The contribution of natural selection to present-day susceptibility to chronic inflammatory and autoimmune disease.

Chronic inflammatory and autoimmune diseases have been the focus of many genome-wide association studies (GWAS) because they represent a significant cause of illness and morbidity, and many are heritable. Almost a decade of GWAS studies suggests that the pathological inflammation associated with these diseases is controlled by a limited number of networked immune system genes. Chronic inflammatory and autoimmune diseases are enigmatic from an evolutionary perspective because they exert a negative affect on reproductive fitness. The persistence of these conditions may be partially explained by the important roles the implicated immune genes play in pathogen defense and other functions thought to be under strong natural selection in humans. The evolutionary reasons for chronic inflammatory and autoimmune disease persistence and uneven distribution across populations are the focus of this review.

• Publication year

  2014

• Venue

  Current Opinion in Immunology

• Publication date

  2014-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.coi.2014.09.008PMID 25458997PMCID PMC4344185
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Conceptus-uterus interactions in pigs: endometrial gene expression in response to estrogens and interferons from conceptuses.

  2020cited by this paper
• Alcohol Consumption Promotes Diethylnitrosamine-Induced Hepatocarcinogenesis in Male Mice through Activation of the Wnt/β-Catenin Signaling Pathway

  2014cited by this paper
• Psoriasis prevalence among adults in the United States.

  2014cited by this paper
• Prevalence of type 1 and type 2 diabetes among children and adolescents from 2001 to 2009.

  2014cited by this paper
• SHP2 Regulates Chondrocyte Terminal Differentiation, Growth Plate Architecture and Skeletal Cell Fates

  2014cited by this paper
• Prevalence and Incidence of Systemic Lupus Erythematosus in a Population‐Based Registry of American Indian and Alaska Native People, 2007–2009

  2014cited by this paper
• Alcohol promotes mammary tumor growth through activation of VEGF-dependent tumor angiogenesis

  2014cited by this paper
• A novel role for interferon regulatory factor 1 (IRF1) in regulation of bone metabolism

  2014cited by this paper
• The timing and spatiotemporal patterning of Neanderthal disappearance

  2014cited by this paper
• The Incidence and Prevalence of Systemic Lupus Erythematosus, 2002–2004: The Georgia Lupus Registry

  2014cited by this paper
• The landscape of Neandertal ancestry in present-day humans

  2014cited by this paper
• Induction or Exacerbation of Psoriasis in Patients with Crohn's Disease under Treatment with Anti-TNF Antibodies

  2014cited by this paper
• Degree of bone marrow oedema in sacroiliac joints of patients with axial spondyloarthritis is linked to gut inflammation and male sex: results from the GIANT cohort

  2013cited by this paper
• Common risk alleles for inflammatory diseases are targets of recent positive selection.

  2013cited by this paper
• Thrombotic Antiphospholipid Syndrome Shows Strong Haplotypic Association with SH2B3-ATXN2 Locus

  2013cited by this paper
• Selective Neuronal and Brain Regional Expession of IL-2 in IL2P 8-GFP Transgenic Mice: Relation to Sensorimotor Gating

  2013cited by this paper
• Inflammatory Bowel Disease Prevalence by Age, Gender, Race, and Geographic Location in the U.S. Military Health Care Population

  2013cited by this paper
• Crohn's disease loci are common targets of protozoa-driven selection.

  2013cited by this paper
• RNA-Guided Human Genome Engineering via Cas9

  2013cited by this paper
• Natural Selection in a Bangladeshi Population from the Cholera-Endemic Ganges River Delta

  2013cited by this paper
• Genomics, the origins of agriculture, and our changing microbe‐scape: Time to revisit some old tales and tell some new ones

  2013cited by this paper
• Pleiotropic effects of obesity-susceptibility loci on metabolic traits: a meta-analysis of up to 37,874 individuals

  2013cited by this paper
• Multiplex Genome Engineering Using CRISPR/Cas Systems

  2013cited by this paper
• Genetic insights into common pathways and complex relationships among immune-mediated diseases

  2013cited by this paper
• Epidemiology and sociodemographics of systemic lupus erythematosus and lupus nephritis among US adults with Medicaid coverage, 2000-2004.

