Inhibition of microglial activation by the herbal flavonoid baicalein attenuates inflammation-mediated degeneration of dopaminergic neurons

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Journal of neural transmission

• Publication date

  2005-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s00702-004-0213-0PMID 15503194
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Alterations in striatal glial fibrillary acidic protein expression in response to 6-hydroxydopamine-induced denervation

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• Primary rat mesencephalic neuron-glia, neuron-enriched, microglia-enriched, and astroglia-enriched cultures.

  2003cited by this paper
• Novel anti-inflammatory therapy for Parkinson's disease.

  2003cited by this paper
• Dextromethorphan Protects Dopaminergic Neurons against Inflammation-Mediated Degeneration through Inhibition of Microglial Activation

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• Lipopolysaccharide (LPS)-induced dopamine cell loss in culture: roles of tumor necrosis factor-α, interleukin-1β, and nitric oxide

  2002cited by this paper
• Microglial activation‐mediated delayed and progressive degeneration of rat nigral dopaminergic neurons: relevance to Parkinson's disease

  2002cited by this paper
• Role of Nitric Oxide in Inflammation‐Mediated Neurodegeneration

  2002influential reference
• Baicalein attenuates oxidant stress in cardiomyocytes.

  2002cited by this paper
• Distinct Role for Microglia in Rotenone-Induced Degeneration of Dopaminergic Neurons

  2002cited by this paper
• Gö6976 inhibits LPS-induced microglial TNFalpha release by suppressing p38 MAP kinase activation.

  2002cited by this paper
• Peroxynitrite Mediates Neurotoxicity of Amyloid β-Peptide1–42- and Lipopolysaccharide-Activated Microglia

  2002cited by this paper
• Nitric Oxide and Superoxide, a Deadly Cocktail

  2002cited by this paper
• Involvement of inducible nitric oxide synthase in inflammation-induced dopaminergic neurodegeneration.

  2002cited by this paper
• Inhibition by Naloxone Stereoisomers of β-Amyloid Peptide (1–42)-induced Superoxide Production in Microglia and Degeneration of Cortical and Mesencephalic Neurons

  2002cited by this paper
• Protective effects of flavonoids in the roots of Scutellaria baicalensis Georgi against hydrogen peroxide-induced oxidative stress in HS-SY5Y cells.

  2001cited by this paper
• The role of glial cells in Parkinson's disease

  2001cited by this paper
• Baicalein protects cortical neurons from β-amyloid (25-35) induced toxicity

  2001cited by this paper
• Tumor Necrosis Factor α Is Toxic to Embryonic Mesencephalic Dopamine Neurons

  2001cited by this paper
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  2001cited by this paper
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  2001cited by this paper
• The plant flavonoid wogonin suppresses death of activated C6 rat glial cells by inhibiting nitric oxide production.

  2001cited by this paper
• Molecular consequences of activated microglia in the brain: overactivation induces apoptosis.

  2001cited by this paper
• Tumor necrosis factor alpha is toxic to embryonic mesencephalic dopamine neurons.

  2001cited by this paper
• Cytoprotective effect of Scutellaria baicalensis in CA1 hippocampal neurons of rats after global cerebral ischemia.

  2001cited by this paper
• Antioxidant and free radical scavenging effects of baicalein, baicalin and wogonin.

  2000cited by this paper
• Regional Difference in Susceptibility to Lipopolysaccharide-Induced Neurotoxicity in the Rat Brain: Role of Microglia

  2000cited by this paper
• Naloxone protects rat dopaminergic neurons against inflammatory damage through inhibition of microglia activation and superoxide generation.

  2000cited by this paper
• Immune modulatory effects of neural cell adhesion molecules on lipopolysaccharide-induced nitric oxide production by cultured glia.

  2000cited by this paper
• Time dependency of the action of nitric oxide in lipopolysaccharide-interferon-gamma-induced neuronal cell death in murine primary neuron-glia co-cultures.

  2000cited by this paper
• Etiology and pathogenesis of Parkinson's disease.

  1999cited by this paper
• Free radical scavenging and antioxidant activities of flavonoids extracted from the radix of Scutellaria baicalensis Georgi.

  1999influential reference
• Stroke therapy in traditional Chinese medicine (TCM): prospects for drug discovery and development.

  1999cited by this paper
• Neuroinflammatory processes are important in neurodegenerative diseases: an hypothesis to explain the increased formation of reactive oxygen and nitrogen species as major factors involved in neurodegenerative disease development.

  1999cited by this paper
• Inhibitory effects of baicalein and wogonin on lipopolysaccharide-induced nitric oxide production in macrophages.

  1999cited by this paper
• Microglia and the immune pathology of Alzheimer disease.

  1999cited by this paper
• Neurodegenerative disorders: the role of peroxynitrite.

  1999cited by this paper
• Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease

  1999cited by this paper
• 12-Lipoxygenase: classification, possible therapeutic benefits from inhibition, and inhibitors.

  1999cited by this paper
• Microglial and astrocytic involvement in a murine model of Parkinson's disease induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).

  1998cited by this paper
• Lipopolysaccharide Intranigral Injection Induces Inflammatory Reaction and Damage in Nigrostriatal Dopaminergic System

  1998cited by this paper
• Protective effects of baicalein against cell damage by reactive oxygen species.

  1998cited by this paper
• Invited Review Free radicals and the pathobiology of brain dopamine systems

  1998cited by this paper
• Interaction of iron with polyphenolic compounds: application to antioxidant characterization.

  1998cited by this paper
• Synergistic neurotoxic effects of combined treatments with cytokines in murine primary mixed neuron/glia cultures.

  1998cited by this paper
• Comparative study of Scutellaria planipes and Scutellaria baicalensis.

