Prevention of Skin Tumorigenesis and Impairment of Epidermal Cell Proliferation by Targeted Aquaporin-3 Gene Disruption

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Molecular and Cellular Biology

• Publication date

  2007-10-29

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/MCB.01482-07PMID 17967887PMCID PMC2223314
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Impaired enterocyte proliferation in aquaporin-3 deficiency in mouse models of colitis

  2007cited by this paper
• Defective glycerol metabolism in aquaporin 9 (AQP9) knockout mice

  2007cited by this paper
• Energy metabolism in tumor cells

  2007cited by this paper
• Identification of a keratinocarcinoma cell line expressing AQP3

  2006cited by this paper
• Aquaporin-3-dependent cell migration and proliferation during corneal re-epithelialization.

  2006cited by this paper
• Multistep skin cancer in mice as a model to study the evolution of cancer cells.

  2005influential reference
• Skin damage and mitochondrial dysfunction after acute ultraviolet B irradiation: relationship with nitric oxide production

  2005cited by this paper
• Impairment of angiogenesis and cell migration by targeted aquaporin-1 gene disruption

  2005cited by this paper
• Novel roles of aquaporins revealed by phenotype analysis of knockout mice

  2005cited by this paper
• Progressive Adipocyte Hypertrophy in Aquaporin-7-deficient Mice

  2005cited by this paper
• Aquaporin 7 deficiency is associated with development of obesity through activation of adipose glycerol kinase.

  2005cited by this paper
• Why do cancers have high aerobic glycolysis?

  2004cited by this paper
• Human epidermal energy metabolism is functionally anaerobic

  2003cited by this paper
• Glycerol replacement corrects defective skin hydration, elasticity, and barrier function in aquaporin-3-deficient mice

  2003influential reference
• Aquaporin 3 colocates with phospholipase d2 in caveolin-rich membrane microdomains and is downregulated upon keratinocyte differentiation.

  2003cited by this paper
• Impaired Stratum Corneum Hydration in Mice Lacking Epidermal Water Channel Aquaporin-3*

  2002influential reference
• [Structure and function of water channels].

  2002cited by this paper
• Functional expression of AQP3 in human skin epidermis and reconstructed epidermis.

  2002cited by this paper
• Selectively Reduced Glycerol in Skin of Aquaporin-3-deficient Mice May Account for Impaired Skin Hydration, Elasticity, and Barrier Recovery*

  2002influential reference
• Structure and function of water channels.

  2002cited by this paper
• Mouse models for multistep tumorigenesis.

  2001cited by this paper
• Glycerol: a neglected variable in metabolic processes?

  2001cited by this paper
• Structure and function of aquaporin water channels.

  2000cited by this paper
• AMP-activated kinase reciprocally regulates triacylglycerol synthesis and fatty acid oxidation in liver and muscle: evidence that sn-glycerol-3-phosphate acyltransferase is a novel target.

  1999cited by this paper
• The Role of Phosphometabolites in Cell Proliferation, Energy Metabolism, and Tumor Therapy

  1997influential reference
• Exposure to the n-3 polyunsaturated fatty acid docosahexaenoic acid impairs α1-adrenoceptor-mediated contractile responses and inositol phosphate formation in rat cardiomyocytes

  1996cited by this paper
• Glycerol 3-phosphate-induced ATP production in intact mitochondria from pancreatic B-cells.

  1995cited by this paper
• Localization of MIWC and GLIP water channel homologs in neuromuscular, epithelial and glandular tissues.

  1995cited by this paper
• Glycerol gluconeogenesis in fasting humans.

  1995cited by this paper
• Multistage carcinogenesis in mouse skin.

  1992influential reference
• Chemical carcinogenesis: from animal models to molecular models in one decade.

  1988influential reference
• Studies on the carbohydrate metabolism in psoriatic epidermis.

  1976cited by this paper

• Aquaporins as Regulators of Cutaneous Malignancies: A Comprehensive Review

  2026cites this paper
• Aquaporins in the Skin: Molecular Regulators of Hydration and Potential Targets for Cosmetic Applications

  2025cites this paper
• Protein targets & therapeutics in psoriasis: toward personalization.