  2013cited by this paper
• Interleukin-4 deficiency induces mild preeclampsia in mice

  2013cited by this paper
• Human population structure and the adaptive response to pathogen-induced selection pressures

  2012cited by this paper
• An integrated map of genetic variation from 1,092 human genomes

  2012cited by this paper
• Genome-wide scans provide evidence for positive selection of genes implicated in Lassa fever

  2012cited by this paper
• The Interleukin 3 Gene (IL3) Contributes to Human Brain Volume Variation by Regulating Proliferation and Survival of Neural Progenitors

  2012cited by this paper
• Materials for : Host-microbe interactions shape genetic risk for inflammatory bowel disease

  2012cited by this paper
• Association of Cardiovascular and Metabolic Disease Genes with Psoriasis

  2012cited by this paper
• The Prevalence of Celiac Disease in the United States

  2012cited by this paper
• The Shaping of Modern Human Immune Systems by Multiregional Admixture with Archaic Humans

  2011cited by this paper
• Genomics for the world

  2011cited by this paper
• Pervasive Sharing of Genetic Effects in Autoimmune Disease

  2011cited by this paper
• Clinical and epidemiological research

  2011cited by this paper
• Dysregulated gene expression during hematopoietic differentiation from human embryonic stem cells.

  2011cited by this paper
• Efficient design and assembly of custom TALEN and other TAL effector-based constructs for DNA targeting

  2011cited by this paper
• Genome-Wide Association Study SNPs in the Human Genome Diversity Project Populations: Does Selection Affect Unlinked SNPs with Shared Trait Associations?

  2011cited by this paper
• Consumption of cow's milk as a cause of iron deficiency in infants and toddlers.

  2011cited by this paper
• The adaptor Lnk (SH2B3): an emerging regulator in vascular cells and a link between immune and inflammatory signaling.

  2011cited by this paper
• Meta-Analysis of Genome-Wide Association Studies in Celiac Disease and Rheumatoid Arthritis Identifies Fourteen Non-HLA Shared Loci

  2011cited by this paper
• Expanded ATXN2 CAG repeat size in ALS identifies genetic overlap between ALS and SCA2

  2011cited by this paper
• The Southern Route “Out of Africa”: Evidence for an Early Expansion of Modern Humans into Arabia

  2011cited by this paper
• Signatures of Environmental Genetic Adaptation Pinpoint Pathogens as the Main Selective Pressure through Human Evolution

  2011cited by this paper
• Goblet cells are derived from a FOXJ1-expressing progenitor in a human airway epithelium.

  2011cited by this paper
• Integration of genetic and immunological insights into a model of celiac disease pathogenesis.

  2011cited by this paper
• Multiple sclerosis in Caucasians and Latino Americans

  2011cited by this paper
• New IBD genetics: common pathways with other diseases

  2011cited by this paper
• Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci

  2010cited by this paper
• The ADH1B Arg47His polymorphism in East Asian populations and expansion of rice domestication in history

  2010cited by this paper
• New loci associated with kidney function and chronic kidney disease

  2010cited by this paper
• miR-200b Targets Ets-1 and Is Down-regulated by Hypoxia to Induce Angiogenic Response of Endothelial Cells*

  2010cited by this paper
• Genome-Wide Identification of Susceptibility Alleles for Viral Infections through a Population Genetics Approach

  2010cited by this paper
• Evolutionary and functional analysis of celiac risk loci reveals SH2B3 as a protective factor against bacterial infection.

  2010cited by this paper
• The Changing Disease-Scape in the Third Epidemiological Transition

  2010cited by this paper
• Evidence of positive selection at codon sites localized in extracellular domains of mammalian CC motif chemokine receptor proteins

  2010cited by this paper
• THE RATE OF MUTATION OF HUMAN GENES

  2010cited by this paper
• Estimation of effect size distribution from genome-wide association studies and implications for future discoveries

  2010cited by this paper
• Targeting DNA Double-Strand Breaks with TAL Effector Nucleases

  2010cited by this paper
• Paleopathology and the origin of agriculture in the Levant.

  2010cited by this paper
• From evolutionary genetics to human immunology: how selection shapes host defence genes

  2010cited by this paper
• Diabetes in African American Youth

  2009cited by this paper
• Common and different genetic background for rheumatoid arthritis and coeliac disease.

  2009cited by this paper
• Parasites represent a major selective force for interleukin genes and shape the genetic predisposition to autoimmune conditions

  2009cited by this paper
• Diabetes in Non-Hispanic White Youth

  2009cited by this paper
• Rasip1 is required for endothelial cell motility, angiogenesis and vessel formation.

