Feline infectious peritonitis: Role of the feline coronavirus 3c gene in intestinal tropism and pathogenicity based upon isolates from resident and adopted shelter cats

Highlights ► Truncated 3c is not essential for enteric to FIP biotype conversion of feline coronaviruses (FCoVs). ► Intact 3c required by both FIP and enteric FCoV biotypes for intestinal replication in cats. ► FIP and enteric FCoV biotypes rarely infect intestinal epithelium following intraperitoneal infection. ► FIP and enteric FCoVs undergo constant mutation within and between host cats. ► Shelter cats are infected with many enteric FCoV strains reflective of their differing origins.

• Publication year

  2012

• Venue

  Virus Research

• Publication date

  2012-01-17

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.virusres.2011.12.020PMID 22280883PMCID 7114484
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Sequence analysis of feline coronaviruses and the circulating virulent/avirulent theory.

  2011influential reference
• Sequence Analysis of Feline Coronaviruses and the Circulating Virulent/Avirulent Theory

  2011cited by this paper
• Sequence analysis of the nucleocapsid gene of feline coronaviruses circulating in Italy.

  2010cited by this paper
• Sites of feline coronavirus persistence in healthy cats.

  2010cited by this paper
• Pathogenic characteristics of persistent feline enteric coronavirus infection in cats

  2010cited by this paper
• Feline infectious peritonitis: insights into feline coronavirus pathobiogenesis and epidemiology based on genetic analysis of the viral 3c gene.

  2010influential reference
• Genetics and Pathogenesis of Feline Infectious Peritonitis Virus

  2009influential reference
• Significance of Coronavirus Mutants in Feces and Diseased Tissues of Cats Suffering from Feline Infectious Peritonitis

  2009influential reference
• A review of feline infectious peritonitis virus infection: 1963–2008

  2009influential reference
• Field strain feline coronaviruses with small deletions in ORF7b associated with both enteric infection and feline infectious peritonitis

  2009cited by this paper
• Pathogenesis of feline enteric coronavirus infection

  2008cited by this paper
• Genomic RNA sequence of feline coronavirus strain FCoV C1Je

  2007cited by this paper
• Glycosylation of the Severe Acute Respiratory Syndrome Coronavirus Triple-Spanning Membrane Proteins 3a and M

  2006cited by this paper
• Genomic RNA sequence of Feline coronavirus strain FIPV WSU-79/1146.

  2005cited by this paper
• Persistence and transmission of natural type I feline coronavirus infection.

  2003influential reference
• Antibody-mediated enhancement of disease in feline infectious peritonitis: Comparisons with dengue hemorrhagic fever

  2002cited by this paper
• Deletions in the 7a ORF of feline coronavirus associated with an epidemic of feline infectious peritonitis

  2001cited by this paper
• One-tube fluorogenic reverse transcription-polymerase chain reaction for the quantitation of feline coronaviruses

  1999cited by this paper
• Feline Infectious Peritonitis Viruses Arise by Mutation from Endemic Feline Enteric Coronaviruses

  1998influential reference
• Persistence and Evolution of Feline Coronavirus in a Closed Cat-Breeding Colony

  1997cited by this paper
• The inheritance of susceptibility to feline infectious peritonitis in purebred catteries

  1996cited by this paper
• Two related strains of feline infectious peritonitis virus isolated from immunocompromised cats infected with a feline enteric coronavirus

  1996cited by this paper
• Elimination of feline coronavirus infection from a large experimental specific pathogen-free cat breeding colony by serologic testing and isolation

  1995cited by this paper
• Isolation of human immunodeficiency virus type 1 (HIV-1) RNA from feces by a simple method and difference between HIV-1 subpopulations in feces and serum

  1995influential reference
• The Molecular Genetics of Feline Coronaviruses: Comparative Sequence Analysis of the ORF7a/7b Transcription Unit of Different Biotypes

  1995cited by this paper
• Monoclonal antibodies to the spike protein of feline infectious peritonitis virus mediate antibody-dependent enhancement of infection of feline macrophages

  1992cited by this paper
• Intrinsic resistance of feline peritoneal macrophages to coronavirus infection correlates with in vivo virulence

  1989cited by this paper
• Virologic and immunologic aspects of feline infectious peritonitis virus infection.

