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Bioactive compounds of Streptomyces: Biosynthesis to applications

R. Salwan,Vivek Sharma

Published 2020 in Unknown venue

ABSTRACT

Abstract Microorganisms are known to produce a plethora of secondary metabolites and enzymes. The genus Streptomyces, belonging to actinobacteria, is a natural source of diverse metabolites having numerous clinical, agricultural and biotechnological applications. These metabolites of Streptomyces are known for their biological roles such as cell-cell communication, morphogenesis, pathogen suppression, pest management, nutrient acquisitions, and several therapeutic applications. So far, chemical structures of less than 30 % of these compounds have been elucidated. In addition, the basic scaffolds of different secondary metabolites obtained from microorganisms are a source of inspiration for chemists. Recent developments in “gene to metabolites” and “metabolites to gene” based approaches have played a major role in mining and linking the structure and role of different genes in an operon responsible for their biosynthesis. Moreover, the advent of synthetic biology and genome editing tool is emerging as a key player in the exploration and metabolic engineering through the modulation of silent gene clusters for enhanced production and the discovery of new bioactive compounds. Keeping in view the importance of secondary metabolites of Streptomyces, an attempt has been made on the elucidation of structure, biosynthetic pathways, organization of biosynthetic gene clusters and scope of metabolic engineering with special emphasis on polyketides derived compounds of Streptomyces.

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