Effects of a germ-free environment on gut immune regulation and diabetes progression in non-obese diabetic (NOD) mice

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Diabetologia

• Publication date

  2011-03-05

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1007/s00125-011-2097-5PMID 21380595
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Inflammatory Tendencies and Overproduction of IL-17 in the Colon of Young NOD Mice Are Counteracted With Diet Change

  2010influential reference
• Enhanced trafficking to the pancreatic lymph nodes and auto-antigen presentation capacity distinguishes peritoneal B lymphocytes in non-obese diabetic mice

  2010influential reference
• Gut barrier disruption by an enteric bacterial pathogen accelerates insulitis in NOD mice

  2010cited by this paper
• B1 Cells Promote Pancreas Infiltration by Autoreactive T Cells

  2010cited by this paper
• Genetics of type 1A diabetes.

  2009cited by this paper
• Nod2 is required for the regulation of commensal microbiota in the intestine

  2009cited by this paper
• Cd1d-dependent regulation of bacterial colonization in the intestine of mice.

  2009cited by this paper
• Induction of intestinal Th17 cells by segmented filamentous bacteria.

  2009influential reference
• ATP drives lamina propria TH17 cell differentiation

  2008cited by this paper
• Innate immunity and intestinal microbiota in the development of Type 1 diabetes

  2008influential reference
• Gut microbiota and lipopolysaccharide content of the diet influence development of regulatory T cells: studies in germ-free mice

  2008cited by this paper
• The “Perfect Storm” for Type 1 Diabetes

  2008cited by this paper
• Incomplete Killing And Enhanced Activation of Islet-Reactive CD8+ T Cells by FasL-Expressing Dendritic Cells Limits Protection from Diabetes.

  2008cited by this paper
• Targeting CD22 Reprograms B-Cells and Reverses Autoimmune Diabetes

  2008cited by this paper
• Commensal-dependent expression of IL-25 regulates the IL-23–IL-17 axis in the intestine

  2008influential reference
• Effect of intestinal microbiota on the induction of regulatory CD25+ CD4+ T cells

  2008cited by this paper
• Purinergic Control of T Cell Activation by ATP Released Through Pannexin-1 Hemichannels

  2008cited by this paper
• Treatment with CD20-specific antibody prevents and reverses autoimmune diabetes in mice.

  2007cited by this paper
• The NOD Mouse and Its Related Strains

  2007cited by this paper
• Gut flora antigens are not important in the maintenance of regulatory T cell heterogeneity and homeostasis

  2007cited by this paper
• Regulation of B1 cell migration by signals through Toll-like receptors

  2006cited by this paper
• Impaired regulatory T cell function in germ‐free mice

  2006cited by this paper
• Vascular adhesion protein-1 is involved in both acute and chronic inflammation in the mouse.

  2005cited by this paper
• Where CD4+CD25+ T reg cells impinge on autoimmune diabetes

  2005cited by this paper
• Peritoneal B cells govern the outcome of diabetes in non‐obese diabetic mice

  2004cited by this paper
• The immunology of mucosal models of inflammation.

  2002cited by this paper
• Diabetogenic Effects of Lymphocyte Transfusion on the NOD or NOD Nude Mouse

  1987influential reference
• Intestinal microflora: elimination of germfree characteristics by components of the normal microbial flora.

  1979cited by this paper

• Ananalysis of the effects of Treg cell therapy intervention on the gut microbiota of type 1 diabetic mice using 16S rRNA gene sequencing

  2026cites this paper
• Autologous fecal microbiota capsules are safe and potentially preserve beta-cell function in individuals with type 1 diabetes

  2025cites this paper
• Accelerated onset of diabetes in non‐obese diabetic mice fed a refined high‐fat diet

  2024cites this paper
• The protective effect of the intestinal microbiota in type-1 diabetes in NOD mice is limited to a time window in early life

  2024cites this paper
• Homeostatic role of B-1 cells in tissue immunity

  2023cites this paper
• Comparative Analysis of Taxonomic and Functional Gut Microbiota Profiles in Relation to Seroconversion of Thyroid Peroxidase Antibodies in Euthyroid Participants

  2023cites this paper
• Impact of gut-peripheral nervous system axis on the development of diabetic neuropathy

  2023cites this paper
• Can Circadian Eating Pattern Adjustments Reduce Risk or Prevent Development of T2D?

