Expansion of Functionally Immature Transitional B Cells Is Associated with Human-Immunodeficient States Characterized by Impaired Humoral Immunity1

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Journal of Immunology

• Publication date

  2006-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.4049/jimmunol.176.3.1506PMID 16424179
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Selective generation of functional somatically mutated IgM+CD27+, but not Ig isotype-switched, memory B cells in X-linked lymphoproliferative disease.

  2006cited by this paper
• B lymphocyte reconstitution after hematopoietic stem cell transplantation: functional immaturity and slow recovery of memory CD27+ B cells.

  2005influential reference
• Impaired early B cell tolerance in patients with rheumatoid arthritis

  2005cited by this paper
• Impaired humoral immunity in X-linked lymphoproliferative disease is associated with defective IL-10 production by CD4+ T cells.

  2005cited by this paper
• Contribution of stromal cells to the migration, function and retention of plasma cells in human spleen: potential roles of CXCL12, IL‐6 and CD54

  2005cited by this paper
• Expression of RAGs in Peripheral B Cells outside Germinal Centers Is Associated with the Expression of CD51

  2005cited by this paper
• Defective B cell tolerance checkpoints in systemic lupus erythematosus

  2005cited by this paper
• Molecular and cellular pathogenesis of X‐linked lymphoproliferative disease

  2005cited by this paper
• Antigen-selected, immunoglobulin-secreting cells persist in human spleen and bone marrow.

  2004cited by this paper
• Common variable immunodeficiency: a review

  2004influential reference
• Alternative routes to maturity: branch points and pathways for generating follicular and marginal zone B cells

  2004influential reference
• Increased Frequency of CD27- (Naive) B Cells and Their Phenotypic Alteration in HIV Type 1-Infected Patients

  2004cited by this paper
• Peripheral development of B cells in mouse and man

  2004influential reference
• A Division-Linked Mechanism for the Rapid Generation of Ig-Secreting Cells from Human Memory B Cells1

  2003cited by this paper
• Transitional B cells: step by step towards immune competence.

  2003influential reference
• BAFF selectively enhances the survival of plasmablasts generated from human memory B cells.

  2003cited by this paper
• Predominant Autoantibody Production by Early Human B Cell Precursors

  2003influential reference
• Transitional B Lymphocyte Subsets Operate as Distinct Checkpoints in Murine Splenic B Cell Development1

  2002cited by this paper
• Severe deficiency of switched memory B cells (CD27(+)IgM(-)IgD(-)) in subgroups of patients with common variable immunodeficiency: a new approach to classify a heterogeneous disease.

  2002influential reference
• Origins and functions of B-1 cells with notes on the role of CD5.

  2002cited by this paper
• Loss of memory (CD27) B lymphocytes in HIV-1 infection

  2001cited by this paper
• CD40-CD40L independent Ig gene hypermutation suggests a second B cell diversification pathway in humans.

  2001cited by this paper
• Increased Frequency of Pre-germinal Center B Cells and Plasma Cell Precursors in the Blood of Children with Systemic Lupus Erythematosus1

  2001influential reference
• Resolution of Three Nonproliferative Immature Splenic B Cell Subsets Reveals Multiple Selection Points During Peripheral B Cell Maturation1

  2001influential reference
• Bm1–Bm5 Classification of Peripheral Blood B Cells Reveals Circulating Germinal Center Founder Cells in Healthy Individuals and Disturbance in the B Cell Subpopulations in Patients with Primary Sjögren’s Syndrome1

  2001influential reference
• Developmental Switches in Chemokine Response Profiles during B Cell Differentiation and Maturation

  2000cited by this paper
• Disturbed Peripheral B Lymphocyte Homeostasis in Systemic Lupus Erythematosus1

  2000influential reference
• Study of the B cell memory compartment in common variable immunodeficiency

  2000influential reference
• Continued RAG expression in late stages of B cell development and no apparent re-induction after immunizion

  1999cited by this paper
• B Cell Development in the Spleen Takes Place in Discrete Steps and Is Determined by the Quality of B Cell Receptor–Derived Signals

  1999cited by this paper
• Inactivating mutations in an SH2 domain-encoding gene in X-linked lymphoproliferative syndrome.

