper
• Involvement of two ESCRT-Ⅲ accessory proteins, MoDid2 and MoVta1, in development, pathogenicity, and endocytosis in Magnaporthe oryzae.

  2026cites this paper
• Role of autophagy in antiviral innate immunity.

  2026cites this paper
• The Role of Autophagy in HIV Infection and Immunological Recovery of ART-Treated PLWH

  2025cites this paper
• E2 conjugating enzymes: A silent but crucial player in Ubiquitin Biology.

  2025cites this paper
• Global Analysis of Protein and Small-Molecule Substrates of Ubiquitin-Like Proteins

  2025cites this paper
• Cancer-associated mutations in autophagy-related proteins analyzed in yeast and human cells

  2025cites this paper
• Parkinson's disease‐linked Kir4.2 mutation R28C leads to loss of ion channel function

  2025cites this paper
• Crosstalk Between Cell Death and the cGAS-STING Pathway in Sepsis-Associated Acute Lung Injury

  2025cites this paper
• Rheb ubiquitination drives LC3 lipidation via non-canonical autophagy to promote porcine sperm acrosome reaction.

  2025cites this paper
• Fundamental mechanisms of cell death for polycystic ovary syndrome

  2025cites this paper
• The p.R321C mutation in the p62 protein is associated with abnormalities in the central nervous system

  2025cites this paper
• Deubiquitinase MoAMSH inhibits autophagy by targeting MoAtg6 in Magnaporthe oryzae

  2025cites this paper
• Mitochondrial protein COX5B orchestrates antiviral autophagy and apoptosis to restrict SRBSDV propagation in Sogatella furcifera

  2025cites this paper
• Lactate-coated polyurea-siRNA dendriplex: a gene therapy-directed and metabolism-based strategy to impair glioblastoma (GBM)

  2025cites this paper
• Reduction of microRNA-221 in BVDV infection enhances viral replication by targeting the ATG7-mediated autophagy pathway

  2025cites this paper
• Regulation of autophagy: Insights into O-GlcNAc modification mechanisms.

  2025cites this paper
• The Dual Role of Autophagy in the Pathogenesis of Arboviruses With a Focus on JEV and DENV

  2025cites this paper
• Multifaceted roles of the ATG8 protein family in plant autophagy: from autophagosome biogenesis to cargo recognition.

  2025cites this paper
• Discovery of Evolutionary Loss of the Ubiquitin-like Autophagy-Related ATG12 System in a Lineage of Apicomplexa

  2025cites this paper
• Interaction Between CsATG8f and CsRAP2.12 Modulates Antioxidant Defense and Hypoxia Response During Submergence in Camellia sinensis

  2025cites this paper
• NAD+ Homeostasis and Autophagy: Integrated Control Through Nutrient Signaling in Yeast and Mammals

  2025cites this paper
• Comprehensive analysis of regulated cell death pathways: intrinsic disorder, protein–protein interactions, and cross-pathway communication

  2025cites this paper
• Astragalin actives autophagy and inhibits apoptosis of astrocytes in AD mice via down-regulating Fas/Fasl-VDAC1 pathway.

  2025cites this paper
• Isolation of Mutants Defective in Cytosolic β-galactosidase Degradation in the Methylotrophic Yeast Komagataella phaffii

  2025cites this paper
• Loss of ATG5 expression in a subset of human prostate cancers promotes tumor growth through accumulation of p62

  2025influential citation
• Autophagy plays a dual role in chromoplast transition and degradation and is essential for fruit coloration and ripening

  2025cites this paper
• Histone deacetylase 6 deacetylates and ubiquitinates ATG3 to regulate autophagy

  2025cites this paper
• FOXO is involved in anti-WSSV immunity by regulating Autophagy-related genes.

  2025cites this paper
• The autophagy-specific exocyst subcomplex contributes to phagophore assembly site integrity by promoting phagophore expansion.

  2025cites this paper
• Targeting autophagy for breast cancer prevention and therapy: From classical methods to phytochemical agents

  2024cites this paper
• Phospholipid Supply for Autophagosome Biogenesis.