  1998cited by this paper
• The Neuroimmune Hypothesis in Parkinson's Disease

  1997cited by this paper
• Antioxidant and prooxidant behavior of flavonoids: structure-activity relationships.

  1997cited by this paper
• Microglia: a sensor for pathological events in the CNS.

  1996cited by this paper
• Microglia: intrinsic immuneffector cell of the brain.

  1995cited by this paper
• Glia-dependent neurotoxicity and neuroprotection in mesencephalic cultures.

  1995cited by this paper
• The inflammatory response system of brain: implications for therapy of Alzheimer and other neurodegenerative diseases.

  1995cited by this paper
• Expression of inducible nitric oxide synthase causes delayed neurotoxicity in primary mixed neuronal-glial cortical cultures.

  1994cited by this paper
• The correlation between active oxygens scavenging and antioxidative effects of flavonoids.

  1994cited by this paper
• Glutathione peroxidase, glial cells and Parkinson's disease.

  1993cited by this paper
• Free radical scavenging action of baicalein.

  1993cited by this paper
• Microglia and cytokines in neurological disease, with special reference to AIDS and Alzheimer's disease

  1993cited by this paper
• Activated microglia mediate neuronal cell injury via a nitric oxide mechanism.

  1992cited by this paper
• Microglial-produced nitric oxide and reactive nitrogen oxides mediate neuronal cell death.

  1992cited by this paper
• Chapter 36: Astrocytes and Parkinson's disease

  1992cited by this paper
• Heterogeneity in the distribution and morphology of microglia in the normal adult mouse brain.

  1990cited by this paper
• Reactive microglia are positive for HLA‐DR in the substantia nigra of Parkinson's and Alzheimer's disease brains

  1988cited by this paper
• Biochemical pathophysiology of Parkinson's disease.

  1987cited by this paper
• Anti-inflammatory and anti-allergic properties of flavonoids.

  1986cited by this paper
• Studies on Scutellariae radix. VII. Anti-arthritic and anti-inflammatory actions of methanolic extract and flavonoid components from Scutellariae radix.

  1984cited by this paper
• Selective inhibition of platelet lipoxygenase by baicalein.

  1982cited by this paper
• [Pharmacological actions of baicalin and baicalein. 2. On passive anaphylaxis].

  1970cited by this paper
• [Pharmacological actions of baicalin and baicalein. 3. Action on experimental asthma].

  1970cited by this paper

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• Pharmacodynamical research of extracts and compounds in traditional Chinese medicines for Parkinson's disease.

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• Herbal medicine and gut microbiota: exploring untapped therapeutic potential in neurodegenerative disease management

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• Insight into the transcription factors regulating Ischemic Stroke and Glioma in Response to Shared Stimuli.

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• Role of nutraceuticals on neurodegenerative diseases: neuroprotective and immunomodulant activity

  2021cites this paper
• Antioxidative role of Traditional Chinese Medicine in Parkinson's disease.

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• Neuroinflammatory penumbra in Parkinson’s disease

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• Baicalein ameliorates ischemic brain damage through suppressing proinflammatory microglia polarization via inhibiting the TLR4/NF-κB and STAT1 pathway.

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• Parkinson's disease a futile entangle of Mankind's credence on an herbal remedy: A review.

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• Plant natural products as source of new P2 receptors ligands.

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• Natural compounds in the treatment of Parkinson's disease

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• The main bioactive compounds of Scutellaria baicalensis Georgi. for alleviation of inflammatory cytokines: A comprehensive review.

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• Role of flavonoids in neurodegenerative disorders with special emphasis on tangeritin.

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• Citationally Enhanced Semantic Literature Based Discovery

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• Baicalein enhances the effect of low dose Levodopa on the gait deficits and protects dopaminergic neurons in experimental Parkinsonism.

  2019cites this paper
• Natural Products for the Treatment of Neurodegenerative Diseases.

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• CURRENT STATUS AND NOVEL STRATEGIES FOR PREVENTION AND TREATMENT OF PARKINSON’S DISEASE

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• The interrelationship between cerebral ischemic stroke and glioma: a comprehensive study of recent reports

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• Herbal Compounds Play a Role in Neuroprotection through the Inhibition of Microglial Activation

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• Flavonoids as Therapeutic Agents in Alzheimer's and Parkinson's Diseases: A Systematic Review of Preclinical Evidences

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• Salvianolic acid B promotes microglial M2-polarization and rescues neurogenesis in stress-exposed mice.

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• Therapeutic potential of baicalein in Alzheimer ’ s and Parkinson ' s disease

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• Plant-Derived Antiinflammatory Steroid Analogs for Neuroprotection: A Recent Update

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• Baicalein as a potent neuroprotective agent: A review.

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• Effect of total flavonoids from Scutellaria baicalensis on dopaminergic neurons in the substantia nigra.

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• Baicalein inhibits α-synuclein oligomer formation and prevents progression of α-synuclein accumulation in a rotenone mouse model of Parkinson's disease.

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• A pharmacological basis of herbal medicines for epilepsy.

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• Therapeutic Effects of Herbal Chemicals in Traditional Chinese Medicine on Alzheimer's Disease.

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• Oxidative stress and Parkinson's disease: New hopes in treatment with herbal antioxidants.

  2015cites this paper
• Baicalin may have a therapeutic effect in attention deficit hyperactivity disorder.

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  2014cites this paper
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• Natural Compounds (Small Molecules) as Potential and Real Drugs of Alzheimer's Disease

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• Recent advances in herbal medicines treating Parkinson's disease.

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• A new animal model of (chronic) depression induced by repeated and intermittent lipopolysaccharide administration for 4 months.

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• Baicalein protects the brain against neuron impairments induced by MPTP in C57BL/6 mice.

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