  2025cites this paper
• The Expanding Role of Aquaporin-1, Aquaporin-3 and Aquaporin-5 as Transceptors: Involvement in Cancer Development and Potential Druggability

  2025cites this paper
• Aquaporin‐1, aquaporin‐3 and aquaporin‐5 differentially modulate cell biophysical and biomechanical properties, impacting cell stiffness and cell–cell adhesion

  2025cites this paper
• Independent divergences of the aquaporins across different genera highlight the distinct adaptation mechanisms within Mytilida

  2025cites this paper
• Aquaporin 5 transfer via MDA-MB-231 cell extracellular vesicles increases recipient endothelial cell invasion.

  2025cites this paper
• Aquaporin 3 inhibition attenuates imiquimod-induced psoriatic symptoms in a murine model

  2025cites this paper
• Relationship between AQP5 and chemotherapy resistance in colorectal cancer cells and its mechanism

  2025cites this paper
• Aquaporins in colorectal cancer: exploring their role in tumorigenesis, metastasis, and drug response

  2024cites this paper
• Peroxiporins and Oxidative Stress: Promising Targets to Tackle Inflammation and Cancer

  2024cites this paper
• Inhibiting aquaporin‐3 to prevent melanoma progression: The potential of organogold

  2024cites this paper
• The Role of PGC-1α in Aging Skin Barrier Function

  2024cites this paper
• Aquaporins in the Cornea

  2024cites this paper
• Aquaporin Channels in Skin Physiology and Aging Pathophysiology: Investigating Their Role in Skin Function and the Hallmarks of Aging

  2024cites this paper
• The role of Aquaporins in tumorigenesis: implications for therapeutic development

  2024cites this paper
• Blockage of aquaporin‐3 peroxiporin activity by organogold compounds affects melanoma cell adhesion, proliferation and migration

  2024cites this paper
• Important functions and molecular mechanisms of aquaporins family on respiratory diseases: potential translational values

  2024cites this paper
• Aquaporin proteins: A promising frontier for therapeutic intervention in cerebral ischemic injury.

  2024cites this paper
• PPAR-γ/NF-kB/AQP3 axis in M2 macrophage orchestrates lung adenocarcinoma progression by upregulating IL-6

  2024cites this paper
• Aquaglyceroporins in Human Breast Cancer

  2023cites this paper
• Aquaporins in Tumor.

  2023cites this paper
• Aquaporin Inhibitors.

  2023cites this paper
• Aquaporins in Skin.

  2023cites this paper
• Nitric oxide hinders club cell proliferation through Gdpd2 during allergic airway inflammation

  2023cites this paper
• Advanced Glycation End Products and Activation of Toll-like Receptor-2 and -4 Induced Changes in Aquaporin-3 Expression in Mouse Keratinocytes

  2023cites this paper
• Phosphatidylglycerol to Treat Chronic Skin Wounds in Diabetes

  2023cites this paper
• Roles and regulation of Aquaporin-3 in maintaining the gut health: an updated review

  2023cites this paper
• Non-Transport Functions of Aquaporins.

  2023cites this paper
• The Skin and Inflamm-Aging

  2023cites this paper
• Aquaporin water channels: roles beyond renal water handling

  2023cites this paper
• Forensic application of aquaporins.

  2023cites this paper
• Pharmacological Inhibition of Membrane Signaling Mechanisms Reduces the Invasiveness of U87-MG and U251-MG Glioblastoma Cells In Vitro

  2023cites this paper
• Aquaporin 3 inhibition suppresses the mitochondrial respiration rate and viability of multiple myeloma cells.

  2023cites this paper
• The aryl hydrocarbon receptor (AhR) activation mediates benzo(a)pyrene‐induced overexpression of AQP3 and Notch1 in HaCaT cells

  2023cites this paper
• Aquaporin 7 is upregulated through the PI3K-Akt pathway and modulates decidualisation of endometrial stromal cells.

