Antibody-mediated enhancement of disease in feline infectious peritonitis: Comparisons with dengue hemorrhagic fever

Non-immune kittens passively immunized with feline serum containing high-titered antibodies reactive with feline infectious peritonitis virus (FIPV) developed a more rapid disease after FIPV challenge than did kittens pretreated with FIPV antibody-negative serum. Antibody-sensitized, FIPV challenged—kittens developed earlier clinical signs (including pyrexia, icterus, and thrombocytopenia) and died more rapidly than did non-sensitized, FIPV-challenged kittens. Mean survival time in sensitized kittens was significantly (P < 0.05) reduced compared to non-sensitized kittens (mean ± SEM, 10.0 ± 0.6 days vs. 28.8 ± 8.3 days, respectively). Lesions induced included fibrinous peritonitis, disseminated pyogranulomatous inflammation and necrotizing phlebitis and periphlebitis. FIPV antigen, immunoglobulin G, complement (C3) and fibrinogen were demonstrated in lesions by immunofluorescence microscopy. The pathogenesis of dengue hemorrhagic fever (DHF) in persons bears striking resemblance to that of FIP in experimental kittens. In both FIP and DHF, non-neutralizing antibody may promote acute disease by enhancement of virus infection in mononuclear phagocytes or by formation of immune complexes, activation of complement and secondary vascular disturbances.

• Publication year

  2002

• Venue

  Comparative Immunology, Microbiology & Infectious Diseases

• Publication date

  2002-11-14

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/0147-9571(81)90003-5PMID 6754243PMCID 7134169
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The virology and pathogenesis of feline infectious peritonitis

  2005cited by this paper
• Essential Immunology

  1981cited by this paper
• Pathogenesis of feline infectious peritonitis: nature and development of viremia.

  1981influential reference
• Immunologic phenomena in the effusive form of feline infectious peritonitis.

  1980influential reference
• Isolation and characterization of feline C3 and evidence for the immune complex pathogenesis of feline infectious peritonitis.

  1980cited by this paper
• Disseminated intravascular coagulation in experimentally induced feline infectious peritonitis.

  1980cited by this paper
• Isolation of dengue viruses from peripheral blood leukocytes of patients with hemorrhagic fever.

  1980cited by this paper
• Pathology of non-effusive type feline infectious peritonitis and experimental transmission.

  1980cited by this paper
• Laboratory diagnosis of feline infectious peritonitis.

  1980cited by this paper
• In vivo enhancement of dengue virus infection in rhesus monkeys by passively transferred antibody.

  1979cited by this paper
• Immunofluorescence study of skin rash in patients with dengue hemorrhagic fever.

  1979cited by this paper
• Circulating immune complexes in serum from patients with dengue haemorrhagic fever.

  1979cited by this paper
• Feline infectious peritonitis: a coronavirus disease of cats.

  1978cited by this paper
• Feline infectious peritonitis. An update.

  1978cited by this paper
• Feline infectious peritonitis. An update.

  1978cited by this paper
• Antibody-enhanced dengue virus infection in primate leukocytes

  1977cited by this paper
• Dengue viruses and mononuclear phagocytes. II. Identity of blood and tissue leukocytes supporting in vitro infection

  1977cited by this paper
• Systemic vascular lesions in feline infectious peritonitis.

  1977cited by this paper
• Dengue viruses and mononuclear phagocytes. I. Infection enhancement by non-neutralizing antibody

  1977cited by this paper
• Seroepidemiology of Feline Infectious Peritonitis Virus Infections Using Transmissible Gastroenteritis Virus as Antigen

  1977cited by this paper
• Fibrinogen Metabolism and Disseminated Intravascular Coagulation in Dengue Hemarrhagic Fever

  1977cited by this paper
• The Raji cell radioimmune assay for detecting immune complexes in human sera.

  1976cited by this paper
• Serologic studies of naturally occurring feline infectious peritonitis.

  1976cited by this paper
• Feline infectious peritonitis.

  1976cited by this paper
• [Diagnosis of feline infections peritonitis (FIP) in domestic cats and leopards in Germany].

  1974cited by this paper
• Feststellung der Felinen Infektiösen Peritonitis (FIP) bei Hauskatzen und Leoparden in Deutschland

  1974cited by this paper
• Aleutian disease of mink.

  1974cited by this paper
• Pathogenetic mechanisms in dengue haemorrhagic fever: report of an international collaborative study.

  1973cited by this paper
• The potential pathogenic role of complement in dengue hemorrhagic shock syndrome.