  2024cites this paper
• Targeting STAT3-Mediated Autophagy with Small Molecules in Cancer Treatment - A Comprehensive Review

  2024cites this paper
• Autophagy-targeting modulation to promote peripheral nerve regeneration

  2024cites this paper
• Oxidative Stress and Cancer Therapy: Controlling Cancer Cells Using Reactive Oxygen Species

  2024cites this paper
• Autophagy related genes mediated mitophagy in yeast, mammals and higher plants.

  2024cites this paper
• Evaluation of Teneligliptin and Retagliptin on the Clearance of Melanosome by Melanophagy in B16F1 Cells

  2024cites this paper
• Targeted proteomics addresses selectivity and complexity of protein degradation by autophagy

  2024cites this paper
• Molecular docking targeting autophagy pathway mediate abrogation of NASH by specific functional foods: update review

  2024cites this paper
• Potential involvement of cuproptosis induced by m6A-modified autophagy gene ATG10 in KICH

  2024cites this paper
• Chondrocyte autophagy mechanism and therapeutic prospects in osteoarthritis

  2024cites this paper
• The Role Played by Autophagy in FcεRI-Dependent Activation of Mast Cells

  2024cites this paper
• Regulation and functions of autophagy during animal development.

  2024cites this paper
• Differential expression of miRNAs associated with pectoral myopathies in young broilers: insights from a comparative transcriptome analysis

  2024cites this paper
• The interplay between autophagy and cGAS-STING signaling and its implications for cancer

  2024cites this paper
• Role of ATG7-dependent non-autophagic pathway in angiogenesis

  2024cites this paper
• NPFs-mediated actin cytoskeleton: a new viewpoint on autophagy regulation

  2024cites this paper
• Natural autophagy modulators in non-communicable diseases: from autophagy mechanisms to therapeutic potential

  2024cites this paper
• Mechanisms and cross-talk of regulated cell death and their epigenetic modifications in tumor progression

  2024cites this paper
• Dinotoms possess two evolutionary distinct autophagy-related ubiquitin-like conjugation systems.

  2024cites this paper
• Autophagy and diabetes

  2023cites this paper
• Drug discovery by targeting the protein–protein interactions involved in autophagy

  2023cites this paper
• mTOR pathway – a potential therapeutic target in stroke

  2023cites this paper
• Role of autophagy in the pathogenesis and regulation of pain.

  2023cites this paper
• Autophagy inhibitors for cancer therapy: Small molecules and nanomedicines.

  2023cites this paper
• The Combined Inhibition of Autophagy and Diacylglycerol Acyltransferase-Mediated Lipid Droplet Biogenesis Induces Cancer Cell Death during Acute Amino Acid Starvation

  2023cites this paper
• FBXW7 promotes autophagy and inhibits proliferation of oral squamous cell carcinoma

  2023cites this paper
• Analysis of the interaction of UBE2Q1 with B4GALT1 and P53: Experimental and molecular modeling study.

  2023cites this paper
• AI-based AlphaFold2 significantly expands the structural space of the autophagy pathway

  2023cites this paper
• Role of autophagy-related proteins ATG8f and ATG8h in the maintenance of autophagic activity in Arabidopsis roots under phosphate starvation

  2023cites this paper
• Nutrient‐dependent signaling pathways that control autophagy in yeast

  2023cites this paper
• High glucose inhibits neural differentiation by excessive autophagy via peroxisome proliferator-activated receptor gamma

  2023cites this paper
• Lactobacillus plantarum postbiotics trigger AMPK‐dependent autophagy to suppress Salmonella intracellular infection and NLRP3 inflammasome activation

  2023cites this paper
• Biological characteristics and pathogenicity of Acanthamoeba

  2023cites this paper
• Research Progress on Autophagy Regulation by Active Ingredients of Traditional Chinese Medicine in the Treatment of Acute Lung Injury

  2023cites this paper
• Autophagy in Inflammatory Response against SARS-CoV-2

  2023cites this paper
• The "Self-eating" of cancer-associated fibroblast: A potential target for cancer.