  2023cites this paper
• Expression Profiles of AQP3 and AQP4 in Lung Adenocarcinoma Samples Generated via Bronchoscopic Biopsies

  2022cites this paper
• Aquaporins: A new target for traditional Chinese medicine in the treatment of digestive system diseases

  2022cites this paper
• Molecular mechanism of aquaporin 3 (AQP3) regulating by LMP2A and its crosstalk with 4E-BP1 via ERK signaling pathway in EBV-associated gastric cancer.

  2022cites this paper
• Bioactive peptides from broccoli stems strongly enhance regenerative keratinocytes by stimulating controlled proliferation

  2022cites this paper
• KLF5-mediated aquaporin 3 activated autophagy to facilitate cisplatin resistance of gastric cancer

  2022cites this paper
• The pathogenesis of idiopathic normal pressure hydrocephalus based on the understanding of AQP1 and AQP4

  2022cites this paper
• Anti-tumor effect of aquaporin 3 monoclonal antibody on syngeneic mouse tumor model

  2022cites this paper
• Aquaporins in Cancer Biology

  2022cites this paper
• Aquaporins Are One of the Critical Factors in the Disruption of the Skin Barrier in Inflammatory Skin Diseases

  2022cites this paper
• Clinical value and molecular mechanism of AQGPs in different tumors

  2022cites this paper
• The Characterization of Structure and Prediction for Aquaporin in Tumour Progression by Machine Learning

  2022influential citation
• Critical Role of Aquaporins in Cancer: Focus on Hematological Malignancies

  2022cites this paper
• The differential role of Leydig cells in the skin and gills of Lissotriton italicus larvae

  2022cites this paper
• Aquaglyceroporin Modulators as Emergent Pharmacological Molecules for Human Diseases

  2022influential citation
• Diversification of the aquaporin family in geographical isolated oyster species promote the adaptability to dynamic environments

  2022cites this paper
• Signaling Mechanisms and Pharmacological Modulators Governing Diverse Aquaporin Functions in Human Health and Disease

  2022cites this paper
• Multilayered Modelling of the Metallation of Biological Targets

  2021cites this paper
• Is vitiligo associated with systemic aquaporin-3 deficiency?

  2021cites this paper
• AQP3 and AQP5—Potential Regulators of Redox Status in Breast Cancer

  2021cites this paper
• Snail Soothing and Repairing Cream Improves Skin Hydration after Ablative Fractional CO2 Laser: A Split-Face Randomized Double-Blinded Placebo-Controlled Trial

  2021cites this paper
• Human Aquaporins: Functional Diversity and Potential Roles in Infectious and Non-infectious Diseases

  2021cites this paper
• Unexpected localization of AQP3 and AQP4 induced by migration of primary cultured IMCD cells

  2021cites this paper
• Aquaporins implicated in the cell proliferation and the signaling pathways of cell stemness.

  2021cites this paper
• Goreisan regulates AQP3 expression and improves diarrhea

  2021cites this paper
• Aquaporin 1, 3, and 5 Patterns in Salivary Gland Mucoepidermoid Carcinoma: Expression in Surgical Specimens and an In Vitro Pilot Study

  2020cites this paper
• Aquaporin 3 promotes human extravillous trophoblast migration and invasion

  2020cites this paper
• AQP5 regulates the proliferation and differentiation of epidermal stem cells in skin aging

  2020cites this paper
• Combined Systematic Review and Transcriptomic Analyses of Mammalian Aquaporin Classes 1 to 10 as Biomarkers and Prognostic Indicators in Diverse Cancers

  2020cites this paper
• Molecular mechanism of AQP3 in regulating differentiation and apoptosis of lung cancer stem cells through Wnt/GSK-3β/β-Catenin pathway.

  2020cites this paper
• Expression of transmembrane protein aquaporin-3 in oral epithelial dysplasia and oral squamous cell carcinoma.

  2020cites this paper
• Aquaporins and placenta.

  2020cites this paper
• Aquaporins in lung health and disease: Emerging roles, regulation, and clinical implications.

