The role of XPC: implications in cancer and oxidative DNA damage.

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Mutation research

• Publication date

  2011-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.mrrev.2011.07.001PMID 21763452PMCID PMC3203325
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Microarray analysis of microRNA expression in skin of Xpc+/− mice and wild-type mice

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• XPC silencing in normal human keratinocytes triggers metabolic alterations that drive the formation of squamous cell carcinomas.

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  2010cited by this paper
• ATM Activation by Oxidative Stress

  2010cited by this paper
• XPC silencing sensitizes glioma cells to arsenic trioxide via increased oxidative damage.

  2010cited by this paper
• Scanning the DNA for damage by the nucleotide excision repair machinery.

  2010cited by this paper
• XPC epigenetic silence coupled with p53 alteration has a significant impact on bladder cancer outcome.

  2010cited by this paper
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  2010cited by this paper
• Genotypes, haplotypes and diplotypes of three XPC polymorphisms in urinary-bladder cancer patients.

  2010cited by this paper
• Localization of xeroderma pigmentosum group A protein and replication protein A on damaged DNA in nucleotide excision repair

  2010cited by this paper
• The oncogenic phosphatase WIP1 negatively regulates nucleotide excision repair.

  2010cited by this paper
• p53 dysfunction by xeroderma pigmentosum group C defects enhance lung adenocarcinoma metastasis via increased MMP1 expression.

  2010cited by this paper
• Checkpoint Kinase ATR Promotes Nucleotide Excision Repair of UV-induced DNA Damage via Physical Interaction with Xeroderma Pigmentosum Group A*

  2009cited by this paper
• A field synopsis on low-penetrance variants in DNA repair genes and cancer susceptibility.

  2009cited by this paper
• Disorders of nucleotide excision repair: the genetic and molecular basis of heterogeneity

  2009influential reference
• Coordination of dual incision and repair synthesis in human nucleotide excision repair

  2009cited by this paper
• ATR kinase as master regulator of nucleotide excision repair during S phase of the cell cycle

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• Human SNF5/INI1, a Component of the Human SWI/SNF Chromatin Remodeling Complex, Promotes Nucleotide Excision Repair by Influencing ATM Recruitment and Downstream H2AX Phosphorylation

  2009cited by this paper
• Versatile DNA damage detection by the global genome nucleotide excision repair protein XPC

  2008cited by this paper
• Dissection of the Molecular Defects Caused by Pathogenic Mutations in the DNA Repair Factor XPC

  2008cited by this paper
• XPC: its product and biological roles.

  2008cited by this paper
• ATR kinase is required for global genomic nucleotide excision repair exclusively during S phase in human cells

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• XPC polymorphisms play a role in tissue-specific carcinogenesis: a meta-analysis

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• The 8,5'-cyclopurine-2'-deoxynucleosides: candidate neurodegenerative DNA lesions in xeroderma pigmentosum, and unique probes of transcription and nucleotide excision repair.

  2008cited by this paper
• Evaluation of oxidative stress in colorectal cancer patients.

  2008cited by this paper
• Oxidative DNA damage in XPC-knockout and its wild mice treated with equine estrogen.

  2008cited by this paper
• Bulky DNA lesions induced by reactive oxygen species.

  2008cited by this paper
• Mouse models for xeroderma pigmentosum group A and group C show divergent cancer phenotypes.

  2008influential reference
• Nucleotide excision repair driven by the dissociation of CAK from TFIIH.

  2008cited by this paper
• Associations between XPC polymorphisms and risk of cancers: A meta-analysis.

  2008cited by this paper
• Population distribution of xeroderma pigmentosum.

  2008cited by this paper
• Transcription-coupled nucleotide excision repair in mammalian cells: molecular mechanisms and biological effects

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  2007cited by this paper
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  2007cited by this paper
• Cockayne syndrome B protein stimulates apurinic endonuclease 1 activity and protects against agents that introduce base excision repair intermediates

  2007cited by this paper
• ATR-dependent checkpoint modulates XPA nuclear import in response to UV irradiation

  2007cited by this paper
• Deficient base excision repair of oxidative DNA damage induced by methylene blue plus visible light in xeroderma pigmentosum group C fibroblasts.

  2007cited by this paper
• The case for 8,5'-cyclopurine-2'-deoxynucleosides as endogenous DNA lesions that cause neurodegeneration in xeroderma pigmentosum.

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• Attenuated expression of xeroderma pigmentosum group C is associated with critical events in human bladder cancer carcinogenesis and progression.

  2007cited by this paper
• The role of glutathione in the regulation of nucleotide excision repair during oxidative stress.

  2007cited by this paper
• Xeroderma pigmentosum group C gene expression is predominantly regulated by promoter hypermethylation and contributes to p53 mutation in lung cancers

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• RNA polymerase II bypasses 8-oxoguanine in the presence of transcription elongation factor TFIIS.

  2007cited by this paper
• The Involvement of Ataxia-telangiectasia Mutated Protein Activation in Nucleotide Excision Repair-facilitated Cell Survival with Cisplatin Treatment*

  2006cited by this paper
• Cockayne syndrome A and B proteins differentially regulate recruitment of chromatin remodeling and repair factors to stalled RNA polymerase II in vivo.

  2006cited by this paper
• Photolyases: capturing the light to battle skin cancer.

  2006influential reference
• Cullin 4A-mediated Proteolysis of DDB2 Protein at DNA Damage Sites Regulates in Vivo Lesion Recognition by XPC*

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• The protein shuffle

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• Nucleotide Excision Repair Disorders and the Balance Between Cancer and Aging

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• DNA Repair and Mutagenesis

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• Recruitment of the Nucleotide Excision Repair Endonuclease XPG to Sites of UV-Induced DNA Damage Depends on Functional TFIIH

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• New functions of XPC in the protection of human skin cells from oxidative damage

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• Centrin 2 Stimulates Nucleotide Excision Repair by Interacting with Xeroderma Pigmentosum Group C Protein

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• Deletion of XPC leads to lung tumors in mice and is associated with early events in human lung carcinogenesis.

  2005cited by this paper
• Ataxia Telangiectasia Mutated (ATM) and ATM and Rad3-related Protein Exhibit Selective Target Specificities in Response to Different Forms of DNA Damage*

  2005cited by this paper
• Cooperation of the Cockayne Syndrome Group B Protein and Poly(ADP-Ribose) Polymerase 1 in the Response to Oxidative Stress

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• UV-induced ubiquitylation of XPC protein mediated by UV-DDB-ubiquitin ligase complex.

  2005cited by this paper
• XPC polymorphisms and lung cancer risk

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  2003cited by this paper
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  2003cited by this paper
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  2003cited by this paper
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• Strand-specific binding of RPA and XPA to damaged duplex DNA.

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• Functional crosstalk between hOgg1 and the helicase domain of Cockayne syndrome group B protein.

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• The Cockayne Syndrome Group B Gene Product Is Involved in Cellular Repair of 8-Hydroxyadenine in DNA*

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• Sequential binding of UV DNA damage binding factor and degradation of the p48 subunit as early events after UV irradiation.

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• An intronic poly (AT) polymorphism of the DNA repair gene XPC and risk of squamous cell carcinoma of the head and neck: a case-control study.

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