  2009cited by this paper
• A history of recurrent positive selection at the toll-like receptor 5 in primates.

  2009cited by this paper
• Type 1 and Type 2 Diabetes in Asian and Pacific Islander U.S. Youth

  2009cited by this paper
• Csf2 Null Mutation Alters Placental Gene Expression and Trophoblast Glycogen Cell and Giant Cell Abundance in Mice1

  2009cited by this paper
• Signals of recent positive selection in a worldwide sample of human populations.

  2009cited by this paper
• Recent insights in the epidemiology of autoimmune diseases: improved prevalence estimates and understanding of clustering of diseases.

  2009cited by this paper
• The Prevalence of Multiple Sclerosis in 3 US Communities

  2009cited by this paper
• Isolation of Mycobacterium avium Subspecies paratuberculosis Reactive CD4 T Cells from Intestinal Biopsies of Crohn's Disease Patients

  2009cited by this paper
• Discovery of genes essential for heme biosynthesis through large-scale gene expression analysis.

  2009cited by this paper
• Evolutionary Dynamics of Human Toll-Like Receptors and Their Different Contributions to Host Defense

  2009cited by this paper
• Detecting shared pathogenesis from the shared genetics of immune-related diseases

  2009cited by this paper
• Genomewide association study of leprosy.

  2009cited by this paper
• Ethnic Related Selection for an ADH Class I Variant within East Asia

  2008cited by this paper
• Deletion of Shp2 Tyrosine Phosphatase in Muscle Leads to Dilated Cardiomyopathy, Insulin Resistance, and Premature Death

  2008cited by this paper
• Natural selection has driven population differentiation in modern humans

  2008cited by this paper
• Newly identified genetic risk variants for celiac disease related to the immune response

  2008cited by this paper
• Balancing Selection Is the Main Force Shaping the Evolution of Innate Immunity Genes1

  2008cited by this paper
• Rates of new-onset psoriasis in patients with rheumatoid arthritis receiving anti-tumour necrosis factor α therapy: results from the British Society for Rheumatology Biologics Register

  2008cited by this paper
• Psoriatic skin lesions induced by tumor necrosis factor antagonist therapy: a literature review and potential mechanisms of action.

  2008cited by this paper
• Natural selection in the TLR-related genes in the course of primate evolution

  2008cited by this paper
• Detection of Mycobacterium avium subspecies paratuberculosis from patients with Crohn's disease using nucleic acid‐based techniques: A systematic review and meta‐analysis

  2008cited by this paper
• Mammalian Long-Chain Acyl-CoA Synthetases

  2008cited by this paper
• Identification of the human N(alpha)-acetyltransferase complex B (hNatB): a complex important for cell-cycle progression.

  2008cited by this paper
• Updated consensus statement on biological agents for the treatment of rheumatic diseases, 2007

  2007cited by this paper
• Genes regulated by interferon-γ in human uterine microvascular endothelial cells

  2007cited by this paper
• Adverse effects of cow's milk in infants.

  2007cited by this paper
• Skeletal Biology of the Central Peruvian Coast Consequences of Changing Population Density and Progressive Dependence on Maize Agriculture

  2007cited by this paper
• Genes regulated by interferon-gamma in human uterine microvascular endothelial cells.

  2007cited by this paper
• Evidence of positive selection on a class I ADH locus.

  2007cited by this paper
• Control of CNS cell-fate decisions by SHP-2 and its dysregulation in Noonan syndrome.

  2007cited by this paper
• Mycobacterium avium subspecies paratuberculosis and Crohn's disease: a systematic review and meta-analysis.

  2007cited by this paper
• Spontaneous development of intestinal and colonic atrophy and inflammation in the carnitine-deficient jvs (OCTN2(-/-)) mice.

  2007cited by this paper
• Convergent adaptation of human lactase persistence in Africa and Europe

  2007cited by this paper

• Ancient DNA study provides clues to leprosy susceptibility in medieval Europe

  2026cites this paper
• On the topical issue of assisted dying: the insurmountable challenges of human existence, and the right to exit.

  2026cites this paper
• Expanding the phenotypic spectrum of PROK2/PROKR2: a recall-by-genotype study

  2025cites this paper
• Pathogen Adaptation of HLA Alleles and Its Correlation with Autoimmune Diseases in the Han Chinese

  2025cites this paper
• The autoimmune disease risk variant NCF1-His90 is associated with a reduced risk of tuberculosis in women

  2025cites this paper
• Shaping immunity: The influence of natural selection on population immune diversity

  2024cites this paper
• Epigenetic variation impacts individual differences in the transcriptional response to influenza infection

  2024cites this paper
• Tracing the Evolution of Human Immunity Through Ancient DNA.

