Immunopathogenesis of Myocarditis: The Interplay Between Cardiac Fibroblast Cells, Dendritic Cells, Macrophages and CD4+T Cells

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Scandinavian Journal of Immunology

• Publication date

  2015-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/sji.12298PMID 25845946
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Macrophage plasticity and polarization in liver homeostasis and pathology

  2014cited by this paper
• Crosstalk between fibroblasts and inflammatory cells.

  2014cited by this paper
• Up-regulated HMGB1 in EAM directly led to collagen deposition by a PKCβ/Erk1/2-dependent pathway: cardiac fibroblast/myofibroblast might be another source of HMGB1

  2014cited by this paper
• Macrophage plasticity and polarization in tissue repair and remodelling

  2013cited by this paper
• TGF-β signaling in tissue fibrosis: redox controls, target genes and therapeutic opportunities.

  2013cited by this paper
• Urokinase Plasminogen Activator Induces Pro-Fibrotic/M2 Phenotype in Murine Cardiac Macrophages

  2013cited by this paper
• Adoptive Transfer of Regulatory T Cells Protects against Coxsackievirus B3-Induced Cardiac Fibrosis

  2013cited by this paper
• IL-1β suppresses TGF-β-mediated myofibroblast differentiation in cardiac fibroblasts

  2013cited by this paper
• Cardiac Fibroblasts Recruit Th17 Cells Infiltration Into Myocardium by Secreting CCL20 in CVB3-Induced acute Viral Myocarditis

  2013cited by this paper
• In Vivo Delivery of Adenoviral Vector Containing Interleukin-17 Receptor A Reduces Cardiac Remodeling and Improves Myocardial Function in Viral Myocarditis Leading to Dilated Cardiomyopathy

  2013cited by this paper
• Reciprocal Interaction between Macrophages and T cells Stimulates IFN-γ and MCP-1 Production in Ang II-induced Cardiac Inflammation and Fibrosis

  2012cited by this paper
• Interleukin-22: Implications for Liver Ischemia-Reperfusion Injury

  2012cited by this paper
• IL-17 contributes to cardiac fibrosis following experimental autoimmune myocarditis by a PKCβ/Erk1/2/NF-κB-dependent signaling pathway.

  2012cited by this paper
• Effects of interleukin-33 on cardiac fibroblast gene expression and activity.

  2012cited by this paper
• IL-13 Promotes Collagen Accumulation in Crohn’s Disease Fibrosis by Down-Regulation of Fibroblast MMP Synthesis: A Role for Innate Lymphoid Cells?

  2012cited by this paper
• Increased Expressions of IL-22 and Th22 cells in the coxsackievirus B3-Induced mice acute viral myocarditis

  2012cited by this paper
• Interleukin-17A contributes to myocardial ischemia/reperfusion injury by regulating cardiomyocyte apoptosis and neutrophil infiltration.

  2012cited by this paper
• Distinct different expression of Th17 and Th9 cells in coxsackie virus B3-induced mice viral myocarditis

  2011cited by this paper
• CD4+CD25+Foxp3+ regulatory T cells suppress cardiac fibrosis in the hypertensive heart

  2011cited by this paper
• The role of Th 17 cells and regulatory T cells in Coxsackievirus B 3-induced myocarditis

  2011cited by this paper
• HMGB1 blockade attenuates experimental autoimmune myocarditis and suppresses Th17‐cell expansion

  2011cited by this paper
• Treatment with a neutralizing anti-murine interleukin-17 antibody after the onset of coxsackievirus b3-induced viral myocarditis reduces myocardium inflammation

  2011cited by this paper
• Protective and pathogenic functions of macrophage subsets

  2011cited by this paper
• NF-κB in the liver—linking injury, fibrosis and hepatocellular carcinoma

  2011cited by this paper
• The role of Th17 cells and regulatory T cells in Coxsackievirus B3-induced myocarditis.

  2011cited by this paper
• Border patrol: regulation of immunity, inflammation and tissue homeostasis at barrier surfaces by IL-22

  2011cited by this paper
• Th17 Cells Contribute to Viral Replication in Coxsackievirus B3-Induced Acute Viral Myocarditis

  2010cited by this paper
• Pivotal role of CD4+ T cells in renal fibrosis following ureteric obstruction.