  1973influential reference
• Extraperitoneal Lesions in Feline Infectious Peritonitis

  1972cited by this paper
• Immunopathologic Mechanisms in the Dengue Shock Syndrome

  1971cited by this paper
• Observations related to pathogenesis of dengue hemorrhagic fever. IV. Relation of disease severity to antibody response and virus recovered.

  1970cited by this paper
• Observations related to pathogensis of dengue hemorrhagic fever. VI. Hypotheses and discussion.

  1970cited by this paper
• Definition of staphylococcal protein A reactivity for human immunoglobulin G fragments.

  1970cited by this paper
• Anti-dengue immunoglobulins and serum beta 1 c-a globulin levels in dengue shock syndrome.

  1969cited by this paper
• Hemorrhagic fever in Thailand; recent knowledge regarding etiology.

  1967cited by this paper
• Mosquito-borne haemorrhagic fevers of South and South-East Asia.

  1966cited by this paper
• Feline Infectious Peritonitis

  1966cited by this paper
• THE DETERMINATION OF BILIRUBIN WITH THE PHOTOELECTRIC COLORIMETER

  1937cited by this paper

• Enhancement of viral infection by antibodies and consequences

  2025cites this paper
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  2025cites this paper
• Perirenal hemorrhage associated with feline infectious peritonitis: a novel presentation of a classic disease

  2025cites this paper
• Mutations in feline infectious peritonitis virus nonstructural protein 14/16 methyltransferase attenuate the pathogenicity of the virus in cats

  2025cites this paper
• Rethinking the drivers of coronavirus virulence and pathogenesis; toward an understanding of the dynamic world of mutations, indels, and recombination within the alphacoronaviruses

  2025cites this paper
• Fc-independent SARS-CoV-2 infection-enhancing antibodies decouple N-terminal and receptor-binding domains by cross-linking neighboring spikes

  2024cites this paper
• No evidence for enhanced disease with human polyclonal SARS-CoV-2 antibody in the ferret model

  2024cites this paper
• Preclinical assessment of a recombinant RBD-Fc fusion protein as SARS-CoV-2 candidate vaccine

  2024cites this paper
• Variants of SARS-CoV-2: Influences on the Vaccines’ Effectiveness and Possible Strategies to Overcome Their Consequences

  2023cites this paper
• No evidence for enhanced disease with polyclonal SARS-CoV-2 antibody in the ferret model

  2023cites this paper
• Natural selection differences detected in key protein domains between non-pathogenic and pathogenic feline coronavirus phenotypes

  2023cites this paper
• Natural selection differences detected in key protein domains between non-pathogenic and pathogenic Feline Coronavirus phenotypes

  2023cites this paper
• Antibody-Dependent Enhancement (ADE) and the role of complement system in disease pathogenesis

  2022cites this paper
• Neutralizing Antibodies and Antibody-Dependent Enhancement in COVID-19: A Perspective

  2022cites this paper
• A chimeric MERS-CoV virus-like particle vaccine protects mice against MERS-CoV challenge

  2022cites this paper
• Antibody-Dependent Enhancement: ″Evil″ Antibodies Favorable for Viral Infections

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• Impact of Reinfection with SARS-CoV-2 Omicron Variants in Previously Infected Hamsters

  2022cites this paper
• Expression of Toll-like receptors 3, 7, 9 and cytokines in feline infectious peritonitis virus-infected CRFK cells and feline peripheral monocytes

  2022cites this paper
• The Role of Antibodies in the Treatment of SARS-CoV-2 Virus Infection, and Evaluating Their Contribution to Antibody-Dependent Enhancement of Infection

  2022cites this paper
• Microscopic changes in some organs of cats at the infectious peritonitis

  2022cites this paper
• History of Feline infectious Peritonitis 1963-2022 – First description to Successful Treatment

  2022cites this paper
• Mathematical modeling the dynamics of SARS-CoV-2 infection with antibody-dependent enhancement

  2022cites this paper
• Targets and strategies for vaccine development against SARS-CoV-2

  2021cites this paper
• An infectivity-enhancing site on the SARS-CoV-2 spike protein targeted by antibodies

  2021cites this paper
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  2021cites this paper
• Cellular and Humoral Immunogenicity of a Candidate DNA Vaccine Expressing SARS-CoV-2 Spike Subunit 1

  2021cites this paper
• [Infectivity-enhancing antibodies against SARS-CoV-2].