  2024cites this paper
• Integrating the Thrifty Genotype and Evolutionary Mismatch Hypotheses to understand variation in cardiometabolic disease risk

  2024cites this paper
• Health Disparities Among Indigenous Peoples: Exploring the Roles of Evolutionary and Developmental Mismatch on Cardiometabolic Health

  2024cites this paper
• The selection landscape and genetic legacy of ancient Eurasians

  2024cites this paper
• Applying an evolutionary mismatch framework to understand disease susceptibility

  2023cites this paper
• From ancient pathogens to modern pandemics: Integrating evolutionary, ecological, and sociopolitical dynamics of infectious disease and pandemics through biological anthropology.

  2023cites this paper
• Evolutionary mismatch and the role of GxE interactions in human disease

  2023cites this paper
• Aspectos evolutivos dos fenômenos imunopatológicos com ênfase na COVID-19

  2022cites this paper
• Inter-individual differences in the transcriptional response of innate immune cells to infectious agents are common and likely contribute to varying susceptibility

  2022cites this paper
• Genomic Assessment of Cancer Susceptibility in the Threatened Catalina Island Fox (Urocyon littoralis catalinae)

  2022cites this paper
• Inflammation, microbiome and colorectal cancer disparity in African-Americans: Are there bugs in the genetics?

  2022cites this paper
• Prioritizing autoimmunity risk variants for functional analyses by fine-mapping mutations under natural selection

  2022cites this paper
• Positive Selection Affects the Expression of Systemic Lupus Erythematosus Associated Loci in Human Populations

  2021influential citation
• Dangerous liaisons: human genetic adaptation to infectious agents.

  2021cites this paper
• Coevolución Microbiota-Humano y sus implicaciones en salud: de cazadores recolectores a sedentarios industrializados

  2021cites this paper
• Revisiting the Hygiene Hypothesis in the Context of Autoimmunity

  2021cites this paper
• Polygenic Adaptation: Integrating Population Genetics and Gene Regulatory Networks.

  2021cites this paper
• The evolution of powerful yet perilous immune systems

  2021cites this paper
• New insights into human immunity from ancient genomics

  2021cites this paper
• Disentangling the Coronavirus Disease 2019 Health Disparities in African Americans: Biological, Environmental, and Social Factors

  2021cites this paper
• Cancer as a prospective sequela of long COVID‐19

  2021cites this paper
• Racial Disparities in Necrotizing Enterocolitis

  2021cites this paper
• Mapping interindividual dynamics of innate immune response at single-cell resolution

  2021cites this paper
• The Sub-Saharan African information potential to unveil adaptations to infectious diseases.

  2021cites this paper
• Evolutionary and population (epi)genetics of immunity to infection

  2020cites this paper
• Patient ancestry significantly contributes to molecular heterogeneity of systemic lupus erythematosus

  2020cites this paper
• Coping with COVID-19 in Sub-Saharan Africa: What Might the Future Hold?

  2020cites this paper
• Cell-Autonomous Immunity and The Pathogen-Mediated Evolution of Humans: Or How Our Prokaryotic and Single-Celled Origins Affect The Human Evolutionary Story

  2020cites this paper
• Single-cell RNA-sequencing reveals pervasive but highly cell type-specific genetic ancestry effects on the response to viral infection

  2020cites this paper
• Detecting � tness epistasis in recently admixed populations with genome-wide data

  2020cites this paper
• Of Genes and Humans

  2020cites this paper
• WEIRD bodies: mismatch, medicine and missing diversity.

  2020cites this paper
• Detecting fitness epistasis in recently admixed populations with genome-wide data

  2019cites this paper
• The Hygiene Hypothesis, Old Friends, and New Genes

  2019cites this paper
• Human Immunology through the Lens of Evolutionary Genetics.

  2019cites this paper
• The ancestral and industrialized gut microbiota and implications for human health

  2019cites this paper
• Experimental immunology and the potential for osteopathological reconstructions : pursuing an experimental foundation for the skeletal inflammatory index.

  2019cites this paper
• Precision medicine in atopic diseases.

