HMGB1 as A Therapeutic Target in Autoimmune Diseases: The Journey So Far.

No abstract is available for this paper.

• Publication year

  2019

• Venue

  Journal of Applied Science and Technology

• Publication date

  2019-06-01

• Fields of study

  Medicine

• Identifiers

  No identifiers available.

• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Targeting HMGB 1 in the treatment of sepsis

  2016cited by this paper
• Immunopathogenesis of Myocarditis: The Interplay Between Cardiac Fibroblast Cells, Dendritic Cells, Macrophages and CD4+T Cells

  2015cited by this paper
• MD-2 is required for disulfide HMGB1–dependent TLR4 signaling

  2015influential reference
• Novel Mechanisms of Herbal Therapies for Inhibiting HMGB1 Secretion or Action

  2015cited by this paper
• Up-regulated HMGB1 in EAM directly led to collagen deposition by a PKCβ/Erk1/2-dependent pathway: cardiac fibroblast/myofibroblast might be another source of HMGB1

  2014influential reference
• Inhibition of HMGB1-Induced Angiogenesis by Cilostazol via SIRT1 Activation in Synovial Fibroblasts from Rheumatoid Arthritis

  2014cited by this paper
• “Bright spotty lesions” on spinal magnetic resonance imaging differentiate neuromyelitis optica from multiple sclerosis

  2014cited by this paper
• Toll-like receptors (TLRs) in aquatic animals: signaling pathways, expressions and immune responses.

  2014cited by this paper
• Molecular mechanism and therapeutic modulation of high mobility group box 1 release and action: an updated review

  2014cited by this paper
• Inhibition of high-mobility group box 1 improves myocardial fibrosis and dysfunction in diabetic cardiomyopathy.

  2014cited by this paper
• Anti‐high mobility group box 1 monoclonal antibody ameliorates experimental autoimmune encephalomyelitis

  2013influential reference
• HMGB1 and leukocyte migration during trauma and sterile inflammation.

  2013influential reference
• Idiopathic inflammatory myopathies: pathogenic mechanisms of muscle weakness

  2013cited by this paper
• Inhibition of High-Mobility Group Box 1 Protein (HMGB1) Enhances Bacterial Clearance and Protects against Pseudomonas Aeruginosa Pneumonia in Cystic Fibrosis

  2012cited by this paper
• HMGB1 conveys immunosuppressive characteristics on regulatory and conventional T cells.

  2012cited by this paper
• Immunology in the clinic review series; focus on cancer: tumour‐associated macrophages: undisputed stars of the inflammatory tumour microenvironment

  2012cited by this paper
• HMGB1 is a therapeutic target for sterile inflammation and infection.

  2011cited by this paper
• Anti-high Mobility Group Box-1 Monoclonal Antibody Protects the Blood–Brain Barrier From Ischemia-Induced Disruption in Rats

  2011cited by this paper
• IL-1 receptor/Toll-like receptor signaling in infection, inflammation, stress and neurodegeneration couples hyperexcitability and seizures.

  2011cited by this paper
• Endogenous HMGB1 contributes to ischemia-reperfusion-induced myocardial apoptosis by potentiating the effect of TNF-α/JNK.

  2011cited by this paper
• Role of transforming growth factor-β in airway remodeling in asthma.

  2011cited by this paper
• Monoclonal Anti-HMGB1 (High Mobility Group Box Chromosomal Protein 1) Antibody Protection in Two Experimental Arthritis Models

  2011cited by this paper
• HMGB1 blockade attenuates experimental autoimmune myocarditis and suppresses Th17‐cell expansion

  2011influential reference
• High mobility group box protein 1 in complex with lipopolysaccharide or IL-1 promotes an increased inflammatory phenotype in synovial fibroblasts

  2011cited by this paper
• Toll-like receptors and their dual role in periodontitis: a review.

  2011cited by this paper
• Linking oxidative stress to inflammation: Toll-like receptors.

  2010cited by this paper
• The expression of HMGB1 protein and its receptor RAGE in human malignant tumors

  2010cited by this paper
• High Mobility Group Box 1 Is Upregulated After Spinal Cord Injury and Is Associated With Neuronal Cell Apoptosis

  2010cited by this paper
• HMGB1 and RAGE in inflammation and cancer.

