SCIENCE@home

Integrins meet complement: The evolutionary tip of an iceberg orchestrating metabolism and immunity

N. Merle,Parul Singh,J. Rahman,C. Kemper

Published 2020 in British Journal of Pharmacology

ABSTRACT

Immunologists have recently realized that there is more to the classic innate immune sensor systems than just mere protection against invading pathogens. It is becoming increasingly clear that such sensors, including the inflammasomes, toll‐like receptors, and the complement system, are heavily involved in the regulation of basic cell physiological processes and particularly those of metabolic nature. In fact, their “non‐canonical” activities make sense as no system directing immune cell activity can perform such task without the need for energy. Further, many of these ancient immune sensors appeared early and concurrently during evolution, particularly during the developmental leap from the single‐cell organisms to multicellularity, and therefore crosstalk heavily with each other. Here, we will review the current knowledge about the emerging cooperation between the major inter‐cell communicators, integrins, and the cell‐autonomous intracellularly and autocrine‐active complement, the complosome, during the regulation of single‐cell metabolism.

PUBLICATION RECORD

CITATION MAP

EXTRACTION MAP

CLAIMS

  • No claims are published for this paper.

CONCEPTS

  • No concepts are published for this paper.

REFERENCES

Showing 1-100 of 170 references · Page 1 of 2

12
Next

CITED BY

Showing 1-26 of 26 citing papers · Page 1 of 1