  2023cites this paper
• Comprehensive Approach to Medical Nutrition Therapy in Patients with Type 2 Diabetes Mellitus: From Diet to Bioactive Compounds

  2023cites this paper
• Development of Type 1 Diabetes in Mice Is Associated with a Decrease in IL-2-Producing ILC3 and FoxP3+ Treg in the Small Intestine

  2023cites this paper
• The microbiome and rheumatic heart disease: current knowledge and future perspectives

  2023cites this paper
• The potential mechanism of gut microbiota-microbial metabolites-mitochondrial axis in progression of diabetic kidney disease

  2023cites this paper
• Akkermansia muciniphila and Bifidobacterium bifidum Prevent NAFLD by Regulating FXR Expression and Gut Microbiota

  2023cites this paper
• Symbiotic bacteria-dependent expansion of MR1-reactive T cells causes autoimmunity in the absence of Bcl11b

  2022cites this paper
• The Interaction of Food Allergy and Diabetes: Food Allergy Effects on Diabetic Mice by Intestinal Barrier Destruction and Glucagon-like Peptide 1 Reduction in Jejunum

  2022cites this paper
• Functional and Taxonomic Traits of the Gut Microbiota in Type 1 Diabetes Children at the Onset: A Metaproteomic Study

  2022cites this paper
• Identification of the DPP-IV Inhibitory Peptides from Donkey Blood and Regulatory Effect on the Gut Microbiota of Type 2 Diabetic Mice

  2022cites this paper
• Antibiotics in the pathogenesis of diabetes and inflammatory diseases of the gastrointestinal tract

  2022cites this paper
• Role of gastrointestinal microbial populations, a terra incognita of the human body in the management of intestinal bowel disease and metabolic disorders.

  2022cites this paper
• A Triple Threat? The Role of Diet, Nutrition, and the Microbiota in T1D Pathogenesis

  2021cites this paper
• Gut mycobiome: The probable determinative role of fungi in IBD patients

  2021cites this paper
• Evaluating the reparative effects and the mechanism of action of docosahexaenoic acid on azithromycin-induced lipid metabolism dysfunction.

  2021cites this paper
• Gut microbiota and the immune system and inflammation

  2021cites this paper
• High‐fat diet prevents the development of autoimmune diabetes in NOD mice

  2021cites this paper
• Formation of Autoimmune Lesions Is Independent of Antibiotic Treatment in NOD Mice

  2021cites this paper
• The gut microbiome of laboratory mice: considerations and best practices for translational research

  2021cites this paper
• Comprehensive Analysis of the Effect of Probiotic Intake by the Mother on Human Breast Milk and Infant Fecal Microbiota

  2021cites this paper
• The relevance of DHA with modulating of host-gut microbiome signatures alterations and repairing of lipids metabolism shifts.

  2021cites this paper
• Early-life fingolimod treatment improves intestinal homeostasis and pancreatic immune tolerance in non-obese diabetic mice

  2021cites this paper
• Dietary Indole-3-Carbinol Activates AhR in the Gut, Alters Th17-Microbe Interactions, and Exacerbates Insulitis in NOD Mice

  2021cites this paper
• Microbiota derived factors as drivers of type 1 diabetes.

  2020cites this paper
• Microbiome and Cellular Players in Type 1 Diabetes: From Pathogenesis to Protection

  2020cites this paper
• Exploring the Triple Interaction between the Host Genome, the Epigenome, and the Gut Microbiome in Type 1 Diabetes

  2020influential citation
• The effects of diet and streptozotocin on metabolism and gut microbiota in a type 2 diabetes mellitus mouse model

  2020cites this paper
• MAIT Cells in Type 1 Diabetes Mouse Models.

