Aquaporin-3 in the Epidermis: More than Skin Deep.

The skin is essential for terrestrial life. It is responsible for regulating water permeability and functions as a mechanical barrier that protects against environmental insults, such as microbial infection, ultraviolet light, injury and heat and cold, which could damage the cells of the body and compromise survival of the organism. This barrier is provided by the outer layer, the epidermis, which is composed predominantly of keratinocytes; keratinocytes undergo a program of differentiation to form the stratum corneum comprising the cornified squame "bricks" and lipid "mortar". Dysregulation of this differentiation program can result in skin diseases, including psoriasis and non-melanoma skin cancers, among others. Accumulating evidence in the literature indicates that the water-, glycerol- and hydrogen peroxide-transporting channel aquaporin-3 (AQP3) plays a key role in various processes involved in keratinocyte function, and abnormalities in this channel have been observed in several human skin diseases. Here we discuss the data linking AQP3 to keratinocyte proliferation, migration, differentiation and survival as well as its role in skin properties and functions like hydration, water retention, wound healing, and barrier repair. We also discuss the mechanisms regulating AQP3 levels, localization, and function and the anomalies in AQP3 that are associated with various skin diseases.

• Publication year

  2020

• Venue

  American Journal of Physiology - Cell Physiology

• Publication date

  2020-04-08

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1152/ajpcell.00075.2020PMID 32267715PMCID PMC7311736
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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