  2020cites this paper
• Computational Modeling on Aquaporin-3 as Skin Cancer Target: A Virtual Screening Study

  2020cites this paper
• Inhibition of aquaporin-3 in macrophages by a monoclonal antibody as potential therapy for liver injury

  2020cites this paper
• Molecular mechanism of aquapontin (AQP3) in regulating differentiation and apoptosis of lung cancer stem cells through Wnt/GSK-3β/β-Catenin pathway.

  2020cites this paper
• Aquaporin-3 in the Epidermis: More than Skin Deep.

  2020cites this paper
• Identification and characterization of potent and selective aquaporin-3 and aquaporin-7 inhibitors

  2019cites this paper
• MicroRNA-325-3p inhibits cell proliferation and induces apoptosis in hepatitis B virus-related hepatocellular carcinoma by down-regulation of aquaporin 5

  2019cites this paper
• Aquaporin‐3 deficiency slows cyst enlargement in experimental mouse models of autosomal dominant polycystic kidney disease

  2019cites this paper
• Propolis Induces AQP3 Expression: A Possible Way of Action in Wound Healing

  2019cites this paper
• Regulation of glycerol efflux in adipocytes

  2019cites this paper
• Aquaporin water channels: New perspectives on the potential role in inflammation.

  2019cites this paper
• Inhibitors of Mammalian Aquaporin Water Channels

  2019cites this paper
• Computational Modeling on Aquaporin-3 as Skin Cancer Target: A Virtual Screening and Molecular Dynamic Simulation Study

  2019cites this paper
• Screening and Validation of Aquaporin Inhibitors for Cancer Therapeutics

  2019cites this paper
• Unveiling the Mechanisms of Aquaglyceroporin-3 Water and Glycerol Permeation by Metadynamics.

  2019cites this paper
• Lipid Profile and Aquaporin Expression under Oxidative Stress in Breast Cancer Cells of Different Malignancies

  2019cites this paper
• Aquaporins in female specific cancers.

  2019cites this paper
• Study of the Mechanism Underlying the Onset of Diabetic Xeroderma Focusing on an Aquaporin-3 in a Streptozotocin-Induced Diabetic Mouse Model

  2019cites this paper
• Integrated analysis and knockdown of RAB23 indicate the role of RAB23 in gastric adenocarcinoma.

  2019cites this paper
• Emergent Nanotechnological Strategies for Systemic Chemotherapy against Melanoma

  2019cites this paper
• Response to Letter to the Editor on “Anti-Psoriatic Drug Monomethylfumarate Increases Nuclear Factor Erythroid 2-Related Factor 2 Levels and Induces Aquaporin-3 mRNA and Protein Expression”

  2018cites this paper
• Effect of Yupingfeng granules on the skin barrier in atopic dermatitis mice models

  2018cites this paper
• Mechanisms of Aquaporin-Facilitated Cancer Invasion and Metastasis

  2018cites this paper
• The Emerging Role of microRNAs in Aquaporin Regulation

  2018cites this paper
• Impact of AQP-5 on the growth of colorectal cancer cells and the underlying mechanism.

  2018cites this paper
• Aquaporin 5 promotes corneal wound healing

  2018cites this paper
• Chapter 4 Role of Aquaporins in Breast Cancer Progression and Metastasis

  2018cites this paper
• Effect of aquaporin 3 knockdown by RNA interference on antrum formation in sheep secondary follicles cultured in vitro

  2018cites this paper
• Ion Channels in Cancer: Are Cancer Hallmarks Oncochannelopathies?

  2018cites this paper
• Protein biomarker for psoriasis: A systematic review on their role in the pathomechanism, diagnosis, potential targets and treatment of psoriasis.

  2018cites this paper
• Inorganic Compounds as Aquaporin Substrates or as Potent Inhibitors: A Coordination Chemistry Point of View

  2018cites this paper
• Ion Channels in Cancer

  2018cites this paper
• Expression of aquaporin 3 and vascular endothelial growth factor in transitional cell carcinoma-urinary bladder: an immunohistochemical study

  2018cites this paper