  1987cited by this paper
• Antibody, immune complexes and complement activity fluctuations in experimental feline infectious peritonitis

  1982cited by this paper
• Antibody, immune complexes, and complement activity fluctuations in kittens with experimentally induced feline infectious peritonitis.

  1982cited by this paper
• An enteric coronavirus infection of cats and its relationship to feline infectious peritonitis.

  1981cited by this paper
• Immunologic phenomena in the effusive form of feline infectious peritonitis.

  1980cited by this paper
• Feline infectious peritonitis.

  1976influential reference
• Serologic studies of naturally occurring feline infectious peritonitis.

  1976cited by this paper
• Morphogenesis of a virus in cats with experimental feline infectious peritonitis

  1970cited by this paper

• Application of versatile reverse genetics system for feline coronavirus

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  2025cites this paper
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  2025cites this paper
• Molecular characteristics of feline coronavirus in South Korea, 2016-2023.

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• Theoretical aspects of the immunopathogenesis of coronavirus infection in cats

  2025cites this paper
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  2024cites this paper
• Serum proteomic analysis identifies ITIH4 as potential novel biomarkers for feline infectious peritonitis.

  2024cites this paper
• Development and characterization of reverse genetics systems of feline infectious peritonitis virus for antiviral research

  2024cites this paper
• An RNA replicon system to investigate promising inhibitors of feline coronavirus

  2024cites this paper
• An updated review of feline coronavirus: mind the two biotypes

  2023cites this paper
• Immunoinformatics-aided rational design of a multi-epitope vaccine targeting feline infectious peritonitis virus

  2023cites this paper
• Analysis of spike and accessory 3c genes mutations of less virulent and FIP-associated feline coronaviruses in Beijing, China.

  2023cites this paper
• Intestinal injury and vasculitis biomarkers in cats with feline enteric coronavirus and effusive feline infectious peritonitis

  2023cites this paper
• Feline Infectious Peritonitis: European Advisory Board on Cat Diseases Guidelines

  2023cites this paper
• Natural selection differences detected in key protein domains between non-pathogenic and pathogenic Feline Coronavirus phenotypes

  2023cites this paper
• Comparison of Clinical and Laboratory Findings at Different Clinical Stages in Cats Naturally Infected with Feline Coronavirus

  2023cites this paper
• Natural selection differences detected in key protein domains between non-pathogenic and pathogenic feline coronavirus phenotypes

  2023cites this paper
• 2022 AAFP/EveryCat Feline Infectious Peritonitis Diagnosis Guidelines

  2022cites this paper
• History of Feline infectious Peritonitis 1963-2022 – First description to Successful Treatment

  2022cites this paper
• Relationship between Uveal Inflammation and Viral Detection in 30 Cats with Feline Infectious Peritonitis

  2022cites this paper
• Detection of Feline Coronavirus Variants in Cats without Feline Infectious Peritonitis

  2022cites this paper
• Fecal Feline Coronavirus RNA Shedding and Spike Gene Mutations in Cats with Feline Infectious Peritonitis Treated with GS-441524

  2022cites this paper
• Role of Feline Coronavirus as Contributor to Diarrhea in Cats from Breeding Catteries

  2022cites this paper
• Clinical and Molecular Relationships between COVID-19 and Feline Infectious Peritonitis (FIP)

  2022cites this paper
• Feline Coronavirus: Insights into the Pathogenesis and Diagnosis

  2022cites this paper
• Clinical and Pathological Studies on Feline Infectious Peritonitis in Egypt

  2022cites this paper
• Comparative sequence analysis of the accessory and nucleocapsid genes of feline coronavirus strains isolated from cats diagnosed with effusive feline infectious peritonitis

  2021cites this paper
• Curing Cats with Feline Infectious Peritonitis with an Oral Multi-Component Drug Containing GS-441524