  2020cites this paper
• Evaluating the Causal Role of Gut Microbiota in Type 1 Diabetes and Its Possible Pathogenic Mechanisms

  2020cites this paper
• The antidiabetic effect and potential mechanisms of natural polysaccharides based on the regulation of gut microbiota

  2020cites this paper
• Amelioration of Autoimmune Diabetes of NOD Mice by Immunomodulating Probiotics

  2020cites this paper
• The crucial role of early-life gut microbiota in the development of type 1 diabetes

  2020cites this paper
• Gut Microbiota and Immune Responses.

  2020cites this paper
• The Gut Microbiome in Autoimmune Diseases

  2019cites this paper
• Activation and pathogenic potential of MOG-specific B cells in spontaneous experimental autoimmune encephalomyelitis

  2019cites this paper
• High Thymic Output of Effector CD4+ Cells May Lead to a Treg : T Effector Imbalance in the Periphery in NOD Mice

  2019cites this paper
• Melatonin regulates the neurotransmitter secretion disorder induced by caffeine through the gut-brain axis in zebrafish (Danio rerio)

  2019cites this paper
• Gut microbiome and type 2 diabetes: where we are and where to go?

  2019cites this paper
• Microbe-metabolite-host axis, two-way action in the pathogenesis and treatment of human autoimmunity.

  2019cites this paper
• Oral LPS Dosing Induces Local Immunological Changes in the Pancreatic Lymph Nodes in Mice

  2019cites this paper
• Autoimmune diabetes mellitus and the leaky gut

  2019cites this paper
• Core Gut Bacteria Analysis of Healthy Mice

  2019cites this paper
• Human gut microbiota transferred to germ-free NOD mice modulate the progression towards type 1 diabetes regardless of the pace of beta cell function loss in the donor

  2019cites this paper
• Germ-free animal experiments in the gut microbiota studies.

  2019cites this paper
• Animal Models of Rheumatoid Arthritis

  2018cites this paper
• Harnessing the power of regulatory T‐cells to control autoimmune diabetes: overview and perspective

  2018cites this paper
• Gut microbiota profiling in Han Chinese with type 1 diabetes.

  2018cites this paper
• Human milk oligosaccharides protect against the development of autoimmune diabetes in NOD-mice

  2018cites this paper
• Diabetes progression and alterations in gut bacterial translocation: prevention by diet supplementation with human milk in NOD mice.

  2018cites this paper
• Evaluation of different mucosal microbiota leads to gut microbiota-based prediction of type 1 diabetes in NOD mice

  2018cites this paper
• Obesity in Type 1 Diabetes: Pathophysiology, Clinical Impact, and Mechanisms.

  2018cites this paper
• Strain-specific helper T cell profile in the gut-associated lymphoid tissue.

  2017cites this paper
• Regulation of type 1 diabetes development and B-cell activation in nonobese diabetic mice by early life exposure to a diabetogenic environment

  2017cites this paper
• Gut Microbiota and IL-17A: Physiological and Pathological Responses

  2017cites this paper
• Animal Models of Type 1 and Type 2 Diabetes Mellitus

  2017cites this paper
• Microbiota in T-cell homeostasis and inflammatory diseases

  2017cites this paper
• Cytotoxic and regulatory roles of mucosal-associated invariant T cells in type 1 diabetes

  2017cites this paper
• Where genes meet environment-integrating the role of gut luminal contents, immunity and pancreas in type 1 diabetes.

