The expression of HMGB1 protein and its receptor RAGE in human malignant tumors

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Molecular and Cellular Biochemistry

• Publication date

  2010-04-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s11010-009-0305-0PMID 19876719
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2001cited by this paper
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  year unknowninfluential reference

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