  2019cites this paper
• ImaGene: a convolutional neural network to quantify natural selection from genomic data

  2019cites this paper
• Impact of Historic Migrations and Evolutionary Processes on Human Immunity

  2019cites this paper
• The Role of the Immune System from an Evolutionary Perspective

  2019cites this paper
• Genetic ancestry and population differences in levels of inflammatory cytokines in women: Role for evolutionary selection and environmental factors

  2018cites this paper
• High Seroprevalence of Autoantibodies Typical of Autoimmune Liver Disease in Eastern Ethiopia: Is Chewing of Khat (Catha edulis) a Triggering Factor?

  2018cites this paper
• A locus on chromosome 5 shows African ancestry-limited association with alloimmunization in sickle cell disease.

  2018cites this paper
• Tuberculosis and impaired IL-23–dependent IFN-γ immunity in humans homozygous for a common TYK2 missense variant

  2018cites this paper
• Exploring the genetic basis of human population differences in DNA methylation and their causal impact on immune gene regulation

  2018cites this paper
• Detecting Signatures of Positive Selection along Defined Branches of a Population Tree Using LSD

  2018cites this paper
• Immune System Promiscuity in Human and Nonhuman Primate Evolution

  2018cites this paper
• Stereotypic Immune System Development in Newborn Children

  2018cites this paper
• Evolutionary and Medical Consequences of Archaic Introgression into Modern Human Genomes

  2018cites this paper
• Genetic and evolutionary determinants of human population variation in immune responses.

  2018cites this paper
• Genetic, Transcriptome, Proteomic, and Epidemiological Evidence for Blood-Brain Barrier Disruption and Polymicrobial Brain Invasion as Determinant Factors in Alzheimer’s Disease

  2017cites this paper
• entenarians as extreme phenotypes : An ecological perspective to get nsight into the relationship between the genetics of longevity and ge-associated diseases

  2017cites this paper
• Population Genetics and Natural Selection in Rheumatic Disease.

  2017cites this paper
• Centenarians as extreme phenotypes: An ecological perspective to get insight into the relationship between the genetics of longevity and age-associated diseases.

  2017cites this paper
• Living in an adaptive world: Genomic dissection of the genus Homo and its immune response

  2017influential citation
• Une perspective génétique sur notre histoire : migrations humaines et adaptation à l’environnement

  2017cites this paper
• Génétique fonctionnelle et validation biologique d’un locus quantitatif d’expression lié en trans- à un réseau de gènes impliqués dans l’immunité innée

  2017cites this paper
• Loss of CMAH during Human Evolution Primed the Monocyte–Macrophage Lineage toward a More Inflammatory and Phagocytic State

  2017cites this paper
• A balance between regulatory constraints and pathogen pressure shapes the evolution of innate immunity

  2017cites this paper
• Gene expression variability across cells and species shapes innate immunity

  2017cites this paper
• [Innate immunity and human diseases: from archaic introgression to natural selection].

  2016cites this paper
• Chronic inflammatory systemic diseases

  2016cites this paper
• An Emerging Epidemic of Noncommunicable Diseases in Developing Populations Due to a Triple Evolutionary Mismatch.

  2016cites this paper
• Statistical Methods in Population Genetics for Next-Generation Sequencing Data

  2016cites this paper
• The Effects of "Preferentialism" on a Genetic Algorithm Population over Elitism and Regular Development in a Binary F6 Fitness Function

  2016cites this paper
• Genetic Ancestry and Natural Selection Drive Population Differences in Immune Responses to Pathogens.

  2016influential citation
• Understanding rare and common diseases in the context of human evolution

  2016influential citation
• Genetic Adaptation and Neandertal Admixture Shaped the Immune System of Human Populations

  2016cites this paper
• Genetic and epigenetic variation of human populations: An adaptive tale.

  2016cites this paper
• [Innate immunity and human diseases: from archaic introgression to natural selection].

  2016cites this paper
• The burden of multiple sclerosis variants in continental Italians and Sardinians

  2015cites this paper
• Rapid Detection of Neutrophil Oxidative Burst Capacity is Predictive of Whole Blood Cytokine Responses

  2015cites this paper
• Gene Expression Profiles from Disease Discordant Twins Suggest Shared Antiviral Pathways and Viral Exposures among Multiple Systemic Autoimmune Diseases

  2015cites this paper
• Evolutionary aspects of immunopathological phenomena with emphasis on COVID-19

  year unknowncites this paper