  2010cited by this paper
• Intramyocardial Fibroblast Myocyte Communication

  2010cited by this paper
• The origin of fibroblasts and mechanism of cardiac fibrosis

  2010cited by this paper
• The role of dendritic cells and regulatory T cells in the regulation of allergic asthma.

  2010cited by this paper
• Dermal fibroblasts promote the migration of dendritic cells.

  2010cited by this paper
• Raised interleukin-17 is immunolocalised to neutrophils in cystic fibrosis lung disease

  2010cited by this paper
• Dendritic cells: bridging innate and adaptive immunity in atopic dermatitis.

  2010cited by this paper
• Cardiovascular effects of arginase inhibition in spontaneously hypertensive rats with fully developed hypertension.

  2010cited by this paper
• Cardiac Fibroblast: The Renaissance Cell

  2009cited by this paper
• Origin of Cardiac Fibroblasts and the Role of Periostin

  2009cited by this paper
• TNF‐α induces TGF‐β1 expression in lung fibroblasts at the transcriptional level via AP‐1 activation

  2009cited by this paper
• Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells

  2009cited by this paper
• The inflammasomes: guardians of the body.

  2009cited by this paper
• Dendritic cells as targets for therapy in rheumatoid arthritis

  2009cited by this paper
• Alternative activation of macrophages: an immunologic functional perspective.

  2009cited by this paper
• Th22 cells represent a distinct human T cell subset involved in epidermal immunity and remodeling.

  2009cited by this paper
• Myocarditis.

  2009cited by this paper
• Myocarditis: Infection Versus Autoimmunity

  2009cited by this paper
• IL-17 induces myocardial fibrosis and enhances RANKL/OPG and MMP/TIMP signaling in isoproterenol-induced heart failure.

  2009cited by this paper
• Migration of dendritic cell subsets and their precursors.

  2008cited by this paper
• Graft-infiltrating dendritic cells and coronary endothelial dysfunction after human heart transplantation.

  2008cited by this paper
• Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces.

  2008cited by this paper
• The biological functions of T helper 17 cell effector cytokines in inflammation.

  2008cited by this paper
• Neonatal and Adult Cardiovascular Pathophysiological Remodeling and Repair

  2008cited by this paper
• Pivotal Advance: Th‐1 cytokines inhibit, and Th‐2 cytokines promote fibrocyte differentiation

  2008cited by this paper
• Cellular and molecular mechanisms of fibrosis

  2008cited by this paper
• Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens

  2008cited by this paper
• Fibroblasts potentiate blood vessel formation partially through secreted factor TIMP-1

  2008cited by this paper
• TLR4 enhances TGF-β signaling and hepatic fibrosis

  2007cited by this paper
• Coxsackievirus-induced myocarditis in mice: a model of autoimmune disease for studying immunotoxicity.

  2007cited by this paper
• Infectious disease, the innate immune response, and fibrosis.

  2007cited by this paper
• Zeisberg, E.M. et al. Endothelial-to-mesenchymal transition contributes to cardiac fibrosis. Nat. Med. 13, 952-961

  2007cited by this paper
• Steady-state and inflammatory dendritic-cell development

  2007cited by this paper
• Taking dendritic cells into medicine

  2007cited by this paper
• Endothelial-to-mesenchymal transition contributes to cardiac fibrosis

  2007cited by this paper
• Macrophage depletion impairs wound healing and increases left ventricular remodeling after myocardial injury in mice.

  2007cited by this paper
• TLR4 enhances TGF-beta signaling and hepatic fibrosis.

  2007cited by this paper
• Structural and functional coupling of cardiac myocytes and fibroblasts.

  2006cited by this paper
• [Cellular and molecular mechanisms of fibrosis].

  2006cited by this paper
• p38 inhibitors prevent TGF-beta-induced myofibroblast transdifferentiation in human tenon fibroblasts.

  2006cited by this paper
• Fibroblasts in cancer

  2006cited by this paper
• Hydrodynamic-Based Delivery of an Interleukin-22-Ig Fusion Gene Ameliorates Experimental Autoimmune Myocarditis in Rats1

  2006cited by this paper
• Renal ischemia-reperfusion injury: new implications of dendritic cell-endothelial cell interactions.