  2010cited by this paper
• HMGB proteins: interactions with DNA and chromatin.

  2010cited by this paper
• Phagocyte partnership during the onset and resolution of inflammation

  2010cited by this paper
• Is HMGB1 a New Indirect Marker for Revealing Fibrosis in Chronic Hepatitis and a New Therapeutic Target in Treatment?

  2010cited by this paper
• Regulation of Adaptive Immunity by the Innate Immune System

  2010cited by this paper
• IL‐6: Regulator of Treg/Th17 balance

  2010cited by this paper
• Site-Specific Production of IL-6 in the Central Nervous System Retargets and Enhances the Inflammatory Response in Experimental Autoimmune Encephalomyelitis1

  2009cited by this paper
• High mobility group box chromosomal protein 1 acts as a proliferation signal for activated T lymphocytes.

  2009cited by this paper
• Therapeutic Targets for Rheumatoid Arthritis

  2009cited by this paper
• The Role of Toll-Like Receptor 2 in Inflammation and Fibrosis during Progressive Renal Injury

  2009cited by this paper
• HMGB1, an innate alarmin, in the pathogenesis of type 1 diabetes.

  2009cited by this paper
• The Hypoxic Synovial Environment Regulates Expression of Vascular Endothelial Growth Factor and Osteopontin in Juvenile Idiopathic Arthritis

  2009cited by this paper
• Tempering the wrath of RAGE: An emerging therapeutic strategy against diabetic complications, neurodegeneration, and inflammation

  2009cited by this paper
• Evolution of the chicken Toll-like receptor gene family: A story of gene gain and gene loss

  2008cited by this paper
• Induction of inflammatory and immune responses by HMGB1–nucleosome complexes: implications for the pathogenesis of SLE

  2008cited by this paper
• Convergence and amplification of toll-like receptor (TLR) and receptor for advanced glycation end products (RAGE) signaling pathways via high mobility group B1 (HMGB1)

  2008cited by this paper
• The interaction of HMGB1 and linker histones occurs through their acidic and basic tails.

  2008cited by this paper
• Pivotal Advance: HMGB1 expression in active lesions of human and experimental multiple sclerosis

  2008cited by this paper
• A brief history of TH17, the first major revision in the TH1/TH2 hypothesis of T cell–mediated tissue damage

  2008cited by this paper
• HMGB1: Endogenous Danger Signaling

  2008cited by this paper
• Extracellular high mobility group box chromosomal protein 1 is a coupling factor for hypoxia and inflammation in arthritis.

  2008cited by this paper
• Dendritic cells and cytokines in human inflammatory and autoimmune diseases.

  2008cited by this paper
• Cholinergic Anti-Inflammatory Pathway Activity and High Mobility Group Box-1 (HMGB1) Serum Levels in Patients with Rheumatoid Arthritis

  2007cited by this paper
• Th17: the third member of the effector T cell trilogy.

  2007cited by this paper
• Anti‐high mobility group box 1 monoclonal antibody ameliorates brain infarction induced by transient ischemia in rats

  2007cited by this paper
• MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment

  2007influential reference
• Increased serum high mobility group box‐1 level in Churg–Strauss syndrome
THIS ARTICLE HAS BEEN RETRACTED

  2007cited by this paper
• The role of the receptor for advanced glycation end-products in lung fibrosis.

  2007cited by this paper
• High mobility group box‐1 protein induces the migration and activation of human dendritic cells and acts as an alarmin

  2007cited by this paper
• A novel pathway of HMGB1‐mediated inflammatory cell recruitment that requires Mac‐1‐integrin

  2007cited by this paper
• High Mobility Group B1 Protein Suppresses the Human Plasmacytoid Dendritic Cell Response to TLR9 Agonists

  2006cited by this paper
• Increased extracellular levels of the novel proinflammatory cytokine high mobility group box chromosomal protein 1 in minor salivary glands of patients with Sjögren's syndrome.

  2006cited by this paper
• HMGB1, a Novel Cytokine-Like Mediator Linking Acute Neuronal Death and Delayed Neuroinflammation in the Postischemic Brain

  2006cited by this paper
• Alarmins: chemotactic activators of immune responses.

  2005cited by this paper
• Intravenous immunoglobulin treatment of multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis.