  1998cited by this paper
• Identification of Functional Human Splenic Memory B Cells by Expression of CD148 and CD27

  1998cited by this paper
• Host response to EBV infection in X-linked lymphoproliferative disease results from mutations in an SH2-domain encoding gene

  1998cited by this paper
• Quiescent memory B cells in human peripheral blood co‐express bcl‐2 and bcl‐xL anti‐apoptotic proteins at high levels

  1998cited by this paper
• Absence of IgD-CD27(+) memory B cell population in X-linked hyper-IgM syndrome.

  1998cited by this paper
• The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM

  1998cited by this paper
• Characterization of immature B cells by a novel monoclonal antibody, by turnover and by mitogen reactivity

  1998cited by this paper
• Human Immunoglobulin (Ig)M+IgD+ Peripheral Blood B Cells Expressing the CD27 Cell Surface Antigen Carry Somatically Mutated Variable Region Genes: CD27 as a General Marker for Somatically Mutated (Memory) B Cells

  1998cited by this paper
• Memory B Cells Are Biased Towards Terminal Differentiation: A Strategy That May Prevent Repertoire Freezing

  1997cited by this paper
• Immunological reconstitution following bone marrow transplantation

  1997cited by this paper
• Germinal Center Founder Cells Display Propensity for Apoptosis before Onset of Somatic Mutation

  1997cited by this paper
• Memory B lymphocytes migrate to bone marrow in humans.

  1997cited by this paper
• Marginal zone B cells exhibit unique activation, proliferative and immunoglobulin secretory responses

  1997cited by this paper
• Transitional B cells are the target of negative selection in the B cell compartment

  1995cited by this paper
• Memory B cells from human tonsils colonize mucosal epithelium and directly present antigen to T cells by rapid up-regulation of B7-1 and B7-2.

  1995cited by this paper
• Analysis of mutations in immunoglobulin heavy chain variable region genes of microdissected marginal zone (MGZ) B cells suggests that the MGZ of human spleen is a reservoir of memory B cells

  1995cited by this paper
• Phenotypic characterization of human B-lymphocyte subpopulations, particularly human CD5+ B-lymphocyte subpopulation within the mantle zones of secondary follicles.

  1994influential reference
• Analysis of somatic mutation in five B cell subsets of human tonsil

  1994cited by this paper
• Developmental regulation of the Bcl‐2 protein and susceptibility to cell death in B lymphocytes.

  1994cited by this paper
• Peripheral B cell maturation. II. Heat-stable antigen(hi) splenic B cells are an immature developmental intermediate in the production of long-lived marrow-derived B cells.

  1993cited by this paper
• B lymphopoiesis in the mouse.

  1993cited by this paper
• Peripheral B cell maturation. I. Immature peripheral B cells in adults are heat-stable antigenhi and exhibit unique signaling characteristics.

  1992cited by this paper
• The ontogeny and functional characteristics of human B-1 (CD5+ B) cells.

  1992cited by this paper
• Identification and analysis of a novel human surface CD5- B lymphocyte subset producing natural antibodies.

  1992cited by this paper
• Human B lymphocytes: phenotype, proliferation, and differentiation.

  1992influential reference
• Regulation of human B-cell ontogeny.

  1990cited by this paper
• B lymphocyte reconstitution after human bone marrow transplantation. Leu-1 antigen defines a distinct population of B lymphocytes.

  1987cited by this paper
• Infection with the human immunodeficiency virus (HIV) is associated with an in vivo increase in B lymphocyte activation and immaturity.