  2021cites this paper
• Feline İnfeksiyöz Peritonitise Genel Bakış ve Antiviral Yaklaşımlar

  2021cites this paper
• The virus–host interface: Molecular interactions of Alphacoronavirus‐1 variants from wild and domestic hosts with mammalian aminopeptidase N

  2021cites this paper
• A comprehensive review of SARS-CoV-2 genetic mutations and lessons from animal coronavirus recombination in one health perspective

  2021cites this paper
• New Insights Into the Physiopathology of COVID-19: SARS-CoV-2-Associated Gastrointestinal Illness

  2021cites this paper
• Evolution, Interspecies Transmission, and Zoonotic Significance of Animal Coronaviruses

  2021cites this paper
• Animal Coronavirus Diseases: Parallels with COVID-19 in Humans

  2021cites this paper
• Establishment of Full-Length cDNA Clones and an Efficient Oral Infection Model for Feline Coronavirus in Cats

  2021cites this paper
• Prospects for a safe COVID-19 vaccine

  2020cites this paper
• Animal coronaviruses and SARS‐CoV‐2

  2020cites this paper
• FCoV Viral Sequences of Systemically Infected Healthy Cats Lack Gene Mutations Previously Linked to the Development of FIP

  2020cites this paper
• Correlation of Feline Coronavirus Shedding in Feces with Coronavirus Antibody Titer

  2020cites this paper
• Feline Infectious Peritonitis: Update on Pathogenesis, Diagnostics, and Treatment.

  2020cites this paper
• Host Gene Expression of Macrophages in Response to Feline Coronavirus Infection

  2020cites this paper
• A comparative study of techniques used for the diagnosis of effusive feline infectious peritonitis

  2020cites this paper
• Development and evaluation of a SYBR Green I RT-qPCR assay for Feline Infection Peritonitis virus detection

  2020cites this paper
• Vorkommen mutierter und nicht-mutierter feliner Coronaviren bei Katzen mit feliner infektiöser Peritonitis

  2020influential citation
• CRFK and Primary Macrophages Transcriptomes in Response to Feline Coronavirus Infection Differ Significantly

  2020cites this paper
• Untersuchung einer diskriminierenden quantitativen reverse-Transkriptase-Polymerase-Kettenreaktion zum Nachweis mutierter Coronaviren bei Katzen mit feliner infektiöser Peritonitis

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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
• Can the Coronavirus Disease 2019 (COVID-19) Affect the Eyes? A Review of Coronaviruses and Ocular Implications in Humans and Animals

  2020cites this paper
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  2019cites this paper
• Characterization of a New Member of Alphacoronavirus with Unique Genomic Features in Rhinolophus Bats

  2019cites this paper
• Characterization of antiviral T cell responses during primary and secondary challenge of laboratory cats with feline infectious peritonitis virus (FIPV)

  2019cites this paper
• Characterization of amino acid substitutions in feline coronavirus 3C-like protease from a cat with feline infectious peritonitis treated with a protease inhibitor

  2019cites this paper
• Feline coronavirus with and without spike gene mutations detected by real-time RT-PCRs in cats with feline infectious peritonitis

  2019cites this paper
• Diagnosis of Feline Infectious Peritonitis: A Review of the Current Literature

  2019cites this paper
• Intracellular trafficking of the M protein of Middle East respiratory syndrome coronavirus (MERS-CoV)

  2019cites this paper
• Differential susceptibility of macrophages to serotype II feline coronaviruses correlates with differences in the viral spike protein

  2018cites this paper
• Reverse Genetics for Type I Feline Coronavirus Field Isolate To Study the Molecular Pathogenesis of Feline Infectious Peritonitis

  2018cites this paper
• Protease inhibitors broadly effective against feline, ferret and mink coronaviruses

  2018cites this paper
• Characterizing replication kinetics and plaque production of type I feline infectious peritonitis virus in three feline cell lines

  2018cites this paper
• Feline coronavirus: Insights into viral pathogenesis based on the spike protein structure and function