  2021cites this paper
• Vaccine-Associated Enhanced Viral Disease: Implications for Viral Vaccine Development

  2021cites this paper
• HAYVANLARDA CORONAVİRUS ENFEKSİYONLARI VE COVID-19

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  2021cites this paper
• Covid-19 pandemic: What is the truth?

  2021cites this paper
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  2021cites this paper
• Establishment of Full-Length cDNA Clones and an Efficient Oral Infection Model for Feline Coronavirus in Cats

  2021cites this paper
• Current Status of COVID-19 Vaccine Development: Focusing on Antigen Design and Clinical Trials on Later Stages

  2021cites this paper
• SARS: A RATIONALE LITERATURE STUDY BASED ON ETIOLOGY, PATHOGENESIS AND MANAGEMENT

  2020cites this paper
• Immunization with the receptor-binding domain of SARS-CoV-2 elicits antibodies cross-neutralizing SARS-CoV-2 and SARS-CoV without antibody-dependent enhancement

  2020cites this paper
• Status of COVID-19 vaccine development.

  2020cites this paper
• Understanding the Molecular Mechanism(s) of SARS-CoV2 Infection and Propagation in Human to Discover Potential Preventive and Therapeutic Approach

  2020cites this paper
• Out of the frying pan and into the fire? Due diligence warranted for ADE in COVID-19

  2020cites this paper
• A systematic review of antibody mediated immunity to coronaviruses: antibody kinetics, correlates of protection, and association of antibody responses with severity of disease

  2020cites this paper
• Early Insights into Immune Responses during COVID-19

  2020cites this paper
• Lessons for COVID-19 Immunity from Other Coronavirus Infections

  2020cites this paper
• Severe acute respiratory syndrome (SARS) vaccines

  2020cites this paper
• Cross-reactive antibody response between SARS-CoV-2 and SARS-CoV infections

  2020cites this paper
• Current Paradigms in COVID-19 Research: Proposed Treatment Strategies, Recent Trends and Future Directions.

  2020cites this paper
• Vorkommen mutierter und nicht-mutierter feliner Coronaviren bei Katzen mit feliner infektiöser Peritonitis

  2020influential citation
• Immunization with the receptor-binding domain of SARS-CoV-2 elicits antibodies cross-neutralizing SARS-CoV-2 and SARS-CoV without antibody-dependent enhancement

  2020cites this paper
• Antibody-dependent enhancement of coronaviruses

  2020cites this paper
• Emerging Pandemic Diseases: How We Got to COVID-19

  2020cites this paper
• Cross-reactive Antibody Response between SARS-CoV-2 and SARS-CoV Infections

  2020cites this paper
• Drawing Comparisons between SARS-CoV-2 and the Animal Coronaviruses

  2020cites this paper
• Learning from the past: development of safe and effective COVID-19 vaccines

  2020cites this paper
• ADE and hyperinflammation in SARS-CoV2 infection- comparison with dengue hemorrhagic fever and feline infectious peritonitis

  2020cites this paper
• Dosing Considerations for Antibodies Against COVID-19

  2020cites this paper
• Correlation of Feline Coronavirus Shedding in Feces with Coronavirus Antibody Titer

  2020cites this paper
• Will SARS-CoV-2 Infection Elicit Long-Lasting Protective or Sterilising Immunity? Implications for Vaccine Strategies (2020)

  2020cites this paper
• A koronavírus okozta COVID–19-pandémia Korábbi tapasztalatok és tudományos evidenciák

  2020cites this paper
• Progress and Concept for COVID‐19 Vaccine Development

  2020cites this paper
• Untersuchung einer diskriminierenden quantitativen reverse-Transkriptase-Polymerase-Kettenreaktion zum Nachweis mutierter Coronaviren bei Katzen mit feliner infektiöser Peritonitis

  2020cites this paper
• Applying Immune Instincts and Maternal Intelligence from Comparative Microbiology to COVID-19

  2020cites this paper
• Antibody-dependent enhancement and SARS-CoV-2 vaccines and therapies

  2020cites this paper
• A systematic review of antibody mediated immunity to coronaviruses: kinetics, correlates of protection, and association with severity

  2020cites this paper
• Emerging Pandemic Diseases: How We Got to COVID-19

  2020cites this paper
• Viral targets for vaccines against COVID-19

  2020cites this paper
• Contribution of monocytes and macrophages to the local tissue inflammation and cytokine storm in COVID-19: Lessons from SARS and MERS, and potential therapeutic interventions

  2020cites this paper
• Reactive mesothelial hyperplasia mimicking mesothelioma in an African green monkey (Chlorocebus aethiops)

  2020cites this paper
• The SARS-CoV-2 receptor-binding domain elicits a potent neutralizing response without antibody-dependent enhancement

  2020influential citation
• [The coronavirus COVID-19 pandemic. Past experience and scientific evidence at the end of March 2020].