  2023cites this paper
• Management of diabetic kidney disease: where do we stand?: A narrative review

  2023cites this paper
• Physiological and pathological characteristics of vascular endothelial injury in diabetes and the regulatory mechanism of autophagy

  2023cites this paper
• Role of ceramides and sphingolipidsin Parkinson's disease.

  2023cites this paper
• Effect of ATG12–ATG5-ATG16L1 autophagy E3-like complex on the ability of LC3/GABARAP proteins to induce vesicle tethering and fusion

  2023cites this paper
• Autophagy and its role in osteosarcoma

  2023cites this paper
• Galectins and galectin-mediated autophagy regulation: new insights into targeted cancer therapy

  2023cites this paper
• Deformed wings is an Atg8a-interacting protein that negatively regulates autophagy

  2023cites this paper
• miR-103-3p Regulates the Differentiation and Autophagy of Myoblasts by Targeting MAP4

  2023cites this paper
• Mitochondrial Dysfunction and Mitophagy in Type 2 Diabetes: Pathophysiology and Therapeutic Targets

  2023cites this paper
• Self-eating while being eaten: Elucidating the relationship between aphid feeding and the plant autophagy machinery in Arabidopsis leaves

  2023cites this paper
• Multiple quality control mechanisms monitor yeast chitin synthase folding in the endoplasmic reticulum

  2023cites this paper
• Revealing the role of epigenetic and post-translational modulations of autophagy proteins in the regulation of autophagy and cancer: a therapeutic approach

  2023cites this paper
• Autophagy as a dual-faced host response to viral infections

  2023cites this paper
• ATG16L1 adopts a dual–binding site mode to interact with WIPI2b in autophagy

  2023cites this paper
• Role of autophagy in dysregulation of oral mucosal homeostasis

  2022cites this paper
• A novel narnavirus is widespread in Saccharomyces cerevisiae and impacts multiple host phenotypes

  2022cites this paper
• Canonical and non-canonical roles for ATG8 proteins in autophagy and beyond

  2022cites this paper
• Interaction between apoptosis and autophagy in testicular function

  2022cites this paper
• Autophagy-Based Intervention Strategy in the Management of Hepatotoxicity

  2022cites this paper
• Molecular Mechanism and Regulation of Autophagy and Its Potential Role in Epilepsy

  2022cites this paper
• The crosstalk between sonodynamic therapy and autophagy in cancer

  2022cites this paper
• Keeping the beat against time: Mitochondrial fitness in the aging heart

  2022cites this paper
• Potential mechanisms of quercetin in cancer prevention: focus on cellular and molecular targets

  2022cites this paper
• Interplay between Autophagy and Herpes Simplex Virus Type 1: ICP34.5, One of the Main Actors

  2022cites this paper
• Human milk oligosaccharide 2'-fucosyllactose promotes melanin degradation via the autophagic AMPK–ULK1 signaling axis

  2022cites this paper
• Hyphal Fusions Enable Efficient Nutrient Distribution in Colletotrichum graminicola Conidiation and Symptom Development on Maize

  2022cites this paper
• Targeting autophagy and neuroinflammation pathways with plant‐derived natural compounds as potential antidepressant agents

  2022cites this paper
• DJ-1 activates the Atg5-Atg12-Atg16L1 complex via Sirt1 to influence microglial polarization and alleviate cerebral ischemia/reperfusion-induced inflammatory injury.

  2022cites this paper
• Pathways of integrins in the endo-lysosomal system

  2022cites this paper
• Cell Autophagy in NASH and NASH-Related Hepatocellular Carcinoma

  2022cites this paper
• cGASylation by a bacterial E1-E2 fusion protein primes antiviral immune signaling

  2022cites this paper
• Relish regulates innate immunity via mediating ATG5 activity in Antheraea pernyi.

  2022cites this paper