  2006cited by this paper
• IL-12 Protects against Coxsackievirus B3-Induced Myocarditis by Increasing IFN-γ and Macrophage and Neutrophil Populations in the Heart1

  2005cited by this paper
• IPC: professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors.

  2005cited by this paper
• IFN-gamma regulates the expression of B7-H1 in dermal fibroblast cells.

  2005cited by this paper
• Postinfarction Gene Therapy Against Transforming Growth Factor-β Signal Modulates Infarct Tissue Dynamics and Attenuates Left Ventricular Remodeling and Heart Failure

  2005cited by this paper
• Inhibition of TGF-beta signaling exacerbates early cardiac dysfunction but prevents late remodeling after infarction.

  2004cited by this paper
• The epicardium and epicardially derived cells (EPDCs) as cardiac stem cells.

  2004cited by this paper
• Organization of fibroblasts in the heart

  2004cited by this paper
• Increased Collagen Type I Synthesis in Patients With Heart Failure of Hypertensive Origin: Relation to Myocardial Fibrosis

  2004cited by this paper
• Activation of dendritic cells: translating innate into adaptive immunity.

  2004cited by this paper
• Postinfarction gene therapy against transforming growth factor-beta signal modulates infarct tissue dynamics and attenuates left ventricular remodeling and heart failure.

  2004cited by this paper
• Activation of dendritic cells: translating innate into adaptive immunity.

  2004cited by this paper
• Cardiac chamber formation: development, genes, and evolution.

  2003cited by this paper
• Epithelial-mesenchymal transition and its implications for fibrosis.

  2003cited by this paper
• Matrix Metalloproteinases and Myocardial Remodeling in Heart Failure

  2003cited by this paper
• Direct Actions of Urotensin II on the Heart: Implications for Cardiac Fibrosis and Hypertrophy

  2003cited by this paper
• Losartan-Dependent Regression of Myocardial Fibrosis Is Associated With Reduction of Left Ventricular Chamber Stiffness in Hypertensive Patients

  2002cited by this paper
• The cardiac fibroblast, another therapeutic target for mending the broken heart?

  2002cited by this paper
• IL-4 and IL-13 induce myofibroblastic phenotype of human lung fibroblasts through c-Jun NH2-terminal kinase-dependent pathway.

  2001cited by this paper
• Matrix metalloproteinases in pathophysiology and treatment of heart failure.

  2001cited by this paper
• The Origin, Formation and Developmental Significance of the Epicardium: A Review

  2001cited by this paper
• Role of Transforming Growth Factor-b 1 in Cardiovascular Inflammatory Changes Induced by Chronic Inhibition of Nitric Oxide Synthesis

  2000cited by this paper
• Renin-angiotensin-aldosterone system and myocardial fibrosis.

  2000cited by this paper
• Giant Cell Myocarditis: Diagnosis and Treatment

  2000cited by this paper
• Giant cell myocarditis: diagnosis and treatment.

  2000cited by this paper
• Role of Transforming Growth Factor-β1 in Cardiovascular Inflammatory Changes Induced by Chronic Inhibition of Nitric Oxide Synthesis

  2000cited by this paper
• Role of transforming growth factor-beta1 in cardiovascular inflammatory changes induced by chronic inhibition of nitric oxide synthesis.

  2000cited by this paper
• An Essential Role for Interleukin 10 in the Function of Regulatory T Cells That Inhibit Intestinal Inflammation

  1999cited by this paper
• Dendritic cells and the control of immunity

  1998cited by this paper
• Novel roles for chemokines and fibroblasts in interstitial fibrosis.

  1998cited by this paper
• Monitoring tissue repair and fibrosis from a distance.

  1997cited by this paper

• The Therapeutic Targeting Effect of Toll-Like Receptors and Their Related Signaling Pathways in Cardiomyopathy

  2025cites this paper
• IL-23 promotes T cell trafficking in experimental autoimmune myocarditis.

  2025cites this paper
• Silicate-based therapy for inflammatory dilated cardiomyopathy by inhibiting the vicious cycle of immune inflammation via FOXO signaling

  2025cites this paper
• Імунопатологічні аспекти етіопатогенезу міокардиту

  2024cites this paper
• Autoimmune Myocarditis, Old Dogs and New Tricks

  2024cites this paper
• Role of Immune Cells in the Pathogenesis of Myocarditis.