  2018influential citation
• Mutation of the S and 3c genes in genomes of feline coronaviruses

  2018cites this paper
• Infectious Diseases of the Felidae : Parasite Communities from Miniature to Massive

  2017cites this paper
• DIAGNOSIS AND TREATMENTS OF FELINE INFECTIOUS PERITONITIS: AN UPDATE

  2017cites this paper
• Limitations of using feline coronavirus spike protein gene mutations to diagnose feline infectious peritonitis

  2017cites this paper
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  2017cites this paper
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  2017cites this paper
• Infectious bronchitis corona virus establishes productive infection in avian macrophages interfering with selected antimicrobial functions

  2017cites this paper
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  2017cites this paper
• Expression profiles of immune mediators in feline Coronavirus-infected cells and clinical samples of feline Coronavirus-positive cats

  2017cites this paper
• An update on feline infectious peritonitis

  2016cites this paper
• Reversal of the Progression of Fatal Coronavirus Infection in Cats by a Broad-Spectrum Coronavirus Protease Inhibitor

  2016cites this paper
• Feline Coronavirus 3c Protein: A Candidate for a Virulence Marker?

  2016cites this paper
• Animal Coronaviruses

  2016cites this paper
• Feline Coronaviruses

  2016cites this paper
• Experimental feline enteric coronavirus infection reveals an aberrant infection pattern and shedding of mutants with impaired infectivity in enterocyte cultures

  2016influential citation
• Natural resistance to experimental feline infectious peritonitis virus infection is decreased rather than increased by positive genetic selection

  2016cites this paper
• Genotyping coronaviruses associated with feline infectious peritonitis

  2015cites this paper
• Therapeutic effect of anti-feline TNF-alpha monoclonal antibody for feline infectious peritonitis

  2015cites this paper
• Zarazni peritonitis mačaka

  2015cites this paper
• Relação da titulação de anticorpos anti-coronavírus felino e anamnese, sinais clínicos e laboratoriais comummente utilizados para diagnóstico da peritonite infeciosa felina

  2015cites this paper
• Genotype-Specific Detection of Ferret Coronavirus by Conventional and Real-Time Reverse Transcription Polymerase Chain Reaction

  2015cites this paper
• An update on feline infectious peritonitis: Diagnostics and therapeutics

  2014influential citation
• ORF7-encoded accessory protein 7a of feline infectious peritonitis virus as a counteragent against IFN-α-induced antiviral response.

  2014cites this paper
• Mutations in the 3c and 7b genes of feline coronavirus in spontaneously affected FIP cats

  2014cites this paper
• The accessory glycoprotein gp3 of canine Coronavirus type 1 : investigations of sequence variability in feline host and of the basic features of the different variants

  2014cites this paper
• Novel antiviral strategies for feline coronavirus and feline calicivirus

  2014cites this paper
• FCoV och FIP hos svenska katter – förekomst, hantering i klinikmiljö och information till kattägare

  2014influential citation
• Levels of feline infectious peritonitis virus in blood, effusions, and various tissues and the role of lymphopenia in disease outcome following experimental infection

  2014influential citation
• Mutations of 3c and spike protein genes correlate with the occurrence of feline infectious peritonitis

  2014influential citation
• Feline Infectious Peritonitis

  2014influential citation
• An update on feline infectious peritonitis: Virology and immunopathogenesis

  2014influential citation
• Common and Emerging Infectious Diseases in the Animal Shelter

  2014cites this paper
• Tackling feline infectious peritonitis via reverse genetics

  2014cites this paper
• The influence of age and genetics on natural resistance to experimentally induced feline infectious peritonitis

  2014cites this paper
• Emergence of Pathogenic Coronaviruses in Cats by Homologous Recombination between Feline and Canine Coronaviruses

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  2014cites this paper
• Comparative In Vivo Analysis of Recombinant Type II Feline Coronaviruses with Truncated and Completed ORF3 Region

  2014cites this paper
• Host cell proteases: Critical determinants of coronavirus tropism and pathogenesis

  2014cites this paper