  2017cites this paper
• Antibiotics, gut microbiota, environment in early life and type 1 diabetes

  2017cites this paper
• Metabolic pressure and the breach of immunological self-tolerance

  2017cites this paper
• Intestinal dysbiosis and probiotic applications in autoimmune diseases

  2017cites this paper
• The hygiene hypothesis in autoimmunity: the role of pathogens and commensals

  2017cites this paper
• Bugging inflammation: role of the gut microbiota

  2016cites this paper
• Modulation of type 1 and type 2 diabetes risk by the intestinal microbiome

  2016cites this paper
• Polyglandular Autoimmune Inflammation Disparate Effects on Manifestations of Cutting Edge : Commensal Microbiota Has

  2016cites this paper
• Targeting gut microbiota: a potential promising therapy for diabetic kidney disease.

  2016cites this paper
• Cutting Edge: Commensal Microbiota Has Disparate Effects on Manifestations of Polyglandular Autoimmune Inflammation

  2016cites this paper
• Antibiotic-treated versus germ-free rodents for microbiota transplantation studies

  2016cites this paper
• Gut microbiota and immunopathogenesis of diabetes mellitus type 1 and 2.

  2016cites this paper
• Development of pipeline to create and validate metagenomic datasets enabling microbiota associations with host traits

  2016cites this paper
• On the pathogenesis of insulin-dependent diabetes mellitus: the role of microbiota

  2016cites this paper
• Role of the microbiome in the normal and aberrant glycemic response

  2016cites this paper
• A conserved bacterial protein induces pancreatic beta cell expansion during zebrafish development

  2016cites this paper
• Imbalance of Fecal Microbiota at Newly Diagnosed Type 1 Diabetes in Chinese Children

  2016cites this paper
• Prolonged antibiotic treatment induces a diabetogenic intestinal microbiome that accelerates diabetes in NOD mice

  2015cites this paper
• Type 1 diabetes and gut microbiota: Friend or foe?

  2015cites this paper
• Antibiotics in Early Life Alter the Gut Microbiome and Increase Disease Incidence in a Spontaneous Mouse Model of Autoimmune Insulin-Dependent Diabetes

  2015cites this paper
• Genes and Environment as Predisposing Factors in Autoimmunity: Acceleration of Spontaneous Thyroiditis by Dietary Iodide in NOD.H2h4 Mice

  2015cites this paper
• Role of the gastrointestinal ecosystem in the development of type 1 diabetes

  2015cites this paper
• Th17 Cells in Type 1 Diabetes: Role in the Pathogenesis and Regulation by Gut Microbiome

  2015cites this paper
• Postnatal Hematopoiesis and Gut Microbiota in NOD Mice Deviate from C57BL/6 Mice

  2015cites this paper
• A model for the role of gut bacteria in the development of autoimmunity for type 1 diabetes

  2015cites this paper
• Impaired Cholecystokinin-Induced Gallbladder Emptying Incriminated in 1 Spontaneous “ Black ” Pigment Gallstone Formation in Germfree

  2015influential citation
• Genes and Environment as Predisposing Factors in Autoimmunity: Acceleration of Spontaneous Thyroiditis by Dietary Iodide in NOD.H2h4 Mice.

  2015cites this paper
• The gut microbiota and Type 1 Diabetes.

  2015cites this paper
• The intestinal microbiota: its role in health and disease

  2015cites this paper
• Contribution à l’étude des agrégats bifides : sélection, caractérisation, mécanisme et prévention du diabète de type 1

  2015cites this paper
• American Diabetes Association and JDRF Research Symposium: Diabetes and the Microbiome

  2015cites this paper
• The Gut Microbiota Modulates Glycaemic Control and Serum Metabolite Profiles in Non-Obese Diabetic Mice

  2014cites this paper
• pH of Drinking Water Influences the Composition of Gut Microbiome and Type 1 Diabetes Incidence

  2014cites this paper
• Antibiotic Treatment of Pregnant Non‐Obese Diabetic Mice Leads to Altered Gut Microbiota and Intestinal Immunological Changes in the Offspring

  2014cites this paper
• Beyond genetics. Influence of dietary factors and gut microbiota on type 1 diabetes

  2014cites this paper
• A Maternal Gluten-Free Diet Reduces Inflammation and Diabetes Incidence in the Offspring of NOD Mice

  2014cites this paper