  2020cites this paper
• Comparative estimation of some immune parameters in three felid species

  2019cites this paper
• A Highly Immunogenic, Protective, and Safe Adenovirus-Based Vaccine Expressing Middle East Respiratory Syndrome Coronavirus S1-CD40L Fusion Protein in a Transgenic Human Dipeptidyl Peptidase 4 Mouse Model

  2019influential citation
• Diagnosis of Feline Infectious Peritonitis: A Review of the Current Literature

  2019cites this paper
• Modulation of Dengue/Zika Virus Pathogenicity by Antibody-Dependent Enhancement and Strategies to Protect Against Enhancement in Zika Virus Infection

  2018cites this paper
• Feline Coronaviruses

  2016cites this paper
• Identification of the peptide derived from S1 domain that inhibits type I and type II feline infectious peritonitis virus infection

  2015cites this paper
• Human HIV Vaccine Trials: Does Antibody-Dependent Enhancement Pose a Genuine Risk?

  2015cites this paper
• Immunogenicity of an adenoviral-based Middle East Respiratory Syndrome coronavirus vaccine in BALB/c mice

  2014cites this paper
• Screening and identification of T helper 1 and linear immunodominant antibody-binding epitopes in spike 1 domain and membrane protein of feline infectious peritonitis virus

  2014cites this paper
• Inflammatory Diseases of the Central Nervous System

  2014cites this paper
• The Ferret in Viral Respiratory Disease Research

  2014cites this paper
• Novel antiviral strategies for feline coronavirus and feline calicivirus

  2014cites this paper
• Evaluation of Protective Efficacy of the Synthetic Peptide Vaccine Containing the T-Helper 1 Epitope with Cpg Oligodeoxynucleotide against Feline Infectious Peritonitis Virus Infection in Cats

  2014cites this paper
• Levels of feline infectious peritonitis virus in blood, effusions, and various tissues and the role of lymphopenia in disease outcome following experimental infection

  2014cites this paper
• Feline Infectious Peritonitis

  2014influential citation
• Animal Virus Infections That Defy Vaccination: Equine Infectious Anemia, Caprine Arthritis-Encephalitis, Maedi-Visna, and Feline Infectious Peritonitis

  2014influential citation
• The role of leukocyte extravasation in the pathogenesis of feline infectious peritonitis

  2014cites this paper
• Pathogenic Exploitation of Fc Activity

  2013cites this paper
• Animal Models of Human Viral Diseases

  2013cites this paper
• Recombinant feline coronaviruses as vaccine candidates confer protection in SPF but not in conventional cats

  2013cites this paper
• The role of cell-mediated immunity during coronavirus infections in cats: opportunities for therapeutic avenues?

  2013cites this paper
• Important mammalian veterinary viral immunodiseases and their control

  2012cites this paper
• Immunization with SARS Coronavirus Vaccines Leads to Pulmonary Immunopathology on Challenge with the SARS Virus

  2012cites this paper
• Untersuchungen zur Diagnose und Therapie der felinen infektiösen Peritonitis

  2012influential citation
• Roadmap to developing a recombinant coronavirus S protein receptor-binding domain vaccine for severe acute respiratory syndrome

  2012cites this paper
• Feline infectious peritonitis: Role of the feline coronavirus 3c gene in intestinal tropism and pathogenicity based upon isolates from resident and adopted shelter cats

  2012cites this paper
• Screening and identification of T helper 1 and linear immunodominant antibody-binding epitopes in the spike 2 domain and the nucleocapsid protein of feline infectious peritonitis virus

  2011cites this paper
• Protective and Pathogenic Effects of Dengue Virus Antibodies in vitro and in vivo

  2011cites this paper
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  2011cites this paper
• Development of monoclonal antibodies (MAbs) to feline interferon (fIFN)-γ as tools to evaluate cellular immune responses to feline infectious peritonitis virus (FIPV)

  2011cites this paper
• Genetic and biological characterization of alphacoronavirus feline infectious peritonitis virus and gammacoronavirus infectious bronchitis virus

  2011cites this paper
• Feline Coronavirus in Multicat Environments

  2011cites this paper