  2023cites this paper
• Modulation of TLR4/NFκB Pathways in Autoimmune Myocarditis

  2023cites this paper
• P2X7 purinergic receptor: A potential target in heart diseases (Review).

  2023cites this paper
• Single-cell transcriptome sequencing of macrophages in common cardiovascular diseases.

  2023cites this paper
• Molecular Imaging Biomarkers in Cardiooncology: A View on Established Technologies and Future Perspectives.

  2023cites this paper
• Exploring the Cellular and Molecular Mechanism of Discoidin Domain Receptors (DDR1 and DDR2) in Bone Formation, Regeneration, and Its Associated Disease Conditions

  2023cites this paper
• Altered Phenotype of Circulating Dendritic Cells and Regulatory T Cells from Patients with Acute Myocarditis

  2022cites this paper
• A model-informed approach to assess the risk of immune checkpoint inhibitor-induced autoimmune myocarditis

  2022cites this paper
• The role of berberine in Covid-19: potential adjunct therapy

  2022cites this paper
• A monocyte/dendritic cell molecular signature of SARS-CoV-2-related multisystem inflammatory syndrome in children with severe myocarditis

  2021cites this paper
• Leaves of Olea europaea L. as a source of oleuropein: characteristics and biological aspects

  2021cites this paper
• Clinical and Translational Article A monocyte/dendritic cell molecular signature of SARS-CoV-2-related multisystem inflammatory syndrome in children with severe myocarditis

  2021cites this paper
• Mathematical modelling of autoimmune myocarditis and the effects of immune checkpoint inhibitors

  2021cites this paper
• THE PROTECTIVE ROLE OF PERICARDIAL MACROPHAGES AND THEIR EFFEROCYTOSIS POTENTIAL DURING EXPERIMENTAL CVB3 MYOCARDITIS

  2020cites this paper
• Analysis of Scars and Keloids by Focused Ion Beam/Scanning Electron Microscopy: Distinguishing Between Hypertrophic Scars and Keloids.

  2020cites this paper
• Deneysel otoi̇mmün mi̇yokardi̇t modeli̇nde ozonun tedavi̇ edi̇ci̇ etki̇si̇ni̇n araştırılması

  2019cites this paper
• Self-reactive CD4+ IL-3+ T cells amplify autoimmune inflammation in myocarditis by inciting monocyte chemotaxis

  2019cites this paper
• HMGB1 as A Therapeutic Target in Autoimmune Diseases: The Journey So Far.

  2019cites this paper
• The role of B regulatory (B10) cells in inflammatory disorders and their potential as therapeutic targets.

  2019cites this paper
• Drug delivery to macrophages: A review of targeting drugs and drug carriers to macrophages for inflammatory diseases.

  2019cites this paper
• Macrophage NLRP3 inflammasome activated by CVB3 capsid proteins contributes to the development of viral myocarditis.

  2019cites this paper
• The Cardiac Microenvironment Instructs Divergent Monocyte Fates and Functions in Myocarditis

  2019cites this paper
• Dual faced HMGB1 plays multiple roles in cardiomyocyte senescence and cardiac inflammatory injury.

  2019cites this paper
• Regulatory Role of CD4+ T Cells in Myocarditis

  2018cites this paper
• Oleuropein prevents the development of experimental autoimmune myocarditis in rats

  2017cites this paper
• Chapter 1 - Cellular Immunity: A Role for Cytokines

  2017cites this paper
• Angiotensin II–C–C chemokine receptor2/5 axis‐dependent monocyte/macrophage recruitment contributes to progression of experimental autoimmune myocarditis

  2017cites this paper
• Transmissible endoplasmic reticulum stress from myocardiocytes to macrophages is pivotal for the pathogenesis of CVB3-induced viral myocarditis

  2017cites this paper
• Macrophages' Role in Tissue Disease and Regeneration.

  2017cites this paper
• Cardiovascular dysfunction in sepsis at the dawn of emerging mediators.

  2017cites this paper
• Developmental origin and lineage plasticity of endogenous cardiac stem cells

  2016cites this paper
• Clinical and Translational Article A monocyte/dendritic cell molecular signature of SARS-CoV-2-related multisystem inflammatory syndrome in children with severe myocarditis

  year unknowncites this paper