  2005cited by this paper
• Diagnostic criteria for multiple sclerosis: 2005 revisions to the “McDonald Criteria”

  2005cited by this paper
• Release of High Mobility Group Box 1 by Dendritic Cells Controls T Cell Activation via the Receptor for Advanced Glycation End Products1

  2005cited by this paper
• Intrathecal activation of the IL-17/IL-8 axis in opticospinal multiple sclerosis.

  2005cited by this paper
• Anti-inflammatory immunotherapy for multiple sclerosis/experimental autoimmune encephalomyelitis (EAE) disease.

  2005cited by this paper
• Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis

  2004cited by this paper
• High Mobility Group Box Protein 1: An Endogenous Signal for Dendritic Cell Maturation and Th1 Polarization

  2004cited by this paper
• Regulated expression and subcellular localization of HMGB1, a chromatin protein with a cytokine function

  2004cited by this paper
• Activation of gene expression in human neutrophils by high mobility group box 1 protein.

  2003cited by this paper
• High mobility group box chromosomal protein 1, a DNA binding cytokine, induces arthritis.

  2003cited by this paper
• HMGB1 interacts differentially with members of the Rel family of transcription factors.

  2003cited by this paper
• High mobility group box chromosomal protein 1 plays a role in the pathogenesis of rheumatoid arthritis as a novel cytokine.

  2003influential reference
• Successful treatment of collagen-induced arthritis in mice and rats by targeting extracellular high mobility group box chromosomal protein 1 activity.

  2003influential reference
• Histone acetyl transferases: a role in DNA repair and DNA replication

  2002cited by this paper
• Occupational exposures and autoimmune diseases.

  2002cited by this paper
• High mobility group box chromosomal protein 1: a novel proinflammatory mediator in synovitis.

  2002influential reference
• Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis

  2002cited by this paper
• HMGB1 Interacts with Many Apparently Unrelated Proteins by Recognizing Short Amino Acid Sequences*

  2002cited by this paper
• HMGB1 as a late mediator of lethal systemic inflammation.

  2001cited by this paper
• High Mobility Group 1 Protein (Hmg-1) Stimulates Proinflammatory Cytokine Synthesis in Human Monocytes

  2000cited by this paper
• Differential in vivo modifications of the HMGI(Y) nonhistone chromatin proteins modulate nucleosome and DNA interactions.

  2000cited by this paper
• Regulation of immune responses through inhibitory receptors.

  1999cited by this paper
• HMG-1 as a late mediator of endotoxin lethality in mice.

  1999cited by this paper
• Regulation of DNA-Dependent Activities by the Functional Motifs of the High-Mobility-Group Chromosomal Proteins

  1999cited by this paper
• Proinflammatory cytokines (tumor necrosis factor and interleukin 1) stimulate release of high mobility group protein-1 by pituicytes.

  1999cited by this paper
• IL‐6‐deficient mice resist myelin oligodendrocyte glycoprotein‐induced autoimmune encephalomyelitis

  1998cited by this paper
• Junctional Adhesion Molecule, a Novel Member of the Immunoglobulin Superfamily That Distributes at Intercellular Junctions and Modulates Monocyte Transmigration

  1998cited by this paper
• Multiple sclerosis: In situ evidence for antibody‐ and complement‐mediated demyelination

  1998cited by this paper
• Epidemiology and estimated population burden of selected autoimmune diseases in the United States.

  1997cited by this paper
• High Mobility Group 1 Protein Is Not Stably Associated with the Chromosomes of Somatic Cells

  1997cited by this paper
• Environmental lupus syndromes.

  1995cited by this paper
• The DNA binding site of HMG1 protein is composed of two similar segments (HMG boxes), both of which have counterparts in other eukaryotic regulatory proteins.

  1992cited by this paper
• A human placental cDNA clone that encodes nonhistone chromosomal protein HMG-1.

  1989cited by this paper
• Isolation and characterisation of two calf-thymus chromatin non-histone proteins with high contents of acidic and basic amino acids.

  1973cited by this paper
• EncephalomyelitisDevelopment of Experimental Autoimmune IL-17 Plays an Important Role in the

  year unknowncited by this paper
• Journal of Translational Medicine Serum High Mobility Group Box-1 (hmgb1) Is Closely Associated with the Clinical and Pathologic Features of Gastric Cancer

  year unknowncited by this paper

• No citing papers are available for this paper.