  1987cited by this paper
• Phenotype of recovering lymphoid cell populations after marrow transplantation

  1985cited by this paper
• A Distinctive Pattern of B Cell Immaturity in Perinatal Humans

  1981cited by this paper
• Identification and characterization of circulating human transitional B cells

  year unknowninfluential reference

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  2026cites this paper
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  2026cites this paper
• Effects of two different variants in the MAGT1 gene on B cell subsets, platelet function, and cell glycome composition

  2025cites this paper
• Immunophenotyping of B-Cell Subpopulations by Flow Cytometry.

  2025cites this paper
• Effect of controlled human Plasmodium falciparum infection on B cell subsets in individuals with different levels of malaria immunity

  2025cites this paper
• The Divergent Effect of Different Infant Vaccination Schedules of the 13-Valent Pneumococcal Conjugate Vaccine on Serotype-Specific Immunological Memory

  2024cites this paper
• Pathogenic TNFRSF13B Variant in an Adult Japanese Patient with Common Variable Immunodeficiency

  2024cites this paper
• B-cell dynamics underlying poor response upon split-inactivated influenza virus vaccination

  2024cites this paper
• INTRINSIC/EXTRINSIC APOPTOSIS AND PYROPTOSIS CONTRIBUTE TO THE SELECTIVE DEPLETION OF B CELL SUBSETS IN SEPTIC SHOCK PATIENTS

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  2023cites this paper
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  2021cites this paper
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  2021cites this paper
• B-cell compartment abnormalities are associated with ACLF and mortality in patients with liver cirrhosis.

  2021cites this paper
• Comprehensive phenotyping of human peripheral blood B lymphocytes in healthy conditions

  2021cites this paper
• Predictive Value of Immune Cell Subsets for Mortality Risk in Patients With Sepsis

  2021cites this paper
• Building the Next Generation of Humanized Hemato-Lymphoid System Mice

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• CD4+ T Cell Dependent B Cell Recovery and Function After Autologous Hematopoietic Stem Cell Transplantation

  2021cites this paper
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  2021cites this paper
• Intrinsic Defects in B Cell Development and Differentiation, T Cell Exhaustion and Altered Unconventional T Cell Generation Characterize Human Adenosine Deaminase Type 2 Deficiency

  2021cites this paper
• Common Variable Immunodeficiency: Epidemiology, Pathogenesis, Clinical manifestations, Diagnosis, Classification and Management.

  2020influential citation
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• Common Variable Immunodeficiency : Epidemiology , Pathogenesis , Clinical manifestations , Diagnosis , Classification and Management Running title : Common Variable Immunodeficiency

  2019cites this paper
• Hematopoietic stem cell transplant effectively rescues lymphocyte differentiation and function in DOCK8 2

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• Clinical and immunological features in a cohort of patients with partial DiGeorge syndrome followed at a single center.

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• Hematopoietic stem cell transplant effectively rescues lymphocyte differentiation and function in DOCK 8-deficient patients

  2019cites this paper
• Flow Cytometric-Based Analysis of Defects in Lymphocyte Differentiation and Function Due to Inborn Errors of Immunity

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• The SLAM family receptors: Potential therapeutic targets for inflammatory and autoimmune diseases.

  2018cites this paper
• Ig light chain expression in B cells from patients with common variable immunodeficiency : Is there a correlation to a particular clinical diagnosis?

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  2018cites this paper
• Multiple Sclerosis: Mechanisms and Immunotherapy

  2018cites this paper
• An optimized protocol to quantify signaling in human transitional B cells by phospho flow cytometry.

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  2018cites this paper
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• Origin of Waldenstrom's macroglobulinaemia.

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• Bone marrow T-cell infiltration during acute GVHD is associated with delayed B-cell recovery and function after HSCT.

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• Human B-Cell Development in a Mouse Environment

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• Severe XLP Phenotype Caused by a Novel Intronic Mutation in the SH2D1A Gene

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• The role of transitional B cells in kidney transplantation tolerance

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